LOCUS       NZ_KB233225.1          10834 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_KB233225.1 Providencia burhodogranariea DSM 19968 scaffold00004,
            whole genome shotgun sequence.
ACCESSION   NZ_KB233225
VERSION     NZ_KB233225.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:21:21
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 154225
            Orig. end    :: 165059
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10834
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[159225:160059](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5834)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10834
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10834
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(867..2006)
                     /locus_tag="ctg4_124"
                     /transl_table=11
                     /translation="MLNYETLRIIWWVLLGVVCICFAVTDGFDMGVGGLIRVIGKTDVE
                     RRIMINSIAPHWDGNQVWLIVAGGGMFAAWPVVYAAAFSGFYVVMILVLASLFFRPIGF
                     DYRSKIEDPRWRGMWDWGIFIGSIVPPFIFGLIIANLLLGVPFTIDEWMRVTYTDSFFA
                     LFNPLGLLGGFIALCMVMMHGSAFLLLRTSDTVYSRARKCVQVTGILTTLLFLIAGAIV
                     ITSVDGYTLTSVIDHASPSDPLSKTVARVSGAWLTNYHHYPILWLLPLMGLVLPLVSAL
                     FARLNRYRLAFLTSGLSILGIISTPAAAMFPFIMPSSVQPNVSLTLWDSTSSLLTLQIM
                     TIVAIVMVPTILAYTSWCYYKMFTRLDEKSIKENSHSLY"
     aSDomain        complement(870..2006)
                     /aSDomain="TIGR00203"
                     /aSTool="tigrfam"
                     /description="cydB: cytochrome d ubiquinol oxidase, subunit
                     II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_124_0001"
                     /evalue="5.70E-159"
                     /identifier="TIGR00203"
                     /label="ctg4_124"
                     /locus_tag="ctg4_124"
                     /protein_end="379"
                     /protein_start="0"
                     /score="527.3"
                     /tool="antismash"
                     /translation="MLNYETLRIIWWVLLGVVCICFAVTDGFDMGVGGLIRVIGKTDVE
                     RRIMINSIAPHWDGNQVWLIVAGGGMFAAWPVVYAAAFSGFYVVMILVLASLFFRPIGF
                     DYRSKIEDPRWRGMWDWGIFIGSIVPPFIFGLIIANLLLGVPFTIDEWMRVTYTDSFFA
                     LFNPLGLLGGFIALCMVMMHGSAFLLLRTSDTVYSRARKCVQVTGILTTLLFLIAGAIV
                     ITSVDGYTLTSVIDHASPSDPLSKTVARVSGAWLTNYHHYPILWLLPLMGLVLPLVSAL
                     FARLNRYRLAFLTSGLSILGIISTPAAAMFPFIMPSSVQPNVSLTLWDSTSSLLTLQIM
                     TIVAIVMVPTILAYTSWCYYKMFTRLDEKSIKENSHSLY"
     PFAM_domain     complement(921..1988)
                     /aSDomain="Cyt_bd_oxida_II"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02322.17"
                     /description="Cytochrome bd terminal oxidase subunit II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_124_0001"
                     /evalue="1.90E-97"
                     /label="ctg4_124"
                     /locus_tag="ctg4_124"
                     /protein_end="362"
                     /protein_start="6"
                     /score="326.4"
                     /tool="antismash"
                     /translation="LRIIWWVLLGVVCICFAVTDGFDMGVGGLIRVIGKTDVERRIMIN
                     SIAPHWDGNQVWLIVAGGGMFAAWPVVYAAAFSGFYVVMILVLASLFFRPIGFDYRSKI
                     EDPRWRGMWDWGIFIGSIVPPFIFGLIIANLLLGVPFTIDEWMRVTYTDSFFALFNPLG
                     LLGGFIALCMVMMHGSAFLLLRTSDTVYSRARKCVQVTGILTTLLFLIAGAIVITSVDG
                     YTLTSVIDHASPSDPLSKTVARVSGAWLTNYHHYPILWLLPLMGLVLPLVSALFARLNR
