LOCUS       c00002_NZ_CABD..       10855 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CABDWD010000002.1 Raoultella ornithinolytica strain NCTC9164,
            whole genome shotgun sequence.
ACCESSION   c00002_NZ_CABD..
VERSION     c00002_NZ_CABD..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:36:15
            Original ID  :: NZ_CABDWD010000002.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3389703
            Orig. end    :: 3400558
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10855
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[3394703:3395558](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5855)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..10855
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10855
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="3"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             963..1697
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 166.7; E-value: 9.5e-51)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_3103"
                     /transl_table=11
                     /translation="VEILLIDDDIELSHLLSQQMALYNINLSICHVPSQALKLIYQRPF
                     DVILLDIMLPDMNGFELCHLLRHNEHLNQKTPLIMLTARNEIVNLIAGLEAGADDYVSK
                     PFEPRELIARISAVRRRNRTQTLLSPPVQQSVVLGPHQLSINMAQAWATVNGRPLKLTS
                     SEMSILAKLIQIPGKVCLRTELEKQIFSDKHQTTRSIDALIYRIRVKFRDITVDEDFIY
                     TVRSHGYMLRGELCTPQNKGLA"
     PFAM_domain     969..1307
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3103_0111"
                     /evalue="6.00E-25"
                     /label="ctg2_3103"
                     /locus_tag="ctg2_3103"
                     /protein_end="115"
                     /protein_start="2"
                     /score="87.7"
                     /tool="antismash"
                     /translation="ILLIDDDIELSHLLSQQMALYNINLSICHVPSQALKLIYQRPFDV
                     ILLDIMLPDMNGFELCHLLRHNEHLNQKTPLIMLTARNEIVNLIAGLEAGADDYVSKPF
                     EPRELIARI"
     PFAM_domain     1428..1655
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3103_0112"
                     /evalue="2.80E-15"
                     /label="ctg2_3103"
                     /locus_tag="ctg2_3103"
                     /protein_end="231"
                     /protein_start="155"
                     /score="56.2"
                     /tool="antismash"
                     /translation="GRPLKLTSSEMSILAKLIQIPGKVCLRTELEKQIFSDKHQTTRSI
                     DALIYRIRVKFRDITVDEDFIYTVRSHGYML"
     CDS             1698..3005
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 140.6; E-value: 1.5e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_3104"
                     /transl_table=11
                     /translation="MCKWFSSRTVFSMLLINTVVSTCALVVVLVFSLQRVADEHPRRYL
                     AKTLFSNLVADKTPEQLAKIEVDGVRLEIIPQNKMNTPEYQFYLPLLEMALRDPDGIAM
                     ITNNDQYMAAAYNEGNFVILPLFGRSLSSQALKLLGWVAAAVIVILLVNFYSIHLLTRP
                     FIELRRGVRHADKGDLKYRIPLERTYGEYRSLADSFNKMLHRINHIHEARRHMLLAIPH
                     EVRTPLARLKVRKDLITDEPLRLAILGDIVNVERILDAILYTEKTQAGEGEISLRKIDL
                     VNFFNEIVTEQQNGKSLVELTINTRATEFYNHPTMMVVLMRNLISNAVFYGQSKPVTVT
                     IDDENGSLQITVADRGIGIAEDQLPFLTEPFWRADQSRQRESGGYGLGLYICKTIVDGL
                     HGKLVIDSVKDQGTSVIISFPDAFKPSQIKEDLSAN"
     PFAM_domain     2166..2318
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00672.27"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3104_0113"
