GCF_003390515.1_ASM339051v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP031479.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	betalactone	671,200	698,091
Region 1.2	arylpolyene	1,196,904	1,240,529	APE Vf	Other	90%
Region 1.3	RiPP-like	1,459,203	1,470,066
Region 1.4	NRPS	2,152,962	2,201,445	vanchrobactin	NRP	100%

NZ_CP031478.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	hserlactone	371,906	392,487

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	betalactone	671,200	698,091
Region 1.2	arylpolyene	1,196,904	1,240,529	APE Vf	Other	90%
Region 1.3	RiPP-like	1,459,203	1,470,066
Region 1.4	NRPS	2,152,962	2,201,445	vanchrobactin	NRP	100%
Region 2.1	hserlactone	371,906	392,487

Compact view

NZ_CP031479.1 - Region 1 - betalactone

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Location: 671,200 - 698,091 nt. (total: 26,892 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000904.1	0.21	Other	FR-900098	Streptomyces rubellomurinus
BGC0001859.1	0.20	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0001441.1	0.16	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001873.1	0.14	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001132.1	0.14	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000632.1	0.13	Terpene, Saccharide	brasilicardin A	Nocardia terpenica
BGC0002009.1	0.13	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000938.1	0.13	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0001150.1	0.13	Polyketide	pamamycin-607	Streptomyces alboniger
BGC0000871.1	0.12	Other (Nucleoside)	VEPE, AEPE, TG-1	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000904.1	0.53	Other	FR-900098	Streptomyces rubellomurinus
BGC0001859.1	0.52	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0001441.1	0.46	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001873.1	0.43	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001132.1	0.43	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000632.1	0.42	Terpene, Saccharide	brasilicardin A	Nocardia terpenica
BGC0002009.1	0.42	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000938.1	0.41	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0001150.1	0.41	Polyketide	pamamycin-607	Streptomyces alboniger
BGC0000871.1	0.40	Other (Nucleoside)	VEPE, AEPE, TG-1	Myxococcus xanthus DK 1622

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP031479.1 - Region 2 - arylpolyene

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Location: 1,196,904 - 1,240,529 nt. (total: 43,626 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000837.1	0.51	Other	APE Vf	Aliivibrio fischeri ES114
BGC0002008.1	0.30	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.27	Other	APE Ec	Escherichia coli CFT073
BGC0000889.1	0.26	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0002029.1	0.26	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.26	Other	ferroverdin	Streptomyces lunaelactis
BGC0000221.1	0.24	Polyketide	erdacin	uncultured soil bacterium V167
BGC0000194.1	0.24	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000343.1	0.24	NRP	enterobactin	Pseudomonas sp. J465
BGC0001895.1	0.23	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000837.1	0.79	Other	APE Vf	Aliivibrio fischeri ES114
BGC0002008.1	0.64	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.61	Other	APE Ec	Escherichia coli CFT073
BGC0000889.1	0.60	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0002029.1	0.60	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.60	Other	ferroverdin	Streptomyces lunaelactis
BGC0000221.1	0.57	Polyketide	erdacin	uncultured soil bacterium V167
BGC0000194.1	0.57	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000343.1	0.57	NRP	enterobactin	Pseudomonas sp. J465
BGC0001895.1	0.56	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP031479.1 - Region 3 - RiPP-like

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Location: 1,459,203 - 1,470,066 nt. (total: 10,864 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000934.1		0.03	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000934.1		0.16	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP031479.1 - Region 4 - NRPS

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Location: 2,152,962 - 2,201,445 nt. (total: 48,484 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000454.1	0.70	NRP	vanchrobactin	Vibrio anguillarum RV22
BGC0001615.1	0.33	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001185.1	0.29	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001399.1	0.26	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000401.1	0.25	NRP	paenibactin	Paenibacillus elgii B69
BGC0001302.1	0.23	Other	lomofungin	Streptomyces lomondensis
BGC0001833.1	0.23	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131.1	0.23	NRP	ambactin	Xenorhabdus miraniensis
BGC0001128.1	0.23	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.23	NRP	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000454.1	0.89	NRP	vanchrobactin	Vibrio anguillarum RV22
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001185.1	0.62	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001399.1	0.59	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000401.1	0.58	NRP	paenibactin	Paenibacillus elgii B69
BGC0001302.1	0.56	Other	lomofungin	Streptomyces lomondensis
BGC0001833.1	0.56	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131.1	0.56	NRP	ambactin	Xenorhabdus miraniensis
BGC0001128.1	0.56	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.56	NRP	xenematide	Xenorhabdus nematophila AN6/1

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2152961 - 2201445:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1789

Search NORINE for peptide: strict or relaxed

AMP-binding (34..444): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

ctg1_1792

Search NORINE for peptide: strict or relaxed

AMP-binding (464..872): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAwDLGfVDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 80% (moderate)

AMP-binding (1983..2386): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

NZ_CP031478.1 - Region 1 - hserlactone

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Location: 371,906 - 392,487 nt. (total: 20,582 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.17	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000554.1	0.16	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000527.1	0.16	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001526.1	0.16	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0000500.1	0.16	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.1	0.16	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.1	0.16	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000502.1	0.16	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000496.1	0.16	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001576.1	0.16	RiPP	divamide A	Prochloron didemni

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001120.1	0.48	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000554.1	0.47	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000527.1	0.47	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001526.1	0.47	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0000500.1	0.47	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.1	0.46	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.1	0.46	RiPP	geobacillin II	Geobacillus thermodenitrificans
BGC0000502.1	0.46	RiPP	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000496.1	0.46	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001576.1	0.46	RiPP	divamide A	Prochloron didemni

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names