LOCUS       NC_014330.1            10810 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_014330.1 Brachyspira pilosicoli 95/1000, complete sequence.
ACCESSION   NC_014330
VERSION     NC_014330.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:19:13
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1676933
            Orig. end    :: 1687743
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10810
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1681933:1682743](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5810)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10810
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10810
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1176..1916
                     /locus_tag="ctg1_1505"
                     /transl_table=11
                     /translation="MKKKLELQTTTLWDYPSQQYLKSEEEKHKHYIGATPSYIIWNLLN
                     RYTKEKDLVVDPMAGSGTTVDVARELGRRALGYDINPKALERKDIFRADARKIPIEDEK
                     VDFVFIDPPYSTHINYSDEKNCIGKLTAKTDEYYNAMEKVISEIFRIMKKDRYMALYVS
                     DSYEKDYPFMPIGFKLFEIMSKYFMPIDIVSVVRHNKSLSKGNYHLSAIEYNYYLRGFN
                     YLFIMYKQGNKTIDKNGKVHLRNL"
     PFAM_domain     1197..1433
                     /aSDomain="N6_N4_Mtase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01555.20"
                     /description="DNA methylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1505_0016"
                     /evalue="1.20E-14"
                     /label="ctg1_1505"
                     /locus_tag="ctg1_1505"
                     /protein_end="86"
                     /protein_start="7"
                     /score="54.7"
                     /tool="antismash"
                     /translation="QTTTLWDYPSQQYLKSEEEKHKHYIGATPSYIIWNLLNRYTKEKD
                     LVVDPMAGSGTTVDVARELGRRALGYDINPKALE"
     PFAM_domain     1488..1874
                     /aSDomain="N6_N4_Mtase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01555.20"
                     /description="DNA methylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1505_0017"
                     /evalue="2.70E-07"
                     /label="ctg1_1505"
                     /locus_tag="ctg1_1505"
                     /protein_end="233"
                     /protein_start="104"
                     /score="30.7"
                     /tool="antismash"
                     /translation="VDFVFIDPPYSTHINYSDEKNCIGKLTAKTDEYYNAMEKVISEIF
                     RIMKKDRYMALYVSDSYEKDYPFMPIGFKLFEIMSKYFMPIDIVSVVRHNKSLSKGNYH
                     LSAIEYNYYLRGFNYLFIMYKQGNK"
     CDS             2054..2980
                     /locus_tag="ctg1_1506"
                     /transl_table=11
                     /translation="MKKNTAIVLGGSFDLSFAIGAFLINLKKYSPNLADDIIIYHDNIS
                     EKDQEIMNSIIPVKFIKFELNEKLNNIDTFVRERFSDLIFFKYECLKLLNEYKTVIVTD
                     FDVLLLDDISEIAIPKNNNVKCKMLKDFIEIIGGDLSHDILNESSFKYDKDMFVMGAGL
                     IVFYDTIKNIDELYNYCLDKTMQYSKYLLLPEQAIFSLMLHDFNIEPEVIDRTIYVVHP
                     REHHKYKNAKILHAFGPQKFWNSIENDSWNANYKEWIKLGGSKKRNSIFVSSKLSHRDF
                     IINKIAWWIPIKKWRGSFKNKFRKSRF"
     CDS             complement(3048..4016)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 311.2; E-value: 1.2e-94)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1507"
                     /sec_met_domain="fabH (E-value: 3e-95, bitscore: 316.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRAYIKNIAYYVPERILDNKYFESILDTNNEWIVTRTGIETRHM
                     ARPDETIFEMGINAVKNLEKKGVDLKEVDAILVPTVTKDYIFPSMAGQLQQALGLNHCF
                     ALDLSAACSGYIYSLNTAVSLIESGQCKNVLIVSSEKLTKDVNWKDRGTAILFGDAATA