                     /evalue="2.30E-06"
                     /label="ctg2_3104"
                     /locus_tag="ctg2_3104"
                     /protein_end="207"
                     /protein_start="156"
                     /score="28.0"
                     /tool="antismash"
                     /translation="IHLLTRPFIELRRGVRHADKGDLKYRIPLERTYGEYRSLADSFNK
                     MLHRIN"
     PFAM_domain     2655..2960
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3104_0114"
                     /evalue="7.70E-20"
                     /label="ctg2_3104"
                     /locus_tag="ctg2_3104"
                     /protein_end="421"
                     /protein_start="319"
                     /score="71.6"
                     /tool="antismash"
                     /translation="LMRNLISNAVFYGQSKPVTVTIDDENGSLQITVADRGIGIAEDQL
                     PFLTEPFWRADQSRQRESGGYGLGLYICKTIVDGLHGKLVIDSVKDQGTSVIISFPD"
     CDS             2995..3672
                     /locus_tag="ctg2_3105"
                     /transl_table=11
                     /translation="VPTNPQYLAATPFLDYNAAAVQAFIAHIVPPHVRDKRAQAIALYY
                     GVRDQIRYDVYDAAMDVTGLRASSVVNAASGMCIHKSLLYCATLRSIGVPARLWFADVR
                     NHLSSPRLREYVGGDIFHFHCLVELCLDGENWLKATPVFNGQLCRLYKMIPLEFDGYHN
                     SMHHPFDELGNKYMEFVNQYGSFDDLPFEWLLAGLREHHPKMFNTEGKRYRQNSLMKDA
                     ISN"
     PFAM_domain     3097..3414
                     /aSDomain="Transglut_core"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01841.21"
                     /description="Transglutaminase-like superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3105_0115"
                     /evalue="1.30E-12"
                     /label="ctg2_3105"
                     /locus_tag="ctg2_3105"
                     /protein_end="140"
                     /protein_start="34"
                     /score="48.3"
                     /tool="antismash"
                     /translation="DKRAQAIALYYGVRDQIRYDVYDAAMDVTGLRASSVVNAASGMCI
                     HKSLLYCATLRSIGVPARLWFADVRNHLSSPRLREYVGGDIFHFHCLVELCLDGENWLK
                     AT"
     CDS             complement(3715..5004)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 51.6; E-value: 1.3e-15)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_3106"
                     /transl_table=11
                     /translation="MKTVHIIGAGIAGLGAAHFLAAQGIQSVVYEAADHIGGRAAGSIE
                     EGTLFEVGGKNFSSQWPRFNALLKEFDIHEHDAQHPDFHIVLKDKLVKLDKRRTLSGDL
                     HLAMQLGLRGSLQLRDFLGYSRKHADELNYTRGLIQQVEQKWDYQPVASHFAPSLVAGP
                     MRMFSIIMGAAEPDEVYPSLLTLFTAGFGKGQHFAIQGGIQRFHQGLANNKNIRLGERV
                     EHIDIEQGKVSGLVVNGADGEKRIAADAVISAVPAHVFKRLLVLPDQAQTAVEQIRYFP
                     LVMINARYDRPVFRDGVNSIMFEPGSVLGHCSANRLYQPELVRFTLSGAAARKVLHHPD
                     ETLIALAETEFSRRMPITGQLVTARVTRHMGGICAYAPNFTRVKAALLAGVERIAGLAI
                     AGDYLEGHTMEGCLHSAELASQRIGRYLAG"
     PFAM_domain     complement(3736..4974)
                     /aSDomain="Amino_oxidase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01593.26"
                     /description="Flavin containing amine oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3106_0116"
                     /evalue="6.80E-32"
                     /label="ctg2_3106"
                     /locus_tag="ctg2_3106"
                     /protein_end="423"
