Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP033719.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NRPS | 646,159 | 698,983 |
Region 2 | NRPS,NRPS-like | 982,467 | 1,041,573 |
Region 3 | sactipeptide | 1,249,543 | 1,270,958 |
Region 4 | arylpolyene | 1,333,477 | 1,374,736 | natamycin | Polyketide | 9%
Region 5 | lanthipeptide-class-iii | 1,479,984 | 1,502,716 |
Region 6 | lassopeptide | 1,902,425 | 1,924,949 | siamycin | RiPP | 33%
Region 7 | RiPP-like | 1,951,569 | 1,963,470 |
Region 8 | NRPS | 2,071,647 | 2,124,177 | streptobactin | NRP | 11%
Region 9 | thiopeptide | 2,370,578 | 2,396,770 | clifednamide A | NRP + Polyketide | 30%
Region 10 | T2PKS | 2,906,566 | 2,979,107 | resistomycin / resistoflavine | Polyketide:Type II | 33%

NZ_CP033719.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 646,159 - 698,983 nt. (total: 52,825 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.24 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000412.1 |  | 0.24 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000373.1 |  | 0.23 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000417.1 |  | 0.21 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001636.1 |  | 0.21 | NRP | KK-1 | Curvularia clavata
BGC0001699.1 |  | 0.21 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001758.1 |  | 0.21 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.21 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001641.1 |  | 0.20 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.20 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.58 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000412.1 |  | 0.57 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000373.1 |  | 0.56 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000417.1 |  | 0.53 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001636.1 |  | 0.53 | NRP | KK-1 | Curvularia clavata
BGC0001699.1 |  | 0.53 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001758.1 |  | 0.53 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.53 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001641.1 |  | 0.53 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.53 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 646158 - 698983:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-cys) + (cys - cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_573: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (582..976): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSmIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1992..2395): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_574: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (33..444): X
  NRPSPredictor2: dhb, sal
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAlGgttK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      60% (weak)
ctg1_576: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (536..928): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)

NZ_CP033719.1 - Region 2 - NRPS,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 982,467 - 1,041,573 nt. (total: 59,107 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000373.1 |  |  | 0.52 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000412.1 |  |  | 0.48 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000389.1 |  |  | 0.48 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001343.1 |  |  | 0.46 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001538.1 |  |  | 0.43 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001185.1 |  |  | 0.43 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001636.1 |  |  | 0.43 | NRP | KK-1 | Curvularia clavata
BGC0000352.1 |  |  | 0.42 | NRP | fimsbactin A | Acinetobacter sp. ADP1
BGC0001699.1 |  |  | 0.41 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001844.1 |  |  | 0.41 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000373.1 |  | 0.61 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001343.1 |  | 0.59 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000412.1 |  | 0.58 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000389.1 |  | 0.57 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001538.1 |  | 0.57 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001591.1 |  | 0.55 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.55 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000352.1 |  | 0.55 | NRP | fimsbactin A | Acinetobacter sp. ADP1
BGC0000249.1 |  | 0.55 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0001444.1 |  | 0.54 | Other | caboxamycin | Streptomyces sp. NTK 937

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 982466 - 1041573:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys - cys) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 982466 - 1033985:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys - cys) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 1000855 - 1041573:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys - cys) + (cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_860: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (575..954): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1601..1985): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_861: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (521..900): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_863: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (12..407): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      egaFVAvmLK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      50% (weak)
ctg1_867: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (34..447): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      AMPplGVVaK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      70% (weak)
ctg1_868: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (152..556): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      AnPAQGVVcK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      80% (moderate)