                     SLITTRDDGKGIIGMHMQSEPDMSIVLNGGSVCPIRADDLEAPEFKIHMDGSETFKRAV
                     TEFSNSIDKVLESTGKQLSDVKYFVPHQANLRIMQAVAKRIGLPMEKVSVVLNKFGNCS
                     SASIGLALTDALEENKINDGDLVLLTGFGGGFTWGSSLMIW"
     PFAM_domain     complement(3051..3320)
                     /aSDomain="ACP_syn_III_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08541.12"
                     /description="3-Oxoacyl-[acyl-carrier-protein (ACP)]
                     synthase III C terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1507_0019"
                     /evalue="4.60E-33"
                     /label="ctg1_1507"
                     /locus_tag="ctg1_1507"
                     /protein_end="322"
                     /protein_start="232"
                     /score="113.3"
                     /tool="antismash"
                     /translation="LESTGKQLSDVKYFVPHQANLRIMQAVAKRIGLPMEKVSVVLNKF
                     GNCSSASIGLALTDALEENKINDGDLVLLTGFGGGFTWGSSLMIW"
     aSDomain        complement(3057..4010)
                     /aSDomain="TIGR00747"
                     /aSTool="tigrfam"
                     /description="fabH: 3-oxoacyl-[acyl-carrier-protein]
                     synthase III"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1507_0006"
                     /evalue="3.50E-103"
                     /identifier="TIGR00747"
                     /label="ctg1_1507"
                     /locus_tag="ctg1_1507"
                     /protein_end="320"
                     /protein_start="2"
                     /score="343.0"
                     /tool="antismash"
                     /translation="RAYIKNIAYYVPERILDNKYFESILDTNNEWIVTRTGIETRHMAR
                     PDETIFEMGINAVKNLEKKGVDLKEVDAILVPTVTKDYIFPSMAGQLQQALGLNHCFAL
                     DLSAACSGYIYSLNTAVSLIESGQCKNVLIVSSEKLTKDVNWKDRGTAILFGDAATASL
                     ITTRDDGKGIIGMHMQSEPDMSIVLNGGSVCPIRADDLEAPEFKIHMDGSETFKRAVTE
                     FSNSIDKVLESTGKQLSDVKYFVPHQANLRIMQAVAKRIGLPMEKVSVVLNKFGNCSSA
                     SIGLALTDALEENKINDGDLVLLTGFGGGFTWGSSLM"
     PFAM_domain     complement(3468..3701)
                     /aSDomain="ACP_syn_III"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08545.12"
                     /description="3-Oxoacyl-[acyl-carrier-protein (ACP)]
                     synthase III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1507_0018"
                     /evalue="1.00E-24"
                     /label="ctg1_1507"
                     /locus_tag="ctg1_1507"
                     /protein_end="183"
                     /protein_start="105"
                     /score="86.3"
                     /tool="antismash"
                     /translation="LDLSAACSGYIYSLNTAVSLIESGQCKNVLIVSSEKLTKDVNWKD
                     RGTAILFGDAATASLITTRDDGKGIIGMHMQSE"
     CDS             complement(4100..4876)
                     /locus_tag="ctg1_1508"
                     /transl_table=11
                     /translation="MCYKKISEYINILADFCATRDISFLNKEELKNKYNINQADIIVLF
                     GGSIIEGGDIFAQAIKEKIAKKYIIVGGYGHTTDTLINNIKEIMPNINYKTEAEIFNEY
                     IKNKYNVEADFLELHSTNCGNNITNLLEIIKKEKLDFNNIILIQDASMQLRMSAVIKKY
                     IDKSIEVINYAAYKVKVINKDSKLIYDSYPLGMWNIDRYINLLMGEIPRLTDNKEGYGP
                     RGKDFLIHIDIPEKVENAFLELKKYYPNMVREAKEK"
     CDS             complement(5001..5810)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1509"
                     /sec_met_domain="Linocin_M18 (E-value: 4.3e-78, bitscore:
                     259.0, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFLARDGSPFDSDFWSKIDKAVIETASRTLIGRRFLSIYGPLGS
