GCF_000314895.2_ASM31489v2_genomic - 2 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CM001773.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	thiopeptide	1,655,700	1,681,972
Region 1.2	betalactone,NRPS-like,NRPS	3,104,557	3,171,910	turnerbactin	NRP	15%

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	thiopeptide	1,655,700	1,681,972
Region 1.2	betalactone,NRPS-like,NRPS	3,104,557	3,171,910	turnerbactin	NRP	15%

No secondary metabolite regions were found in these records:: NZ_CM001853.1; NZ_CM001854.1; NZ_CM001855.1

Compact view

NZ_CM001773.1 - Region 1 - thiopeptide

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Location: 1,655,700 - 1,681,972 nt. (total: 26,273 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000619.1	0.12	RiPP	gassericin T	Lactobacillus gasseri
BGC0001388.1	0.12	RiPP	gassericin E	Lactobacillus gasseri
BGC0001602.1	0.12	RiPP	gassericin-T	Lactobacillus gasseri
BGC0000504.1	0.12	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001311.1	0.12	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0001391.1	0.11	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0000555.1	0.10	RiPP	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001889.1	0.10	RiPP	fusilassin	Thermobifida fusca YX
BGC0001285.1	0.10	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001407.1	0.08	RiPP	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000619.1	0.41	RiPP	gassericin T	Lactobacillus gasseri
BGC0001388.1	0.41	RiPP	gassericin E	Lactobacillus gasseri
BGC0001602.1	0.41	RiPP	gassericin-T	Lactobacillus gasseri
BGC0000504.1	0.39	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001311.1	0.39	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0001391.1	0.39	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0000555.1	0.35	RiPP	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001889.1	0.35	RiPP	fusilassin	Thermobifida fusca YX
BGC0001285.1	0.35	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001407.1	0.32	RiPP	bicereucin	Bacillus cereus SJ1

Similar known gene clusters

No matches found.

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Thiopeptides

Core peptide predictions

No core peptides found.

NZ_CM001773.1 - Region 2 - NRPS,NRPS-like,betalactone

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Location: 3,104,557 - 3,171,910 nt. (total: 67,354 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002002.1	0.63	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0001527.1	0.62	Other	basidioferrin	Gelatoporia subvermispora
BGC0001444.1	0.57	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.57	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000375.1	0.57	NRP	indigoidine	Streptomyces chromofuscus
BGC0001758.1	0.55	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001343.1	0.52	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0002000.1	0.51	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000449.1	0.50	NRP	tridecaptin	Paenibacillus terrae
BGC0001723.1	0.49	Polyketide	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002002.1	0.65	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0001527.1	0.64	Other	basidioferrin	Gelatoporia subvermispora
BGC0001444.1	0.62	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.62	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001343.1	0.59	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0002000.1	0.59	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000236.1	0.58	Polyketide	kinamycin	Streptomyces murayamaensis
BGC0001596.1	0.58	Polyketide	fluostatins M-Q	Streptomyces albus
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000231.1	0.58	Polyketide	griseusin	Streptomyces griseus

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 3104556 - 3171910:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 3128029 - 3170039:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 3130050 - 3171910:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2620

Search NORINE for peptide: strict or relaxed

AMP-binding (25..474): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: erWcLGgatK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 40% (weak)

ctg1_2645

Search NORINE for peptide: strict or relaxed

AMP-binding (89..469): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALFlGLVmK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 80% (moderate)