GCF_000018045.1_ASM1804v1_genomic - 7 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_009792.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS,T1PKS	800,841	929,423	N-myristoyl-D-asparagine / cis-7-tetradecenoyl-D-asparagine / (R)-N1-((S)-5-oxohexan-2-yl)-2-tetradecanamidosuccinamide	NRP + Polyketide:Modular type I + Polyketide:Trans-AT type I	95%
Region 1.2	siderophore	964,475	978,937	aerobactin	Other	77%
Region 1.3	T1PKS,NRPS	1,182,445	1,238,096	yersiniabactin	NRP + Polyketide	16%
Region 1.4	thiopeptide	1,995,511	2,022,061	O-antigen	Saccharide	14%
Region 1.5	NRPS	2,357,363	2,401,247	turnerbactin	NRP	30%
Region 1.6	arylpolyene	4,492,276	4,535,872	aryl polyenes	Other	100%

NC_009793.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	RiPP-like	566	9,294

No secondary metabolite regions were found in these records:: NC_009794.1

Compact view

NC_009792.1 - Region 1 - NRPS,T1PKS

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Location: 800,841 - 929,423 nt. (total: 128,583 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	2.08	NRP	yersiniabactin	Yersinia enterocolitica
BGC0000972.1	1.72	NRP, Polyketide	N-myristoyl-D-asparagine, cis-7-tetradecenoyl-D-asparagine, (R)-N1-((S)-5-oxohexan-2-yl)-2-tetradecanamidosuccinamide	Escherichia coli
BGC0001560.1	1.05	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000457.1	1.04	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000410.1	1.02	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000412.1	1.01	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0001833.1	1.00	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001050.1	1.00	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001185.1	0.99	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000465.1	0.98	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.94	NRP	yersiniabactin	Yersinia enterocolitica
BGC0000972.1	0.87	NRP, Polyketide	N-myristoyl-D-asparagine, cis-7-tetradecenoyl-D-asparagine, (R)-N1-((S)-5-oxohexan-2-yl)-2-tetradecanamidosuccinamide	Escherichia coli
BGC0001050.1	0.67	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001023.1	0.67	NRP, Polyketide	myxochromide S1	Stigmatella aurantiaca
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000389.1	0.64	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001833.1	0.64	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001560.1	0.63	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001166.1	0.62	NRP	HC-toxin	Alternaria jesenskae

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 800840 - 929423:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - redmal) + (X) + (mal) + (gly - cys) + (cys) + (asn) + (Me-ohmal) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 800840 - 880991:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - redmal) + (X) + (mal) + (gly - cys) + (cys) + (asn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 875526 - 922938:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 885637 - 929423:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_720

Search NORINE for peptide: strict or relaxed

AMP-binding (502..890): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DVFWtGGiFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 80% (moderate)

PKS_AT (1604..1895): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 155.9
inactive: 95.9
Methoxymalonyl-CoA: 53.4
Methylmalonyl-CoA: 38.8
Propionyl-CoA: 26.7
Isobutyryl-CoA: 21.1
fatty_acid: 18.9
CHC-CoA: 16.9
2-Methylbutyryl-CoA: 11.0
Benzoyl-CoA: 10.3
Ethylmalonyl-CoA: 9.3
Acetyl-CoA: 8.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg1_725

PKS_AT (7..296): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 57.2
Methoxymalonyl-CoA: 41.1
Methylmalonyl-CoA: 34.3
inactive: 30.1
Ethylmalonyl-CoA: 18.1
Propionyl-CoA: 16.0
Acetyl-CoA: 14.6
Benzoyl-CoA: 12.9
2-Methylbutyryl-CoA: 12.5
CHC-CoA: 9.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg1_726

Search NORINE for peptide: strict or relaxed

AMP-binding (24..422): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (992..1384): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: asGsLGGiCK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 60% (weak)

ctg1_727

PKS_AT (531..813): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 135.2
inactive: 78.0
Methoxymalonyl-CoA: 66.0
Methylmalonyl-CoA: 56.3
Isobutyryl-CoA: 28.5
Propionyl-CoA: 26.3
Ethylmalonyl-CoA: 20.5
2-Methylbutyryl-CoA: 14.2
Benzoyl-CoA: 11.6
trans-1,2-CPDA: 11.4
CHC-CoA: 9.8
3-Methylbutyryl-CoA: 6.9
fatty_acid: 0.0
Acetyl-CoA: 0.0

ctg1_728

Search NORINE for peptide: strict or relaxed

AMP-binding (507..894): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)

AMP-binding (1555..1950): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg1_729

Search NORINE for peptide: strict or relaxed

AMP-binding (1269..1664): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg1_732

Search NORINE for peptide: strict or relaxed

AMP-binding (453..844): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

ctg1_761

Search NORINE for peptide: strict or relaxed

AMP-binding (20..422): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLCK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

ctg1_764

PKS_AT (552..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.0
Methoxymalonyl-CoA: 49.3
inactive: 45.5
Methylmalonyl-CoA: 42.8
Benzoyl-CoA: 42.7
Propionyl-CoA: 33.6
Isobutyryl-CoA: 30.8
fatty_acid: 25.6
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 24.6
3-Methylbutyryl-CoA: 19.5
CHC-CoA: 16.3
trans-1,2-CPDA: 11.2
Ethylmalonyl-CoA: 6.5