NZ_CP033719.1 - Region 3 - sactipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,249,543 - 1,270,958 nt. (total: 21,416 nt) Show pHMM detection rules used
sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Sactipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | sactipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.1 |  | 0.17 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000783.1 |  | 0.17 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000780.1 |  | 0.16 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0001929.1 |  | 0.16 | RiPP | WGK | Streptococcus ferus
BGC0000601.1 |  | 0.15 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000736.1 |  | 0.13 | Saccharide | capsular polysaccharide | Mannheimia haemolytica
BGC0000643.1 |  | 0.13 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0000523.1 |  | 0.12 | RiPP | lactocin S | Lactobacillus sakei
BGC0000568.1 |  | 0.12 | RiPP | microcin B17 | Escherichia coli
BGC0000497.1 |  | 0.11 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.1 |  | 0.49 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000783.1 |  | 0.48 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000780.1 |  | 0.46 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0001929.1 |  | 0.46 | RiPP | WGK | Streptococcus ferus
BGC0000601.1 |  | 0.45 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000736.1 |  | 0.41 | Saccharide | capsular polysaccharide | Mannheimia haemolytica
BGC0000643.1 |  | 0.41 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0000523.1 |  | 0.41 | RiPP | lactocin S | Lactobacillus sakei
BGC0000568.1 |  | 0.40 | RiPP | microcin B17 | Escherichia coli
BGC0000497.1 |  | 0.37 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Sactipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Sactipeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Sactipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its RODEO score and predicted core sequence.
No core peptides found.
NZ_CP033719.1 - Region 4 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,333,477 - 1,374,736 nt. (total: 41,260 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.1 |  | 0.28 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.27 | Other | bacilysin | Bacillus sp. CS93
BGC0001526.1 |  | 0.22 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001510.1 |  | 0.21 | Other | anisomycin | Streptomyces hygrospinosus
BGC0001525.1 |  | 0.20 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000714.1 |  | 0.20 | Saccharide | sisomicin | Micromonospora inyonensis
BGC0000204.1 |  | 0.20 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000679.1 |  | 0.20 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0001177.1 |  | 0.19 | Polyketide | mensacaricin | Streptomyces bottropensis
BGC0002008.1 |  | 0.19 | Other | aryl polyenes | Xenorhabdus doucetiae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.1 |  | 0.61 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.61 | Other | bacilysin | Bacillus sp. CS93
BGC0001526.1 |  | 0.54 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001510.1 |  | 0.54 | Other | anisomycin | Streptomyces hygrospinosus
BGC0001525.1 |  | 0.53 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000714.1 |  | 0.53 | Saccharide | sisomicin | Micromonospora inyonensis
BGC0000204.1 |  | 0.52 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000679.1 |  | 0.52 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0001177.1 |  | 0.51 | Polyketide | mensacaricin | Streptomyces bottropensis
BGC0002008.1 |  | 0.51 | Other | aryl polyenes | Xenorhabdus doucetiae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NZ_CP033719.1 - Region 5 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,479,984 - 1,502,716 nt. (total: 22,733 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000513.1 |  | 0.35 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000553.1 |  | 0.35 | RiPP | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000551.1 |  | 0.28 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000501.1 |  | 0.28 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000496.1 |  | 0.19 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000546.1 |  | 0.18 | RiPP | SAL-2242 | Streptomyces albidoflavus
BGC0000519.1 |  | 0.17 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000527.1 |  | 0.17 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001210.1 |  | 0.17 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001787.1 |  | 0.17 | RiPP | suicin 3908 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000513.1 |  | 0.68 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000553.1 |  | 0.68 | RiPP | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000551.1 |  | 0.62 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000501.1 |  | 0.61 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000496.1 |  | 0.51 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000546.1 |  | 0.49 | RiPP | SAL-2242 | Streptomyces albidoflavus
BGC0000519.1 |  | 0.49 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000527.1 |  | 0.48 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001210.1 |  | 0.48 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001787.1 |  | 0.47 | RiPP | suicin 3908 | Streptococcus suis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_1247 - Putative Class III

ctg1_1248 leader / core peptide
  MHGILVLQSLDTHSEPTRSPSN - WDhaNWDhb CYDha DhbRDhaIWFC
ctg1_1251 leader / core peptide
  MQYILDLQRTETEPTGGMR - Dhb CNPVDhaFADha C DhaLC DhaVDhaFADhaVAVCLDhbV

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_1248 - Class III
  Cleavage pHMM score: 3.80
  RODEO score: 0
  Monoisotopic mass: 1848.8 Da
  Molecular weight: 1850.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1868.1 Da N = 1
    1886.1 Da N = 2
    1904.1 Da N = 3
ctg1_1251 - Class III
  Cleavage pHMM score: 7.50
  RODEO score: 0
  Monoisotopic mass: 2450.2 Da
  Molecular weight: 2451.9 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2469.9 Da N = 1
    2487.9 Da N = 2
    2505.9 Da N = 3
    2523.9 Da N = 4

