Select genomic region:
Overview
1.1
1.2
1.3
1.4
2.1
3.1
4.1
6.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_KB233222.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | betalactone | 338,218 | 363,711 |
Region 1.2 | NRPS-like | 1,394,654 | 1,437,674 | 3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole / 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole / 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole / 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole | Polyketide:Type III | 37%
Region 1.3 | ladderane | 2,019,862 | 2,062,834 |
Region 1.4 | thiopeptide | 2,179,257 | 2,205,509 |

NZ_KB233223.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | RiPP-like | 573,658 | 584,917 |

NZ_KB233224.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | RRE-containing | 82,963 | 104,084 |

NZ_KB233225.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | RiPP-like | 154,226 | 165,059 |

NZ_KB233227.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 6.1 | T1PKS | 102,643 | 145,516 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | betalactone | 338,218 | 363,711 |
Region 1.2 | NRPS-like | 1,394,654 | 1,437,674 | 3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole / 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole / 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole / 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole | Polyketide:Type III | 37%
Region 1.3 | ladderane | 2,019,862 | 2,062,834 |
Region 1.4 | thiopeptide | 2,179,257 | 2,205,509 |
Region 2.1 | RiPP-like | 573,658 | 584,917 |
Region 3.1 | RRE-containing | 82,963 | 104,084 |
Region 4.1 | RiPP-like | 154,226 | 165,059 |
Region 6.1 | T1PKS | 102,643 | 145,516 |

No secondary metabolite regions were found in these records:
  NZ_KB233226.1
  NZ_KB233228.1
  NZ_KB233229.1

Compact view
NZ_KB233222.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 338,218 - 363,711 nt. (total: 25,494 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.24 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.21 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001441.1 |  | 0.17 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001131.1 |  | 0.14 | NRP | ambactin | Xenorhabdus miraniensis
BGC0000597.1 |  | 0.13 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000892.1 |  | 0.13 | Other | caryoynencin | Burkholderia gladioli BSR3
BGC0000595.1 |  | 0.13 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.13 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000805.1 |  | 0.13 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001464.1 |  | 0.13 | Other | tetrabromopyrrole | Pseudoalteromonas sp. PS5

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.58 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.54 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001441.1 |  | 0.48 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001131.1 |  | 0.43 | NRP | ambactin | Xenorhabdus miraniensis
BGC0000597.1 |  | 0.41 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000892.1 |  | 0.41 | Other | caryoynencin | Burkholderia gladioli BSR3
BGC0000595.1 |  | 0.41 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.41 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000805.1 |  | 0.41 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001464.1 |  | 0.41 | Other | tetrabromopyrrole | Pseudoalteromonas sp. PS5

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB233222.1 - Region 2 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,394,654 - 1,437,674 nt. (total: 43,021 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.32 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.32 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.31 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.27 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000343.1 |  | 0.22 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000189.1 |  | 0.22 | Polyketide | 3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole | Xenorhabdus bovienii SS-2004
BGC0001538.1 |  | 0.22 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000427.1 |  | 0.22 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.21 | NRP | indigoidine | Streptomyces chromofuscus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.66 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.65 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.65 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.61 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000343.1 |  | 0.55 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000189.1 |  | 0.55 | Polyketide | 3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole | Xenorhabdus bovienii SS-2004
BGC0001538.1 |  | 0.55 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.54 | NRP | indigoidine | Streptomyces chromofuscus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 1394653 - 1437674:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1202: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (24..421): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALlMGvtyK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      60% (weak)
ctg1_1203: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (19..416): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DglFLGCTiK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      70% (weak)

NZ_KB233222.1 - Region 3 - ladderane
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,019,862 - 2,062,834 nt. (total: 42,973 nt) Show pHMM detection rules used
ladderane: ladderane

