LOCUS       NZ_CP033844.1          10624 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP033844.1 Klebsiella oxytoca strain FDAARGOS_500 chromosome,
            complete genome.
ACCESSION   NZ_CP033844
VERSION     NZ_CP033844.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:33:22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3569047
            Orig. end    :: 3579671
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10624
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3574047:3574671](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5624
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10624
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10624
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(2486..2992)
                     /locus_tag="ctg1_3327"
                     /transl_table=11
                     /translation="MIPLLAIAAWSGTGKTTLLKALIPALRAEGLRPGLIKHTHHDMDV
                     DKPGKDSYELRKAGAAQTIVASSQRWALMTETPDKPSLDLAWLVSRMDASTLDLVLVEG
                     FKHEPVPKILLYRHNSGHSTEELVFDDNVIAIASDRPVETSLPLLDLNDVPQIAAFIMQ
                     WLKGV"
     aSDomain        complement(2501..2980)
                     /aSDomain="TIGR00176"
                     /aSTool="tigrfam"
                     /description="mobB: molybdopterin-guanine dinucleotide
                     biosynthesis protein B"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3327_0009"
                     /evalue="7.90E-52"
                     /identifier="TIGR00176"
                     /label="ctg1_3327"
                     /locus_tag="ctg1_3327"
                     /protein_end="164"
                     /protein_start="4"
                     /score="173.4"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKALIPALRAEGLRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTIVASSQRWALMTETPDKPSLDLAWLVSRMDASTLDLVLVEGFKHE
                     PVPKILLYRHNSGHSTEELVFDDNVIAIASDRPVETSLPLLDLNDVPQIAAFIMQW"
     PFAM_domain     complement(2576..2980)
                     /aSDomain="MobB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03205.16"
                     /description="Molybdopterin guanine dinucleotide synthesis
                     protein B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3327_0063"
                     /evalue="3.80E-48"
                     /label="ctg1_3327"
                     /locus_tag="ctg1_3327"
                     /protein_end="139"
                     /protein_start="4"
                     /score="162.9"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKALIPALRAEGLRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTIVASSQRWALMTETPDKPSLDLAWLVSRMDASTLDLVLVEGFKHE
                     PVPKILLYRHNSGHSTEELVFDDNVIAIASD"
     CDS             complement(2989..3570)
                     /locus_tag="ctg1_3328"
                     /transl_table=11
                     /translation="MQGEVITGVVLAGGRGTRMGGIDKGLQLLNGKALWRHVADTLQPQ
                     VARLVISANRNLDCWRSSGYPIITDSLNDFPGPLAGMLSVMHQVEGEWFLFCPCDTPFI
                     PSFLATRLVQHKTSALAVWVHDGERDHPAIALVNRKVIGELETYLAAGERRVMVFLHKI
                     GGHSVDFSDVKSAFINVNTLDDLQHMQVPS"
     aSDomain        complement(3010..3555)
                     /aSDomain="TIGR02665"
                     /aSTool="tigrfam"
                     /description="molyb_mobA: molybdenum cofactor
                     guanylyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3328_0010"
                     /evalue="1.40E-66"
                     /identifier="TIGR02665"
                     /label="ctg1_3328"
                     /locus_tag="ctg1_3328"
                     /protein_end="187"
                     /protein_start="5"
                     /score="222.1"
                     /tool="antismash"
