GCF_000021925.1_ASM2192v1_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_011830.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	cyclic-lactone-autoinducer	997,975	1,017,155
Region 2	cyclic-lactone-autoinducer	3,911,390	3,931,875
Region 3	NRPS	4,188,030	4,237,316	equibactin	NRP	14%
Region 4	ranthipeptide	5,232,600	5,254,306

NC_011830.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 997,975 - 1,017,155 nt. (total: 19,181 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000842.1	0.14	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000847.1	0.13	Other (Non-NRP beta-lactam)	thienamycin	Streptomyces cattleya
BGC0000275.1	0.08	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001417.1	0.07	NRP, Polyketide	myxochromide D	Cystobacterineae bacterium
BGC0000544.1	0.07	RiPP	planosporicin	Planomonospora alba
BGC0001093.1	0.07	NRP, Polyketide	disorazol A	Sorangium cellulosum
BGC0001052.1	0.06	NRP, Polyketide	tirandamycin	Streptomyces sp. 307-9
BGC0000529.1	0.06	RiPP	microbisporicin A2	Microbispora corallina
BGC0000187.1	0.05	Polyketide	asukamycin	Streptomyces nodosus subsp. asukaensis
BGC0000023.1	0.05	Polyketide	aurafuron A	Stigmatella aurantiaca DW4/3-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000842.1	0.44	Other (Non-NRP beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000847.1	0.41	Other (Non-NRP beta-lactam)	thienamycin	Streptomyces cattleya
BGC0000275.1	0.30	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001417.1	0.29	NRP, Polyketide	myxochromide D	Cystobacterineae bacterium
BGC0000544.1	0.28	RiPP	planosporicin	Planomonospora alba
BGC0001093.1	0.28	NRP, Polyketide	disorazol A	Sorangium cellulosum
BGC0001052.1	0.27	NRP, Polyketide	tirandamycin	Streptomyces sp. 307-9
BGC0000529.1	0.26	RiPP	microbisporicin A2	Microbispora corallina
BGC0000187.1	0.22	Polyketide	asukamycin	Streptomyces nodosus subsp. asukaensis
BGC0000023.1	0.21	Polyketide	aurafuron A	Stigmatella aurantiaca DW4/3-1

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NC_011830.1 - Region 2 - cyclic-lactone-autoinducer

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Location: 3,911,390 - 3,931,875 nt. (total: 20,486 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	cyclic-lactone-autoinducer	Similarity score	Type	Compound(s)	Organism
BGC0000495.1		0.03	RiPP	actagardine	Actinoplanes garbadinensis
BGC0001755.1		0.03	Polyketide	reedsmycins	Streptomyces sp.

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000495.1		0.16	RiPP	actagardine	Actinoplanes garbadinensis
BGC0001755.1		0.16	Polyketide	reedsmycins	Streptomyces sp.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NC_011830.1 - Region 3 - NRPS

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Location: 4,188,030 - 4,237,316 nt. (total: 49,287 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000412.1	0.32	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000389.1	0.32	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000373.1	0.27	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001399.1	0.26	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000343.1	0.25	NRP	enterobactin	Pseudomonas sp. J465
BGC0000400.1	0.23	NRP	paenibacterin	Paenibacillus sp. OSY-SE
BGC0000347.1	0.23	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000460.1	0.22	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0001343.1	0.22	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000351.1	0.22	NRP	exochelin	Mycolicibacterium smegmatis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000412.1	0.66	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000389.1	0.66	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000373.1	0.61	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001399.1	0.59	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000343.1	0.59	NRP	enterobactin	Pseudomonas sp. J465
BGC0000400.1	0.57	NRP	paenibacterin	Paenibacillus sp. OSY-SE
BGC0000347.1	0.56	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000460.1	0.55	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0001343.1	0.55	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000351.1	0.55	NRP	exochelin	Mycolicibacterium smegmatis

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 4188029 - 4237316:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_3935

Search NORINE for peptide: strict or relaxed

AMP-binding (527..968): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNfSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

ctg1_3936

Search NORINE for peptide: strict or relaxed

AMP-binding (584..999): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSLiWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

ctg1_3937

Search NORINE for peptide: strict or relaxed

AMP-binding (29..433): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: N/A
Small clusters prediction:: dhb, sal
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PLPgQGiiCK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 70% (weak)

NC_011830.1 - Region 4 - ranthipeptide

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Location: 5,232,600 - 5,254,306 nt. (total: 21,707 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.18	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000601.1	0.18	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0000758.1	0.17	Saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0001808.1	0.17	Other	toyocamycin	Streptomyces diastatochromogenes
BGC0000881.1	0.17	Other	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001311.1	0.16	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0000527.1	0.16	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001579.1	0.16	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000506.1	0.16	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000487.1	0.16	RiPP	carnocyclin	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.50	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000601.1	0.49	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0000758.1	0.48	Saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0001808.1	0.48	Other	toyocamycin	Streptomyces diastatochromogenes
BGC0000881.1	0.48	Other	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001311.1	0.47	RiPP	flavecins	Ruminococcus flavefaciens FD-1
BGC0000527.1	0.47	RiPP	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001579.1	0.47	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000506.1	0.47	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0000487.1	0.47	RiPP	carnocyclin	Carnobacterium maltaromaticum

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names