GCF_000091565.1_ASM9156v1_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_013961.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS,T1PKS	498,053	551,163	zorbamycin	NRP:Glycopeptide + Polyketide:Modular type I + Saccharide:Hybrid/tailoring	6%
Region 1.2	NRPS	2,563,035	2,624,112	rhizomide A / rhizomide B / rhizomide C	NRP	100%
Region 1.3	RRE-containing	3,161,667	3,181,948	basiliskamide A / basiliskamide B	Polyketide	9%
Region 1.4	siderophore	3,334,781	3,347,135	desferrioxamine E	Other	75%

No secondary metabolite regions were found in these records:: NC_013957.1

Compact view

NC_013961.1 - Region 1 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 498,053 - 551,163 nt. (total: 53,111 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.63	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001187.1	0.58	NRP, Polyketide	xenolozoyenone	Glarea lozoyensis
BGC0001050.1	0.57	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000999.1	0.56	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0000417.1	0.52	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001560.1	0.51	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001023.1	0.51	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000313.1	0.51	NRP	beauvericin	Beauveria bassiana
BGC0000436.1	0.50	NRP	syringolin A	Rhizobium sp. AP16
BGC0001538.1	0.50	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001187.1	0.62	NRP, Polyketide	xenolozoyenone	Glarea lozoyensis
BGC0001050.1	0.62	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000999.1	0.62	NRP, Polyketide	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0000417.1	0.61	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000935.1	0.60	Other (Aminocoumarin), Polyketide	esmeraldin	Streptomyces antibioticus
BGC0000855.1	0.59	Other	ectoine	Methylomicrobium kenyense
BGC0001560.1	0.59	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000859.1	0.59	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.59	Other	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 498052 - 551163:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (ccmal) + (ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 498052 - 540645:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (ccmal) + (ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 500762 - 551163:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (ccmal) + (ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_440

Search NORINE for peptide: strict or relaxed

AMP-binding (478..869): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLwTcCfVfK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 60% (weak)

ctg1_441

PKS_AT (553..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 66.7%; CE-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 83.5
Methylmalonyl-CoA: 82.4
Methoxymalonyl-CoA: 70.5
Propionyl-CoA: 54.7
Isobutyryl-CoA: 54.7
inactive: 41.9
Ethylmalonyl-CoA: 35.3
2-Methylbutyryl-CoA: 34.0
trans-1,2-CPDA: 33.6
CHC-CoA: 28.9
3-Methylbutyryl-CoA: 27.7
Acetyl-CoA: 23.7
fatty_acid: 18.1
Benzoyl-CoA: 16.9

ctg1_442

PKS_AT (549..827): mmal

ATSignature: (unknown)

No matches above 50%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 40.5
Methoxymalonyl-CoA: 39.1
Isobutyryl-CoA: 26.6
Propionyl-CoA: 23.5
Ethylmalonyl-CoA: 13.4
Malonyl-CoA: 12.7
CHC-CoA: 12.7
Benzoyl-CoA: 11.0
inactive: 9.1
Acetyl-CoA: 8.0
2-Methylbutyryl-CoA: 6.7
trans-1,2-CPDA: 4.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

NC_013961.1 - Region 2 - NRPS

Download region GenBank file

Download region SVG

Location: 2,563,035 - 2,624,112 nt. (total: 61,078 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001131.1	0.37	NRP	ambactin	Xenorhabdus miraniensis
BGC0001758.1	0.37	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.36	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.36	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.35	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.34	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.34	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.1	0.30	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.30	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001220.1	0.29	NRP	aculeacin A	Aspergillus japonicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001131.1	0.69	NRP	ambactin	Xenorhabdus miraniensis
BGC0001758.1	0.69	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.69	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.68	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.68	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.67	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.67	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.1	0.63	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.63	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001220.1	0.63	NRP	aculeacin A	Aspergillus japonicus

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2563034 - 2624112:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ala - thr - thr - X - tyr - ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2312

Search NORINE for peptide: strict or relaxed

AMP-binding (830..1221): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

AMP-binding (1877..2280): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (2954..3357): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (4033..4435): X

NRPSPredictor2: ser, thr, dhpg, hpg

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DlWQiGmIDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 70% (weak)

AMP-binding (5091..5484): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)

AMP-binding (6159..6561): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHIShIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)

NC_013961.1 - Region 3 - RRE-containing

Download region GenBank file

Download region SVG

Location: 3,161,667 - 3,181,948 nt. (total: 20,282 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000894.1	0.16	Other	citrinin	Monascus aurantiacus
BGC0001241.1	0.16	Terpene	ergotamine	Claviceps fusiformis
BGC0001267.1	0.16	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0000811.1	0.14	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0000584.1	0.14	RiPP	colicin V	Escherichia coli
BGC0000906.1	0.13	Other	heme D1	Heliophilum fasciatum
BGC0000905.1	0.13	Other	heme D1	Heliobacillus mobilis
BGC0000348.1	0.11	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001338.1	0.11	Polyketide	citrinin	Monascus ruber
BGC0000172.1	0.08	Polyketide	basiliskamide A, basiliskamide B	Brevibacillus laterosporus PE36

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000894.1	0.47	Other	citrinin	Monascus aurantiacus
BGC0001241.1	0.47	Terpene	ergotamine	Claviceps fusiformis
BGC0001267.1	0.47	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0000811.1	0.43	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0000584.1	0.42	RiPP	colicin V	Escherichia coli
BGC0000906.1	0.42	Other	heme D1	Heliophilum fasciatum
BGC0000905.1	0.41	Other	heme D1	Heliobacillus mobilis
BGC0000348.1	0.38	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001338.1	0.37	Polyketide	citrinin	Monascus ruber
BGC0000172.1	0.32	Polyketide	basiliskamide A, basiliskamide B	Brevibacillus laterosporus PE36

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_013961.1 - Region 4 - siderophore

Download region GenBank file

Download region SVG

Location: 3,334,781 - 3,347,135 nt. (total: 12,355 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.49	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.33	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.31	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.29	Other	desferrioxamine	Streptomyces argillaceus
BGC0000940.1	0.29	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0000888.1	0.29	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.25	Other	bacilysin	Bacillus velezensis FZB42
BGC0001499.1	0.19	Other	aerobactin	Pantoea ananatis
BGC0001713.1	0.19	Other	ochrobactin	Ochrobactrum anthropi
BGC0001531.1	0.18	Other	bisucaberin B	Tenacibaculum mesophilum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.78	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.67	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.64	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.63	Other	desferrioxamine	Streptomyces argillaceus
BGC0000940.1	0.63	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0000888.1	0.62	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.59	Other	bacilysin	Bacillus velezensis FZB42
BGC0001499.1	0.51	Other	aerobactin	Pantoea ananatis
BGC0001713.1	0.50	Other	ochrobactin	Ochrobactrum anthropi
BGC0001531.1	0.50	Other	bisucaberin B	Tenacibaculum mesophilum

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names