                     /translation="ITGVVLAGGRGTRMGGIDKGLQLLNGKALWRHVADTLQPQVARLV
                     ISANRNLDCWRSSGYPIITDSLNDFPGPLAGMLSVMHQVEGEWFLFCPCDTPFIPSFLA
                     TRLVQHKTSALAVWVHDGERDHPAIALVNRKVIGELETYLAAGERRVMVFLHKIGGHSV
                     DFSDVKSAFINVNTLDDLQ"
     PFAM_domain     complement(3097..3549)
                     /aSDomain="NTP_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12804.9"
                     /description="MobA-like NTP transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3328_0064"
                     /evalue="7.00E-31"
                     /label="ctg1_3328"
                     /locus_tag="ctg1_3328"
                     /protein_end="158"
                     /protein_start="7"
                     /score="107.8"
                     /tool="antismash"
                     /translation="GVVLAGGRGTRMGGIDKGLQLLNGKALWRHVADTLQPQVARLVIS
                     ANRNLDCWRSSGYPIITDSLNDFPGPLAGMLSVMHQVEGEWFLFCPCDTPFIPSFLATR
                     LVQHKTSALAVWVHDGERDHPAIALVNRKVIGELETYLAAGERRVMV"
     PFAM_domain     3642..3899
                     /aSDomain="DUF1040"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06288.15"
                     /description="Protein of unknown function (DUF1040)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3329_0065"
                     /evalue="1.40E-45"
                     /label="ctg1_3329"
                     /locus_tag="ctg1_3329"
                     /protein_end="86"
                     /protein_start="0"
                     /score="153.7"
                     /tool="antismash"
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAKEAGYAGELSDL
                     SDDILIYHLKMRDSAKEAVIPGIQKDYEEDFKTALLRARGV"
     CDS             3642..3911
                     /locus_tag="ctg1_3329"
                     /transl_table=11
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAKEAGYAGELSDL
                     SDDILIYHLKMRDSAKEAVIPGIQKDYEEDFKTALLRARGVIKE"
     CDS             3987..4973
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3330"
                     /sec_met_domain="APH (E-value: 1.7e-42, bitscore: 144.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDKAFTFQTLHPDTIIDGLFDLGMRVDSGLTPLNSYENRVYQFQ
                     DEGRRRYVVKFYRPERWSAEQILEEHHFSLQLVEDDVPVAAPLSFNESTLHQHQGFFFA
                     VFPSLGGRQFEADNLDQMEWVGRYLGRMHQTGRKQRFVARPEIGTNEYLLEPRQVFELS
                     PLIPAGLKDAFLSATDKLIDAVMAQWHGRANILRLHGDCHAGNILWRDGPLFVDLDDSR
                     NGPAIQDLWMLLNGDKPEQRMQLEMIIEAYEEFSPFNTDEIALIEPLRAMRLVYYLAWL
                     LRRWEDPAFPKNFPWLTGEDYWRGQTTTFLEQVKVLQEPPLQLTPMY"
     PFAM_domain     4080..4751
                     /aSDomain="APH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01636.25"
                     /description="Phosphotransferase enzyme family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3330_0066"
                     /evalue="7.70E-43"
                     /label="ctg1_3330"
                     /locus_tag="ctg1_3330"
                     /protein_end="255"
                     /protein_start="31"
                     /score="147.1"
                     /tool="antismash"
                     /translation="TPLNSYENRVYQFQDEGRRRYVVKFYRPERWSAEQILEEHHFSLQ
                     LVEDDVPVAAPLSFNESTLHQHQGFFFAVFPSLGGRQFEADNLDQMEWVGRYLGRMHQT
                     GRKQRFVARPEIGTNEYLLEPRQVFELSPLIPAGLKDAFLSATDKLIDAVMAQWHGRAN
                     ILRLHGDCHAGNILWRDGPLFVDLDDSRNGPAIQDLWMLLNGDKPEQRMQLEMIIEAYE
                     EF"
     CDS             5001..5624
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3331"
                     /sec_met_domain="TIGR03651 (E-value: 0.0004, bitscore:
                     18.9, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIWLALAGMILAFSASAAQITDGKQYITLDKPVAGEPQVLEFF
                     SFYCPHCYQFEEVLHVSDNVKKKLPEGVKMTKYHVEFLGPLGKDLTQAWAVAMALGVED
                     KITVPMFEAVQKNQTVQTVADIRKVFVDAGVKGEDYDAAWNSFVVKSLVAQQEKAAADF
                     QLQGVPAMYVNGKYQLNPQGMDTSNMDAFVAQYADTVKQLVDKK"
     PFAM_domain     5118..5588
                     /aSDomain="DSBA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01323.22"
                     /description="DSBA-like thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3331_0067"
                     /evalue="1.40E-28"
                     /label="ctg1_3331"
                     /locus_tag="ctg1_3331"
                     /protein_end="196"
                     /protein_start="39"
                     /score="100.1"
                     /tool="antismash"
                     /translation="QVLEFFSFYCPHCYQFEEVLHVSDNVKKKLPEGVKMTKYHVEFLG
                     PLGKDLTQAWAVAMALGVEDKITVPMFEAVQKNQTVQTVADIRKVFVDAGVKGEDYDAA
                     WNSFVVKSLVAQQEKAAADFQLQGVPAMYVNGKYQLNPQGMDTSNMDAFVAQY"
     CDS             complement(5674..6573)
                     /locus_tag="ctg1_3332"
                     /transl_table=11
                     /translation="MPRLLAAITLPLSIALTIIVTVICSVPIIIAGLIKLLVPVPAVWR
                     SISVFCNFMMYCWCEGLAWLLRLNPCLKWDVQGLDGLSKKNWYLLISNHHSWADIVVLC
                     VLFRKHIPMNKYFLKQQLAWVPFIGLACWALDMPFMRRYSRGYLLRHPERRGRDVETTR
                     RSCEKFRAHPTTIVNFVEGSRFTEEKRQLTRSPYHNLLAPKAAGIAMALSVLGSQFDKL
                     LNVTVCYPENNQRPFYDMLSGRLTRIVVRIHLEPVAEELHGDYVNDKNFKRRFQRWLNT
                     LWEEKDRQLTEIMQQAKK"
     PFAM_domain     complement(5980..6351)
                     /aSDomain="Acyltransferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01553.23"
                     /description="Acyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3332_0068"
                     /evalue="5.10E-12"
                     /label="ctg1_3332"
                     /locus_tag="ctg1_3332"
                     /protein_end="198"
                     /protein_start="74"
                     /score="45.7"
                     /tool="antismash"
                     /translation="DVQGLDGLSKKNWYLLISNHHSWADIVVLCVLFRKHIPMNKYFLK
                     QQLAWVPFIGLACWALDMPFMRRYSRGYLLRHPERRGRDVETTRRSCEKFRAHPTTIVN
                     FVEGSRFTEEKRQLTRSPYH"
     CDS             6970..9759
                     /locus_tag="ctg1_3333"
                     /transl_table=11
                     /translation="MVQIPENPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNM
                     LRSLILQYQPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGL
                     PLMAVPGVEADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPD
                     EVVTKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIA
                     GLTFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELDLGCEDLLVEQPVADELLTLFKK
                     YEFKRWITDVESGKWMQAKGAKSAARPLAAAAEVAEAEEETATVLSAENYVTILDEQTL
                     LTWIENLKKAPLFAFDTETDSLDNVSANMVGLSFAIEPGVAAYVPVAHDYLDAPDQIPR
                     DRVLELLKPLLEDGKVLKVGQNLKYDRGILANYGIELRGIAFDTMLESYILDSVAGRHD
                     MDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPEL
                     QQNEGPLNVFKNIEMPLVPVLSRVERNGVKIDPAVLHAHSQEIAKRLIELEKKAYDIAG
                     EEFNLSSPKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLA
                     KLKSTYTDKLPLMISPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAF
                     IAPEDYLIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLESVSSE
                     QRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRTQAKE
                     QGYVETLDGRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDGWLLSE
                     KPRVRMIMQVHDELVFEVHKDDLEAVAKKIHELMESSTTLAVPLLVEVGSGENWDQAH"
     PFAM_domain     6994..7479
                     /aSDomain="5_3_exonuc_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02739.18"
                     /description="5'-3' exonuclease, N-terminal resolvase-like
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3333_0069"
                     /evalue="2.40E-54"
                     /label="ctg1_3333"
                     /locus_tag="ctg1_3333"
                     /protein_end="170"
                     /protein_start="8"
                     /score="183.6"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLMAVPGV
                     EADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPDEVVTKYG"
     aSDomain        6994..9756
                     /aSDomain="TIGR00593"
                     /aSTool="tigrfam"
                     /description="pola: DNA polymerase I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3333_0011"
                     /evalue="8.70E-287"
                     /identifier="TIGR00593"
                     /label="ctg1_3333"
                     /locus_tag="ctg1_3333"
                     /protein_end="929"
                     /protein_start="8"
                     /score="952.1"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLMAVPGV
                     EADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPDEVVTKYGV
                     PPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIAGLTFRGAK
                     TMAAKLEQNKEVAYLSYQLATIKTDVELDLGCEDLLVEQPVADELLTLFKKYEFKRWIT
                     DVESGKWMQAKGAKSAARPLAAAAEVAEAEEETATVLSAENYVTILDEQTLLTWIENLK
                     KAPLFAFDTETDSLDNVSANMVGLSFAIEPGVAAYVPVAHDYLDAPDQIPRDRVLELLK
                     PLLEDGKVLKVGQNLKYDRGILANYGIELRGIAFDTMLESYILDSVAGRHDMDSLSDRW
                     LKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPELQQNEGPLN
                     VFKNIEMPLVPVLSRVERNGVKIDPAVLHAHSQEIAKRLIELEKKAYDIAGEEFNLSSP
                     KQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTD
                     KLPLMISPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYLI
                     VSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLESVSSEQRRSAKAI
                     NFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRTQAKEQGYVETLD
                     GRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDGWLLSEKPRVRMIM
                     QVHDELVFEVHKDDLEAVAKKIHELMESSTTLAVPLLVEVGSGENWDQAH"
     PFAM_domain     7480..7779
                     /aSDomain="5_3_exonuc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01367.22"
                     /description="5'-3' exonuclease, C-terminal SAM fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3333_0070"
                     /evalue="1.50E-29"
                     /label="ctg1_3333"
                     /locus_tag="ctg1_3333"
                     /protein_end="270"
                     /protein_start="170"
                     /score="102.5"
                     /tool="antismash"
                     /translation="VPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLY
                     AEPEKIAGLTFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELDLGCEDLLVEQP"
     PFAM_domain     7960..8523
                     /aSDomain="DNA_pol_A_exo1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01612.22"
                     /description="3'-5' exonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3333_0071"
                     /evalue="1.60E-42"
                     /label="ctg1_3333"
                     /locus_tag="ctg1_3333"
                     /protein_end="518"
                     /protein_start="330"