                     GTISVQYDRNDREEVFQDGIVKTSGRHSVELPQLYQDFTLLWRDIENNEKNKMPLDLSV
                     TSFAAQTLSNKEDELIFYGNEFVGVTGILNTKGVQKLKISDWSAGENPYIDIVKAINMI
                     REKGIVGRIILALSQGLFFDLQRIQQGTGMTEAQRITNMIHNLYNIPTIKGKKAAIICV
                     EPQYIDLAIGVDMSTAYLEQKDLNHTFRIMETVLPRIKEPNAIVVLE"
     PFAM_domain     complement(5046..5810)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1509_0020"
                     /evalue="8.90E-70"
                     /label="ctg1_1509"
                     /locus_tag="ctg1_1509"
                     /protein_end="255"
                     /protein_start="0"
                     /score="235.0"
                     /tool="antismash"
                     /translation="MDFLARDGSPFDSDFWSKIDKAVIETASRTLIGRRFLSIYGPLGS
                     GTISVQYDRNDREEVFQDGIVKTSGRHSVELPQLYQDFTLLWRDIENNEKNKMPLDLSV
                     TSFAAQTLSNKEDELIFYGNEFVGVTGILNTKGVQKLKISDWSAGENPYIDIVKAINMI
                     REKGIVGRIILALSQGLFFDLQRIQQGTGMTEAQRITNMIHNLYNIPTIKGKKAAIICV
                     EPQYIDLAIGVDMSTAYLEQKDLNHTFRIMETV"
     CDS             complement(5857..6207)
                     /locus_tag="ctg1_1510"
                     /transl_table=11
                     /translation="MPSFANPFNANVERKISKEELIQAVRLDIAGELEAIYLYDAHCMA
                     TDDPVAKAVLADIRDEEKAHVGELMALLRHLDPKEAEHFASGEMEVKEMMEELGIKEPD
                     LSGLTVGSLKKE"
     PFAM_domain     complement(5983..6141)
                     /aSDomain="COQ7"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03232.15"
                     /description="Ubiquinone biosynthesis protein COQ7"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1510_0021"
                     /evalue="5.70E-06"
                     /label="ctg1_1510"
                     /locus_tag="ctg1_1510"
                     /protein_end="75"
                     /protein_start="22"
                     /score="26.3"
                     /tool="antismash"
                     /translation="QAVRLDIAGELEAIYLYDAHCMATDDPVAKAVLADIRDEEKAHVG
                     ELMALLRH"
     CDS             6413..7042
                     /locus_tag="ctg1_1511"
                     /transl_table=11
                     /translation="MTIQEEYFKNLSNILKINFNKKGFAFDSFSNKEEAKKFLLSQIKK
                     DDVITFGGSTSVNQMGILEDLKDYKNFVDRNNKELKTEAEIKAFTADVYLCSANALSKN
                     GDVIAIDGGGNRVSAMIYGPKKVYLVVGRNKIANTQQDALKRAKDFAASQNSIRFKVNN
                     PCSVGDMVCNENCNIEERLCAYTVIINKCHIKNRIHILFIDEELGF"
     PFAM_domain     6458..7021
                     /aSDomain="LUD_dom"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02589.17"
                     /description="LUD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1511_0022"
                     /evalue="3.50E-32"
                     /label="ctg1_1511"
                     /locus_tag="ctg1_1511"
                     /protein_end="203"
                     /protein_start="15"
                     /score="111.7"
                     /tool="antismash"
                     /translation="KINFNKKGFAFDSFSNKEEAKKFLLSQIKKDDVITFGGSTSVNQM
                     GILEDLKDYKNFVDRNNKELKTEAEIKAFTADVYLCSANALSKNGDVIAIDGGGNRVSA
                     MIYGPKKVYLVVGRNKIANTQQDALKRAKDFAASQNSIRFKVNNPCSVGDMVCNENCNI
                     EERLCAYTVIINKCHIKNRIHILFI"
     CDS             complement(7088..7615)
                     /locus_tag="ctg1_1512"
                     /transl_table=11
                     /translation="MRKIFIIILILTNLAFSNNISNNQYKNIDDYAGIYYGTLIAYSDA
                     AGEVHLQNFKIEISKSGNIISVIPTSLIIGIDTDTDVEVNKSKIIRKSSTQYEVIDNIT
                     KYIIPNISSVSASGNIMLNFYDNGNTLEVNGICEGSVSFNIEAFDKTIIEANKSTKVNI