ctg1_766

Search NORINE for peptide: strict or relaxed

AMP-binding (573..966): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

NC_009792.1 - Region 2 - siderophore

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Location: 964,475 - 978,937 nt. (total: 14,463 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001499.1	0.63	Other	aerobactin	Pantoea ananatis
BGC0001498.1	0.39	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001555.1	0.30	RiPP	colicin V	Escherichia coli chi7122
BGC0001572.1	0.29	Other	desferrioxamine E	Pantoea agglomerans
BGC0001713.1	0.28	Other	ochrobactin	Ochrobactrum anthropi
BGC0000939.1	0.26	Other	aerobactin	Grimontia hollisae
BGC0000941.1	0.21	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.21	Other	desferrioxamine	Streptomyces argillaceus
BGC0001531.1	0.21	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0001870.1	0.19	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001499.1	0.86	Other	aerobactin	Pantoea ananatis
BGC0001498.1	0.71	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001555.1	0.64	RiPP	colicin V	Escherichia coli chi7122
BGC0001572.1	0.63	Other	desferrioxamine E	Pantoea agglomerans
BGC0001713.1	0.62	Other	ochrobactin	Ochrobactrum anthropi
BGC0000939.1	0.59	Other	aerobactin	Grimontia hollisae
BGC0000941.1	0.54	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1	0.54	Other	desferrioxamine	Streptomyces argillaceus
BGC0001531.1	0.54	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0001870.1	0.51	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_009792.1 - Region 3 - NRPS,T1PKS

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Location: 1,182,445 - 1,238,096 nt. (total: 55,652 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	1.66	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001055.1	0.68	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0000373.1	0.53	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001560.1	0.50	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001185.1	0.49	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001415.1	0.47	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0000225.1	0.44	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0000351.1	0.42	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001131.1	0.42	NRP	ambactin	Xenorhabdus miraniensis
BGC0001699.1	0.42	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.94	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001055.1	0.66	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0000373.1	0.61	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001560.1	0.58	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001185.1	0.58	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000225.1	0.57	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0001415.1	0.57	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0000935.1	0.55	Other (Aminocoumarin), Polyketide	esmeraldin	Streptomyces antibioticus
BGC0001890.1	0.54	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0001343.1	0.54	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 6, location 1182444 - 1238096:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 1182444 - 1231936:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 1192602 - 1238096:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1040

Search NORINE for peptide: strict or relaxed

AMP-binding (20..422): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLCK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

ctg1_1043

PKS_AT (552..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.0
Methoxymalonyl-CoA: 49.3
inactive: 45.5
Methylmalonyl-CoA: 42.8
Benzoyl-CoA: 42.7
Propionyl-CoA: 33.6
Isobutyryl-CoA: 30.8
fatty_acid: 25.6
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 24.6
3-Methylbutyryl-CoA: 19.5
CHC-CoA: 16.3
trans-1,2-CPDA: 11.2
Ethylmalonyl-CoA: 6.5

ctg1_1044

Search NORINE for peptide: strict or relaxed

AMP-binding (573..966): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

NC_009792.1 - Region 4 - thiopeptide

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Location: 1,995,511 - 2,022,061 nt. (total: 26,551 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.25	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.16	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.10	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.07	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.07	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.06	Other	lomofungin	Streptomyces lomondensis
BGC0000070.1	0.05	Polyketide	griseofulvin, epidechlorogriseofulvin, norlichexanthone, dehydrogriseofulvin, 4-desmethylgriseofulvin, griseoxanthone B	Penicillium aethiopicum
BGC0002012.1	0.05	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.05	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.04	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.59	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.47	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.34	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001441.1	0.29	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000981.1	0.28	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.24	Other	lomofungin	Streptomyces lomondensis
BGC0000070.1	0.24	Polyketide	griseofulvin, epidechlorogriseofulvin, norlichexanthone, dehydrogriseofulvin, 4-desmethylgriseofulvin, griseoxanthone B	Penicillium aethiopicum
BGC0002012.1	0.23	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.22	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000957.1	0.19	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Thiopeptides

Core peptide predictions

No core peptides found.

NC_009792.1 - Region 5 - NRPS

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Location: 2,357,363 - 2,401,247 nt. (total: 43,885 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.34	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000401.1	0.30	NRP	paenibactin	Paenibacillus elgii B69
BGC0001833.1	0.24	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001302.1	0.24	Other	lomofungin	Streptomyces lomondensis
BGC0001132.1	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001831.1	0.23	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001149.1	0.23	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0000426.1	0.23	NRP	sevadicin	Paenibacillus larvae
BGC0001758.1	0.23	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.67	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000401.1	0.64	NRP	paenibactin	Paenibacillus elgii B69
BGC0001833.1	0.58	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001302.1	0.57	Other	lomofungin	Streptomyces lomondensis
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001831.1	0.56	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001149.1	0.56	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0000426.1	0.56	NRP	sevadicin	Paenibacillus larvae
BGC0001758.1	0.56	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 10, location 2357362 - 2401247:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2120

Search NORINE for peptide: strict or relaxed

AMP-binding (35..437): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: AMPAQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

ctg1_2128

Search NORINE for peptide: strict or relaxed

AMP-binding (461..863): ser

NRPSPredictor2: ser

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

NC_009792.1 - Region 6 - arylpolyene

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Location: 4,492,276 - 4,535,872 nt. (total: 43,597 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.58	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.55	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.26	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001591.1	0.21	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.21	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001861.1	0.21	RiPP	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0000248.1	0.21	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.21	Polyketide	spore pigment	Streptomyces collinus
BGC0001862.1	0.20	RiPP	geocillicin	Aeribacillus pallidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.83	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.82	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.59	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001591.1	0.54	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.54	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001861.1	0.54	RiPP	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0000248.1	0.54	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.54	Polyketide	spore pigment	Streptomyces collinus
BGC0001862.1	0.53	RiPP	geocillicin	Aeribacillus pallidus

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NC_009793.1 - Region 1 - RiPP-like

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Location: 566 - 9,294 nt. (total: 8,729 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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core biosynthetic genes

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Gene details

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KnownClusterBlast

Pfam domains

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Analysis type:

No matches found.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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