                     /protein_start="10"
                     /score="111.4"
                     /tool="antismash"
                     /translation="IAGLGAAHFLAAQGIQSVVYEAADHIGGRAAGSIEEGTLFEVGGK
                     NFSSQWPRFNALLKEFDIHEHDAQHPDFHIVLKDKLVKLDKRRTLSGDLHLAMQLGLRG
                     SLQLRDFLGYSRKHADELNYTRGLIQQVEQKWDYQPVASHFAPSLVAGPMRMFSIIMGA
                     AEPDEVYPSLLTLFTAGFGKGQHFAIQGGIQRFHQGLANNKNIRLGERVEHIDIEQGKV
                     SGLVVNGADGEKRIAADAVISAVPAHVFKRLLVLPDQAQTAVEQIRYFPLVMINARYDR
                     PVFRDGVNSIMFEPGSVLGHCSANRLYQPELVRFTLSGAAARKVLHHPDETLIALAETE
                     FSRRMPITGQLVTARVTRHMGGICAYAPNFTRVKAALLAGVERIAGLAIAGDYLEGHTM
                     EGCLHSAELASQRI"
     CDS             complement(5001..5855)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_3107"
                     /sec_met_domain="AfsA (E-value: 5e-12, bitscore: 43.9,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLETPGLRQRAENQVLTELRIAHDEGTARLLINQKHRFFFDHPQD
                     HVPGLLLLEGGHQLAERLLPAGEWLASELQACFSKYCLFDSPVKVQGKRSPLDEGWQCE
                     IVIAQRLQVRASMHWVFIPMPPTRVVQLHSTAEVPVEKALVNKKRLENVMIGQPYTFQQ
                     TGHECHALLPHPANLLADSRQQTHPLYLLEAFMQLQRSLNYAQPVRLRDILLGISMQVF
                     KPLAVGSAFHLQMEPQLDNGEARHFNRGADLWAAGQRFARCEMHSGRIQRKKHTVTQGS
                     SAE"
     PFAM_domain     complement(5676..5834)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3107_0117"
                     /evalue="4.20E-09"
                     /label="ctg2_3107"
                     /locus_tag="ctg2_3107"
                     /protein_end="60"
                     /protein_start="7"
                     /score="36.6"
                     /tool="antismash"
                     /translation="RQRAENQVLTELRIAHDEGTARLLINQKHRFFFDHPQDHVPGLLL
                     LEGGHQLA"
     CDS             complement(5848..6642)
                     /locus_tag="ctg2_3108"
                     /transl_table=11
                     /translation="MTKHLQPLAPLRQRALCLLVMAGDGGIAQTRELLSCCVENGIDAI
                     ELCAPFPNAFTDGETVRQAHRRALEQGIVWQDLLPLIAEFSARIRIVALLDYSHVFARQ
                     DTASILQRLYEVGAAAVLPHGLSPRFRNAFYCAAADIGLPVVGTLYPQSGDVVRGEVLQ
                     QSGGFIYLVSHFGRSGSAAPQPLQLRHEIARLKAESRLPIALGFGLKSAADVAAVFELG
                     ADMAIVGSRACAVVADALAQGQSATGALGKYINLLHQGEKHA"
     aSDomain        complement(5878..6606)
                     /aSDomain="TIGR00262"
                     /aSTool="tigrfam"
                     /description="trpA: tryptophan synthase, alpha subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_3108_0021"
                     /evalue="7.20E-36"
                     /identifier="TIGR00262"
                     /label="ctg2_3108"
                     /locus_tag="ctg2_3108"
                     /protein_end="255"
                     /protein_start="12"
                     /score="121.3"
                     /tool="antismash"
                     /translation="QRALCLLVMAGDGGIAQTRELLSCCVENGIDAIELCAPFPNAFTD
                     GETVRQAHRRALEQGIVWQDLLPLIAEFSARIRIVALLDYSHVFARQDTASILQRLYEV
                     GAAAVLPHGLSPRFRNAFYCAAADIGLPVVGTLYPQSGDVVRGEVLQQSGGFIYLVSHF
                     GRSGSAAPQPLQLRHEIARLKAESRLPIALGFGLKSAADVAAVFELGADMAIVGSRACA
                     VVADALAQGQSATGALGKYIN"
     PFAM_domain     complement(5902..6606)
                     /aSDomain="Trp_syntA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00290.22"
