LOCUS       NC_008345.1            10864 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_008345.1 Shewanella frigidimarina NCIMB 400, complete sequence.
ACCESSION   NC_008345
VERSION     NC_008345.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:44:44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2871458
            Orig. end    :: 2882322
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10864
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2876458:2877322](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5864)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10864
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10864
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(2812..3360)
                     /locus_tag="ctg1_2436"
                     /transl_table=11
                     /translation="MMNQDSLALIKQSIKTIPDYPIPGIMFRDVTSLLENAEAYKATIA
                     ILVAHYQSKGFTKVVGTEARGFLFGAPLALELGVGFVPVRKPGKLPRKTISQTYDLEYG
                     KDTLEIHVDAINANDKVLVIDDLLATGGTIEATVKLIRELGGEVSHAAFVISLPEIGGE
                     KRLQGMGIEVLSLCEFDGE"
     aSDomain        complement(2827..3333)
                     /aSDomain="TIGR01090"
                     /aSTool="tigrfam"
                     /description="apt: adenine phosphoribosyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2436_0018"
                     /evalue="2.10E-71"
                     /identifier="TIGR01090"
                     /label="ctg1_2436"
                     /locus_tag="ctg1_2436"
                     /protein_end="178"
                     /protein_start="9"
                     /score="237.4"
                     /tool="antismash"
                     /translation="IKQSIKTIPDYPIPGIMFRDVTSLLENAEAYKATIAILVAHYQSK
                     GFTKVVGTEARGFLFGAPLALELGVGFVPVRKPGKLPRKTISQTYDLEYGKDTLEIHVD
                     AINANDKVLVIDDLLATGGTIEATVKLIRELGGEVSHAAFVISLPEIGGEKRLQGMGIE
                     VLSLCE"
     PFAM_domain     complement(2893..3273)
                     /aSDomain="Pribosyltran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00156.29"
                     /description="Phosphoribosyl transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2436_0116"
                     /evalue="4.30E-13"
                     /label="ctg1_2436"
                     /locus_tag="ctg1_2436"
                     /protein_end="156"
                     /protein_start="29"
                     /score="49.0"
                     /tool="antismash"
                     /translation="VTSLLENAEAYKATIAILVAHYQSKGFTKVVGTEARGFLFGAPLA
                     LELGVGFVPVRKPGKLPRKTISQTYDLEYGKDTLEIHVDAINANDKVLVIDDLLATGGT
                     IEATVKLIRELGGEVSHAAFVIS"
     CDS             complement(3498..3863)
                     /locus_tag="ctg1_2437"
                     /transl_table=11
                     /translation="MAVKRGFFLIIGLCSLVLGIIGIALPLLPTVPFILLAAFCFARSS