                     HGTFYITEKLSD"
     CDS             complement(7663..8631)
                     /locus_tag="ctg1_1513"
                     /transl_table=11
                     /translation="MKEIKITDIENIKIGNAQNIEAATGCTVIICERGANTSLDVRGGG
                     PASRESELTKPFATTEVIHAVLLSGGSAFGLDASGGVMKYLEERNIGFDVGVTKVPLVC
                     ESCIFDLRVGDYKVRPDIEMGYNACIDAQNNNPKMGNYGAGTGASVGKILGVDYAMKSG
                     LGFYALEVDGVKVGAVVSVNAFGDIFDYDTGEKLAGLLGEDKKSFRSSEEELIKLTRDK
                     EISFNLVENTTIGAIITNAKFTKTQMGKIASMAHNGFARTIKPVHTTLDGDSIYAMSVG
                     DIKASIDAVGSLAAIVMGRAINNAVKNAESSYGLKAYNDIF"
     PFAM_domain     complement(7687..8619)
                     /aSDomain="Peptidase_S58"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03576.16"
                     /description="Peptidase family S58"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1513_0023"
                     /evalue="2.10E-37"
                     /label="ctg1_1513"
                     /locus_tag="ctg1_1513"
                     /protein_end="315"
                     /protein_start="4"
                     /score="129.4"
                     /tool="antismash"
                     /translation="KITDIENIKIGNAQNIEAATGCTVIICERGANTSLDVRGGGPASR
                     ESELTKPFATTEVIHAVLLSGGSAFGLDASGGVMKYLEERNIGFDVGVTKVPLVCESCI
                     FDLRVGDYKVRPDIEMGYNACIDAQNNNPKMGNYGAGTGASVGKILGVDYAMKSGLGFY
                     ALEVDGVKVGAVVSVNAFGDIFDYDTGEKLAGLLGEDKKSFRSSEEELIKLTRDKEISF
                     NLVENTTIGAIITNAKFTKTQMGKIASMAHNGFARTIKPVHTTLDGDSIYAMSVGDIKA
                     SIDAVGSLAAIVMGRAINNAVKNAESSYGL"
     CDS             8765..9475
                     /locus_tag="ctg1_1514"
                     /transl_table=11
                     /translation="MRVLVYDSNHTIRDNITTILLMQGYDVVAVKDKKHILPTCSKMPF
                     SIAIIETSPYDEEANNILEKMYYNDIYKNIKVLIYVPEITPGFVSKMFKIGVAGILFKP
                     FNEKDFFNRFSNILSKSNLLPKRLKYPVIGNVNYDIVFRHEETKQIVHSMILEMSARGI
                     KFLIPNEHVRLNVGYNIQLVYMSIGSYKMTFSLNIIEVIGKEYIGLFENLSSFDHKVIC
                     KFIYEKYIEKNLIS"
     CDS             9494..10303
                     /locus_tag="ctg1_1515"
                     /transl_table=11
                     /translation="MIKTLTIAGFDGSGGAGIQADLKVFSALGCYGMCVLTALPVQNTQ
                     GVRSCYEIDIKAIEEQLYCIFDDIVPDAIKIGMLFNNDIIKLVANFLENNAKNIPIIVD
                     PVMVAKSGDRLLLEDAVESLKKYIIPISTVITPNIPEAEDITNKKITTDEDMIAAANDI
                     LKMGAKNVMLKGGHLDGKLSRDLFINSKEHEFLDAIRIDTKNTHGTGCTLSAAICSYIA
                     HGKTPLEACILAKNYLFNALESAKIDSVGKGHGPVNHFYELWKYLKF"
     aSDomain        9506..10273
                     /aSDomain="TIGR00097"
                     /aSTool="tigrfam"
                     /description="HMP-P_kinase: hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1515_0007"
                     /evalue="3.30E-95"
                     /identifier="TIGR00097"
                     /label="ctg1_1515"
                     /locus_tag="ctg1_1515"
                     /protein_end="260"
                     /protein_start="4"
                     /score="316.1"
                     /tool="antismash"
                     /translation="LTIAGFDGSGGAGIQADLKVFSALGCYGMCVLTALPVQNTQGVRS
                     CYEIDIKAIEEQLYCIFDDIVPDAIKIGMLFNNDIIKLVANFLENNAKNIPIIVDPVMV
                     AKSGDRLLLEDAVESLKKYIIPISTVITPNIPEAEDITNKKITTDEDMIAAANDILKMG
                     AKNVMLKGGHLDGKLSRDLFINSKEHEFLDAIRIDTKNTHGTGCTLSAAICSYIAHGKT
                     PLEACILAKNYLFNALESAKIDSVGKGHGPVNHF"
     PFAM_domain     9524..10267