                     YRLAFLTSGLSILGIISTPAAAMFPFIMPSSVQPNVSLTLWDSTSSLLTLQIMTIVAIV
                     MVPTILAYTSWCYYKM"
     CDS             complement(2022..3584)
                     /locus_tag="ctg4_125"
                     /transl_table=11
                     /translation="MKKLIMIDVILLSRFQFAGSALFHFLFVPLTLGLSVMLAIMNTLY
                     VVTGKEIYKDLTKFWGKLFGINFALGVTTGLTFEFQFGTNWSYYSHYVGDIFGAPLAIE
                     ALLAFFLESTFVGLFFFGWDRLSKVQHMTVTWLVALGSNLSAMWILVANAWMQNPVGAE
                     FSAKTMRMEMTSFTDVLFNPVAQVKFVHTASAGYVTAAMFVIGISAWYLLKNRDVLFAK
                     RSYIIAAAFGMMSCLSVIVLGDESGYVMGDVQKVKLAAIEAEWETQPAPASFNLFAIPD
                     QKNGVNHYALEIPYVMGLMTTRSLNKQVTGLNDLKAEHRLKIMNGIKAWTLLEQIRLGD
                     NSPLLASQFDDVKKDLGYGLLLKQYVAHPQDVTTADINKAADATIPEVTPLYFAFRIMV
                     ASGMILLAAVSMAFYSVIRKKVGKSRWLNRILFYCIPLPWIACESGWFVAEYGRQPWAV
                     GEVLPTAIATSSLSSGDLIYSIILICGLYSLFFIAEMYLMIKFARQGPSSLHTGRYHFE
                     KSL"
     PFAM_domain     complement(2067..3551)
                     /aSDomain="Cyt_bd_oxida_I"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01654.19"
                     /description="Cytochrome bd terminal oxidase subunit I"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_125_0002"
                     /evalue="1.10E-169"
                     /label="ctg4_125"
                     /locus_tag="ctg4_125"
                     /protein_end="506"
                     /protein_start="11"
                     /score="564.6"
                     /tool="antismash"
                     /translation="LSRFQFAGSALFHFLFVPLTLGLSVMLAIMNTLYVVTGKEIYKDL
                     TKFWGKLFGINFALGVTTGLTFEFQFGTNWSYYSHYVGDIFGAPLAIEALLAFFLESTF
                     VGLFFFGWDRLSKVQHMTVTWLVALGSNLSAMWILVANAWMQNPVGAEFSAKTMRMEMT
                     SFTDVLFNPVAQVKFVHTASAGYVTAAMFVIGISAWYLLKNRDVLFAKRSYIIAAAFGM
                     MSCLSVIVLGDESGYVMGDVQKVKLAAIEAEWETQPAPASFNLFAIPDQKNGVNHYALE
                     IPYVMGLMTTRSLNKQVTGLNDLKAEHRLKIMNGIKAWTLLEQIRLGDNSPLLASQFDD
                     VKKDLGYGLLLKQYVAHPQDVTTADINKAADATIPEVTPLYFAFRIMVASGMILLAAVS
                     MAFYSVIRKKVGKSRWLNRILFYCIPLPWIACESGWFVAEYGRQPWAVGEVLPTAIATS
                     SLSSGDLIYSIILICGLYSLFFIAEMYLMIKFARQGP"
     CDS             complement(3668..4264)
                     /locus_tag="ctg4_126"
                     /transl_table=11
                     /translation="MIKKLIDWYDLIVSKVMKADFVALLLVRLYLLPVIYEGAHSKVLG
                     FSGTVAWFSQSTAEGGLGLPFPWLLAFLATSTEVLGLICIALGLFTRIIAIPMMVVMSA
                     ASLMVHWSHGWLAIASNSMESSQRMSGFLQWLIENFPGRYNYITQLGDPIILNNGIEFS
                     ATYFIMLLVLLCYGGGKFISTDYWLSKGLKSWLNK"
     PFAM_domain     complement(3932..4198)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_126_0003"
                     /evalue="1.20E-12"
                     /label="ctg4_126"
                     /locus_tag="ctg4_126"
                     /protein_end="111"
                     /protein_start="22"
                     /score="48.4"
                     /tool="antismash"
                     /translation="ALLLVRLYLLPVIYEGAHSKVLGFSGTVAWFSQSTAEGGLGLPFP
                     WLLAFLATSTEVLGLICIALGLFTRIIAIPMMVVMSAASLMVHW"
     CDS             complement(4269..4991)
                     /locus_tag="ctg4_127"
                     /transl_table=11
                     /translation="VIIAHSVPALLAAAEEEFSILLRSPNASDEKLPRGISLYRKIVRE
                     NITGVLKSVFPLFSQRLKEEDINEIVDMFLYRHQANQPEFHQIATELLLFMRQQCQLSV
