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Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP085627.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | thiopeptide | 1,560,661 | 1,586,894 | O-antigen | Saccharide | 14%
Region 1.2 | arylpolyene | 1,675,926 | 1,719,507 | aryl polyenes | Other | 94%
Region 1.3 | NRPS | 1,874,435 | 1,922,975 | salinichelins | NRP | 23%
Region 1.4 | T1PKS | 1,946,487 | 1,989,378 |
Region 1.5 | butyrolactone | 4,354,941 | 4,365,717 |
Region 1.6 | redox-cofactor | 4,370,833 | 4,393,001 | lankacidin C | NRP + Polyketide | 13%
Region 1.7 | betalactone | 4,583,850 | 4,612,053 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | thiopeptide | 1,560,661 | 1,586,894 | O-antigen | Saccharide | 14%
Region 1.2 | arylpolyene | 1,675,926 | 1,719,507 | aryl polyenes | Other | 94%
Region 1.3 | NRPS | 1,874,435 | 1,922,975 | salinichelins | NRP | 23%
Region 1.4 | T1PKS | 1,946,487 | 1,989,378 |
Region 1.5 | butyrolactone | 4,354,941 | 4,365,717 |
Region 1.6 | redox-cofactor | 4,370,833 | 4,393,001 | lankacidin C | NRP + Polyketide | 13%
Region 1.7 | betalactone | 4,583,850 | 4,612,053 |

No secondary metabolite regions were found in these records:
  NZ_CP085628.1

Compact view
NZ_CP085627.1 - Region 1 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,560,661 - 1,586,894 nt. (total: 26,234 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000784.1 |  | 0.24 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000781.1 |  | 0.16 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001285.1 |  | 0.07 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000981.1 |  | 0.06 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0001302.1 |  | 0.06 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.05 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.05 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0000123.1 |  | 0.03 | Polyketide | phoslactomycin B | Streptomyces sp. HK803

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000784.1 |  | 0.57 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000781.1 |  | 0.47 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001285.1 |  | 0.29 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000981.1 |  | 0.24 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0001302.1 |  | 0.24 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.23 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.22 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0000123.1 |  | 0.15 | Polyketide | phoslactomycin B | Streptomyces sp. HK803

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP085627.1 - Region 2 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,675,926 - 1,719,507 nt. (total: 43,582 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.50 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.46 | Other | APE Ec | Escherichia coli CFT073
BGC0000837.1 |  | 0.30 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000228.1 |  | 0.23 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001197.1 |  | 0.22 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000194.1 |  | 0.22 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0001897.1 |  | 0.22 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000272.1 |  | 0.21 | Polyketide | spore pigment | Streptomyces collinus
BGC0000220.1 |  | 0.20 | Polyketide | enterocin | Streptomyces maritimus
BGC0001940.1 |  | 0.20 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.79 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.76 | Other | APE Ec | Escherichia coli CFT073
BGC0000837.1 |  | 0.64 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000228.1 |  | 0.56 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001197.1 |  | 0.55 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000194.1 |  | 0.55 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0001897.1 |  | 0.54 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000272.1 |  | 0.54 | Polyketide | spore pigment | Streptomyces collinus
BGC0000220.1 |  | 0.53 | Polyketide | enterocin | Streptomyces maritimus
BGC0001940.1 |  | 0.53 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP085627.1 - Region 3 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,874,435 - 1,922,975 nt. (total: 48,541 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001615.1 |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000410.1 |  | 0.30 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000349.1 |  | 0.25 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001890.1 |  | 0.24 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001833.1 |  | 0.24 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.1 |  | 0.23 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001825.1 |  | 0.23 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001149.1 |  | 0.23 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001132.1 |  | 0.22 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000410.1 |  | 0.63 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000349.1 |  | 0.59 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001890.1 |  | 0.58 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001833.1 |  | 0.57 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.1 |  | 0.56 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001825.1 |  | 0.56 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001149.1 |  | 0.56 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001132.1 |  | 0.55 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 1874434 - 1922975:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-X - ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1781: X - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (479..889): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DsWdmGyIDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2006..2409): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)

NZ_CP085627.1 - Region 4 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,946,487 - 1,989,378 nt. (total: 42,892 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001343.1 |  | 0.26 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001281.1 |  | 0.26 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000099.1 |  | 0.26 | Polyketide | monascorubrin | Talaromyces marneffei
BGC0001338.1 |  | 0.25 | Polyketide | citrinin | Monascus ruber
BGC0001075.1 |  | 0.24 | Terpene, Polyketide | aurachin RE | Rhodococcus erythropolis
BGC0001441.1 |  | 0.24 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001895.1 |  | 0.24 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000495.1 |  | 0.24 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000862.1 |  | 0.24 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0001444.1 |  | 0.24 | Other | caboxamycin | Streptomyces sp. NTK 937

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001343.1 |  | 0.60 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001281.1 |  | 0.60 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000099.1 |  | 0.59 | Polyketide | monascorubrin | Talaromyces marneffei
BGC0001338.1 |  | 0.58 | Polyketide | citrinin | Monascus ruber
BGC0001075.1 |  | 0.57 | Terpene, Polyketide | aurachin RE | Rhodococcus erythropolis
BGC0001441.1 |  | 0.57 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001895.1 |  | 0.57 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000495.1 |  | 0.57 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000862.1 |  | 0.57 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0001444.1 |  | 0.57 | Other | caboxamycin | Streptomyces sp. NTK 937