                     /aSDomain="Phos_pyr_kin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08543.14"
                     /description="Phosphomethylpyrimidine kinase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1515_0024"
                     /evalue="1.60E-88"
                     /label="ctg1_1515"
                     /locus_tag="ctg1_1515"
                     /protein_end="258"
                     /protein_start="10"
                     /score="296.4"
                     /tool="antismash"
                     /translation="DGSGGAGIQADLKVFSALGCYGMCVLTALPVQNTQGVRSCYEIDI
                     KAIEEQLYCIFDDIVPDAIKIGMLFNNDIIKLVANFLENNAKNIPIIVDPVMVAKSGDR
                     LLLEDAVESLKKYIIPISTVITPNIPEAEDITNKKITTDEDMIAAANDILKMGAKNVML
                     KGGHLDGKLSRDLFINSKEHEFLDAIRIDTKNTHGTGCTLSAAICSYIAHGKTPLEACI
                     LAKNYLFNALESAKIDSVGKGHGPVN"
ORIGIN
        1 ctagctcctg atgctcctat tgggtggcct atagcaatag cgcctccatt aacatttact
       61 atatccatat tgaattttag ctcacgtgca acagcaatag actgagcagc aaaagcttcg
      121 ttgctttcta ttaagtccat gtcttcaacc gtgagattag ccatttttaa agcctttctg
      181 ctagcttcta ttggtccaat tcccattatc ctaggctcaa caccatgagt agcataaccc
      241 aaaactttag ccataggttt aattccaagc tcatcagcct tttctttaga cataagtact
      301 acagcagaag cagcatcatt aataccagaa gcattaccag cagtaacagt accatctttt
      361 ttgaatgcag gctttaatct ggctaaagat tccatagtag taccaaatgt agggtgctca
      421 tcagtatcta ctactatttc tccttttttg gtctttattg taacaggcac tatctcatct
      481 ttaaatcttc cgctttttat agcagcctca gctctgtttt gacttctgca tgcaaactca
      541 tcttgttctt ctcttgttat tttccactgt tctgctatat tttctgcagt aacccccata
      601 tgataatgct caaaagcaca tacaagagca tcattaagta aagtgtcttg catttttgtc
      661 tcacccattc ttgcccccat tctcatagca gaagaagtat acggtgccat gctcatattt
      721 tcagttcctc cagcaaccac tatatcagca tcacccgcct taatcatttg tgctgccatt
      781 gatacagctc taagtccaga accgcataat atgtttatgg tcaatgcagg tttttctaca
      841 ggtataccag cattaacaga aacctgcctt gcaacgtttg gaagaagtgc tgattgtata
      901 acacagccaa aataagtttc atcaacttgc tctggtttta tatttgctct ttttaacgcc
      961 tctttcactg caatagtacc aagctctaca gctgaagtgt ttgcaaatga gcctaaaaac
     1021 ttaccgacag gtgttctaac ggcacttgct attactattt ctctcataat ataatctcct
     1081 aataaaaagc ttattatgta tagtatagtc aataaaaata tgttttacaa tactttatac
     1141 ttgttaatat agttttatag tgtataatga ggaaaatgaa aaagaagcta gaattacaaa
     1201 ccacaactct ttgggattat ccttcccagc aatatttaaa aagtgaagaa gaaaagcata
     1261 aacattatat aggagcaaca ccttcgtata taatatggaa tttattaaat agatacacaa
     1321 aagaaaaaga tttagttgta gacccaatgg ctggaagcgg aacaacggtt gatgttgcaa
     1381 gagaactcgg aagaagggct ttagggtatg atattaatcc aaaggcttta gagagaaaag
     1441 acatttttag agcagatgct agaaagatac ctatagaaga tgaaaaggta gattttgttt
     1501 ttattgaccc tccttatagc acgcatatca attactctga tgaaaaaaat tgcataggaa
     1561 aattaactgc taaaacagat gagtattata atgctatgga gaaagttata tctgaaatat
     1621 ttagaataat gaaaaaagat aggtatatgg ctttatatgt ttctgattct tatgaaaaag
     1681 attatccttt tatgcctata ggttttaagc tttttgagat tatgagtaaa tattttatgc
     1741 ctatagatat agtttctgtt gtaaggcaca ataaaagttt aagcaagggt aattatcatt
     1801 tatctgctat agaatataat tattatttaa gaggttttaa ttatcttttt ataatgtaca
     1861 aacaaggaaa taaaaccata gataaaaacg gcaaggttca tttaaggaat ttgtaaatat
     1921 attattttta tgagttaatt atcagtaaga tatttttatt gataaagaat tatcgaaaaa
     1981 gtatatagtt aaaacaattt gacaaataaa aaaaatatta tatattgtaa taaaaaaggt
     2041 atgtaataat cttatgaaga aaaatacggc tattgtatta ggcggcagtt tcgatttatc
     2101 atttgcaatt ggtgcttttt taataaattt aaaaaaatat tctccaaatt tagctgatga