                     DRLHHWLINHPWFAEGISQWQSKRALSRSLKRKAMLMSGLSFAISIMIVPIIWVKIMLL
                     CMMLILLFFLWRIPELE"
     PFAM_domain     complement(3507..3848)
                     /aSDomain="DUF454"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04304.15"
                     /description="Protein of unknown function (DUF454)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2437_0117"
                     /evalue="4.10E-40"
                     /label="ctg1_2437"
                     /locus_tag="ctg1_2437"
                     /protein_end="119"
                     /protein_start="5"
                     /score="136.5"
                     /tool="antismash"
                     /translation="GFFLIIGLCSLVLGIIGIALPLLPTVPFILLAAFCFARSSDRLHH
                     WLINHPWFAEGISQWQSKRALSRSLKRKAMLMSGLSFAISIMIVPIIWVKIMLLCMMLI
                     LLFFLWRIPE"
     CDS             complement(3947..4066)
                     /locus_tag="ctg1_2438"
                     /transl_table=11
                     /translation="MSQPFKDPFNIFYFIGFILVLLIPTLPASLSWLKATGLI"
     CDS             complement(4240..5001)
                     /locus_tag="ctg1_2439"
                     /transl_table=11
                     /translation="MGFIEVQQQFMDYIRDPSLPLPEGIEPRRMKIYRELFFNNIAGFV
                     SSAFPVLKSVYEDDQWQALVQQFFVSHDCKTPIFVEIAGEFLAFLQHEYQMTEDDPVFM
                     LQLAHYEWLELCVAVAPDTPAAQSINTIELNLHRLCLAACAKVAQYAFDVQHISVDYQP
                     IEPTAQANFFCVFRGADDEVAFLQLTPLSAQVLAYIEQMTHSQQGVTVDAIISWLSEHY
                     PQMPNDTLLSGCLPLLQQLAQKGIVISSIES"
     PFAM_domain     complement(4732..4989)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2439_0118"
                     /evalue="1.30E-26"
                     /label="ctg1_2439"
                     /locus_tag="ctg1_2439"
                     /protein_end="90"
                     /protein_start="4"
                     /score="92.7"
                     /tool="antismash"
                     /translation="EVQQQFMDYIRDPSLPLPEGIEPRRMKIYRELFFNNIAGFVSSAF
                     PVLKSVYEDDQWQALVQQFFVSHDCKTPIFVEIAGEFLAFL"
     CDS             complement(5001..5864)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2440"
                     /sec_met_domain="DUF692 (E-value: 2e-106, bitscore: 353.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIQHRNTPGQASVGLGLRREMLDEFCQQVPSAINFFEVAPENWM
                     TLGGKFGRRFKQLTEQHAFFCHGLSLSIGSPEPLDSHFVQNIKRFLDEHNIEVYSEHLS
                     YCSGTGHMYDLMPIPFTDDAVIHTAKRIKQVEDILERPFILENVSFYAAPGAQMTEQEF
                     VNAVLQEADCKLLLDVNNIYVNSINHQYDAAAYLAAMPTKRIAYLHIAGHYEEEADLMV
                     DTHGADIIDPVWALLQQCYQIHGVHPTLLERDFNIPKTDILLNEINQIHQYQQNALTQQ
                     SILRKA"
     PFAM_domain     complement(5040..5825)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2440_0119"