                     HELALIEYEWLMYAVEIDDSKVPIPQKISLGNREIPDIEIVLNPTLKIVVLPFSLPLTE
                     ETNDKESSFTHYFALYRKYDNAIWQKKLSEIEVYLLSKMTHEVISAVSLMLFTQEISFQ
                     SWLEANNNDEIFSIIFKS"
     PFAM_domain     complement(4704..4946)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_127_0004"
                     /evalue="2.30E-11"
                     /label="ctg4_127"
                     /locus_tag="ctg4_127"
                     /protein_end="96"
                     /protein_start="15"
                     /score="43.9"
                     /tool="antismash"
                     /translation="EEFSILLRSPNASDEKLPRGISLYRKIVRENITGVLKSVFPLFSQ
                     RLKEEDINEIVDMFLYRHQANQPEFHQIATELLLFM"
     CDS             complement(5001..5834)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_128"
                     /sec_met_domain="DUF692 (E-value: 5.8e-88, bitscore: 288.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCWWRMRQIAQDSAGIGLRSEHITTLLQQPKHKDIDFLELAPDNW
                     MNIGGLKKEHLKDIANKYPLIAHSLSLSIGDTCPLNESYINDIRCFLDEYHIDTYSDHL
                     CFSRDKQGYLYDLLPIPRFANVLPYLVERIERVQDLLGRQLVLENVSSYHSYEGEMPEA
                     EFWGELLHRSDCGMLLDINNVYVNAFNHGFDALEYIRTIPSSSIVYFHIAGHLEYEEFR
                     LDTHGMPVLQEVLDLVKQTVTLHGARPLLLERDNNVPPLNELCGELTDIKKHISQ"
     PFAM_domain     complement(5013..5795)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_128_0005"
                     /evalue="1.70E-92"
                     /label="ctg4_128"
                     /locus_tag="ctg4_128"
                     /protein_end="274"
                     /protein_start="13"
                     /score="309.5"
                     /tool="antismash"
                     /translation="AGIGLRSEHITTLLQQPKHKDIDFLELAPDNWMNIGGLKKEHLKD
                     IANKYPLIAHSLSLSIGDTCPLNESYINDIRCFLDEYHIDTYSDHLCFSRDKQGYLYDL
                     LPIPRFANVLPYLVERIERVQDLLGRQLVLENVSSYHSYEGEMPEAEFWGELLHRSDCG
                     MLLDINNVYVNAFNHGFDALEYIRTIPSSSIVYFHIAGHLEYEEFRLDTHGMPVLQEVL
                     DLVKQTVTLHGARPLLLERDNNVPPLNELCGELTDIKKH"
     CDS             complement(5807..6121)
                     /locus_tag="ctg4_129"
                     /transl_table=11
                     /translation="MKKDIVLSIIVGSVLTMGAAATAVAAEPSQANRIENKAPTSSGKC
                     ASGKCGTEKIYGQATLKHDPQDQMVRARDGKCGLTGEGIKQDTPKEVKVDKCVGGVCGK
                     "
     CDS             complement(6125..7075)
                     /locus_tag="ctg4_130"
                     /transl_table=11
                     /translation="MRTRFNNAMLLSLSLLFSANVLADALQCENKDFTVQTLGSGGPIT
                     DDQRASSGEVIWINGKSAILIDAGGGVFLRFGQAGARLEDLKLLALTHFHTDHVSDVAA
                     ILKGGYFLSNKEEITLAGPEKGGAFPSMTEYFSDLFKKDGGAYSYLNGLYNATDGLKIS
                     SNIKDISYTSHEPSLVYQDDEMKITAIGIPHGDVPCLAYRIETDKGTIVVSADQNGSNK
                     DFISFAKDADILVMPLAIDENADEQSKFMHAAPDVVGKVAAEINPKVLVLNHFMGKGLR
                     LKDQSVKIVKQYYHGNVYSSRDLSCFPISLAKDKE"
     PFAM_domain     complement(6251..6886)
                     /aSDomain="Lactamase_B_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12706.9"
                     /description="Beta-lactamase superfamily domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_130_0006"
                     /evalue="2.90E-11"
                     /label="ctg4_130"
                     /locus_tag="ctg4_130"
                     /protein_end="275"
                     /protein_start="63"
                     /score="43.4"
                     /tool="antismash"