     2161 tataattatt tatcatgata atatatctga aaaagatcag gagattatga atagcataat
     2221 tcctgtcaaa tttattaaat ttgaattaaa tgaaaaatta aataatatag atacttttgt
     2281 aagagaaaga ttttctgatt tgatattttt taaatatgaa tgtcttaaat tattaaacga
     2341 atataaaaca gtaatagtta cagattttga tgtattatta ttagatgata tttctgaaat
     2401 agctatacca aaaaataata atgtgaaatg taaaatgctt aaagacttta tagaaattat
     2461 tggcggtgat ttgtctcatg atattcttaa tgagtcatca tttaaatatg ataaagatat
     2521 gtttgtaatg ggtgctggtt taatagtttt ttatgatact ataaaaaata ttgatgagtt
     2581 atataattat tgtttagata aaactatgca atatagtaaa tatttacttt tgccggagca
     2641 agcaattttt agtttaatgc ttcatgattt taatatagag ccggaagtaa tagatagaac
     2701 aatatatgtt gtacacccta gggaacatca taaatataaa aatgctaaaa ttttacatgc
     2761 ttttggtcct cagaaatttt ggaattctat agaaaatgat tcttggaatg cgaattataa
     2821 ggaatggatt aagcttgggg gaagcaaaaa aagaaattct atttttgtaa gttcaaaatt
     2881 aagccataga gattttatca ttaataaaat tgcttggtgg attcctataa aaaaatggcg
     2941 tggtagtttt aaaaataaat ttagaaaaag cagattctaa tttatttaat ttaaaaaaaa
     3001 ggacagcctt aaagctatcc tttttatata tttttaaaaa ggtcttatta ccaaatcatt
     3061 aaactggaac cccaagtaaa tccgccaccg aatcctgtaa gaagaactaa atctccgtca
     3121 ttaattttat tttcttctaa agcatcagtt aaagctaagc ctatacttgc tgaagaacag
     3181 tttccgaatt tatttaatac aacgcttact ttttccatag gaagacctat tctttttgca
     3241 acagcctgca taattcttaa attagcttga tgcggtacaa aatatttaac atcgcttaat
     3301 tgttttccag tagattctaa aactttatct atactattag aaaactcagt aacagctctc
     3361 ttaaaagttt cagaaccgtc catatgtatt ttaaactcag gagcttctaa atcatcggct
     3421 cttatagggc aaacgcttcc gccattaagt acaatactca tatcaggctc gctttgcata
     3481 tgcatgccta ttattccttt tccgtcatct cttgttgtaa ttaatgaagc agtagcagca
     3541 tctccaaaaa gaattgcagt acctctgtct ttccaattaa catctttagt aagtttttca
     3601 cttgaaacta taagtacatt tttacactgt ccgctttcta tcaaagaaac agctgtgttt
     3661 agagaatata tatatccaga acaagcagca gataagtcta aagcaaaaca atgattaagt
     3721 cctaatgctt gttgtaattg tccagccata gatggaaata tataatcttt tgttacagta
     3781 ggaactaata tagcatcaac ttcttttaaa tccacacctt ttttctctaa gtttttaaca
     3841 gcattaattc ccatttcaaa aatagtttca tcaggtcttg ccatatgtct tgtttctata
     3901 cctgtacgag ttactatcca ttcattattg gtgtctaata tgctttcaaa atatttgttg
     3961 tctaatattc tttctggtac ataataggct atgtttttaa tgtatgctct tttcattata
     4021 agctccaatt taaaatatac ttttctagta taaaatatat tactttttaa aaaaaatgat
     4081 atagttatta gtaactattt tatttctctt ttgcctctct taccatattg ggataatatt
     4141 tttttaattc taaaaatgca ttctccactt tttctggtat atctatatga attaaaaaat
     4201 ctttacccct tggtccgtaa ccttctttat tgtctgttaa tcttggtatc tctcccataa
     4261 gaagattaat atatctatct atattccaca ttccaagagg gtagctgtca taaattaatt
     4321 ttgaatcttt atttattact tttactttat atgctgcata gttaataact tctatacttt
     4381 tatctatata cttttttata acagcactca ttcttagctg catagatgca tcttgaatta
     4441 atattatatt gttgaaatct aatttttctt tttttattat ttctaataga ttagtaatat
     4501 tatttccgca atttgtagaa tgcagctcca aaaaatctgc ttctacattg tatttatttt
     4561 ttatatattc attaaatatt tctgcttctg ttttatagtt tatgtttggc attatttctt
     4621 ttatattatt tattaaagta tctgttgtgt gtccgtatcc tccaactatt atgtattttt
     4681 tagcaatttt ttcttttata gcttgagcaa atatatcgcc tccttcaatt atgcttcctc
     4741 caaataatac gataatatct gcttgattta tattatattt attttttaac tcttctttat
     4801 ttaaaaaact aatatctctt gtagcgcaaa aatctgctaa tatgtttata tattctgata
     4861 tttttttgta acacataaat tattccataa tattttttgt atctatattt ttaaataaaa
     4921 ctatataaat aaaaaaaagc aaaaataagc cttattgcct acttttgctt ttttataata
     4981 tttaaaaaat tattggggta ttattctagt acaacaatag cattaggttc ttttattcta
