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Overview
1.1
1.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LR699007.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | betalactone | 1,077,495 | 1,102,926 |
Region 2 | thiopeptide | 2,710,764 | 2,736,926 | O-antigen | Saccharide | 14%

NZ_LR699007.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,077,495 - 1,102,926 nt. (total: 25,432 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.20 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.16 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001441.1 |  | 0.14 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001128.1 |  | 0.14 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.14 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000597.1 |  | 0.13 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.13 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.13 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000805.1 |  | 0.13 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001160.1 |  | 0.13 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.53 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.46 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001441.1 |  | 0.44 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001128.1 |  | 0.43 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.43 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000597.1 |  | 0.42 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.42 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.42 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000805.1 |  | 0.41 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001160.1 |  | 0.41 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LR699007.1 - Region 2 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,710,764 - 2,736,926 nt. (total: 26,163 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000784.1 |  | 0.25 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000781.1 |  | 0.16 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001285.1 |  | 0.07 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000981.1 |  | 0.04 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0001302.1 |  | 0.04 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.04 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.04 | Polyketide | arsono-polyketide | Streptomyces lividans 1326

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000784.1 |  | 0.59 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000781.1 |  | 0.47 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001285.1 |  | 0.29 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000981.1 |  | 0.20 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0001302.1 |  | 0.20 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.20 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.19 | Polyketide | arsono-polyketide | Streptomyces lividans 1326

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.