                     /translation="ILIDAGGGVFLRFGQAGARLEDLKLLALTHFHTDHVSDVAAILKG
                     GYFLSNKEEITLAGPEKGGAFPSMTEYFSDLFKKDGGAYSYLNGLYNATDGLKISSNIK
                     DISYTSHEPSLVYQDDEMKITAIGIPHGDVPCLAYRIETDKGTIVVSADQNGSNKDFIS
                     FAKDADILVMPLAIDENADEQSKFMHAAPDVVGKVAAEINPKVLVLNHF"
     CDS             complement(7513..8373)
                     /locus_tag="ctg4_131"
                     /transl_table=11
                     /translation="MKKVVALLLALSVSAISACSQDDKPKETADSDAQGRQKIIIGSHG
                     SDADIWQFIAQSQAAKDAGLDLDVKIIDDGVTLNIATIDGDVDVNAFQSWGFLKDFNHN
                     NKNQLTAITTTYFEPMAVYSAKYKTLDQIPDRALVAIPNDAANHARALLLLQKAKLITL
                     KPDFNQATGSVNDIVDNPKDLVFRQIKYAHGPRALPDVDIAVIGNTAAQEGGLNALNDS
                     LFREQNDGSINDMINVLVVKSENKDNPGLNKLGELYHTDFVKDYIRDNFGGTKIQIVQP
                     LSTLN"
     PFAM_domain     complement(7543..8241)
                     /aSDomain="Lipoprotein_9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03180.16"
                     /description="NlpA lipoprotein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_131_0007"
                     /evalue="1.90E-65"
                     /label="ctg4_131"
                     /locus_tag="ctg4_131"
                     /protein_end="277"
                     /protein_start="44"
                     /score="220.5"
                     /tool="antismash"
                     /translation="GSDADIWQFIAQSQAAKDAGLDLDVKIIDDGVTLNIATIDGDVDV
                     NAFQSWGFLKDFNHNNKNQLTAITTTYFEPMAVYSAKYKTLDQIPDRALVAIPNDAANH
                     ARALLLLQKAKLITLKPDFNQATGSVNDIVDNPKDLVFRQIKYAHGPRALPDVDIAVIG
                     NTAAQEGGLNALNDSLFREQNDGSINDMINVLVVKSENKDNPGLNKLGELYHTDFVKDY
                     IRDNFGGTKIQ"
     CDS             8760..9794
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2OG-FeII_Oxy"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_132"
                     /sec_met_domain="2OG-FeII_Oxy (E-value: 5e-24, bitscore:
                     79.1, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSYQLPIIDLRELDNPETRDDFYKKLRFIAREIGFFYLVGHNIT
                     PEERETLLATTKRFFALPKVEKEKIAMSHSRHFRGYTASTQESTRNQPDYREQIDIGEE
                     LPALELTKQDPIWFNLHGPNQWPEALPELKTQALEWQSKTRDISVKLIKAFLVALELPE
                     NSFDTIIAEPAQHLLKLIHYPAREDNNEGEQGVGAHKDAGILTLLWQDNIGGLQVETDN
                     GWIDVEPMENAFVVNIGEVFELATNGYLRANVHQVVRKQNSVSRYSIAYFITPSVFADE
                     VPLLPLPAYLAQQALGPDSDPLNPLFTNLGKNVIKGRLRSHLDVTRQFYPEEYEQIIKN
                     SNIL"
     PFAM_domain     8775..9143
                     /aSDomain="DIOX_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14226.8"
                     /description="non-haem dioxygenase in morphine synthesis
                     N-terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_132_0008"
                     /evalue="1.40E-33"
                     /label="ctg4_132"
                     /locus_tag="ctg4_132"
                     /protein_end="128"
                     /protein_start="5"
                     /score="116.3"
                     /tool="antismash"
                     /translation="LPIIDLRELDNPETRDDFYKKLRFIAREIGFFYLVGHNITPEERE
                     TLLATTKRFFALPKVEKEKIAMSHSRHFRGYTASTQESTRNQPDYREQIDIGEELPALE
                     LTKQDPIWFNLHGPNQWPE"
     PFAM_domain     9285..9584
                     /aSDomain="2OG-FeII_Oxy"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03171.22"
                     /description="2OG-Fe(II) oxygenase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_132_0009"