                     /description="Tryptophan synthase alpha chain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3108_0118"
                     /evalue="1.40E-34"
                     /label="ctg2_3108"
                     /locus_tag="ctg2_3108"
                     /protein_end="247"
                     /protein_start="12"
                     /score="119.3"
                     /tool="antismash"
                     /translation="QRALCLLVMAGDGGIAQTRELLSCCVENGIDAIELCAPFPNAFTD
                     GETVRQAHRRALEQGIVWQDLLPLIAEFSARIRIVALLDYSHVFARQDTASILQRLYEV
                     GAAAVLPHGLSPRFRNAFYCAAADIGLPVVGTLYPQSGDVVRGEVLQQSGGFIYLVSHF
                     GRSGSAAPQPLQLRHEIARLKAESRLPIALGFGLKSAADVAAVFELGADMAIVGSRACA
                     VVADALAQGQSAT"
     CDS             complement(6635..7288)
                     /locus_tag="ctg2_3109"
                     /transl_table=11
                     /translation="VKIKICGATQLNEIDIANQCAVDYIGLWTGIEQHPRTLSEDNLVQ
                     LAKTCHGPQPVAVCVKPVFPLLGEMLQRCAIPWLQLHGFTPPGEVARLKQQQLKIIKTL
                     HVSDNGDCPELRWLPDYDAAGVDIYLIDRFVNRQRLGSTGQALPRTVIDTLLGQLAGRR
                     IWLAGGITAATIGEFSAIPGIETLDIDSAARSDGIIGEPLRELVKALGSGRKND"
     PFAM_domain     complement(6695..7279)
                     /aSDomain="PRAI"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00697.24"
                     /description="N-(5'phosphoribosyl)anthranilate (PRA)
                     isomerase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3109_0119"
                     /evalue="2.90E-15"
                     /label="ctg2_3109"
                     /locus_tag="ctg2_3109"
                     /protein_end="198"
                     /protein_start="3"
                     /score="56.6"
                     /tool="antismash"
                     /translation="KICGATQLNEIDIANQCAVDYIGLWTGIEQHPRTLSEDNLVQLAK
                     TCHGPQPVAVCVKPVFPLLGEMLQRCAIPWLQLHGFTPPGEVARLKQQQLKIIKTLHVS
                     DNGDCPELRWLPDYDAAGVDIYLIDRFVNRQRLGSTGQALPRTVIDTLLGQLAGRRIWL
                     AGGITAATIGEFSAIPGIETLDIDSAARSDGI"
     CDS             7706..8590
                     /locus_tag="ctg2_3110"
                     /transl_table=11
                     /translation="VMECKNRLLSLFTVALLASISTFSTESVSAPLPEVKSCNDVLLGI
                     QNRYHGYNSWRMIKMVITDEHGNVKTRTITATHQNNGVNRTLRSRVVAPPELANSESYV
                     IDYNEEDKRDRIWRYLPASKKLLEVQSKDLSSRLYGSDMNIGEMLIRMARDYDCQSLGE
                     GEYQGLPVYKIHVVPNNEQELLRLGLKDGEIWVEKGTFLPVYSAFNAESPNEQRLFETS
                     DQRWVDGIFVAEKYQISTLKDGRKVSQSAFQVYGEGFNLPLPDSWYNIKDLGNEQSTWR
                     EYHSPNYTLKTLP"
     PFAM_domain     8012..8524
                     /aSDomain="LolA_like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17131.6"
                     /description="Outer membrane lipoprotein-sorting protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_3110_0120"
                     /evalue="3.90E-20"
                     /label="ctg2_3110"
                     /locus_tag="ctg2_3110"
                     /protein_end="273"
                     /protein_start="102"
                     /score="72.4"
                     /tool="antismash"
                     /translation="YVIDYNEEDKRDRIWRYLPASKKLLEVQSKDLSSRLYGSDMNIGE
                     MLIRMARDYDCQSLGEGEYQGLPVYKIHVVPNNEQELLRLGLKDGEIWVEKGTFLPVYS
                     AFNAESPNEQRLFETSDQRWVDGIFVAEKYQISTLKDGRKVSQSAFQVYGEGFNLPLPD