                     /evalue="2.70E-103"
                     /label="ctg1_2440"
                     /locus_tag="ctg1_2440"
                     /protein_end="275"
                     /protein_start="13"
                     /score="344.9"
                     /tool="antismash"
                     /translation="VGLGLRREMLDEFCQQVPSAINFFEVAPENWMTLGGKFGRRFKQL
                     TEQHAFFCHGLSLSIGSPEPLDSHFVQNIKRFLDEHNIEVYSEHLSYCSGTGHMYDLMP
                     IPFTDDAVIHTAKRIKQVEDILERPFILENVSFYAAPGAQMTEQEFVNAVLQEADCKLL
                     LDVNNIYVNSINHQYDAAAYLAAMPTKRIAYLHIAGHYEEEADLMVDTHGADIIDPVWA
                     LLQQCYQIHGVHPTLLERDFNIPKTDILLNEINQIHQYQQ"
     CDS             complement(5965..6393)
                     /locus_tag="ctg1_2441"
                     /transl_table=11
                     /translation="MNSIKQTTLAVALGSVVMTAGFSAQVEANPFGFQQLTSGYQIDGG
                     EGKCGEGKCGENMKKSAEKAAEGKCGEGKCGGDMKKSAEKAAEGKCGEGKCGGDMKKSA
                     EKAVEGKCGEGKCGGDMKKSAEKAKEGKCGEGKCGGQK"
     CDS             6721..7665
                     /locus_tag="ctg1_2442"
                     /transl_table=11
                     /translation="VRVILAPMEGVVDDHMREILSAINPFDLVVTEFVRVVNQLIPDKV
                     FYKLCPELLHQGLTASGTPVRVQLLGQEPEWMAQNAIRAIELGSNGVDANFGCPAKTVN
                     KSKGGAVLLQYPENIYSIVKAMRDAVPSEHPVTAKIRLGYEDKSLFMENALAVYEAGAT
                     ELAIHARSKTDGYKPPAYWEYITEVRQRLPIPVIANGEIWNAADAQRCMDVTGCDSIMI
                     GRGAISLPNLGDTIKTGATPFSWQQTLSLLMAYTDKELNGRKSDYYPSRIKQWFSYLNR
                     QYPEADTLFRELRVFKTTEEIVKVLQHAHRSLI"
     PFAM_domain     6730..7623
                     /aSDomain="Dus"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01207.19"
                     /description="Dihydrouridine synthase (Dus)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2442_0120"
                     /evalue="7.30E-77"
                     /label="ctg1_2442"
                     /locus_tag="ctg1_2442"
                     /protein_end="301"
                     /protein_start="3"
                     /score="258.5"
                     /tool="antismash"
                     /translation="ILAPMEGVVDDHMREILSAINPFDLVVTEFVRVVNQLIPDKVFYK
                     LCPELLHQGLTASGTPVRVQLLGQEPEWMAQNAIRAIELGSNGVDANFGCPAKTVNKSK
                     GGAVLLQYPENIYSIVKAMRDAVPSEHPVTAKIRLGYEDKSLFMENALAVYEAGATELA
                     IHARSKTDGYKPPAYWEYITEVRQRLPIPVIANGEIWNAADAQRCMDVTGCDSIMIGRG
                     AISLPNLGDTIKTGATPFSWQQTLSLLMAYTDKELNGRKSDYYPSRIKQWFSYLNRQYP
                     EADTLFRELRVFKTTEE"
     CDS             8064..8369
                     /locus_tag="ctg1_2443"
                     /transl_table=11
                     /translation="MLLIKDSLKATEVAHISMETPLGKVIDYLPQVKLINTDIFTKFMK
                     LDAAYCQLELGLYGLCSDCEMDIEPPRLFADPTEQRCTGCEQKFRREHRHELRLNH"
     PFAM_domain     8229..8330