                     /evalue="3.00E-22"
                     /label="ctg4_132"
                     /locus_tag="ctg4_132"
                     /protein_end="275"
                     /protein_start="175"
                     /score="79.1"
                     /tool="antismash"
                     /translation="HLLKLIHYPAREDNNEGEQGVGAHKDAGILTLLWQDNIGGLQVET
                     DNGWIDVEPMENAFVVNIGEVFELATNGYLRANVHQVVRKQNSVSRYSIAYFITP"
ORIGIN
        1 aaatctccta gatatttgct agcgcacggc atttttaaca gttccagacg ccgttgttcg
       61 tttattgagt attactataa ctctatagat aataaatcat agaaaaaatt tttaacgata
      121 aggttcaaat ttttaggttt agtttttatt gctatatttt tcttttaatt caatctctta
      181 tgtgtttggt tttatttatt tatcataaat gtagatgttt tgctataagt tggaagagaa
      241 taattgaact ggatttaatg gcgagaaaca gatttatcgc caaaataatt tgaggtagct
      301 gtagctgata aaggcgatct ctagggaata ttgaagatta tttttgtagt aatatttgaa
      361 taaaagcaaa gcgaatatga cttattatcc atacgataaa gccagctata gatccccgat
      421 tgggaattaa tcgtaaatat gatattaagt gctaccaaca tacgagataa aacggttatt
      481 aattgaaaac aataattttt atccgttaaa tgagcttatt caattattgg caataagccc
      541 atttgaatac tttgagatta gaaaagagtt accgatattt ccgataatag tgaattgata
      601 tcgaattaaa gcaacgttct ctcatttata tattcttcat actttaagtt ataggattgc
      661 tgactacgta tagcggggcg agtcatagag tttgtctatg ctctcccgcc gatcttctct
      721 tgtcgactat atgcaagtcg aattatttaa agtattgctt atatcagtca ttcatcatcc
      781 gttgctatcg ctgcaatcat agcaactgca caggcgagta aagtgcctaa tacccaagcg
      841 aaataccaca taatgattcc ttaagctcaa tagagcgagt gtgaattttc tttaatagat
      901 ttttcatcta gccgcgtaaa cattttgtag tagcaccagc tggtataagc cagaatagtc
      961 ggtaccatca cgatggctac aatagtcata atctgtaaag tcaatagact cgaagtactg
     1021 tcccacaatg tcagactgac attaggttgt accgatgagg gcatgataaa tggaaacata
     1081 gccgctgccg gtgtgctaat aatgcctaag atggataacc cagaggttaa aaatgctagg
     1141 cggtaacgat ttaaacgagc aaatagcgct gacactaatg gtagaaccag tcccatcagc
     1201 ggtaataacc ataatatagg gtagtggtgg taattagtta accatgcgcc tgatactcgg
     1261 gcgactgttt tactgagtgg atcggaaggt gaggcatggt caataaccga agtcaacgta
     1321 taaccatcaa cactggtgat cacaattgcg cctgctatca aaaatagtag agtggttagt
     1381 attccggtta cttgtacaca ttttcgcgct cgtgagtata cggtatcgga agttcgcaat
     1441 agcaaaaagg cgctaccgtg catcatcacc atgcataagg cgataaatcc accaagcaaa
     1501 cctaatgggt tgaacaaggc aaagaaactg tcagtataag tcactctcat ccattcatcg
     1561 attgtgaatg gtacacccag tagtaggttc gcaatgatta atccaaaaat aaatggaggg
     1621 actatactgc caataaaaat accccagtcc cacatcccac gccagcgagg atcctcaatt
     1681 tttgaacggt aatcaaagcc aattgggcga aaaaagagtg aggctagtac taaaatcatg
     1741 acgacataga atccagaaaa tgcggcagca tacacgacag gccaagctgc gaacattcca
     1801 ccaccagcca caattagcca gacttgatta ccgtcccaat gtggggcaat gctattaatc
     1861 attatccgtc gttctacgtc ggttttacca atgactcgga taagcccacc tacacccata
     1921 tcaaatccgt cggtaacagc aaagcagata caaacgactc ctaataggac ccaccagata
     1981 attctcaagg tttcataatt cagcataaaa cgtctctctg attacaatga tttttcaaaa
     2041 tggtaacgac cagtatggag actgcttggc ccttggcggg caaatttgat catcagatac
     2101 atttcagcaa taaagaacag gctgtataac ccacagataa gaataatgga gtagattaaa
     2161 tcaccggaac ttagactcga agtcgctatt gctgtaggaa gtacttcacc gacagcccaa
     2221 ggttgacgtc catattcagc gacaaaccaa cccgattcac aagctatcca aggtaatggg
     2281 atacaataga atagtattcg gtttagccag cgtgatttac caactttctt gcgtattacg
     2341 ctataaaatg ccatagatac tgcggccagt aatatcatgc cgcttgctac catgatacga
     2401 aaagcaaagt acagtggtgt aacttcaggg atagttgcat cagccgcttt atttatgtct