                     /score="145.3"
                     /tool="antismash"
                     /translation="YVTILDEQTLLTWIENLKKAPLFAFDTETDSLDNVSANMVGLSFA
                     IEPGVAAYVPVAHDYLDAPDQIPRDRVLELLKPLLEDGKVLKVGQNLKYDRGILANYGI
                     ELRGIAFDTMLESYILDSVAGRHDMDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALE
                     EAGRYAAEDADVTLQLHLKMWPELQ"
     PFAM_domain     8626..9747
                     /aSDomain="DNA_pol_A"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00476.22"
                     /description="DNA polymerase family A"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3333_0072"
                     /evalue="6.60E-158"
                     /label="ctg1_3333"
                     /locus_tag="ctg1_3333"
                     /protein_end="926"
                     /protein_start="552"
                     /score="525.8"
                     /tool="antismash"
                     /translation="LHAHSQEIAKRLIELEKKAYDIAGEEFNLSSPKQLQTILFEKQGI
                     KPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMISPKTGRV
                     HTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYLIVSADYSQIELRIM
                     AHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLESVSSEQRRSAKAINFGLIYGMSAFGL
                     ARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRTQAKEQGYVETLDGRRLYLPDIKSSN
                     GARRAGAERAAINAPMQGTAADIIKRAMIAVDGWLLSEKPRVRMIMQVHDELVFEVHKD
                     DLEAVAKKIHELMESSTTLAVPLLVEVGSGENWD"
ORIGIN
        1 agcactgttt cggctagggg gtcatcccga cttaccaacc cgatgcaaac tacgaatacc
       61 gaagaatgtt atcacgggag acacacggcg ggtgctaacg tccgtcgtga agagggaaac
      121 aacccagacc gccagctaag gtcccaaagt catggttaag tgggaaacga tgtgggaagg
      181 cccagacagc caggatgttg gcttagaagc agccatcatt taaagaaagc gtaatagctc
      241 actggtcgag tcggcctgcg cggaagatgt aacggggcta aaccatgcac cgaagctgcg
      301 gcagcgacac tatgtgttgt tgggtagggg agcgttctgt aagccgttga aggtggcctg
      361 tgagggttgc tggaggtatc agaagtgcga atgctgacat aagtaacgat aatgcgggtg
      421 aaaaacccgc acgccggaag accaagggtt cctgtccaac gttaatcggg gcagggtgag
      481 tcgaccccta aggcgaggcc gaaaggcgta gtcgatggga aacaggttaa tattcctgta
      541 cttggtgtta ctgcgaaggg ggacggagaa ggctatgttg gccgggcgac ggttgtcccg
      601 gtttaagcat gtaggcggat gttccaggta aatccggaac gtcactaacg ctgaggtgtg
      661 atgacgaggc actacggtgc tgaagtgaca aatgccctgc ttccaggaaa agcctctaag
      721 catcaggtaa catcaaatcg taccccaaac cgacacaggt ggtcaggtag agaataccaa
      781 ggcgcttgag agaactcggg tgaaggaact aggcaaaatg gtgccgtaac ttcgggagaa
      841 ggcacgctga tggtaggtga agtgacttgc tcatggagct gaaatcagtc gaagatacca
      901 gctggctgca actgtttatt aaaaacacag cactgtgcaa acacgaaagt ggacgtatac
      961 ggtgtgacgc ctgcccggtg ccggaaggtt aattgatggg gttatcctca cggagaagct
     1021 cttgatcgaa gccccggtaa acggcggccg taactataac ggtcctaagg tagcgaaatt
     1081 ccttgtcggg taagttccga cctgcacgaa tggcgtaatg atggccaggc tgtctccacc
     1141 cgagactcag tgaaattgaa ctcgctgtga agatgcagtg tacccgcggc aagacggaaa
     1201 gaccccgtga acctttacta tagcttgaca ctgaacactg gtccttgatg tgtaggatag
     1261 gtgggaggct ttgaagtgtg gacgccagtc tgcatggagc cgtccttgaa ataccaccct
     1321 ttaatggctg gtgttctaac gtgggcccgt gatccgggtt gcggacagtg tctggtgggt
     1381 agtttgactg gggcggtctc ctcctaaaga gtaacggagg agcacgaagg tcagctaatc
     1441 ctggtcggac atcaggaggt tagtgcaatg gcataagctg gcttgactgc gagcgtgacg
     1501 gcgcgagcag gtgcgaaagc aggtcatagt gatccggtgg ttctgaatgg aagggccatc
     1561 gctcaacgga taaaaggtac tccggggata acaggctgat accgcccaag agttcatatc
     1621 gacggcggtg tttggcacct cgatgtcggc tcatcacatc ctggggctga agtaggtccc
     1681 aagggtatgg ctgttcgcca tttaaagtgg tacgcgagct gggtttagaa cgtcgtgaga