NZ_CP033719.1 - Region 6 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,902,425 - 1,924,949 nt. (total: 22,525 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001634.1 |  | 0.34 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.34 | RiPP | lariatin | Rhodococcus jostii
BGC0001548.1 |  | 0.32 | RiPP | citrulassin A | Streptomyces albulus
BGC0001539.1 |  | 0.32 | RiPP | cattlecin | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001356.1 |  | 0.32 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001307.1 |  | 0.31 | RiPP | chaxapeptin | Streptomyces leeuwenhoekii
BGC0001889.1 |  | 0.31 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001645.1 |  | 0.30 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001551.1 |  | 0.30 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001673.1 |  | 0.28 | RiPP | moomysin | Streptomyces cattleya NRRL 8057 = DSM 46488

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001634.1 |  | 0.67 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.67 | RiPP | lariatin | Rhodococcus jostii
BGC0001548.1 |  | 0.65 | RiPP | citrulassin A | Streptomyces albulus
BGC0001539.1 |  | 0.65 | RiPP | cattlecin | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001356.1 |  | 0.65 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001307.1 |  | 0.65 | RiPP | chaxapeptin | Streptomyces leeuwenhoekii
BGC0001889.1 |  | 0.64 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001645.1 |  | 0.64 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001551.1 |  | 0.63 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001673.1 |  | 0.62 | RiPP | moomysin | Streptomyces cattleya NRRL 8057 = DSM 46488

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lassopeptide(s) for allorf_1912032_1912307 - Putative Class II

allorf_1912032_1912307 leader / core peptide / cleaved tail
  LVGRPDIIRCQSCVQMLTELKTELKEVRELCYAQLNRAVEAARQEGGSDMYETPVLTRIADFADATN - G A G H A P L K DVWGFRALAVVYWPWS

#### Legend:

Red: Putative macrolactam
Purple: Putative cleaved off residues
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_1912032_1912307 - Class II
  Cleavage pHMM score: 1.40
  RODEO score: 19
  Monoisotopic mass: 2664.4 Da
  Molecular weight: 2666.0 Da
  Number of bridges: 0

NZ_CP033719.1 - Region 7 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,951,569 - 1,963,470 nt. (total: 11,902 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.1 |  | 0.17 | Other | 3-demethylchuangxinmycin | Actinoplanes tsinanensis
BGC0001546.1 |  | 0.17 | Alkaloid | chuangxinmycin | Actinoplanes tsinanensis
BGC0001157.1 |  | 0.07 | RiPP | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000468.1 |  | 0.07 | RiPP | bottromycin A2 | Streptomyces bottropensis
BGC0000470.1 |  | 0.07 | RiPP | bottromycin D | Streptomyces sp. WMMB 272
BGC0000469.1 |  | 0.05 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0000604.1 |  | 0.05 | RiPP | GE2270A | Nonomuraea sp. WU8817
BGC0001155.1 |  | 0.05 | RiPP | GE2270 | Planobispora rosea

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.1 |  | 0.48 | Other | 3-demethylchuangxinmycin | Actinoplanes tsinanensis
BGC0001546.1 |  | 0.48 | Alkaloid | chuangxinmycin | Actinoplanes tsinanensis
BGC0001157.1 |  | 0.28 | RiPP | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000468.1 |  | 0.28 | RiPP | bottromycin A2 | Streptomyces bottropensis
BGC0000470.1 |  | 0.27 | RiPP | bottromycin D | Streptomyces sp. WMMB 272
BGC0000469.1 |  | 0.23 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0000604.1 |  | 0.22 | RiPP | GE2270A | Nonomuraea sp. WU8817
BGC0001155.1 |  | 0.21 | RiPP | GE2270 | Planobispora rosea

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP033719.1 - Region 8 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,071,647 - 2,124,177 nt. (total: 52,531 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001985.1 |  | 0.21 | Other | pyrazomycin | Streptomyces candidus
BGC0001636.1 |  | 0.21 | NRP | KK-1 | Curvularia clavata
BGC0001591.1 |  | 0.21 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.21 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001343.1 |  | 0.21 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001699.1 |  | 0.21 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001863.1 |  | 0.20 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000484.1 |  | 0.20 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000347.1 |  | 0.20 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001862.1 |  | 0.20 | RiPP | geocillicin | Aeribacillus pallidus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001985.1 |  | 0.54 | Other | pyrazomycin | Streptomyces candidus
BGC0001636.1 |  | 0.54 | NRP | KK-1 | Curvularia clavata
BGC0001591.1 |  | 0.54 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.54 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001343.1 |  | 0.53 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001699.1 |  | 0.53 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001863.1 |  | 0.52 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000484.1 |  | 0.52 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000347.1 |  | 0.52 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001862.1 |  | 0.52 | RiPP | geocillicin | Aeribacillus pallidus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 2071646 - 2124177:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys - Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1744: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..856): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSmIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (2832..3218): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)