     2461 gctgtagtaa catcttgtgg atgtgcaaca tactgtttta ggagtaaacc gtaacctaaa
     2521 tcttttttca catcatcaaa ctggctagca agtaaagggg aattatctcc taatcggatc
     2581 tgttctaata acgtccatgc cttaatacca ttcatgattt tcaatctatg ctcagctttc
     2641 agatcattaa gacctgtaac ctgcttattt aatgaacgag ttgtcatcaa ccccataaca
     2701 taaggaattt cgagagcgta gtgattgacc ccatttttct gatcagggat agcgaataga
     2761 ttaaacgaag ctggtgcagg ctgggtttcc cactctgctt caattgcggc aagtttgact
     2821 ttttggacat cgcccatcac atagccagat tcgtcaccaa gaacaataac ggataggcaa
     2881 gacatcatcc cgaaagctgc ggcgatgata taagaacgtt tagcaaataa gacatcacga
     2941 tttttcagta aataccaagc actgatccca atgacaaaca ttgcagcggt cacatatcca
     3001 gccgaagcgg tatggacaaa tttcacttga gcgacaggat taaacaaaac atcagtgaag
     3061 ctggtcattt ccattcgcat agttttggca ctgaattcag cgccaactgg attttgcatc
     3121 caagcatttg ctaccaatat ccacatcgca gacagattcg atccgagagc gacaagccaa
     3181 gtcaccgtca tatgttgaac tttactcagc ctatcccagc caaagaaaaa taatccaaca
     3241 aacgttgatt caaggaaaaa agctaatagc gcttcaatcg caaggggggc accaaaaata
     3301 tcaccaacat aatgagagta ataagaccag ttagtaccga attggaattc aaaagtgagc
     3361 ccggtcgtca cgccaagagc aaagttaata ccaaataatt ttccccaaaa cttggtgaga
     3421 tctttataaa tttccttacc tgtcacgaca tataaggtgt tcatgattgc tagcatcacg
     3481 gacaacccta atgttaatgg aacaaataga aaatgaaaaa gtgcagaacc tgcaaattgg
     3541 aaacgagaaa gtaatattac atctatcata attagctttt tcatccgatg aaagtatgag
     3601 taatttcagt gaactctgga actcagagcc acttaaatta taattcttga ttaatatgga
     3661 gaggaaatta tttattaagc caagatttta aacctttgct cagccaataa tccgtactaa
     3721 taaatttacc accaccgtaa cataataaaa ctaatagcat gataaaatag gttgcagaga
     3781 attcaatgcc attatttaaa ataatagggt cgccaagttg agtaatataa ttataacgac
     3841 cagggaaatt ctcaattaac cattgtaaga atccactcat acgctggctt gactccatgc
     3901 tattactagc aatagccaac caaccatgtg accagtgaac catcaagcta gcagcactca
     3961 taacgaccat cataggaata gcaataattc tcgtgaatag acctaatgca atgcagataa
     4021 gccctaatac ttcggttgag gttgctaaaa atgctaataa ccaaggaaat ggcagaccta
     4081 aaccaccttc cgctgtagat tgtgaaaacc aagcaacagt accactaaat ccaagtactt
     4141 tagaatgtgc tccttcataa attacgggta ataaatataa acgaacaagt aataaagcaa
     4201 cgaaatctgc tttcataact ttagatacaa ttaaatcgta ccaatctatt aattttttta
     4261 tcatagtatt aactcttaaa gattatagaa aagatttcat cattattatt ggcttctagc
     4321 caggactgaa aagatatttc ttgtgtaaat aacattaatg agacagcaga aattacttca
     4381 tgtgtcattt ttgataataa atacacttct atttcagaaa gtttcttttg ccaaatggca
     4441 ttgtcatatt ttctgtagag tgcgaaataa tgtgtaaaag aactctcttt atcgttagtc
     4501 tcttctgtta atggtaatga aaaaggtaaa acaactattt taagtgttgg atttaatact
     4561 atttcaatat ctggtatttc tctattccct agtgatattt tttgcggtat tggaacttta
     4621 ctatcatcaa tttcaactgc atacatcaac cattcatatt caatgagtgc cagttcatga
     4681 actgataatt gacattgttg tcgcataaat agcaataact cagttgctat ttgatgaaat
     4741 tctggttgat ttgcttgatg tcgataaaga aacatatcaa cgatttcatt tatatcttct
     4801 tcttttagac gttgactaaa taacggaaaa acactcttta atacacccgt aatattttct
     4861 cttacaattt tccgatacaa cgaaatacct cgaggaagtt tttcgtctga agcattaggg
     4921 gagcgcagta aaatagagaa ttcctcctct gctgcggcca ataatgcggg tacagaatga
     4981 gctatgatca cgctaattcc ttactgtgag atatgttttt tgatatcggt taattcaccg
     5041 cataattcgt ttaatggagg aacattgtta tcacgttcta gcaataaagg tctggcacca
     5101 tgaagcgtaa cggtctgttt taccaaatct aatacttctt gcaacactgg cataccatga
     5161 gtatcgagcc taaactcttc gtattccaaa tgacctgcaa tgtgaaagta aactatggag
