GCF_901421005.1_39282_A01_genomic - 7 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

c00002_NZ_CABD.. (original name was: NZ_CABDWD010000002.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	arylpolyene	275,359	318,955	aryl polyenes	Other	94%
Region 2.2	T1PKS,NRPS	1,838,954	1,892,977	yersiniabactin	NRP + Polyketide	23%
Region 2.3	butyrolactone	3,389,704	3,400,558
Region 2.4	ectoine	3,401,737	3,412,123
Region 2.5	thiopeptide	3,561,707	3,587,984	O-antigen	Saccharide	14%
Region 2.6	NRPS	3,905,181	3,949,062	enterobactin	NRP	12%
Region 2.7	RiPP-like	5,368,101	5,378,724

No secondary metabolite regions were found in these records:: c00001_NZ_CABD.. (original name was: NZ_CABDWD010000001.1)

Compact view

c00002_NZ_CABD.. - Region 1 - arylpolyene

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Location: 275,359 - 318,955 nt. (total: 43,597 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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MIBiG comparison

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Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.50	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.50	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.34	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000194.1	0.23	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000234.1	0.23	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000719.1	0.21	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000219.1	0.21	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000248.1	0.21	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.21	Polyketide	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.79	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.78	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000837.1	0.67	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000194.1	0.56	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000234.1	0.56	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000719.1	0.54	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0000219.1	0.54	Polyketide, Saccharide	elloramycin	Streptomyces olivaceus
BGC0000248.1	0.54	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000272.1	0.54	Polyketide	spore pigment	Streptomyces collinus

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00002_NZ_CABD.. - Region 2 - NRPS,T1PKS

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Location: 1,838,954 - 1,892,977 nt. (total: 54,024 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	1.39	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001055.1	0.67	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0000373.1	0.50	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001560.1	0.50	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000389.1	0.49	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001444.1	0.49	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.49	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001185.1	0.48	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000392.1	0.47	NRP	mirubactin	Actinosynnema mirum DSM 43827
BGC0001415.1	0.47	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.89	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001055.1	0.64	NRP, Polyketide	yersiniabactin	Escherichia coli
BGC0001444.1	0.60	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.60	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000373.1	0.60	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001560.1	0.58	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0000389.1	0.58	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001185.1	0.58	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000392.1	0.57	NRP	mirubactin	Actinosynnema mirum DSM 43827
BGC0001415.1	0.56	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 1838953 - 1892977:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 1838953 - 1888445:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 1849285 - 1892977:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_1691

Search NORINE for peptide: strict or relaxed

AMP-binding (20..422): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVLCK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

ctg2_1694

PKS_AT (552..839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 139.3
Methoxymalonyl-CoA: 51.4
inactive: 49.0
Methylmalonyl-CoA: 47.3
Benzoyl-CoA: 38.1
Isobutyryl-CoA: 32.3
Propionyl-CoA: 30.5
Acetyl-CoA: 27.0
fatty_acid: 25.2
2-Methylbutyryl-CoA: 23.0
3-Methylbutyryl-CoA: 17.9
CHC-CoA: 15.0
Ethylmalonyl-CoA: 11.3
trans-1,2-CPDA: 9.4

ctg2_1695

Search NORINE for peptide: strict or relaxed

AMP-binding (573..966): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

c00002_NZ_CABD.. - Region 3 - butyrolactone

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Location: 3,389,704 - 3,400,558 nt. (total: 10,855 nt) Show pHMM detection rules used

butyrolactone: AfsA

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.1	0.34	Other (Butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000550.1	0.15	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000928.1	0.14	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.14	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000043.1	0.11	Polyketide	curacin A	Moorea producens 19L
BGC0000527.1	0.11	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.1	0.11	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000506.1	0.10	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000556.1	0.10	RiPP	streptin	Streptococcus pyogenes
BGC0000535.1	0.09	RiPP	nisin A	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.1	0.67	Other (Butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000550.1	0.45	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000928.1	0.44	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.44	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000043.1	0.39	Polyketide	curacin A	Moorea producens 19L
BGC0000527.1	0.38	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.1	0.37	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000506.1	0.36	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000556.1	0.35	RiPP	streptin	Streptococcus pyogenes
BGC0000535.1	0.33	RiPP	nisin A	Lactococcus lactis subsp. lactis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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c00002_NZ_CABD.. - Region 4 - ectoine