NZ_CP033719.1 - Region 9 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,370,578 - 2,396,770 nt. (total: 26,193 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000542.1 |  | 0.22 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000541.1 |  | 0.22 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000568.1 |  | 0.21 | RiPP | microcin B17 | Escherichia coli
BGC0000605.1 |  | 0.19 | RiPP | GE37468 | Streptomyces sp. ATCC 55365
BGC0001171.1 |  | 0.18 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000556.1 |  | 0.17 | RiPP | streptin | Streptococcus pyogenes
BGC0000560.1 |  | 0.17 | RiPP | subtilomycin | Bacillus subtilis
BGC0001727.1 |  | 0.17 | RiPP | paenilan | Paenibacillus polymyxa E681
BGC0001655.1 |  | 0.17 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000554.1 |  | 0.17 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000542.1 |  | 0.55 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000541.1 |  | 0.55 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000568.1 |  | 0.53 | RiPP | microcin B17 | Escherichia coli
BGC0000605.1 |  | 0.51 | RiPP | GE37468 | Streptomyces sp. ATCC 55365
BGC0001171.1 |  | 0.50 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000556.1 |  | 0.49 | RiPP | streptin | Streptococcus pyogenes
BGC0000560.1 |  | 0.48 | RiPP | subtilomycin | Bacillus subtilis
BGC0001727.1 |  | 0.48 | RiPP | paenilan | Paenibacillus polymyxa E681
BGC0001655.1 |  | 0.48 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000554.1 |  | 0.48 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP033719.1 - Region 10 - T2PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 2,906,566 - 2,979,107 nt. (total: 72,542 nt) Show pHMM detection rules used
T2PKS: (t2ks and t2clf)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T2PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000248.1 |  | 0.29 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000272.1 |  | 0.29 | Polyketide | spore pigment | Streptomyces collinus
BGC0001723.1 |  | 0.26 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000271.1 |  | 0.26 | Polyketide | spore pigment | Streptomyces avermitilis
BGC0000231.1 |  | 0.25 | Polyketide | griseusin | Streptomyces griseus
BGC0001513.1 |  | 0.25 | Polyketide | anthrabenzoxocinone | Actinobacteria bacterium
BGC0000234.1 |  | 0.24 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000275.1 |  | 0.24 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0001366.1 |  | 0.24 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0000228.1 |  | 0.23 | Polyketide | granaticin | Streptomyces violaceoruber

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000248.1 |  | 0.62 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000272.1 |  | 0.62 | Polyketide | spore pigment | Streptomyces collinus
BGC0001723.1 |  | 0.59 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000271.1 |  | 0.59 | Polyketide | spore pigment | Streptomyces avermitilis
BGC0000231.1 |  | 0.59 | Polyketide | griseusin | Streptomyces griseus
BGC0001513.1 |  | 0.59 | Polyketide | anthrabenzoxocinone | Actinobacteria bacterium
BGC0000234.1 |  | 0.57 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000275.1 |  | 0.57 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0001366.1 |  | 0.57 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0000228.1 |  | 0.57 | Polyketide | granaticin | Streptomyces violaceoruber

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Type II PKS
Type II PKS gene cluster prediction details
Predictions of starter units, elongations, product classes, and potential molecular weights for type II PKS clusters.
More detailed information is available here.

Cluster section:
  2906565 to 2979107
Starter unit(s):
  acetyl-CoA (Score: 0.0; E-value: 0)

ctg1_2479
  MET (Score: 144.0; E-value: 1.4e-44)
ctg1_2481
  KS (Score: 476.2; E-value: 1.9e-145)
ctg1_2482
  CLF (Score: 362.3; E-value: 6.8e-111)
ctg1_2483
  CYC C9-C14 (Score: 123.2; E-value: 1.7e-38)
ctg1_2484
  CYC C5-C14/C3-C16 (Score: 256.9; E-value: 4.7e-79)