     5041 ggtaaaacag tttccataat tctaaaagta tgattaaggt ctttttgctc taagtatgca
     5101 gtagacatat caacaccaat agctaaatct atatattgag gctctacaca tataatagca
     5161 gcttttttac cttttattgt aggtatatta tatagattat gaatcatatt agttattctt
     5221 tgagcttcag tcatgccagt accttgctgt attctctgta agtcgaaaaa taatccctga
     5281 ctcaaagcta gtattattct tccaactatt cctttttctc taatcatatt aatagctttt
     5341 acaatatcaa tgtaaggatt ttcaccagca gaccaatcgc taatttttag tttttgtaca
     5401 cctttagtgt ttagtattcc agtaactcca acaaactcat taccataaaa aattaattca
     5461 tcttctttat ttgataaagt ttgtgctgca aatgatgtta cagataaatc taaaggcatt
     5521 ttattttttt cattattttc tatatctctc caaagaagag tgaagtcttg atatagctga
     5581 ggaagttcca cagaatgcct tccagaagtt tttactatac catcttgaaa aacttcttct
     5641 ctatcatttc tatcatattg cacgcttata gtgccggaac ctaaaggtcc atatatactt
     5701 aagaatcttc ttcctattaa agttctgctt gcagtttcta ttactgcttt atctatttta
     5761 ctccaaaagt cgctatcaaa aggcgaacca tctcttgcta aaaagtccat atattctcct
     5821 tttaaattta ttttataata tttagtataa taataattat tcttttttca aacttccaac
     5881 tgtaagacct gataaatctg gttcttttat tcccaactct tccatcattt cttttacttc
     5941 catttctcca gaagcaaaat gttcagcctc tttagggtct aaatgtctta aaagagccat
     6001 aagttcacct acatgtgcct tttcctcatc tctaatatca gctaaaactg ccttagcaac
     6061 agggtcatct gtagccatac aatgagcatc atataaatat atagcctcta attctccagc
     6121 tatatccaat ctcacagcct gtattaattc ttctttacta atctttcttt caacatttgc
     6181 attaaacggg tttgcaaaac taggcatatt ttcctccttt gaaataccta attatactaa
     6241 tacaataaat tacttattaa tattaattac taataacaag tatagtataa aaaattataa
     6301 aagtcaacat ataaaacaaa tataaaaaga aaaaatgata tgtatttaca aatattttta
     6361 tattaagtat aatttattag aatatttatt taattatttt atggagtttt ttatgactat
     6421 tcaagaagag tattttaaga atttatctaa tatattaaaa ataaatttca ataaaaaggg
     6481 ttttgctttt gatagctttt ctaataaaga agaggctaaa aagtttttgt tatctcaaat
     6541 aaaaaaagat gatgttataa cattcggcgg aagtactagt gttaatcaga tgggtatatt
     6601 agaagattta aaagattata aaaactttgt agatagaaac aataaagaat taaaaacaga
     6661 ggcagagatt aaggcattta ctgctgatgt atatttatgt tctgctaatg ctttgagtaa
     6721 gaatggagat gttatcgcta tagacggagg cggaaatagg gtttctgcta tgatttacgg
     6781 accaaaaaaa gtatatttag ttgttggaag aaataagatt gctaatactc aacaagatgc
     6841 attaaagaga gctaaagatt ttgctgcttc acaaaactct ataagattta aagtaaataa
     6901 tccttgcagt gtaggtgata tggtttgtaa tgagaattgc aatatagaag agagattatg
     6961 tgcttatact gttattataa ataaatgcca tataaaaaac agaatacata tattatttat
     7021 agatgaagaa ttaggttttt aatttattac aaattatagg gcttttaagt ttactagaag
     7081 tttttattta atcactcaat ttttcagtaa tataaaaagt tccgtgaata tttacttttg
     7141 tagatttatt agcctctata attgttttat cgaatgcttc tatattaaag cttacacttc
     7201 cttcgcagat gccgtttact tctaaagtgt ttccattatc ataaaaatta agcattatat
     7261 ttccgcttgc tgaaactgat gagatattgg gtataatata ttttgtgata ttgtctatta
     7321 cctcatattg agtgcttgat tttcttataa ttttactttt atttacttct acatctgtgt
     7381 ctgtatctat tcctattatt aatgatgttg gtattacgga tataatattt ccagattttg
     7441 aaatttctat tttaaaattt tgtaaatgca cttctcctgc tgcatcagaa tatgcaatca
     7501 atgttccata atatattcca gcataatcat cgatattttt atattgatta ttgcttatat
     7561 tattgctgaa agctaaattt gtaagtatta atataataat aaatattttt ctcattaatt
     7621 taaatatatc aatttttaat atacttatta ataaaaaaat aattaaaaaa tatcattata
     7681 agcttttagt ccataactag attcagcatt ttttacagca ttgttaatag ctcttcccat
     7741 tacaatggca gccaaacttc caaccgcatc aatactagcc ttaatatctc caacagacat
     7801 agcataaata ctgtccccgt ctaatgtagt atgtactggc tttatagttc tagcaaaacc
     7861 attatgagcc atagaggcaa tttttcccat ttgtgttttt gtaaacttag catttgttat
