GCF_000008865.2_ASM886v2_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_002695.2

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS	675,814	719,695	turnerbactin	NRP	30%
Region 1.2	thiopeptide	1,069,984	1,096,276	O-antigen	Saccharide	14%
Region 1.3	RiPP-like	1,289,426	1,299,677
Region 1.4	ladderane,arylpolyene	1,338,880	1,381,438
Region 1.5	arylpolyene	4,324,110	4,367,697	APE Ec	Other	94%

No secondary metabolite regions were found in these records:: NC_002127.1; NC_002128.1

Compact view

NC_002695.2 - Region 1 - NRPS

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Location: 675,814 - 719,695 nt. (total: 43,882 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.34	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000410.1	0.29	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000401.1	0.29	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.25	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.24	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001302.1	0.24	Other	lomofungin	Streptomyces lomondensis
BGC0001844.1	0.23	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758.1	0.23	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.23	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.67	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000410.1	0.63	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000401.1	0.62	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132.1	0.58	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.58	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001302.1	0.57	Other	lomofungin	Streptomyces lomondensis
BGC0001844.1	0.57	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758.1	0.56	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.56	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 675813 - 719695:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_609

Search NORINE for peptide: strict or relaxed

AMP-binding (461..863): ser

NRPSPredictor2: ser

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg1_617

Search NORINE for peptide: strict or relaxed

AMP-binding (34..437): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: AMPAQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

NC_002695.2 - Region 2 - thiopeptide

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Location: 1,069,984 - 1,096,276 nt. (total: 26,293 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.25	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.16	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.12	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.09	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.07	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.07	Other	lomofungin	Streptomyces lomondensis
BGC0000070.1	0.07	Polyketide	griseofulvin, epidechlorogriseofulvin, norlichexanthone, dehydrogriseofulvin, 4-desmethylgriseofulvin, griseoxanthone B	Penicillium aethiopicum
BGC0002012.1	0.06	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.06	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.05	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.59	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.47	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.39	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.32	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.28	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.28	Other	lomofungin	Streptomyces lomondensis
BGC0000070.1	0.28	Polyketide	griseofulvin, epidechlorogriseofulvin, norlichexanthone, dehydrogriseofulvin, 4-desmethylgriseofulvin, griseoxanthone B	Penicillium aethiopicum
BGC0002012.1	0.25	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.25	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.22	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Thiopeptides

Core peptide predictions

No core peptides found.

NC_002695.2 - Region 3 - RiPP-like

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Location: 1,289,426 - 1,299,677 nt. (total: 10,252 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

No matches found.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NC_002695.2 - Region 4 - arylpolyene,ladderane

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Location: 1,338,880 - 1,381,438 nt. (total: 42,559 nt) Show pHMM detection rules used

ladderane: ladderane
arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.1	0.54	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.47	Other	bacilysin	Bacillus velezensis FZB42
BGC0000044.1	0.43	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0000231.1	0.42	Polyketide	griseusin	Streptomyces griseus
BGC0001591.1	0.38	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.38	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000272.1	0.36	Polyketide	spore pigment	Streptomyces collinus
BGC0000218.1	0.36	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000228.1	0.36	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000836.1	0.35	Other	APE Ec	Escherichia coli CFT073

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.1	0.60	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.57	Other	bacilysin	Bacillus velezensis FZB42
BGC0000044.1	0.54	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0000231.1	0.53	Polyketide	griseusin	Streptomyces griseus
BGC0001591.1	0.51	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.51	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000272.1	0.50	Polyketide	spore pigment	Streptomyces collinus
BGC0000218.1	0.50	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000228.1	0.49	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000836.1	0.49	Other	APE Ec	Escherichia coli CFT073

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_002695.2 - Region 5 - arylpolyene

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Location: 4,324,110 - 4,367,697 nt. (total: 43,588 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.63	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.56	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.28	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000410.1	0.24	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000228.1	0.22	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000194.1	0.22	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001897.1	0.22	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001895.1	0.21	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000248.1	0.21	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.21	Polyketide	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.85	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.82	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.62	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000410.1	0.58	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000228.1	0.55	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000194.1	0.54	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001897.1	0.54	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001895.1	0.54	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000248.1	0.54	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.54	Polyketide	spore pigment	Streptomyces collinus

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names