                     /aSDomain="zf-dskA_traR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01258.19"
                     /description="Prokaryotic dksA/traR C4-type zinc finger"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2443_0121"
                     /evalue="1.10E-05"
                     /label="ctg1_2443"
                     /locus_tag="ctg1_2443"
                     /protein_end="89"
                     /protein_start="55"
                     /score="25.4"
                     /tool="antismash"
                     /translation="GLYGLCSDCEMDIEPPRLFADPTEQRCTGCEQKF"
ORIGIN
        1 ccgatgaaag cgtttgcgta actcaagcgg tgtttctcgt ttttgcacca caccaatctg
       61 gatttcaact tcagttggtc gctcaaggta ctcagataat gccacttgta attgatcgat
      121 agcagtttgc gcagacaaat gtttctggtc tggttttaac actaatacta ttggatttga
      181 caatgttggg cacacggagt tcacccctaa ttgcctaact ctcccgccaa cagacacatt
      241 agtcattatt ttataccaat gtaaatcaac ttcatcgcct tgaatgctgt gtggttcaaa
      301 tttggcaagc acattagatt gaatcaccgg ctctgcatta atgttttgcg gatcggcagc
      361 aagtgattgt gtgctggctg gtttttgatg ttgatgaccg gcttgctgac tgacagaatt
      421 cgatggttga agtgttgttt caactgctgg tttagtctct tgattagtat ctgcaaacgc
      481 attaacgttc tcaccttctt tgggcgcgac ccaaggtggc ctatcataat ctgtcacaac
      541 ttgagacttg tctgttccgc tgagtgttgc cgttgacgct tcgctggcct taggtgcagg
      601 ttctgactta tcagaacctg aaggctcagt agcggccgtt ggtgatgttg atgccgcagc
      661 cgctttgctc actctagaac tgattgtttt tgtcgactct tttttggcca gttcttcttg
      721 ttgctgtaat gcgccaacat ctgcaatgag agaatctcga ctggctagca cttcatctaa
      781 aaagtcgtct aagttatcat cttcactcgc gaggttttga cgtgcatcat cacttatcaa
      841 gtcgctgtta tcgtcagcga gatgattaac cgttttcggt ttagacatcg actccgaagc
      901 ttcagtaaca tggttaacgt cagttgcctc acttgaagca gaaaacgcaa catattcgtc
      961 atgatcagag ggttgatatt ccattgacgg atcatctgct tcgttataat ccataaaaga
     1021 ataggcatca agtgagctat tatctgcact atcactggat tgactatttt ctaatgaatt
     1081 ggtgtctgcc gtacttggcg ccaatgcagg ttgctctgca acttcttcag actcgataac
     1141 atcgcttatc acatttttag tactggattc atccgttgct tcagcatctg cgctatgaac
     1201 aacattatca gatgaagttg cattaacaac gtcaacttcg gcatcatcat taacaagctg
     1261 gtcagtgtgc atatcgacac tttctagcgg caatgaatca aaccctaagc tttgtgcttg
     1321 gtccaacaat aaagcttgct cagccgccaa cgaaggctca acagcgatat cgtcgagagg
     1381 atcagcatct tcaacttcgg cagtcggcaa cacttcagcc tgaatagctt gtgctgctgt
     1441 cgttaaacca taatgcgctt gaggcagagc atcaggcttt gggcctgttt caatgacctc
     1501 ttgtgttgaa gttgatgcgt gatcgataac gcttaaatca atattagctg gtgtcgttgt
     1561 tacccaacgt tttacttgtt tctcgggcgt aaaggctacc gcacgaagca gtgccatttc
     1621 caagcccgat ttaggatcgg gagcaaaggg taaatcttta cggccgttaa gcagcatttg
     1681 gtaataaagc tgtacttgtt caggtgctaa ttgctgcgcg aatgccacaa tttgctcact
     1741 aaacagcgat tgttgtgctg cggctggggc aaattgagtt aaggtgattt gatgtaatag
