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Overview
1.1
1.2
1.3
1.4
1.5
2.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_OW968328.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | T1PKS,NRPS | 444,508 | 492,247 | saquayamycin A | Polyketide | 5%
Region 1.2 | NRPS | 1,201,053 | 1,244,910 | colicin V | RiPP | 3%
Region 1.3 | thiopeptide | 1,603,900 | 1,630,197 | O-antigen | Saccharide | 14%
Region 1.4 | siderophore | 3,110,619 | 3,125,047 | aerobactin | Other | 66%
Region 1.5 | arylpolyene | 4,535,580 | 4,579,173 | aryl polyenes | Other | 88%

NZ_OW968329.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | lassopeptide | 1 | 19,176 | microcin J25 | RiPP:Linaridin | 100%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | T1PKS,NRPS | 444,508 | 492,247 | saquayamycin A | Polyketide | 5%
Region 1.2 | NRPS | 1,201,053 | 1,244,910 | colicin V | RiPP | 3%
Region 1.3 | thiopeptide | 1,603,900 | 1,630,197 | O-antigen | Saccharide | 14%
Region 1.4 | siderophore | 3,110,619 | 3,125,047 | aerobactin | Other | 66%
Region 1.5 | arylpolyene | 4,535,580 | 4,579,173 | aryl polyenes | Other | 88%
Region 2.1 | lassopeptide | 1 | 19,176 | microcin J25 | RiPP:Linaridin | 100%

No secondary metabolite regions were found in these records:
  NZ_OW968330.1

Compact view
NZ_OW968328.1 - Region 1 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 444,508 - 492,247 nt. (total: 47,740 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001909.1 |  |  | 0.63 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001281.1 |  |  | 0.49 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0001264.1 |  |  | 0.44 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  |  | 0.44 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001265.1 |  |  | 0.42 | Polyketide | melanin | Bipolaris oryzae
BGC0000107.1 |  |  | 0.41 | Polyketide | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001257.1 |  |  | 0.41 | Polyketide | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0001906.1 |  |  | 0.41 | Polyketide | naphthalene | Daldinia eschscholzii IFB-TL01
BGC0000030.1 |  |  | 0.41 | Polyketide | bikaverin | Fusarium fujikuroi IMI 58289
BGC0000057.1 |  |  | 0.41 | Polyketide | F9775A, F9775B, orsellinic acid | Aspergillus nidulans FGSC A4

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.65 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001281.1 |  | 0.58 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0001264.1 |  | 0.55 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.55 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001265.1 |  | 0.54 | Polyketide | melanin | Bipolaris oryzae
BGC0000107.1 |  | 0.53 | Polyketide | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001257.1 |  | 0.53 | Polyketide | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0001906.1 |  | 0.53 | Polyketide | naphthalene | Daldinia eschscholzii IFB-TL01
BGC0000030.1 |  | 0.53 | Polyketide | bikaverin | Fusarium fujikuroi IMI 58289
BGC0000057.1 |  | 0.53 | Polyketide | F9775A, F9775B, orsellinic acid | Aspergillus nidulans FGSC A4

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 444507 - 492247:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_432: pk - mal
  CAL_domain (180..470): pk
  minowa: NH2
  Prediction, score:
    NH2: 109.7
    Acetyl-CoA: 54.3
    AHBA: 24.0
    shikimic_acid: 16.5
    fatty_acid: 14.1
  PKS_AT (1171..1451): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 71.1
    Methylmalonyl-CoA: 48.4
    Methoxymalonyl-CoA: 47.3
    inactive: 37.8
    2-Methylbutyryl-CoA: 29.5
    Ethylmalonyl-CoA: 23.2
    Isobutyryl-CoA: 14.8
    fatty_acid: 14.6
    trans-1,2-CPDA: 11.2
    Propionyl-CoA: 1.8
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0

NZ_OW968328.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,201,053 - 1,244,910 nt. (total: 43,858 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.36 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001615.1 |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000401.1 |  | 0.30 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001184.1 |  | 0.27 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.27 | Other | bacilysin | Bacillus sp. CS93
BGC0001833.1 |  | 0.24 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001197.1 |  | 0.24 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0001844.1 |  | 0.23 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001132.1 |  | 0.23 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.1 |  | 0.23 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.1 |  | 0.69 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000401.1 |  | 0.64 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001184.1 |  | 0.60 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.60 | Other | bacilysin | Bacillus sp. CS93
BGC0001833.1 |  | 0.58 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001197.1 |  | 0.57 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0001844.1 |  | 0.57 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001132.1 |  | 0.56 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.1 |  | 0.56 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 1201052 - 1244910:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1125: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (456..856): ser
  NRPSPredictor2: ser
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg1_1132: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (35..437): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      aMPSQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      90% (moderate)