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ladderane | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001591.1 |  | 0.20 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.20 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001197.1 |  | 0.20 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000204.1 |  | 0.17 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001281.1 |  | 0.17 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001525.1 |  | 0.16 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0001526.1 |  | 0.16 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000509.1 |  | 0.16 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0000521.1 |  | 0.16 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001591.1 |  | 0.53 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.53 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001197.1 |  | 0.52 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000204.1 |  | 0.49 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001281.1 |  | 0.48 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000486.1 |  | 0.46 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001525.1 |  | 0.46 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0001526.1 |  | 0.46 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000509.1 |  | 0.46 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0000521.1 |  | 0.46 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB233222.1 - Region 4 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,179,257 - 2,205,509 nt. (total: 26,253 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000908.1 |  | 0.15 | Other | melanin | Streptomyces avermitilis
BGC0000703.1 |  | 0.13 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001285.1 |  | 0.10 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000430.1 |  | 0.07 | NRP, Polyketide | spumigin E | Nodularia spumigena CCY9414
BGC0001312.1 |  | 0.07 | NRP | viscosin | Pseudomonas fluorescens SBW25
BGC0001776.1 |  | 0.07 | Terpene | shearinine D | Penicillium janthinellum
BGC0001215.1 |  | 0.06 | NRP | conglobatin | Streptomyces conglobatus
BGC0000988.1 |  | 0.06 | NRP, Polyketide | epothilone B | Sorangium cellulosum
BGC0000990.1 |  | 0.06 | NRP, Polyketide | epothilone | Sorangium cellulosum
BGC0000991.1 |  | 0.06 | NRP, Polyketide | epothilone | Sorangium cellulosum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000908.1 |  | 0.46 | Other | melanin | Streptomyces avermitilis
BGC0000703.1 |  | 0.42 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001285.1 |  | 0.35 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000430.1 |  | 0.29 | NRP, Polyketide | spumigin E | Nodularia spumigena CCY9414
BGC0001312.1 |  | 0.28 | NRP | viscosin | Pseudomonas fluorescens SBW25
BGC0001776.1 |  | 0.28 | Terpene | shearinine D | Penicillium janthinellum
BGC0001215.1 |  | 0.25 | NRP | conglobatin | Streptomyces conglobatus
BGC0000988.1 |  | 0.25 | NRP, Polyketide | epothilone B | Sorangium cellulosum
BGC0000990.1 |  | 0.25 | NRP, Polyketide | epothilone | Sorangium cellulosum
BGC0000991.1 |  | 0.25 | NRP, Polyketide | epothilone | Sorangium cellulosum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_KB233223.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 573,658 - 584,917 nt. (total: 11,260 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001191.1 |  | 0.04 | Other | A-102395 | Amycolatopsis sp. SANK 60206

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001191.1 |  | 0.19 | Other | A-102395 | Amycolatopsis sp. SANK 60206

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB233224.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 82,963 - 104,084 nt. (total: 21,122 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.1 |  | 0.26 | RiPP | microcin C7 | Escherichia coli
BGC0000434.1 |  | 0.05 | NRP | SW-163C, UK-63598, SW-163E, SW-163F, SW-163G | Streptomyces sp. SNA15896
BGC0001003.1 |  | 0.05 | NRP, Polyketide, Saccharide | α-lipomycin | Kitasatospora aureofaciens
BGC0001073.1 |  | 0.04 | NRP, Polyketide | kosinostatin | Micromonospora sp. TP-A0468

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.1 |  | 0.59 | RiPP | microcin C7 | Escherichia coli
BGC0000434.1 |  | 0.23 | NRP | SW-163C, UK-63598, SW-163E, SW-163F, SW-163G | Streptomyces sp. SNA15896
BGC0001003.1 |  | 0.21 | NRP, Polyketide, Saccharide | α-lipomycin | Kitasatospora aureofaciens
BGC0001073.1 |  | 0.20 | NRP, Polyketide | kosinostatin | Micromonospora sp. TP-A0468