     1801 ttctaataag ctgcgtagta cttcttcggc atctgcacca aatgccaata cttttgccac
     1861 ggtttgcatt aatggcccaa catcggcatc acacaaggct tttaataacg cgagcacatg
     1921 ttgctcatca atactgccca acatggtttg cacttgtgta agcatcactt ggccactgcc
     1981 aaatgctatg gcttgatccg ttaaactgag cgcatcacgc atactgccat tggccgcttt
     2041 ggctaataaa ctcagtgctt gcgactcaaa tggtaacttt tcttgagtga taacatactc
     2101 aagttgcttg ctaatttcgt cctgcgataa acttttcaaa ttgaactgta aacaacgaga
     2161 tagcacagta accggcagtt tgtgcggatc ggttgtcgct aataaaaact taacgtgctc
     2221 aggaggctct tctaaggtct ttagtagtgc gttaaaactg ctgcgcgaca acatgtgtac
     2281 ttcatcaatt aagtacacct taaaacgacc acgggatggg cgatactgta cattgtcgag
     2341 aagttcgcga gtatcatcaa ctttggtgcg ggaagcggca tcgacttcaa ttaaatcaac
     2401 aaatcggcct tgggcaattt caatacaact agagcattca ccgcacggcg tagcagtaac
     2461 gcctgtttca caattaagac ctttagcaaa caaacgtgcc aaactggttt tacccacgcc
     2521 gcgggtacca gtaaacagat aagcatgatg taaacgttgt tggctcaatg cattggttaa
     2581 tgccattaat acatgggatt ggccgaccat ttgttcaaat ttagctggac gccatttgcg
     2641 ggctagtact tggtaagaca tgaaattccc cacagagagc tatcgggagt caatcccttt
     2701 aaaggggtta acaataacat gccaagggct ggcatgctat tgttgagcaa gcatttgata
     2761 gagtaaaacc tagttaactg cttaataaaa tggcagttta ttttacttta cttactctcc
     2821 gtcaaactcg cataaactta atacttcaat tcccatacct tgtaaacgct tctcgccacc
     2881 aatttctggt aatgagataa caaatgcagc atggctcact tcaccgccta attcacgaat
     2941 aagttttacc gtcgcttcaa tcgtgccacc ggtggctaat agatcatcaa taacgagcac
     3001 tttatcatta gcattaattg catcaacatg aatttctaag gtgtctttac cgtattctaa
     3061 gtcataagtt tggcttatgg ttttacgggg taatttaccc ggtttacgca caggtacaaa
     3121 accgacgccg agctctaacg ctaatggtgc gccaaataaa aaaccacgcg cttcagtacc
     3181 aaccacttta gtgaaacctt ttgattgata atgagccact agaatcgcaa tagtggcttt
     3241 ataagcttct gcattttcaa gcaaactggt gacgtcacgg aacatgatgc ctggtattgg
     3301 ataatcagga atggttttaa tgctctgctt aataagcgct aaactgtctt ggttcatcat
     3361 aatgtagtta actctgtctg aaagtgatta cgcaataaaa aagtccacgt cattggtgga
     3421 ctctggtaaa aatactggtg tgatcttatg cccgtttaat ctcagttgca acaggcatgc
     3481 attaaccagg ctatttatta ttctaactct gggatccgcc acaagaaaaa taataaaata
     3541 agcatcatgc acaacaacat aattttcacc catattatcg gtactatcat gatactaata
     3601 gcaaaactaa ggccgctcat taacatggct tttcgcttga gcgatcggct caacgcacgt
     3661 ttagattgcc actgagagat accttcagca aaccaagggt gattgattag ccaatgatga
     3721 agtcgatcgc tagaacgagc aaaacaaaac gcagccaata atataaacgg cactgttggt
     3781 aataaaggca gtgcaatgcc aataatgcct aacactagac tgcacaagcc aataatgaga
     3841 aaaaatccgc gtttcaccgc catatacgcc ctcatacaaa caaaaaacca ctctatctga
     3901 gtggtctaat aagacaatat catgacaggt taacctgaag taagcgttaa attaatcctg
     3961 ttgctttcaa ccatgaaagg ctcgcgggca atgttggaat taataaaacc aaaataaaac
     4021 caataaaata aaagatgtta aacgggtctt taaacggctg gctcatgatt attcctacat