                     SWYNIKDL"
ORIGIN
        1 tcctggcgat gggtggcagg gcgcaccaat atccgtaacg gtgtcgccag cggttttaac
       61 ccgaccgact ggttcaaaga taacagtcag gtgatttttg agagtcttga taccgctgac
      121 cgacgtgaag atcgccttgg cgtggttgcc ctggaaggcg tctggctgag tgaggaaagc
      181 gtcctgagct tcggctatcg ccccaaccta catgccaaac ccgacaccgt tgccagtaat
      241 agcaatgtgg tcggccttgg cctggatcgc accaataata aagacggttt ttttgtaaaa
      301 tatgctccct cccccgcctc ctggaacaat ctgtcgctga cggtgagttc gctgtatgaa
      361 aacgatcggc ccggtctggg gaccgaagtg agtctggcag tggtggacaa tgtggtgcta
      421 tacagcgaat ggtttggtca acggcggcaa aacctgacgg atgaggccac acgatcaagc
      481 caagacaata tgcggattta taaccagctg gccagcgggt tcacctggtc agtaccagaa
      541 agcctggttg gcaatgaaga catcgcgctc agcgttgaat accacgttaa cgaggcgggg
      601 cttaaacagt cacaaccaag gacctggcgc atcgcgatcg cagaaagcaa ccgtcaggtt
      661 cacagcgtgg cactgcttgc cgcgaccaag caggaacctt tggccgagca acaatttttc
      721 ggccgtctgg cttggaatga tttttgggta gacaacgacc tttcatttat caccacggta
      781 acccccatgg atggcagcgg cttcggccag ctaaccctta gcacgccaat ccagccaaac
      841 atgcgcatcg acctgcaggg ctatcactat tttggtagca gcaataccat ttacggcacc
      901 gccggacgta aagacggttg gatgctgtcg tttattttga ctatttaatt gtggggagaa
      961 cggtggaaat attactgatt gatgatgata ttgagctctc gcacctgctt tcgcaacaaa
     1021 tggcgctcta taacattaac ctgtcaattt gccatgttcc ttctcaagcg ctgaaattaa
     1081 tctaccagcg accgttcgac gtgatcctgt tggatatcat gctgcccgat atgaacggat
     1141 ttgagctttg ccatttgctg agacacaacg agcatctcaa tcaaaaaacg ccactaatca
     1201 tgctgaccgc acgtaatgaa attgtcaatc tgatcgcagg cctggaagca ggggccgacg
     1261 attatgtgag taaacctttc gagcctcgtg aactgatagc acgtatttct gcagtgcggc
     1321 gacgcaaccg gacacagaca ctgctttccc ctcctgtgca gcaatcggtg gtgcttggcc
     1381 cacaccaact ttcgatcaat atggcacaag cctgggcgac ggtgaatgga cggccgttaa
     1441 aactcacctc cagtgaaatg agcattttag ccaaactgat ccaaatacct gggaaagtct
     1501 gtttacgaac ggagttagaa aaacagatat tttctgataa acatcagaca acgcggagta
     1561 ttgatgcgct aatttatcgt atacgggtca aattccgcga tattaccgtt gatgaggact
     1621 ttatttatac cgtacgctct cacggctata tgctgcgggg cgaattgtgt accccacaaa
     1681 acaaaggact ggcataaatg tgtaaatggt tttcttctcg aaccgtcttt tctatgctgt
     1741 taatcaatac ggtggtatca acctgtgctt tggtagtcgt actggtattt tctttgcagc
     1801 gtgttgccga tgaacacccg cggagatatt tggccaaaac actgttttcc aatctcgtgg
     1861 cggataagac gcctgagcaa ctagccaaga tcgaagtaga tggcgtacgg ctggaaatta
     1921 tcccgcaaaa taagatgaac acccccgagt atcaatttta tctgcccctg ttagaaatgg
     1981 cattgcgcga tcctgatggc atcgccatga tcacgaataa cgatcagtac atggccgcgg
     2041 catacaatga gggtaacttc gtcatcctgc cgctgtttgg ccgttcgtta tcttcccagg
     2101 ccctgaaact gcttgggtgg gtggctgccg ccgtcatcgt gatcttactg gtcaatttct
     2161 attctattca cctgctgacc cggccattca tagagcttcg ccgcggggtc aggcatgcgg
     2221 acaaaggcga tctcaagtat agaatccccc ttgagcgaac ctatggtgag taccgtagcc
     2281 tggcagacag ttttaacaaa atgctgcatc gtatcaatca tattcacgaa gcccgtcgcc
     2341 atatgctatt ggcgatcccc catgaggtgc gtacaccgtt ggcccgtctg aaggtacgta
     2401 aggatctaat caccgatgaa ccattacgtc tggcaatcct cggggacatc gttaacgtag
     2461 agcgcattct ggatgccatt ttatataccg agaaaaccca ggccggtgaa ggagagatca
     2521 gcctgcgaaa aatcgatctg gtgaacttct tcaacgagat cgttacggag cagcaaaatg
     2581 gcaagagcct ggttgagctg acaattaaca cccgtgccac agagttttat aaccacccca
     2641 ccatgatggt agtgttaatg cgtaatctca tcagtaatgc cgtcttctac ggccagtcaa