     1741 cagttcggtc cctatctgcc gtgggcgctg gagaattgag ggggctgctc ctagtacgag
     1801 aggaccggag tggacgcatc actggtgttc gggttgtcat gccaatggca ttgcccggta
     1861 gctaaatgcg gaagagataa gtgctgaaag catctaagca cgaaacttgc cccgagatga
     1921 gttctccctg actccttgag agtcctgaag gaacgttgaa gacgacgacg ttgataggcc
     1981 gggtgtgtaa gcgcagcgat gcgttgagct aaccggtact aatgaaccgt gaggcttaac
     2041 cttacaacgc cgaagatgtt ttggcggatt tgagaagaca acaatttcag cattgattac
     2101 agattttcgg gaacgaaaga ttttacgctg aggcaaggcg gcaaatgaag gaaaggaagg
     2161 agcatactga agtatgtgac tgactttacg aatgcagcca acgcagcatc ggtgtaaaag
     2221 attcgtttct gacaacagaa tttgcctggc ggcgatagcg cggtggtccc acctgacccc
     2281 atgccgaact cagaagtgaa acgccgtagc gccgatggta gtgtggggtc tccccatgtg
     2341 agagtaggga actgccaggc atcaaacaag tgaagagccc atcctgacgg atgggctttt
     2401 tgcgtttttg tcgtctgaaa ataccaacag aaaccttcag gtcgatagat caaggctatg
     2461 ttcctgaaaa tttacctgct cctggctaaa ccccttttaa ccactgcata ataaaagcgg
     2521 ctatctgcgg aacatcgttt aaatctaaca gtggaagcga cgtctcgacc ggcctatcgc
     2581 tggcgatagc aatcacatta tcgtcaaaca ctaattcttc tgtactatgc ccgctgttgt
     2641 gccgataaag caggattttg ggcacgggtt catgtttaaa accctcaacc aggactaaat
     2701 ccaacgttga ggcatccatt cggctgacca gccatgccag atccagtgaa ggcttatctg
     2761 gcgtttccgt cattaatgcc caacgctgcg aactggcgac aatggtctga gccgctccgg
     2821 ctttacgcag ttcataactg tctttacccg gcttatccac gtccatatcg tgatgggtat
     2881 gtttaattag ccctggccgt aaaccttctg cgcgcagtgc cggaatcaga gccttcaata
     2941 aggttgtttt acctgtaccg ctccaggcgg cgatggctaa aagtgggatc atgatggcac
     3001 ctgcatatgt tgcaaatcgt cgagagtatt aacgtttata aatgctgatt ttacatcgct
     3061 aaaatcgacg ctatgaccgc caattttgtg cagaaatacc attactcgcc gctctcctgc
     3121 ggccagatac gtttccagtt cgccgatcac cttgcgattt accagagcaa tggccggatg
     3181 gtctcgttca ccatcgtgta cccaaacggc cagggctgat gttttgtgct gcactaagcg
     3241 agtcgccaga aatgatggga taaatggcgt atcgcacgga caaaacagaa accattcgcc
     3301 ctcgacctga tgcattacgg aaagcatgcc ggccaacggc ccgggaaagt cgttcagaga
     3361 gtcggtaata atcgggtagc cgctgcttcg ccagcaatca agattgcggt tagcgctaat
     3421 caccagcctg gcgacctgag gctgcagcgt atcggcgaca tgacgccaca gggccttacc
     3481 attcagcagc tgtaatcctt tatctattcc tcccatgcgc gtgcctcttc cccccgctag
     3541 cacaacgccg gttattacct caccctgcat atcaatatcg cctctttcat tgtgggtttg
     3601 tccctgctaa cgtactccta tcaagattaa ggagcattgc tatgaaatgt aaacgcctga
     3661 atgaagtgat tgaactcctc cagccggcct ggcagaaaga acctgaactg aatttgatgc
     3721 aattcttgca aaaactagcg aaagaagcgg gttatgctgg cgaattgagc gatctttccg
     3781 acgatattct gatctaccat ttgaaaatgc gcgactcggc aaaagaggcc gttattccgg
     3841 gtatccagaa agattatgaa gaagatttta aaaccgcctt gctacgcgcc cgcggcgtga
     3901 ttaaagagta aaaggttgta agcgctgccg cggaatcggc aatgagatga tatcctgtat
     3961 cattcgtacg attatcggat gtcaggatgc acgataaggc tttcactttt cagacgcttc
     4021 acccggatac catcattgat ggtttatttg atctgggtat gcgggtagat tccggtctca
     4081 ctccgcttaa tagctatgag aaccgagttt atcagtttca ggacgaaggt cgtcgccgct
     4141 atgtggtgaa gttctatcgt cctgagcgct ggtctgccga acaaatcctc gaagaacacc
     4201 acttttcgct tcagctcgtt gaggacgacg tgcccgttgc ggcgcctttg tcgtttaacg
     4261 agagcacgct tcaccaacat cagggattct ttttcgccgt cttccccagc ctgggtggac
     4321 gtcagtttga ggcggataat ctcgatcaga tggagtgggt tgggcgttat cttggccgta
     4381 tgcatcaaac gggacgcaaa cagcgctttg tcgctcgtcc ggagataggc accaatgagt
     4441 atcttctgga gccccgacag gtctttgagc tctccccgct gattcctgct ggcctgaaag
     4501 atgcctttct cagcgctacc gataaactca ttgacgcggt aatggcgcaa tggcacggac
     4561 gcgccaatat tttacggtta cacggtgatt gccatgcggg aaacatcctc tggcgcgatg
     4621 gccccttgtt tgttgattta gatgattcac gtaacggccc tgctatccag gatctgtgga