     7921 aatagctcct attgttgtgt tttctactaa attaaatgat atctctttat ctcttgtgag
     7981 ttttatcaat tcttcttcag agcttctaaa acttttttta tcttcaccta aaagccctgc
     8041 taatttctct ccagtgtcat aatcaaatat atccccaaaa gcattaacag aaacaactgc
     8101 tcccacttta actccatcaa cttctaaagc ataaaaacct aatccagatt tcatagcata
     8161 atcaacaccc aatatcttac caacagaagc cccagtacca gctccataat tacccatttt
     8221 aggattatta ttctgagcat caatacaagc attatatccc atttctatat caggacgaac
     8281 cttataatct ccaacacgca aatcaaatat acaagactca caaaccaaag gcactttagt
     8341 aacacccaca tcaaaaccaa tattcctctc ttcaagatac ttcataaccc cgccagaagc
     8401 atcaagacca aaagcacttc caccgcttaa tagtacagca tgtataactt ctgtagttgc
     8461 aaaaggtttt gtaagttcgc tttctctcga agcaggtcct cctccgcgta catcaagaga
     8521 agtgttagca ccgcgttcgc atattattac agtgcatcct gtggcagctt ctatattttg
     8581 agcgtttcct atttttatat tttctatatc tgtgattttt atttctttca tttttgatgt
     8641 ccttacttta ttattaaatt gtgagttaaa tgtatatttg ataattataa cataatttag
     8701 ttttttttct tgattttaat tttaactatc ttataattaa tatataggca aatggaggtg
     8761 ctttatgagg gtattagttt acgattctaa tcacactata agagataata tcacaacaat
     8821 actgcttatg caaggttatg atgttgtagc agtaaaagat aaaaaacata tacttcctac
     8881 ttgttcaaaa atgcctttct ctattgctat tatagaaaca tctccttatg atgaagaagc
     8941 taataatatt ttagaaaaaa tgtattataa tgatatatat aaaaatatta aagttttaat
     9001 ttacgttcca gaaattacgc ctgggtttgt ttctaagatg tttaaaatag gtgttgctgg
     9061 aatattattt aagccgttta atgaaaaaga ttttttcaat agattttcaa atatattatc
     9121 taaatctaat ttacttccta agagattaaa atatcctgtt attggcaatg taaattatga
     9181 tatagtattt agacatgaag aaactaagca gatagtacat agtatgatat tagagatgtc
     9241 tgctaggggt ataaagtttt taataccaaa tgagcatgta cgtcttaatg ttggatataa
     9301 tatacagctt gtttatatgt ctataggttc ttataagatg acattttctc taaatattat
     9361 agaggtaata ggtaaagaat atattggatt atttgagaat ttatcttctt ttgaccataa
     9421 agtaatttgt aaatttatat acgaaaaata tatagaaaaa aatttaatat cttaagtatt
     9481 gggatttgtt attatgatta agactttaac tatagctggt tttgatggtt ctggcggtgc
     9541 tggaatacag gcagatttaa aggtgttttc tgctttgggc tgttatggaa tgtgtgtatt
     9601 aactgcattg cctgtacaga atactcaagg ggtgaggagc tgttatgaga tagatattaa
     9661 ggctatagaa gagcagttat attgcatatt tgatgatata gtgccagatg ctataaaaat
     9721 aggaatgctt tttaataatg atataataaa acttgttgct aactttttag agaataatgc
     9781 taaaaatata cctataatag ttgatcctgt tatggttgca aaaagcggag ataggcttct
     9841 tttggaagat gcggttgaaa gcttaaaaaa atatattata cctatttcta cagtgattac
     9901 tccaaatata ccagaggcag aggatattac aaacaaaaaa attactacag atgaagacat
     9961 gattgctgct gctaatgata tactaaaaat gggagcaaaa aatgtaatgc ttaagggcgg
    10021 gcatttagac ggaaagcttt caagagattt atttataaac tccaaagagc atgagtttct
    10081 tgatgctatt agaatagata ctaaaaatac acatggcaca ggatgcacat tatctgctgc
    10141 tatttgcagt tatattgcac atggtaaaac tcctttagaa gcatgcattt tagctaagaa
    10201 ttatttattt aatgctttag agtctgctaa aattgatagt gttggtaaag gtcatggacc
    10261 tgttaatcat ttttatgagc tttggaagta tttgaagttt taattagttt tttctaaatt
    10321 gtctattaac tcataataat attttttacc ttgaaatata tcttgcgaca atattttttg
    10381 agcgttttcg tatttaaaaa tttcagagtt ttcatcaata ttattttcta ttatcaatga
    10441 gttgttagta attttataat atttatgata tgtgcttata gtgttatcaa tattttcttt
    10501 gtaaagcagt gaaataatag agtttttata atttgttgct ccagcattaa tagctataaa
    10561 cattggtata ttttctggaa caatatttac tggtgctttg tatgctccgt tagtgccgtc
    10621 ccatataaga agcggacttg gactactatc ttctaaaaag cttttcttta tgttttcgtc
    10681 tatagttgaa cgctctacta ttgcttttaa atatggatac aaatggtcat gcttgaatat
    10741 tatcaatgca tttggtgaat gttttagtat tgtgtctcta atttttatta tttcaattgc
    10801 tgccattgcg
//