     4081 taaggttatg ttttaactgc gataacttac atctttcatc tgttatattg tgccaactgt
     4141 tcagttagca tcgcgacaac agacgtgaag tcgatcacaa aaagtggctt attttagacg
     4201 catcttcaca aaataaaaac cttaaatata ttatgtctat tatgactcga ttgatgaaat
     4261 aacgatgccc ttttgtgcca gttgttgcaa taaaggtaag cagcctgaca acaaggtgtc
     4321 atttggcatt tgtgggtaat gctcacttaa ccaacttata atggcatcga ctgttacacc
     4381 ttgttgagaa tgagtcattt gttcaatgta agctaacact tgcgcactta atggtgtcag
     4441 ttgtaaaaat gcgacctcat catcagcacc tctaaataca caaaaaaagt tcgcttgtgc
     4501 tgtcggctct ataggctggt agtcaacact aatatgctga acgtcaaagg catattgcgc
     4561 cactttggca caagctgcta ggcataacct atgcaggttt agttcgatgg tattgatcga
     4621 ttgagccgct ggagtatctg gcgcgacggc gacacataat tctaaccatt cataatgtgc
     4681 caactgcaac ataaaaacag gatcatcttc tgtcatctgg tattcatgtt gtaaaaacgc
     4741 taaaaactca ccggctattt caacaaatat tggtgtctta caatcgtggc ttacaaaaaa
     4801 ttgttgtact aaggcctgcc attggtcgtc ctcatataca cttttcaaca ccggaaatgc
     4861 actcgacaca aaacctgcaa tattattaaa aaataattct cgatagattt tcatgcgcct
     4921 aggctcaatc ccctcgggca atggcaaact aggatcacgg atatagtcca taaattgttg
     4981 ttgtacttca atgaaaccca ttatgccttc ctcaatattg actgctgcgt taaggcattt
     5041 tgttgatact gatgaatttg attaatctca ttaagaagta tgtctgtttt aggaatatta
     5101 aaatcacgct caagcaacgt cggatgcacg ccatgtattt ggtaacactg ctgcaataag
     5161 gcccatactg gatcgataat atccgcaccg tgagtatcga ccattaaatc ggcctcctct
     5221 tcatagtgtc ctgcgatatg cagataagcg attcgtttgg taggcatcgc cgctaagtaa
     5281 gctgctgcat cgtattgatg gttaattgaa ttaacgtaaa tgttatttac atcgagcagt
     5341 aatttgcagt cggcctcttg cagcaccgca ttgacaaact cttgttcggt catttgtgca
     5401 ccaggcgccg cataaaaaga cacattctct aaaataaacg gacgctcgag tatgtcttcg
     5461 acttgcttta tccgcttagc ggtatggatg actgcatcat cagtaaatgg gattggcatc
     5521 aaatcataca tatggccagt acctgagcaa taacttaaat gctctgaata cacttcaata
     5581 ttatgctcat ccaaaaagcg ttttatattt tgtacaaagt gactatcaag cggttcagga
     5641 ctaccaatgg ataacgaaag cccgtggcag aaaaaagcgt gttgttcagt taattgttta
     5701 aaccgacgcc caaacttgcc acctaatgtc atccaatttt caggtgcaac ttcgaaaaaa
     5761 ttaatggcag atggcacctg ctgacaaaat tcatccagca tttcacggcg aagtcctaaa
     5821 ccgacactag cctgacccgg tgtgttgcga tgctgaatag acataatgcg tcctttaaaa
     5881 taaaaagcag ataaaactaa ggcctgaata tcaggcctta attgtgtcag ataagccaag
     5941 gcattatcaa atagaagtca ttaattattt ctgaccgcca cacttacctt caccacactt
     6001 accttctttg gctttctcag cagacttttt catgtcgccg ccacatttgc cttcgccgca
     6061 cttaccttca accgctttct cagcagattt tttcatgtcg ccgccacatt tgccttcgcc
     6121 gcacttgcct tcagccgctt tctcagcaga ctttttcatg tcgccgccgc atttgccttc
     6181 gccacattta ccttcagccg ctttctctgc agactttttc atgttctcgc cacatttgcc
     6241 ttcaccacac ttgccttctc cgccatcaat ttgataacca gaagttaatt gttgaaaacc
     6301 aaatgggtta gcttctactt gagcagaaaa gccagcagtc attacaacag aacctaatgc
