GCF_000146345.1_ASM14634v1_genomic - 3 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_GL397071.1

Region	Type	From	To
Region 1.1	NRPS	593,759	640,754
Region 1.2	ranthipeptide	1,502,360	1,522,509
Region 1.3	RRE-containing	1,818,248	1,839,603

Region	Type	From	To	Similarity
Region 1.1	NRPS	593,759	640,754
Region 1.2	ranthipeptide	1,502,360	1,522,509
Region 1.3	RRE-containing	1,818,248	1,839,603

No secondary metabolite regions were found in these records:: NZ_GL397072.1; NZ_GL397073.1; NZ_GL397074.1; NZ_GL397075.1; NZ_GL397076.1; NZ_GL397077.1; NZ_GL397078.1

Compact view

NZ_GL397071.1 - Region 1 - NRPS

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Location: 593,759 - 640,754 nt. (total: 46,996 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001444.1	0.24	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.24	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000889.1	0.24	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001636.1	0.22	NRP	KK-1	Curvularia clavata
BGC0002029.1	0.22	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.22	Other	ferroverdin	Streptomyces lunaelactis
BGC0001699.1	0.20	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0001615.1	0.20	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001479.1	0.20	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000410.1	0.20	NRP	pseudomonine	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001444.1	0.58	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.58	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000889.1	0.57	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001636.1	0.55	NRP	KK-1	Curvularia clavata
BGC0002029.1	0.54	Other	bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C	Streptomyces lunaelactis
BGC0001592.1	0.54	Other	ferroverdin	Streptomyces lunaelactis
BGC0001699.1	0.53	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0001615.1	0.52	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001479.1	0.52	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000410.1	0.52	NRP	pseudomonine	Pseudomonas fluorescens

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 593758 - 640754:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_558

Search NORINE for peptide: strict or relaxed

AMP-binding (23..446): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vAliIGVsaK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 50% (weak)

ctg1_560

Search NORINE for peptide: strict or relaxed

AMP-binding (505..864): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

NZ_GL397071.1 - Region 2 - ranthipeptide

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Location: 1,502,360 - 1,522,509 nt. (total: 20,150 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.16	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000489.1	0.16	RiPP	enterocin AS-48	Enterococcus faecalis
BGC0001222.1	0.15	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.15	RiPP	gassericin A	Lactobacillus gasseri
BGC0000539.1	0.15	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0001743.1	0.15	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0000703.1	0.15	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001484.1	0.14	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001891.1	0.14	Other	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001925.1	0.14	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.46	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000489.1	0.46	RiPP	enterocin AS-48	Enterococcus faecalis
BGC0001222.1	0.46	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.46	RiPP	gassericin A	Lactobacillus gasseri
BGC0000539.1	0.45	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0001743.1	0.45	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0000703.1	0.45	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001484.1	0.44	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001891.1	0.43	Other	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001925.1	0.43	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_GL397071.1 - Region 3 - RRE-containing

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Location: 1,818,248 - 1,839,603 nt. (total: 21,356 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000725.1	0.13	Saccharide	alginate	Pseudomonas aeruginosa PAO1
BGC0000599.1	0.13	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0001887.1	0.13	RiPP	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000344.1	0.05	NRP	entolysin	Pseudomonas entomophila L48
BGC0001902.1	0.04	NRP, Polyketide	bengamide	Myxococcus virescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000725.1	0.42	Saccharide	alginate	Pseudomonas aeruginosa PAO1
BGC0000599.1	0.42	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0001887.1	0.41	RiPP	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000344.1	0.23	NRP	entolysin	Pseudomonas entomophila L48
BGC0001902.1	0.20	NRP, Polyketide	bengamide	Myxococcus virescens

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names