     2701 aacccgtcac cgtcaccatt gatgatgaaa atggcagcct gcagattacc gtagctgacc
     2761 gcggtattgg cattgccgag gatcaacttc ctttccttac cgaacctttc tggcgggccg
     2821 accaatcacg ccaacgcgaa tctggcggtt atgggctcgg cctgtatatc tgtaagacca
     2881 tcgtggatgg actacacggg aagctggtga ttgacagtgt taaagaccaa ggcaccagcg
     2941 taatcatttc atttcctgac gcctttaaac cttctcaaat caaggaggat ctaagtgcca
     3001 actaaccctc aatatctggc agccacaccc tttctggact ataacgctgc cgccgtacag
     3061 gcatttattg cacacattgt gccgccacac gtacgtgata aacgggcaca ggcgatcgca
     3121 ttatattatg gtgtccgcga tcaaatccgt tatgacgttt atgatgccgc catggatgtc
     3181 acaggtttgc gcgcaagcag cgtcgtgaat gcggcaagtg gcatgtgtat ccataagtca
     3241 ctgctctatt gcgccaccct gcgctccatt ggtgtccctg cccggctatg gtttgccgac
     3301 gtgcgcaacc acctcagttc cccccgcctg cgcgaatatg ttggcggtga tattttccat
     3361 ttccactgcc tggtagaact ttgcctggac ggggagaact ggctaaaagc cactccggtg
     3421 ttcaacggac aactctgccg attgtataag atgatcccgt tagaatttga tggttatcat
     3481 aacagcatgc accatccctt tgacgagttg ggcaataagt acatggagtt tgtcaatcag
     3541 tatggcagct ttgatgacct gccattcgag tggctgctcg caggcctgcg cgaacatcac
     3601 ccgaagatgt tcaataccga aggcaagcgt taccggcaaa actcattaat gaaagatgcc
     3661 atcagcaatt aagcaaatag aaagggccca cagggccctg acaacaatca gaactcaacc
     3721 ggccagatag cggccgatac gctgtgaagc cagctctgcc gagtgtaaac atccttccat
     3781 cgtatgccct tccagatagt cccccgcaat cgccaggcca gcaatgcgct caacgccagc
     3841 cagcagcgcc gctttaacac gagtaaaatt aggcgcatag gcacaaatac cgcccatgtg
     3901 gcgcgttaca cgcgcggtga ccagttgccc agtgatcggc atccggcgag aaaactcggt
     3961 ctcggctagc gcaataagtg tctcatccgg gtggtgtaac accttgcgtg ccgctgcccc
     4021 agaaagcgtg aagcgtacca attctggctg atagagccgg ttagcggagc agtggcctag
     4081 cacggaaccg ggctcaaaca taatcgagtt gaccccatcg cggaacaccg ggcgatcgta
     4141 acgcgcattg atcatcacca atgggaaata gcgaatctgc tcgacagcgg tctgggcttg
     4201 atcgggcaat accagcagcc gtttgaacac gtgcgcgggt acggcagaaa tcacggcatc
     4261 ggcagcaatc cgtttttcac catcagcacc gttgaccacc aatccgctga ccttaccctg
     4321 ctctatatca atatgctcaa cccgctcgcc aaggcggatg tttttgttgt tggccaatcc
     4381 ctgatgaaag cgctggatcc ccccctggat agcaaaatgt tgccccttac caaaaccggc
     4441 agtaaacaga gtcagcaagg aggggtaaac ttcgtcgggt tccgccgcac ccataatgat
     4501 agagaacatg cgcatcgggc cagccaccag tgaaggagca aagtgcgacg cgaccggttg
     4561 ataatcccat ttctgttcaa cctgctggat tagtccgcgg gtataattca gctcatcggc
     4621 atgtttgcgc gaataaccaa ggaagtccct cagttgcaac gagccgcgca agccaagttg
     4681 catcgccagg tgcaaatcgc cgctcagcgt gcgcctcttg tccagcttca ccagtttgtc
     4741 tttaagcaca atatgaaagt cagggtgttg tgcatcatgc tcgtgaatat cgaactcttt
     4801 aagcaaagca ttaaaacgag gccattgtga ggagaaattc ttgccgccga cttcaaacag
     4861 cgttccctcc tcaatgctgc ccgcagcacg accaccaata tggtcagcgg cctcgtaaac
     4921 cacactctgg atcccttgcg ccgctaaaaa atgtgcggcc cctaatccgg cgataccggc
     4981 accaataata tggactgttt tcattcggcc gaactcccct gtgtcacggt gtgtttttta
     5041 cgttgaatac ggccgctgtg catttcacag cgagcaaaac gctgccctgc cgcccacaaa
     5101 tccgccccgc ggttaaaatg gcgtgcctcg ccattatcca gttgcggttc catttgcagg
     5161 tggaaagcgc tacccacggc caacggtttg aaaacctgca tgctaatgcc aagtaaaatg
     5221 tcgcgcagtc gaacgggctg agcatagtta aggctacgct gtagctgcat aaacgcttcc
     5281 aacagataca gcggatgcgt ttgttggcgg ctgtccgcca acaaattggc aggatgagga
     5341 agtagcgcgt gacattcatg gccggtttgt tggaaggtat aaggctgccc aatcatcacg
