GCF_000014705.1_ASM1470v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_008345.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	arylpolyene	345,049	388,759	APE Vf	Other	45%
Region 2	RiPP-like	1,060,404	1,068,175
Region 3	PUFA,hglE-KS	1,411,202	1,467,108	eicosapentaenoic acid	Other	83%
Region 4	RiPP-like	2,871,459	2,882,322
Region 5	betalactone	3,267,535	3,296,946	fengycin	NRP	13%

NC_008345.1 - Region 1 - arylpolyene

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Location: 345,049 - 388,759 nt. (total: 43,711 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.29	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.28	Other	APE Ec	Escherichia coli CFT073
BGC0000837.1	0.26	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000221.1	0.25	Polyketide	erdacin	uncultured soil bacterium V167
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0002029.1	0.23	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.23	Other	ferroverdin	Streptomyces lunaelactis
BGC0000889.1	0.23	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0000234.1	0.23	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000194.1	0.22	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.63	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.62	Other	APE Ec	Escherichia coli CFT073
BGC0000837.1	0.59	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000221.1	0.59	Polyketide	erdacin	uncultured soil bacterium V167
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0002029.1	0.57	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.57	Other	ferroverdin	Streptomyces lunaelactis
BGC0000889.1	0.56	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0000234.1	0.56	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000194.1	0.55	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NC_008345.1 - Region 2 - RiPP-like

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Location: 1,060,404 - 1,068,175 nt. (total: 7,772 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001589.1	0.16	Saccharide	exopolysaccharides	Burkholderia cenocepacia J2315
BGC0001588.1	0.16	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0001120.1	0.14	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001838.1	0.05	NRP	WLIP	Pseudomonas putida
BGC0000080.1	0.05	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0002025.1	0.04	NRP	thaxteramide C	Jahnella sp. MSr9139
BGC0001093.1	0.04	NRP, Polyketide	disorazol A	Sorangium cellulosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001589.1	0.46	Saccharide	exopolysaccharides	Burkholderia cenocepacia J2315
BGC0001588.1	0.46	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0001120.1	0.44	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001838.1	0.24	NRP	WLIP	Pseudomonas putida
BGC0000080.1	0.21	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0002025.1	0.19	NRP	thaxteramide C	Jahnella sp. MSr9139
BGC0001093.1	0.18	NRP, Polyketide	disorazol A	Sorangium cellulosum

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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NC_008345.1 - Region 3 - PUFA,hglE-KS

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Location: 1,411,202 - 1,467,108 nt. (total: 55,907 nt) Show pHMM detection rules used

PUFA: PUFA_KS
hglE-KS: (hglE or hglD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000861.1	0.92	Other	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000862.1	0.68	Other	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000863.1	0.61	Other	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000284.1	0.46	Polyketide	phenolic lipids	Azotobacter vinelandii DJ
BGC0000869.1	0.45	Other	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0000865.1	0.39	Other	eicoseicosapentaenoic acid	Photobacterium profundum SS9
BGC0000864.1	0.39	Other	eicosapentaenoic acid-like compound	Moritella marina ATCC 15381
BGC0001872.1	0.38	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0000044.1	0.35	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001264.1	0.31	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000861.1	0.76	Other	eicosapentaenoic acid	Shewanella sp. BR-2
BGC0000862.1	0.67	Other	eicosapentaenoic acid	Shewanella pneumatophori
BGC0000863.1	0.64	Other	eicosapentaenoic acid	Pseudoalteromonas sp. DS-12
BGC0000284.1	0.56	Polyketide	phenolic lipids	Azotobacter vinelandii DJ
BGC0000869.1	0.55	Other	heterocyst glycolipids	Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0000865.1	0.52	Other	eicoseicosapentaenoic acid	Photobacterium profundum SS9
BGC0000864.1	0.52	Other	eicosapentaenoic acid-like compound	Moritella marina ATCC 15381
BGC0001872.1	0.51	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0000044.1	0.49	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001264.1	0.46	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 1411201 - 1467108:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 1419245 - 1467108:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1226

PKS_AT (322..625): pk

ATSignature: (unknown)

No matches above 50%

minowa: Isobutyryl-CoA

Prediction, score:

Isobutyryl-CoA: 13.8
Malonyl-CoA: 8.7
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg1_1227

PKS_AT (601..914): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 85.8
inactive: 35.7
Methoxymalonyl-CoA: 30.1
fatty_acid: 19.0
Methylmalonyl-CoA: 18.7
Isobutyryl-CoA: 17.8
Propionyl-CoA: 17.6
CHC-CoA: 10.2
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

NC_008345.1 - Region 4 - RiPP-like

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Location: 2,871,459 - 2,882,322 nt. (total: 10,864 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0001387.1		0.18	Other	nucleocidin	Streptomyces calvus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001387.1		0.49	Other	nucleocidin	Streptomyces calvus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_008345.1 - Region 5 - betalactone

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Location: 3,267,535 - 3,296,946 nt. (total: 29,412 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.1	0.29	Other	showdomycin	Streptomyces showdoensis
BGC0000234.1	0.20	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001465.1	0.20	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0000890.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000891.1	0.20	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0000260.1	0.18	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0000791.1	0.17	Saccharide	O-antigen	Cronobacter sakazakii
BGC0000733.1	0.17	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000732.1	0.17	Saccharide	capsular polysaccharide	Raoultella planticola
BGC0000730.1	0.17	Saccharide	capsular polysaccharide	Klebsiella pneumoniae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.1	0.62	Other	showdomycin	Streptomyces showdoensis
BGC0000234.1	0.53	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001465.1	0.52	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0000890.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0000891.1	0.52	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0000260.1	0.50	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0000791.1	0.48	Saccharide	O-antigen	Cronobacter sakazakii
BGC0000733.1	0.48	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000732.1	0.48	Saccharide	capsular polysaccharide	Raoultella planticola
BGC0000730.1	0.48	Saccharide	capsular polysaccharide	Klebsiella pneumoniae

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names