     5221 gaacttggaa tagtgcgaat atattccaat gcatcaaatc catgattgaa ggcattaaca
     5281 taaacattgt taatatctaa aagcataccg caatcacttc gatgtagaag ttcaccccaa
     5341 aattcagctt caggcatttc accttcgtag ctgtgataag aagaaacatt ttcgagtact
     5401 agctgtcgtc ctaataaatc ttgaactcgc tcaatgcgct caactaaata aggaagtaca
     5461 ttggcgaatc taggaatagg cagtaagtca tagaggtatc cttgtttatc acgcgaaaaa
     5521 cataaatgat cactataagt atcaatatga tactcatcca aaaaacatcg aatatcgttg
     5581 atgtagcttt cattcaatgg acaagtatca ccaattgata gacttaaact atgagcaatt
     5641 aatggatatt tattagcaat atctttcaaa tgttcctttt ttaatccacc aatattcatc
     5701 cagttatcag gagctaattc taaaaaatcg atatccttat gttttggctg ctgtaatagc
     5761 gttgttatat gctcgctacg aagccctatt ccagcactat cttgagctat ttgccgcata
     5821 cgccaccaac acacttatct acttttactt ctttaggcgt atcttgttta attccttcac
     5881 cggtcaaacc acatttgcca tctctggctc gaaccatttg atcttgagga tcatgtttaa
     5941 gagttgcctg cccgtaaatt ttttcggtac cacatttacc actggcgcat ttaccgctac
     6001 ttgttggagc tttattttca attctattag cttgtgatgg ctcggctgcg acagcggttg
     6061 ctgctgctcc catggttaaa acggatccaa caataatgga aagtacgata tcttttttca
     6121 tgacttattc cttatcttta gctaatgaga ttggaaagca agaaagatcg cggctagagt
     6181 aaacattccc atgataatat tgcttaacaa ttttaactga ctgatctttc agacgtaatc
     6241 ctttccccat aaagtggttg agtactaaga cttttggatt gatttctgct gctaccttgc
     6301 cgacaacatc tggagccgca tgcataaatt ttgattgttc atcagcattt tcatcaatag
     6361 ctaaaggcat aacgagtatg tcagcgtctt ttgcaaaaga gataaagtct ttgttgctac
     6421 cattctgatc tgctgaaacg acgatggtgc ctttatccgt ttcgattcga taagctaagc
     6481 aaggaacatc accatgtggg atcccaatag cagtgatttt catttcatca tcttggtata
     6541 ctaatgatgg ctcatgtgag gtataactaa tatctttgat attactggat atttttaaac
     6601 cgtcagtcgc attgtatagc ccattaagat aagagtaagc cccaccatct tttttaaata
     6661 gatcggaaaa atattccgtc atagacggaa atgcaccgcc tttttcagga ccagcgagag
     6721 taatttcttc cttattactc aagaaatagc cacctttaag tattgctgct acatctgaga
     6781 cgtggtcggt atgaaagtgt gtgagtgcaa gaagttttag atcttctaaa cgtgctcctg
     6841 cctgaccaaa gcgtaaaaat acccctccgc cagcatcaat taaaatcgca gatttaccat
     6901 taatccaaat aacttctccg gatgaggctc gttggtcatc tgtaatagga ccacctgacc
     6961 ccagtgtttg tactgtaaaa tccttatttt cacactgtaa tgcatctgct aatacgtttg
     7021 cagagaaaag cagagaaagg gacaataaca tggcgttgtt aaaacgagtt ctcataaagc
     7081 ttccttcaat tttgtagcga taagctaaat catccttctg atgaccataa ggttattcta
     7141 atattatgaa cttgttaaat tgattattta tatgatatgt accagtcaaa tcgatagatt
     7201 attttgaata ggttttgatg gaatatgtaa ttaaataaaa ttgatatatt tatcaatgaa
     7261 ttatatttat tttattattt tgataatcaa gaaatgagtt ggttgctatt tttagcatat
     7321 tatttagcga catatttaat caaaaaaagg attaaaataa gttgattata cgaatccgga
     7381 aatatgttta tctagcatgg aattaaattg aagtgtgatg aataagtcgt cgctataatc
     7441 acaatagagg taagataatt gaattagaac aggtataacg atatagaaac cgttatacct
     7501 aagggagata aattaattaa gagtcgataa tggttgaaca atctgaattt tggtaccacc
     7561 aaaattatcg cgaatataat ctttaacaaa gtcagtatga taaagttcac ccagcttatt
     7621 taagcctgga ttatctttat tttctgattt aacgacaaga acattaatca tatcgttaat
     7681 gctgccatca ttttgttctc taaataaaga gtcatttaat gcatttaatc caccttcttg
     7741 tgccgcggta ttaccaatca cagcaatatc aacatctggc aaagctcttg ggccatgtgc
     7801 atatttaatt tgtctaaata ctaaatcttt tggattatca acaatatcat tgactgaacc
     7861 agttgcttga ttaaagtctg gtttaagcgt gataagtttt gctttttgta ataacaataa
     7921 tgctcttgca tggtttgccg catcattagg tatcgccact aatgcgcgat caggtatttg
     7981 atctaaggtt ttatatttgg cagagtaaac agccattggt tcgaaatagg ttgtcgtaat