     4681 tgctgttgaa cggtgataaa cccgagcagc gtatgcagct tgagatgatt attgaagcgt
     4741 atgaagagtt tagccctttc aatacggatg agattgctct tatcgagcct ttacgtgcaa
     4801 tgcggttagt ttattatctg gcgtggttgt taaggcgctg ggaagatccc gctttcccta
     4861 aaaatttccc atggttgacc ggggaagatt actggcgcgg gcagacaaca acttttcttg
     4921 agcaggtaaa ggttctgcaa gaaccgcctc ttcagttaac gccaatgtat taatgtgata
     4981 tatccaggag agagttaatc atgaaaaaaa tttggctggc gctggctggt atgattctgg
     5041 cttttagtgc atccgctgcc cagatcaccg acggtaagca gtatattacc ctcgataaac
     5101 ccgttgccgg tgagcctcag gtgctcgagt ttttctcgtt ctattgcccg cattgctatc
     5161 agtttgaaga agtccttcac gtatcagata acgtgaagaa aaagctgccg gaaggcgtca
     5221 aaatgacaaa ataccacgtt gagttcctgg gcccactagg caaggatctg actcaggcat
     5281 gggctgtggc gatggcgctg ggcgtggaag ataagatcac cgtcccaatg tttgaagcgg
     5341 tacagaaaaa ccagaccgtc cagaccgtgg ccgatattcg taaggtcttc gttgatgccg
     5401 gcgtcaaagg tgaagattac gatgcggcct ggaacagctt tgtggtgaaa tctctggtgg
     5461 ctcagcaaga gaaagccgct gctgatttcc agctgcaggg cgtgcctgct atgtacgtta
     5521 atggtaaata ccagcttaat ccgcagggta tggataccag caacatggac gcatttgttg
     5581 cccagtatgc tgataccgtt aagcagctgg ttgataagaa ataaaaaata aacgccggtc
     5641 actgaccggc gtttttcttt tctgcgtccc aagtcacttc tttgcctgct gcatgatttc
     5701 cgttagctgc cgatctttct cttcccagag cgtatttagc caacgctgaa agcgtcgctt
     5761 aaagttttta tcatttacat agtcgccatg cagctcttcc gctacgggct caagatggat
     5821 tcgcaccaca atgcgtgtta atcgaccgct cagcatatcg taaaacggtc tttggttatt
     5881 ttccgggtaa cacaccgtga cgttcaacag cttatcaaac tgcgagccca gcacgcttaa
     5941 tgccattgcg atacctgccg cttttggcgc taacagattg tggtatggcg aacgggttag
     6001 ctgtcgcttt tcttcagtaa aacgtgaacc ttcaacaaag ttgacgatag tggtgggatg
     6061 cgcgcggaat ttctcgcagg agcggcgagt agtttcaaca tctctgccac ggcgctcggg
     6121 atggcggagt aaatagcctc gggaataacg gcgcataaaa ggcatatcca gcgcccagca
     6181 ggccagccca ataaacggaa cccaggcgag ctgttgcttg aggaaatatt tattcatcgg
     6241 aatatgtttg cggaacagga cgcaaagtac cacgatatcg gcccagctgt gatggttgct
     6301 gataagcaga taccagttct ttttactcag accatcaagg ccctgtacat cccatttaag
     6361 acagggatta aggcgcagca gccacgccag tccttcacac cagcagtaca tcatgaaatt
     6421 gcaaaaaacg gatatcgagc gccagaccgc aggaacgggc acaagaagtt taatcagccc
     6481 ggcgatgatg attggcacgg agcagatgac ggtgactatg atagtcaggg cgatactcag
     6541 cgggagcgtt atcgcggcga gtaatctcgg catagttaaa ttattcagaa agttaggctg
     6601 ataaagaacg cctataaaca gcgcaagggg ctgattttat cagaaaatag agtaaataac
     6661 gggtcttacc agaacagaaa aatttctgga tcttatatcc acatggaaca tcgagtcgcc
     6721 atgatgataa taaagcaggt tgtgaaccta taattgcatg ataaatatgg aatatttttc
     6781 cgttatatta ttttattaat cattggtcga tcaacgttat aaaactattc acaaagttat
     6841 ccacaggtta ggccgcaacg cgatcctggg gatcgctgaa tcttttcgac gaaatgtggg
     6901 aaaaattcag gatttaatgt ccgtctgtgg catcctttac cgataatctg ataaacaggc
     6961 acggaaaata tggttcagat cccagaaaac cctctcatcc tcgttgacgg ctcttcttac
     7021 ctttatcggg cataccacgc gttccccccg ctgacgaaca gcgcaggcga accgacaggc
     7081 gccatgtatg gcgtgctgaa tatgctgcga agcctgatcc tgcagtatca accgacccat
     7141 gctgtcgttg tgtttgatgc caagggaaag actttccggg atgaactgtt tgagcactat
     7201 aaatctcatc gtccaccgat gccggacgat ctccgtgcgc agatcgagcc gctgcatgcc
     7261 atggtgaaag cgatgggcct tccgctaatg gccgttcctg gcgtggaagc agacgatgtc
     7321 atcggtaccc tggcccgtga agctgaaaaa gtagggcgtc cggtgctgat cagcaccggt
     7381 gataaagata tggctcagct ggttacgccg ggtattacgc tcattaatac catgactaac
     7441 accatccttg gccccgacga agtcgtgaca aaatacggcg ttccaccgga actgatcatc
     7501 gattttctgg ccctgatggg tgactcctcg gataacattc cgggcgtgcc tggggtgggg
     7561 gagaaaaccg cgcaggcgct tctgcaggga ctgggtggtc ttgatacgtt atatgctgag
     7621 cctgaaaaaa tcgccggatt gactttccgc ggcgcgaaaa cgatggcggc aaagctggaa