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB233225.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 154,226 - 165,059 nt. (total: 10,834 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001965.1 |  | 0.14 | Other | nybomycin | Streptomyces albus subsp. chlorinus
BGC0001621.1 |  | 0.08 | NRP | imizoquin A, imizoquin B, imizoquin C, imizoquin D, TMC-2A, TMC-2B | Aspergillus flavus NRRL3357
BGC0001338.1 |  | 0.06 | Polyketide | citrinin | Monascus ruber
BGC0001857.1 |  | 0.06 | Polyketide, Alkaloid | burnettramic acid A | Aspergillus sp. CLMG-2019a
BGC0001978.1 |  | 0.06 | NRP, Polyketide | burnettramic acid | Aspergillus sp. CLMG-2019a
BGC0000297.1 |  | 0.05 | NRP, Polyketide, Saccharide | aeruginoside 126B, aeruginoside 126A | Planktothrix agardhii NIVA-CYA 126
BGC0000934.1 |  | 0.05 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001371.1 |  | 0.05 | NRP | echinocandin B | Aspergillus nidulans NRRL 8112
BGC0001035.1 |  | 0.04 | Other (Aminocoumarin), Polyketide, NRP | pneumocandin B0, pneumocandin A0 | Glarea lozoyensis ATCC 20868
BGC0000998.1 |  | 0.03 | NRP, Polyketide | guadinomine | Streptomyces sp. K01-0509

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001965.1 |  | 0.43 | Other | nybomycin | Streptomyces albus subsp. chlorinus
BGC0001621.1 |  | 0.30 | NRP | imizoquin A, imizoquin B, imizoquin C, imizoquin D, TMC-2A, TMC-2B | Aspergillus flavus NRRL3357
BGC0001338.1 |  | 0.27 | Polyketide | citrinin | Monascus ruber
BGC0001857.1 |  | 0.25 | Polyketide, Alkaloid | burnettramic acid A | Aspergillus sp. CLMG-2019a
BGC0001978.1 |  | 0.25 | NRP, Polyketide | burnettramic acid | Aspergillus sp. CLMG-2019a
BGC0000297.1 |  | 0.23 | NRP, Polyketide, Saccharide | aeruginoside 126B, aeruginoside 126A | Planktothrix agardhii NIVA-CYA 126
BGC0000934.1 |  | 0.23 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001371.1 |  | 0.21 | NRP | echinocandin B | Aspergillus nidulans NRRL 8112
BGC0001035.1 |  | 0.17 | Other (Aminocoumarin), Polyketide, NRP | pneumocandin B0, pneumocandin A0 | Glarea lozoyensis ATCC 20868
BGC0000998.1 |  | 0.15 | NRP, Polyketide | guadinomine | Streptomyces sp. K01-0509

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB233227.1 - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 102,643 - 145,516 nt. (total: 42,874 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001444.1 |  | 0.22 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0000044.1 |  | 0.22 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001441.1 |  | 0.20 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001131.1 |  | 0.20 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001488.1 |  | 0.20 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0001927.1 |  | 0.19 | Other | A-94964 | Streptomyces sp.
BGC0001895.1 |  | 0.19 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001264.1 |  | 0.19 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.19 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001366.1 |  | 0.18 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001444.1 |  | 0.55 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0000044.1 |  | 0.55 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001441.1 |  | 0.53 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001131.1 |  | 0.53 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001488.1 |  | 0.52 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0001927.1 |  | 0.51 | Other | A-94964 | Streptomyces sp.
BGC0001895.1 |  | 0.51 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001264.1 |  | 0.51 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.51 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001366.1 |  | 0.50 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 102642 - 145516:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg6_97: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (15..426): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      vLPslGcLCK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      60% (weak)
ctg6_99: mal
  PKS_AT (518..809): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 79.2%
    inactive: 75.0%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 113.4
    Methoxymalonyl-CoA: 72.2
    Methylmalonyl-CoA: 57.9
    inactive: 47.7
    Propionyl-CoA: 41.3
    Ethylmalonyl-CoA: 36.6
    2-Methylbutyryl-CoA: 29.9
    CHC-CoA: 25.5
    Isobutyryl-CoA: 19.2
    trans-1,2-CPDA: 17.7
    fatty_acid: 15.2
    Benzoyl-CoA: 9.9
    Acetyl-CoA: 8.6
    3-Methylbutyryl-CoA: 0.0