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 1946486 - 1989378:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1831: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (18..426): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      viPtQGcLCK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      60% (weak)
ctg1_1836: mal
  PKS_AT (518..809): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 79.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 131.4
    Methoxymalonyl-CoA: 73.5
    Methylmalonyl-CoA: 66.2
    inactive: 58.7
    Propionyl-CoA: 48.7
    Ethylmalonyl-CoA: 44.8
    2-Methylbutyryl-CoA: 42.4
    Isobutyryl-CoA: 26.8
    CHC-CoA: 24.2
    trans-1,2-CPDA: 19.6
    fatty_acid: 18.2
    Acetyl-CoA: 16.2
    Benzoyl-CoA: 13.0
    3-Methylbutyryl-CoA: 0.0

NZ_CP085627.1 - Region 5 - butyrolactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,354,941 - 4,365,717 nt. (total: 10,777 nt) Show pHMM detection rules used
butyrolactone: AfsA

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | butyrolactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001480.1 |  | 0.22 | Other | tundrenone | Methylobacter tundripaludum 21/22
BGC0000866.1 |  | 0.20 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.1 |  | 0.19 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000914.1 |  | 0.09 | Other | methylenomycin A | Streptomyces coelicolor A3(2)
BGC0000997.1 |  | 0.06 | NRP, Polyketide | glidobactin | [Polyangium] brachysporum
BGC0001771.1 |  | 0.05 | NRP | scleric acid | Streptomyces sclerotialus
BGC0000893.1 |  | 0.05 | NRP | chloramphenicol | Streptomyces venezuelae ATCC 10712
BGC0001590.1 |  | 0.04 | Polyketide | formicamycins A-M | Streptomyces sp. KY5
BGC0001762.1 |  | 0.04 | Alkaloid | rubrolone A, rubrolone B | Streptomyces sp. KIB-H033

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001480.1 |  | 0.55 | Other | tundrenone | Methylobacter tundripaludum 21/22
BGC0000866.1 |  | 0.52 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.1 |  | 0.51 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000914.1 |  | 0.33 | Other | methylenomycin A | Streptomyces coelicolor A3(2)
BGC0000997.1 |  | 0.24 | NRP, Polyketide | glidobactin | [Polyangium] brachysporum
BGC0001771.1 |  | 0.22 | NRP | scleric acid | Streptomyces sclerotialus
BGC0000893.1 |  | 0.22 | NRP | chloramphenicol | Streptomyces venezuelae ATCC 10712
BGC0001590.1 |  | 0.19 | Polyketide | formicamycins A-M | Streptomyces sp. KY5
BGC0001762.1 |  | 0.18 | Alkaloid | rubrolone A, rubrolone B | Streptomyces sp. KIB-H033

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP085627.1 - Region 6 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,370,833 - 4,393,001 nt. (total: 22,169 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001929.1 |  | 0.19 | RiPP | WGK | Streptococcus ferus
BGC0001633.1 |  | 0.16 | Other | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0002009.1 |  | 0.15 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000883.1 |  | 0.13 | Other | arginomycin | Streptomyces arginensis
BGC0001495.1 |  | 0.11 | Polyketide | actinoallolide A | Actinoallomurus fulvus
BGC0000103.1 |  | 0.11 | Polyketide | mycolactone B | Mycobacterium ulcerans Agy99
BGC0000353.1 |  | 0.11 | NRP | tacrolimus | Streptomyces sp. MA6548
BGC0001029.1 |  | 0.11 | NRP, Polyketide | nostophycin | Nostoc sp. 152
BGC0001049.1 |  | 0.11 | NRP, Polyketide | tenellin | Beauveria bassiana
BGC0000147.1 |  | 0.10 | Polyketide | soraphen A | Sorangium cellulosum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001929.1 |  | 0.51 | RiPP | WGK | Streptococcus ferus
BGC0001633.1 |  | 0.46 | Other | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0002009.1 |  | 0.45 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000883.1 |  | 0.41 | Other | arginomycin | Streptomyces arginensis
BGC0001495.1 |  | 0.38 | Polyketide | actinoallolide A | Actinoallomurus fulvus
BGC0000103.1 |  | 0.38 | Polyketide | mycolactone B | Mycobacterium ulcerans Agy99
BGC0000353.1 |  | 0.38 | NRP | tacrolimus | Streptomyces sp. MA6548
BGC0001029.1 |  | 0.38 | NRP, Polyketide | nostophycin | Nostoc sp. 152
BGC0001049.1 |  | 0.37 | NRP, Polyketide | tenellin | Beauveria bassiana
BGC0000147.1 |  | 0.36 | Polyketide | soraphen A | Sorangium cellulosum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP085627.1 - Region 7 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,583,850 - 4,612,053 nt. (total: 28,204 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001441.1 |  | 0.16 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001440.1 |  | 0.14 | Other | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0000506.1 |  | 0.14 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0001128.1 |  | 0.14 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000597.1 |  | 0.14 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.13 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.13 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000896.1 |  | 0.13 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000922.1 |  | 0.13 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0000805.1 |  | 0.13 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001441.1 |  | 0.47 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001440.1 |  | 0.44 | Other | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0000506.1 |  | 0.43 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0001128.1 |  | 0.43 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000597.1 |  | 0.43 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.42 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.42 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000896.1 |  | 0.42 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000922.1 |  | 0.42 | Other | pseudomonas quinolone signal (PQS) | Pseudomonas aeruginosa PAO1
BGC0000805.1 |  | 0.41 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names