     7681 cagaataaag aggtggctta cctctcttat cagctggcga cgatcaaaac ggacgttgaa
     7741 ctggatttgg gctgtgaaga tctgctggtt gaacaacctg ttgcggatga actgctgacg
     7801 ctgtttaaaa aatatgaatt taaacgctgg atcactgatg tagagtccgg taagtggatg
     7861 caggcaaaag gcgctaagtc tgcggccagg ccgctggcag cggctgccga agtggccgag
     7921 gcagaagaag aaaccgcgac agtgctctcc gctgaaaact acgtcaccat tctggatgaa
     7981 caaacattgc tcacctggat tgaaaacctg aagaaagcgc cgctttttgc ctttgatacc
     8041 gaaaccgaca gcctggataa cgtatccgcc aatatggtgg gcctctcctt cgccattgaa
     8101 cctggcgtgg cggcctatgt accggtcgcc catgattatc tggacgcgcc ggatcaaatc
     8161 cctcgcgacc gcgtcctgga attgctgaaa ccgttactgg aagatggcaa ggttctgaag
     8221 gttggacaaa acctcaaata tgaccgcggg atcctggcta actacggcat tgaactgcgc
     8281 ggtattgcct tcgataccat gctggagtcc tacattctcg acagcgtggc gggccgtcat
     8341 gatatggata gtctctccga tcgctggctg aagcacaaaa ccattacctt cgaagaaatc
     8401 gcggggaaag gtaaaaacca gctcacattt aaccaaattg cgctggaaga agcaggccgc
     8461 tacgcggcgg aagatgcgga tgtcaccctg cagctgcacc tcaaaatgtg gcctgaactt
     8521 cagcaaaatg aaggtccgct gaacgtcttt aaaaatattg aaatgccgct ggtgccggtg
     8581 ctatcccgcg tggagcgtaa cggcgtgaag attgatccgg ccgtgctgca tgcgcattct
     8641 caggagatag ccaagcgcct gattgaactg gagaagaagg cgtacgatat tgcgggtgaa
     8701 gagtttaacc tctcgtcgcc gaagcagctg caaacgatct tgtttgaaaa acaaggcatt
     8761 aagccgctga agaaaacccc tggcggtgcg ccttctacct cggaagaggt gctggaagag
     8821 ctggcgctgg actatccgct gccgaaagtt atcctcgaat atcgtggact ggcaaaactt
     8881 aaatccacct ataccgataa gctgccgctg atgatcagcc cgaaaacggg gcgggttcat
     8941 acttcctatc accaggcggt gaccgctacg gggcgtttgt cgtctaccga cccgaacctg
     9001 cagaatattc cggtacgcaa cgaagaaggg cgacgtatcc gccaggcgtt tattgcaccg
     9061 gaagattatc tcattgtctc ggccgactac tcgcaaattg aactgcgcat catggcgcat
     9121 ctctcccgcg ataagggtct gctgaccgca tttgcggaag gcaaagatat ccaccgggcg
     9181 acggcggctg aggtctttgg tttgccgctg gagagcgtta gcagcgagca gcgccgtagc
     9241 gcgaaggcga tcaactttgg tctgatttac ggcatgagcg cattcggtct tgcgcgacag
     9301 ctgaatatcc cacgcaaaga agcgcaaaag tatatggatc tctactttga gcgctatccg
     9361 ggcgttctgg agtatatgga gcgtactcgc acccaggcca aagagcaggg gtatgttgaa
     9421 acgctggacg gtcgtcgtct ctatctgccg gacatcaaat ccagcaatgg cgcgcgtcgc
     9481 gctggcgccg aacgtgcggc gatcaatgcg ccaatgcagg gtaccgcggc cgatatcatt
     9541 aaacgtgcaa tgatcgcggt agacggctgg ctgctaagcg aaaaacctcg cgtgcggatg
     9601 atcatgcagg tgcacgatga actggtcttt gaagtgcata aggacgatct tgaagcggtc
     9661 gcgaaaaaga tccacgaact gatggagagc agtacgacgc tggcggttcc gctgctggtg
     9721 gaagtcggta gtggagaaaa ctgggatcaa gcgcactaag tattcgtcgg gtaaggtcat
     9781 tttttgtaag tgagtaacat aacttatcgt gttttgtgat gatcatttga atttgctatg
     9841 taaagagtga aaaaaaacta caaaaaatgc tttatccgta accgaaagaa gagtagagtt
     9901 aaagacgtag ggtacagagg taagatgttc tatctttcag accttttact tcacgtaatc
     9961 ggatttggct gaatatttta gccgccccgg tcatttatga ccggggcgtt ttttattgcg
    10021 cgaaagaaaa ttttacgcat cgatgcatgc aaaggcgggg agcccggata aggcttcacg
    10081 cgccgctatc cggggttttt tgcgaactta ttcgccgtct tcgggttctt cctgcggcgg
    10141 gatatcgtta taccagctat ccagcttctg acgcagttta tccacacctt gcttcttcag
    10201 ggaagaaaac gcttctacct gcacatctcc gttaaaggcg atgaccgctt cgcgaaccat
    10261 attgatctgc gctttccgcg caccgctggc gagcttatcg gctttagtca gcagtaccag
    10321 caccgggata tcgctttcga cggcccactg gatcatctgc tgatcgagat ctttaagcgg
    10381 atgacgaata tccatcagca ccaccagccc tttcagacag aggcgtttct caagatattc
    10441 acccagcgcg cgctgccact tgatcttcat ctcttccgga acctgggcgt aaccatagcc
    10501 cggcaggtcg acaaggcgtt tgccctcagc gacttcaaac aggttgatca gctgcgtacg
    10561 cccgggcgtc ttcgacgtgc gcgccaggct tttttggtta gtcagcgtat tcagagcgct
    10621 ggat
//