     8041 tgctgttaat tgatttttat tattatgatt gaagtctttt aagaaacccc atgattggaa
     8101 tgcgttaaca tcaacatcac catcaattgt cgcaatattt aatgtcacac catcatcaat
     8161 aattttaaca tcaagatcta atccagcatc tttagctgct tgtgattgag caataaattg
     8221 ccagatatca gcatcacttc catggctacc gataattatt ttttgtctgc cttgtgcgtc
     8281 cgagtcggct gtttctttag gcttatcatc ttgtgaacaa gcactaatcg cagaaacaga
     8341 aagagctaac aacaatgcca ctactttttt cattttgata tctcacgagt tatttactct
     8401 catatctaat cagattcagt gactgctttt gaaataacat tttataaaca aaaaattttt
     8461 ttagttatat aaaaaattaa acttaacaca aatggttata tggatatatt ttaaagttat
     8521 ttttagtctc ttcttaatat ggtgtttact tataattaaa ataattcaag ttttatgtag
     8581 aacgccaatg cggttatatt gataaaaaca attaagtcat tgttattact ttgatttttt
     8641 gtaattaaag taattggcag ctttgcatct tgaaatgtga tcgtgattta tattcatggg
     8701 ctccgcgtac ccagatttat agatctcagt atgataatta aatatcaaag ggtttaacta
     8761 tgtcatcata tcaattacca attattgacc ttcgcgagct agataaccca gaaacgcgag
     8821 acgattttta taaaaaactg cgttttattg cacgtgaaat aggtttcttt tatctggttg
     8881 ggcacaatat tacaccagaa gaacgtgaga ctttattggc aacaactaag cgtttttttg
     8941 ctctgcctaa agtagaaaaa gaaaaaattg cgatgagtca ttcacgtcat tttcgaggct
     9001 atactgcttc aacgcaggaa agtacgagaa atcaaccaga ctatcgtgaa cagattgata
     9061 ttggtgaaga gctacccgct ttagaattga ccaaacaaga tcctatttgg tttaacctac
     9121 atggtccaaa ccaatggcct gaagcattgc ctgaactgaa aacacaagct ttagagtggc
     9181 aatctaaaac cagagatatt tcagttaaat taattaaagc ttttctagtt gcgttggaac
     9241 tacctgaaaa tagttttgat accataattg cagaacctgc tcagcattta ttaaagctaa
     9301 ttcattatcc agcacgagaa gataataatg aaggtgagca gggagttggt gctcacaaag
     9361 atgcgggtat tttaacatta ttatggcagg ataatattgg cggcttacaa gttgaaacag
     9421 ataacggctg gattgatgtc gagccaatgg aaaacgcctt tgttgtaaat attggggaag
     9481 tatttgaatt ggcaacaaat ggttatttac gcgctaatgt gcaccaagta gtgagaaagc
     9541 aaaatagcgt ttcacgttat tcgattgctt attttattac tccaagtgtt tttgcggacg
     9601 aagtaccatt attaccattg ccagcttacc ttgcccagca agcgttaggg ccagatagcg
     9661 atccattaaa cccactgttt acaaatttag gtaaaaacgt tattaaaggg cgactgcgtt
     9721 cacatttaga tgtgacccgt cagttttatc ctgaagaata cgagcaaatt attaaaaata
     9781 gcaatatttt ataatgtact cagtataaag ttattgattc attattaccg gagtacgact
     9841 atgtcagacc tttattataa gaaagagtta aatgggcaca ctttgtcgcc tgaaactttg
     9901 atgatgagct atggatatga tcctcagcta tcggaaggtg cgattaaacc acctgttttc
     9961 ttaacatcca cttttgtgtt taaaacagcg caggaaggaa aagccttttt taatatggtt
    10021 agtgggcgca caccaacgcc tgaagagcaa aaacaagggc ttgtctattc acgttttaat
    10081 catccaaata gtgaaattgt tgaagacagg ctcgccttat atgaaggagc cgaaagtgca
    10141 gcgcttttct catcgggtat gtcggcgatc acgacttgct tgatggcatt tatcaaacct
    10201 ggggatgtct tactacattc ccaagcgtta tatggcggga ctgagacact atttttgaat
    10261 acactcgcgc gttttggtat cacttctatt tcttttccag atggatgtga tggcgactct
    10321 attcgcgaag ttattaaagg tattgatcct gcaaaaaata ttgctgctat ttatatcgaa
    10381 acgccgtcta atccgttgaa cacgttagta gacattagct tattaagcga aattagcaaa
    10441 gagattgctc agactcggca aagtgaaaaa ccacttttaa tttgtgataa caccatgcta
    10501 ggccctgtgt ttcaaaagcc aatagcccta ggtgctgatt taagtgtgta ctcactaaca
    10561 aaatatgttg gtggacattc tgatctagtc gcaggtggag ttattggtag ccgtgaattg
    10621 attaaaaagg ttcgcggaca gcggaatgct atcggtactc aacttgatcc acattcaagt
    10681 tggatgttgg gacgttcatt ggaaacctta cagttacgta tggaaagagc caatgaaaat
    10741 gcccaaaaat tagcgacctt tttggctcaa catccaaaag ttaagaaggt gcatcatccc
    10801 gactttttac caaaagacag tgctgagtat caag
//