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Location: 3,401,737 - 3,412,123 nt. (total: 10,387 nt) Show pHMM detection rules used

ectoine: ectoine_synt

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000854.1	0.20	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000857.1	0.20	Other	ectoine	Methylophaga alcalica
BGC0000783.1	0.19	Saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000856.1	0.18	Other	ectoine	Methylophaga thalassica
BGC0000859.1	0.18	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000858.1	0.18	Other	ectoine	Methylobacter marinus
BGC0000855.1	0.17	Other	ectoine	Methylomicrobium kenyense
BGC0000853.1	0.17	Other	ectoine	Streptomyces anulatus
BGC0000774.1	0.16	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0000244.1	0.15	Polyketide	macrotetrolide	Streptomyces griseus subsp. griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000854.1	0.53	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000857.1	0.53	Other	ectoine	Methylophaga alcalica
BGC0000783.1	0.51	Saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000856.1	0.49	Other	ectoine	Methylophaga thalassica
BGC0000859.1	0.49	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000858.1	0.49	Other	ectoine	Methylobacter marinus
BGC0000855.1	0.49	Other	ectoine	Methylomicrobium kenyense
BGC0000853.1	0.48	Other	ectoine	Streptomyces anulatus
BGC0000774.1	0.46	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0000244.1	0.45	Polyketide	macrotetrolide	Streptomyces griseus subsp. griseus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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c00002_NZ_CABD.. - Region 5 - thiopeptide

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Location: 3,561,707 - 3,587,984 nt. (total: 26,278 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

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Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.25	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001361.1	0.23	Terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0000781.1	0.16	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.12	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000981.1	0.07	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.07	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.06	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001956.1	0.06	Polyketide	miharamycin A, miharamycin B	Streptomyces miharaensis
BGC0001283.1	0.06	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000414.1	0.05	NRP	quinocarcin	Streptomyces melanovinaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.58	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001361.1	0.56	Terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0000781.1	0.47	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.39	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000981.1	0.28	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.28	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.26	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001956.1	0.25	Polyketide	miharamycin A, miharamycin B	Streptomyces miharaensis
BGC0001283.1	0.25	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000414.1	0.23	NRP	quinocarcin	Streptomyces melanovinaceus

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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Thiopeptides

Core peptide predictions

No core peptides found.

c00002_NZ_CABD.. - Region 6 - NRPS

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Location: 3,905,181 - 3,949,062 nt. (total: 43,882 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

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regulatory genes

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Gene details

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NRPS/PKS domains

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.36	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.30	NRP	paenibactin	Paenibacillus elgii B69
BGC0001184.1	0.28	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.28	Other	bacilysin	Bacillus sp. CS93
BGC0001132.1	0.25	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001594.1	0.25	Alkaloid	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001197.1	0.24	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001833.1	0.24	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000836.1	0.24	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.24	Other	aryl polyenes	Xenorhabdus doucetiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.68	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.64	NRP	paenibactin	Paenibacillus elgii B69
BGC0001184.1	0.61	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.61	Other	bacilysin	Bacillus sp. CS93
BGC0001132.1	0.58	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001594.1	0.58	Alkaloid	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001197.1	0.58	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001833.1	0.58	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000836.1	0.57	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.57	Other	aryl polyenes	Xenorhabdus doucetiae

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 8, location 3905180 - 3949062:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_3575

Search NORINE for peptide: strict or relaxed

AMP-binding (34..436): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: aMPSQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

ctg2_3582

Search NORINE for peptide: strict or relaxed

AMP-binding (461..862): ser

NRPSPredictor2: ser

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

c00002_NZ_CABD.. - Region 7 - RiPP-like

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Location: 5,368,101 - 5,378,724 nt. (total: 10,624 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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core biosynthetic genes

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KnownClusterBlast

Pfam domains

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Analysis type:

No matches found.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names