NZ_OW968328.1 - Region 3 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,603,900 - 1,630,197 nt. (total: 26,298 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000784.1 |  | 0.24 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000781.1 |  | 0.16 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001285.1 |  | 0.09 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001441.1 |  | 0.07 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000981.1 |  | 0.07 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0001302.1 |  | 0.06 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.05 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.05 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0000957.1 |  | 0.04 | NRP, Polyketide | mycotrienin I | Streptomyces sp. XZQH13
BGC0000123.1 |  | 0.03 | Polyketide | phoslactomycin B | Streptomyces sp. HK803

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000784.1 |  | 0.58 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000781.1 |  | 0.47 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001285.1 |  | 0.34 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001441.1 |  | 0.29 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000981.1 |  | 0.28 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0001302.1 |  | 0.24 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.23 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.22 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0000957.1 |  | 0.19 | NRP, Polyketide | mycotrienin I | Streptomyces sp. XZQH13
BGC0000123.1 |  | 0.15 | Polyketide | phoslactomycin B | Streptomyces sp. HK803

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_OW968328.1 - Region 4 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,110,619 - 3,125,047 nt. (total: 14,429 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001499.1 |  | 0.56 | Other | aerobactin | Pantoea ananatis
BGC0001498.1 |  | 0.37 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001572.1 |  | 0.29 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001713.1 |  | 0.28 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000939.1 |  | 0.26 | Other | aerobactin | Grimontia hollisae
BGC0001870.1 |  | 0.24 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001555.1 |  | 0.24 | RiPP | colicin V | Escherichia coli chi7122
BGC0001478.1 |  | 0.22 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.21 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  | 0.21 | Other | desferrioxamine | Streptomyces argillaceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001499.1 |  | 0.82 | Other | aerobactin | Pantoea ananatis
BGC0001498.1 |  | 0.69 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001572.1 |  | 0.63 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001713.1 |  | 0.62 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000939.1 |  | 0.59 | Other | aerobactin | Grimontia hollisae
BGC0001870.1 |  | 0.58 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001555.1 |  | 0.57 | RiPP | colicin V | Escherichia coli chi7122
BGC0001478.1 |  | 0.55 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.54 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  | 0.54 | Other | desferrioxamine | Streptomyces argillaceus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_OW968328.1 - Region 5 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,535,580 - 4,579,173 nt. (total: 43,594 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.50 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.49 | Other | APE Ec | Escherichia coli CFT073
BGC0000837.1 |  | 0.34 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000228.1 |  | 0.25 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001723.1 |  | 0.25 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0001895.1 |  | 0.22 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000194.1 |  | 0.22 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000219.1 |  | 0.21 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001897.1 |  | 0.21 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000719.1 |  | 0.21 | Saccharide | tobramycin | Streptoalloteichus hindustanus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.79 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.78 | Other | APE Ec | Escherichia coli CFT073
BGC0000837.1 |  | 0.67 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000228.1 |  | 0.59 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001723.1 |  | 0.58 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0001895.1 |  | 0.55 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000194.1 |  | 0.55 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000219.1 |  | 0.54 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001897.1 |  | 0.54 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000719.1 |  | 0.54 | Saccharide | tobramycin | Streptoalloteichus hindustanus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
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Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
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NZ_OW968329.1 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 1 - 19,176 nt. (total: 19,176 nt) Show pHMM detection rules used
Region on contig edge.
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000581.1 |  | 1.00 | RiPP | microcin J25 | Escherichia coli
BGC0001889.1 |  | 0.25 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001639.1 |  | 0.23 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0001549.1 |  | 0.23 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001634.1 |  | 0.23 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001550.1 |  | 0.23 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.23 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001356.1 |  | 0.22 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001655.1 |  | 0.20 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0001551.1 |  | 0.18 | RiPP | citrulassin E | Streptomyces glaucescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000581.1 |  | 1.00 | RiPP | microcin J25 | Escherichia coli
BGC0001889.1 |  | 0.59 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001639.1 |  | 0.57 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0001549.1 |  | 0.56 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001634.1 |  | 0.56 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001550.1 |  | 0.56 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.56 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001356.1 |  | 0.55 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001655.1 |  | 0.52 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0001551.1 |  | 0.49 | RiPP | citrulassin E | Streptomyces glaucescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lassopeptide(s) for ctg2_11 - Putative Class II

ctg2_11 leader / core peptide / cleaved tail
  MIKHFHFNKLSSGKKNNVPSPAKGVIQIKKSASQLTK - G G A G H V P EYFVGIGTPISFYG

#### Legend:

Red: Putative macrolactam
Purple: Putative cleaved off residues
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg2_11 - Class II
  Cleavage pHMM score: 5.40
  RODEO score: 23
  Monoisotopic mass: 2106.0 Da
  Molecular weight: 2107.3 Da
  Number of bridges: 0