     5401 ttttccagac gctttttatt gaccagagcc ttctcaacag gaacctctgc ggtactatgc
     5461 agctgtacca cccgcgtagg cggcatgggt atgaaaaccc aatgcatgct ggcacgaacc
     5521 tgcaaccgct gtgctatgac gatttcacat tgccatcctt cgtccagcgg cgagcgttta
     5581 ccctgtacct taaccgggct atcgaacagg cagtatttgc taaaacacgc ctgcagctca
     5641 ctcgccaacc actcacccgc aggtaacaag cgttcggcca actgatgccc cccctccagc
     5701 aacagtaacc ctggaacatg atcctgagga tgatcgaaga aaaaccggtg cttctggtta
     5761 atcagtaacc gggcagttcc ctcatcatga gcgatcctta actcggtcag cacctgattc
     5821 tctgctcttt gccgcaatcc tggtgtttca agcatgcttc tctccttggt gtaacagatt
     5881 gatatatttg cctaatgcgc ctgtagcgct ctgcccctgg gccaaggcgt cggctaccac
     5941 agcacaggcc cggctaccaa caatcgccat gtccgccccc agttcaaaaa ccgcagcaac
     6001 gtcagccgcg cttttcaaac caaagcccag cgctatcggt aagcggcttt cagctttcaa
     6061 ccgggctatt tcatggcgaa gctgcagtgg ctgtggagcg gcgctaccgg aacggccaaa
     6121 atgagaaacc agataaataa agccacctga ctgctgcaaa acctcaccgc gtaccacatc
     6181 gccgctctgt gggtacagcg tccctaccac cggcaagcct atgtcggcgg ctgcacaata
     6241 aaaagcgtta cgaaaacggg gggataatcc atgaggcaaa acggcagccg ctccgacctc
     6301 gtagagccgt tgcaggatac tggcggtatc ctggcgggca aaaacgtggc tgtaatcaag
     6361 cagtgcaaca atacggatac gggctgaaaa ctcggcaatc aagggcagca gatcttgcca
     6421 cacaatgcct tgctccaaag ctctgcgatg ggcctgacga acagtttcgc catcggtaaa
     6481 ggcgttggga aatggcgcac aaagctctat ggcatctatg ccattttcga cacagcagct
     6541 aagtagttcg cgggtttgcg ctatgccacc gtcgcccgcc atcaccaaca ggcagagggc
     6601 tcgttgacgc agtggagcca atggctgtaa atgcttagtc atttttcctc cctgagccca
     6661 gcgccttcac cagctcacgt agtggctcgc cgataatgcc atcgctacgt gccgcactat
     6721 cgatgtccaa cgtctcaatg ccggggatag cagaaaattc gccgatggta gctgccgtga
     6781 tgccgcccgc cagccagatc ctccgccctg ccaattggcc aagcagcgta tcaatcaccg
     6841 tacgcggcaa cgcctggccg gtactgccaa gccgctggcg attgacaaaa cgatcgatga
     6901 gataaatatc gacccctgca gcatcgtaat caggtaacca gcgcaattcg gggcaatcac
     6961 cattatcact aacgtgtaat gtcttgataa ttttcaactg ctgttgcttt agtcgcgcca
     7021 cttcaccggg aggggtaaaa ccgtgcagtt gcaaccatgg gatagcgcaa cgctgcaaca
     7081 tctcccccag tagtggaaaa acaggtttga cacaaacggc caccggctgt ggaccatgac
     7141 aggtcttggc taactgcacc aggttatctt ccgacagcgt acgcgggtgc tgttctatcc
     7201 cggtccatag accgatataa tcaaccgcac attggtttgc tatatcgatt tcattcagct
     7261 gcgttgcccc acatattttt attttcactt tcgtttccta caatagaacc tgaaccccct
     7321 aaaccatcag catacccccg ataaataaca ctgagtaaat cattatctat atttagagat
     7381 tcaagagtaa caatacatca caaaacacat ccaaatatcc tgatattggc ccagttcttt
     7441 tgtgctctcc ccctcattcg acatcatttt ttgtgataaa taaaaataaa accagcataa
     7501 tatgtagagt tatagcaatc gtaaaaagta gattgcacac ttattcattt gttttatctt
     7561 atcggcattg ttagtctcac tattaaaatc aaacgcagcc atttttaata cctgagagta
     7621 tatacattat tgatttcaag ttaccgcaag attatcagct tgaaaaatgt cataaataaa
     7681 cccatgaaac aggagagaca ctattgtgat ggaatgcaaa aatcggctac tttcattatt
     7741 caccgttgcg ctattggcca gtatctccac gtttagtaca gaatcggttt ccgccccact
     7801 accggaagtc aaaagctgta acgacgtatt gctcggcatc caaaaccgct atcacggata
     7861 taacagctgg cgcatgatca aaatggtcat caccgacgaa catggcaacg tcaagacccg
     7921 taccattacc gcgacccacc aaaacaacgg tgttaatcgc actctgcgca gccgcgtggt
     7981 agccccacca gaactggcaa attcagaatc atatgtaatt gattataatg aagaagataa
     8041 aagagaccgt atttggcgct atctccccgc cagtaaaaaa ctgttggaag tgcagtctaa
     8101 agatctaagc agccgcctgt atggttccga tatgaacatc ggtgaaatgt taatccgtat