     6361 aaccgccaaa gtagtttgtt tgattgaatt cataataatt atcttcctat atcttgattg
     6421 tgtatggtga ccaacatcat tgccggcttg gttaaagaga cctgcagtaa gtaaatttta
     6481 ttgcaaaaaa attaaaaaaa cgtgaaaaat gtctatttat ttaacacaaa tacttgctag
     6541 gcaagcctca aaactaatgc catgtatatt taacataaat acaacaagat cgctatcaat
     6601 atgattatta gcaataattt tattagttaa tcgacaaaag aactcgtatc gtaatttagt
     6661 actgatatca aataataaac acgctaaaat agcgcacttt tgacttcagc aaggtgtact
     6721 gtgcgcgtta ttttagctcc aatggaaggt gtggttgatg accatatgcg tgaaatatta
     6781 tctgccatca atccatttga cctggttgtg actgaatttg tcagggtcgt caatcaactc
     6841 ataccagata aagtgttcta taaactgtgc cctgagctac ttcatcaagg gctaaccgca
     6901 tcaggaactc ctgtacgtgt tcagttgtta ggacaagaac cagagtggat ggcacaaaat
     6961 gccataagag ccatagagct aggctcaaat ggtgttgatg caaattttgg ttgcccagct
     7021 aaaactgtca ataaaagcaa aggcggcgca gtattactcc aatatcctga gaatatttac
     7081 agtatcgtca aagccatgcg cgacgcagta ccctctgagc atcctgttac agctaaaatc
     7141 cgtttaggct acgaagataa atcgttattt atggaaaacg ccttagccgt gtatgaggct
     7201 ggcgcaacag agctcgctat tcatgctcgc agtaaaaccg atggttataa acctccggca
     7261 tattgggaat acattactga agtgagacag cgcctgccaa ttcctgttat cgctaacgga
     7321 gaaatttgga atgccgctga tgctcagaga tgcatggatg tcactggctg tgacagtata
     7381 atgattggtc gaggagccat atcgttgcct aatctaggcg ataccatcaa aactggtgcg
     7441 acgccattta gttggcaaca aaccttaagc ttacttatgg cctataccga caaagaactt
     7501 aatggtcgta aatctgacta ttatccttca cggattaaac aatggtttag ttacttaaac
     7561 cgtcaatacc ctgaagcgga tactctattt agagagctac gagtgttcaa aacaactgaa
     7621 gaaatcgtta aggttctaca gcatgctcac aggtcgctta tataagcttg caacaacaca
     7681 ccaactttac atctaggctt aaattaacct ttttgataat gtgtcatcaa ggttataaac
     7741 tctgttaatc ctacacaacc ataagcgttt cttagtcttc aatcgacagt gattcagtca
     7801 ccatattgac gcgacaatca accctagctt aacgcccaga cagacaataa tgattgttaa
     7861 catgaataaa tgataaatta ttattcatgt ttttatcgca gaaatcttat cgagaattga
     7921 tcttcatcat aacgtctgct ttatttgtgc ctaaaataga aattctacat tggcattgtc
     7981 agttaaggtt atttcagttg cacaacactc aggacataca gcaaaaactt caacatcttg
     8041 aacttatttt gagacatgag ttaatgctac ttataaagga ttcattaaaa gctactgaag
     8101 ttgctcatat ttcgatggaa acccctcttg gaaaagtgat tgattacttg ccacaagtca
     8161 aactaatcaa tactgatatt ttcactaagt tcatgaagct agatgctgct tactgtcaac
     8221 ttgaattggg tttatatggt ctttgctctg attgtgaaat ggacatagag ccgccccgct
     8281 tattcgccga tccaacggaa caacgttgca caggttgtga acagaaattt cgccgagaac
     8341 atcgacatga attacgctta aatcactaac catgctttgc tttattagcg acttaaaatc
     8401 aacgtaataa aaaggcctac aataatgtag gcctttttat gtcagacaat gtaactgtca
     8461 cattgtctga tgtttagctc tctaactaaa ctgttattta gaacttaaca gttacgccac
     8521 cgtagtactg gcgaccaata gtgtcataca cttctggtac tgtaccacca tcactaccat
