GCF_007632255.1_ASM763225v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP041925.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	arylpolyene	270,216	313,812	aryl polyenes	Other	88%
Region 1.2	redox-cofactor	2,525,778	2,547,943	lankacidin C	NRP + Polyketide	13%
Region 1.3	thiopeptide	3,419,579	3,445,844	O-antigen	Saccharide	14%
Region 1.4	NRPS	3,736,817	3,780,698	turnerbactin	NRP	30%
Region 1.5	ladderane	3,942,220	3,984,616	12-epi-hapalindole C isonitrile / 12-epi-hapalindole E / 12-epi-fischerindole U isonitrile / fischerindole L / 12-epi-fischerindole I isonitrile / welwitindolinone A isonitrile / welwitindolinone B isothiocyanate / welwitindolinone C isothiocyanate / N-methylwelwitindolinone C isothiocyanate / N-methylwelwitinsolinone C isonitrile / 3-epi-welwitindolinone B isothiocyanate / 3-(Z-2'-isocyanoethenyl)-indole	Terpene + Alkaloid	6%

No secondary metabolite regions were found in these records:: NZ_CP041926.1

Compact view

NZ_CP041925.1 - Region 1 - arylpolyene

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Location: 270,216 - 313,812 nt. (total: 43,597 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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core biosynthetic genes

additional biosynthetic genes

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.51	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.50	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.31	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000410.1	0.23	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000194.1	0.23	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001895.1	0.22	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000719.1	0.21	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000219.1	0.21	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0001591.1	0.21	Other	fatty acid enol ester	uncultured bacterium CSLC2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.79	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.78	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.65	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000410.1	0.56	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000194.1	0.56	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001895.1	0.54	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000719.1	0.54	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000219.1	0.54	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0001591.1	0.54	Other	fatty acid enol ester	uncultured bacterium CSLC2

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NZ_CP041925.1 - Region 2 - redox-cofactor

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Location: 2,525,778 - 2,547,943 nt. (total: 22,166 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000386.1	0.23	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0000843.1	0.19	Other (Non-NRP beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0001572.1	0.17	Other	desferrioxamine E	Pantoea agglomerans
BGC0000941.1	0.17	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.17	Other	desferrioxamine	Streptomyces argillaceus
BGC0000940.1	0.17	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001478.1	0.17	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0001531.1	0.17	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0000928.1	0.16	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.16	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000386.1	0.56	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0000843.1	0.51	Other (Non-NRP beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0001572.1	0.49	Other	desferrioxamine E	Pantoea agglomerans
BGC0000941.1	0.48	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.48	Other	desferrioxamine	Streptomyces argillaceus
BGC0000940.1	0.48	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001478.1	0.48	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0001531.1	0.48	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0000928.1	0.46	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.46	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP041925.1 - Region 3 - thiopeptide

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Location: 3,419,579 - 3,445,844 nt. (total: 26,266 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.25	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.16	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.09	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.07	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.07	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.06	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.05	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.05	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.04	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13
BGC0000123.1	0.03	Polyketide	phoslactomycin B	Streptomyces sp. HK803

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.58	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.47	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.34	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.29	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.28	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.24	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.23	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.22	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.19	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13
BGC0000123.1	0.15	Polyketide	phoslactomycin B	Streptomyces sp. HK803

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Thiopeptides

Core peptide predictions

No core peptides found.

NZ_CP041925.1 - Region 4 - NRPS

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Location: 3,736,817 - 3,780,698 nt. (total: 43,882 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.36	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.31	NRP	paenibactin	Paenibacillus elgii B69
BGC0001184.1	0.28	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.28	Other	bacilysin	Bacillus sp. CS93
BGC0001833.1	0.25	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.25	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001197.1	0.24	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001131.1	0.24	NRP	ambactin	Xenorhabdus miraniensis
BGC0000228.1	0.23	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001844.1	0.23	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.69	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.65	NRP	paenibactin	Paenibacillus elgii B69
BGC0001184.1	0.62	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.61	Other	bacilysin	Bacillus sp. CS93
BGC0001833.1	0.59	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.59	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001197.1	0.57	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001131.1	0.57	NRP	ambactin	Xenorhabdus miraniensis
BGC0000228.1	0.56	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001844.1	0.56	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 3736816 - 3780698:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_3486

Search NORINE for peptide: strict or relaxed

AMP-binding (34..436): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: AMPsQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

ctg1_3494

Search NORINE for peptide: strict or relaxed

AMP-binding (461..862): ser

NRPSPredictor2: ser

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

NZ_CP041925.1 - Region 5 - ladderane

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Location: 3,942,220 - 3,984,616 nt. (total: 42,397 nt) Show pHMM detection rules used

ladderane: ladderane

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001361.1	0.28	Terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0001591.1	0.23	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.23	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000044.1	0.22	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0000234.1	0.21	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001366.1	0.20	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000271.1	0.19	Polyketide	spore pigment	Streptomyces avermitilis
BGC0000194.1	0.19	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000228.1	0.18	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000204.1	0.18	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001361.1	0.62	Terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0001591.1	0.56	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.56	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000044.1	0.55	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0000234.1	0.53	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001366.1	0.53	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000271.1	0.52	Polyketide	spore pigment	Streptomyces avermitilis
BGC0000194.1	0.51	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000228.1	0.50	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000204.1	0.50	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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