     8161 ggcacgtgat tatgattgcc aatcgttggg tgaaggggaa tatcagggcc tgccggttta
     8221 caagatccac gtcgtgccta acaacgagca agaattgctg cgtctgggcc tgaaagacgg
     8281 tgagatctgg gttgaaaaag gtacgttcct gccggtttat agcgccttta acgccgagtc
     8341 tccgaatgaa caacggctgt tcgaaacgtc cgatcaacga tgggtcgatg gaatattcgt
     8401 cgcggaaaaa tatcaaattt ccacgctaaa agatggacga aaagtttctc aatcggcatt
     8461 ccaggtttat ggcgaaggct tcaaccttcc tctgccagat agctggtata acattaagga
     8521 cctggggaat gaacaatcca cctggcgcga gtaccattca cctaattaca ctttaaaaac
     8581 attgccataa cgggtgttct ctgacttaaa tctgcccgtt atcgcaatgc tgcgggcaga
     8641 gtcatttcta attaaggatt gataatgcaa tgtggataat taattttatc gaccacacca
     8701 tgactgcgct cctcaattgg gtgtttctca atcgtctcaa gagtgcgctg ttgctattat
     8761 tattagtcgc tggctttgtc ggctacggcc tacctaaatt acaacatgat ggccgtatag
     8821 aggcctttat gtatgatgaa gacccttcat tattgaaata ttaccaactg cgcaaacagt
     8881 ttggccaaga taaccgggtg gtcattaccg tgacaggtaa tgacgtattc actactccat
     8941 ttattaaaaa gctttcagaa cttcacttgg ctttacagaa agacgttccc tatatttcag
     9001 aaatattcag cctgtataac atcccgttta tcgaatatga gaatggcggc ctgtatctcg
     9061 aagagttgat gcgtaacgtg ctgcatgagg gaaaagaccc ggcagagctg aaagaacggg
     9121 tgctatctac cccgctctac cagaactttg taatcgacaa gtctggcaaa accgccgcca
     9181 ttttcatcga accctatcgt tacacgccaa gcaagcatga ctgcgttgcc gacccttcgg
     9241 tgggcaaaac ttgtggttca gatagccaac agggcgttga ccgagacttt cttgcctcag
     9301 cagaatatac ggagatggca tacaatatcg cgaaggtgac tcagcgcttt aacagcgaag
     9361 attttgttat tcataccgca ggggcaccga tcgtcagcaa tcagattgtg cagattatct
     9421 cgcaggatat gccacgcttt accatcgcct gtatcttgat tgccatgctg tcgattgcga
     9481 ttattttccg cagcgtgatc atcaccattg gcgcgctgct ggcgtttggc tgcagtattc
     9541 tgaccatgct ggcgttgatg gccatttgtg gcgtcgccat caccccgcca acacagttcc
     9601 tgatcccgat ggcattgact atcatgctct gcgtgtatat tcactttatg ctggcgagcg
     9661 ccaacatctg caagccaggc gcctcacgcg tcggcctgct gacgcatgcc atgaaacata
     9721 ctcaccatcc gatcctgttc agcatcctga ccagtgccga tggtttgctg ggatttctgg
     9781 cttccgatct ggcccccatc gccgcgctag gcattttcgg tatgctggtt accatcacca
     9841 gctacttttt tgccctgttc tggggaaccc aggcacttgc cttcctgcct gaacgctata
     9901 tcaacagcga acgcacaaac gtggccacct ccagacgctg ggtggttgcc atcggcagtc
     9961 tggggatcaa gcaccccaaa aaaaccgtgg cggcattcac cttgatagtg gtagcagtca
    10021 ttgcccagtt gccacagctg cgcttctccc ataactctct gttatggttg gcccctgaaa
    10081 acccggtacg ccaggcgaca gaatttatcg acagtcattt caatggcacg gtcaatctgg
    10141 aactgattgt cacaccgcgt gagggatatg attttcgtag tgagccgctg ctgaaagcaa
    10201 tacagcgagc ggtagaacgc gtttatgacg aggtcgatat tcccattggc cgccatacca
    10261 gcctggtgtc ttttatggat gaagtgaaca tggcgctgca cgatggcgat ccgcaacatc
    10321 gcaccatccc cgcacaagaa caaatctggg agcagttctt cctgctggaa ggtgagggta
    10381 actctaccat tatgcgttat gccagtatcg actacagcca agggcgcatt accttcctgg
    10441 taccctggtt ggaagcgacg cgctacagcg gaatatcgga acaggtaaac cagatcttca
    10501 gtcaagagtt ggccaatatg gcgaccatca acgtgaccgg cctgatcaac ctgttagcca
    10561 atacctccaa ggcagtcttg gacgatatgg tcagtagtta cctcattaca ctggcgatta
    10621 tcgccgtgct gatgtgctac tgcttacgca acttcaaaat gggattcatc agtattatcc
    10681 ccaacatttt gccgtatgtc ttcgtgctgg gggtcatggc aatggccgat attccaatgg
    10741 ataccttcac cattctgatc ggggggatcc ttaccgggct gatcgtcgat gaaacattac
    10801 atatgtttta tacctaccgc cataacctgg aatcacatcc cgaaccgcaa gatgc
//