     8581 tcgatacgcc tgatggctct tcatcagtga tgtttttcac accagcgctt agagtaatca
     8641 tgtcagtaac ataataagta ccggctaagt tgtggtacag aatcgcatcc actttatcgc
     8701 ctgtatttag atcgtccatt tcgccaatgt aacggttgaa gtagttaaca ctccagctat
     8761 cttgacctgc ttgaatgctg aagttgttac gaacttctgc ataagcacca aaattaccat
     8821 cgatcttgtt ggtgtaatca ttgtcttctt gttcgaaatt caacaagtaa gttgtgtcat
     8881 tgctgatttt ccaatctaac gacaaggctt caaagttata agctaagttg aagtctaaac
     8941 cgctagtgtc ttggctacct acgtttgtta acgagttagt aagattagat aaatcaccgt
     9001 ttgcaccaat gttaaaggtt tcacatgctg cagctgaagc attagcaaaa cattcttcta
     9061 aaccagcttg aacatctaaa cgagtgattg cattggacac tttaaagcgc cagtaatcaa
     9121 gcgtgaccga tagaccttca acatagtttg gtgagtaaac taagccagct gtataagagt
     9181 cagactcttc agcttttaga tcatcatcag acgtgtaacg aactagaatc tgtgggtcct
     9241 gagcattgcc ccatggatca tccaagtagt cgtaagagcc agtgtcacca ccaaataact
     9301 cactgatgct tggagcacgg aaacctgttg ccgctacagt acgaagcatc aaatcatcag
     9361 ttgcttcata ggttagacct actttccaag tagacgcttt accgaatgtt gagtaatcgt
     9421 cataacgcag tgcaaattca ccggttaatt tttcagtgaa aggaacgctg acttcttgga
     9481 atacagacaa tacattgtaa tcgccgtctg tagcatcttg ctgtgcagca gtactgtcac
     9541 cagccactgt tacagggtct ggattataaa aaccgctttc ataacggtat tcagcaccaa
     9601 tagcaaatgc aactgcacca gcactcagat caaacaactc accatttaga ccagcagaaa
     9661 caacatgttg ctcattgccg ccgtcagcat tatcagtgaa gctaatgtca ttaacgattt
     9721 cacctgttaa tggaacacct gtgaaccatg catcttggtt agcataaaca gattgcttaa
     9781 gattggttgc attgattgag ttctcaacac ttgaatcagc tttgtttttg ccataggtat
     9841 aaccgatatc ccagttcatg cctgtattaa tatcaagctc acccgctaat gcagcagaga
     9901 tacggaaagt atcagtgtct tgagaataaa tacgaggacc ggcatcggta gtacgacgac
     9961 gataatttac acgaccagta tcatcagcag caatttcacc gtctgtcatc gcttgatcaa
    10021 gtgtaataca tgctgcacca gcagtaacac ctggagcacc acatacgttt aacattacgt
    10081 cagcaggttg tggagctaat tgctgatcag acttacgttt agtgtaaagc acgtcgcctg
    10141 ttagcactaa attgttgtct aattcttgga tcatattagc aaacaagctg taacgctcgt
    10201 ttggtgtttg gtaataactg ctagtggtgt agtcataacc tgtagaacga gcaacccatt
    10261 caccagcgtc attgcgtact ttcccgccta atgaacctgt aggtaaaaat gaacttgcac
    10321 caggctctgt ccagctacga tctgactgaa taacactttc gcgtttcgaa tacgcagcac
    10381 caatagtgta gttaccacca tcggtattga agccgtataa accactaatt tcgccagttt
    10441 caccatcact ttcactggta gtactaccgt taagatctag ttgaaagcct tcgaaatctt
    10501 tcttagtaat gatgttaaca acaccagcga tagcatctga accgtatact gctgatgcgc
    10561 catcttttaa gatttcaaca cgagatatca tcgatacagg gatagagttc aaatcgacag
    10621 agctatctgc acctgaacca gagttaacca tacgacgacc atttaatagt actagcgtac
    10681 gttgtgaacc cataccgcgt aagtcaactt gcgcaacacc gtctgaaccg ttgttcgagc
    10741 tagaacctag agcagcacca gccattgacg tttgggcttg aagtagttgg tcaactgaag
    10801 tgaaaccttc tgcgcgaata gcttcagctg aaatgatggt tactggagaa gcagattcca
    10861 tgtc
//
