LOCUS       NZ_CP021520.1          10843 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP021520.1 Neisseria meningitidis strain 11-7 chromosome,
            complete genome.
ACCESSION   NZ_CP021520
VERSION     NZ_CP021520.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:25:56
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1884986
            Orig. end    :: 1895829
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10843
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1889986:1890829](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5843)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10843
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10843
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(265..918)
                     /locus_tag="ctg1_1727"
                     /transl_table=11
                     /translation="MKITHCKLKKKVQKELLRFFVLEVTARSAADILGIHPNSAALFYR
                     KIRTVINHHLALAADEVFEDPVEPDESDFGGWRKGRCGRGAAGKVVVFDILKRNGRVYT
                     VVVNNAKSETLLPVIKKKIMPDSIVYTDSLSSCDKLDVSGFIYYRINHSKEFADRQNHI
                     NGIENFWNQAKRVLRKYNGIDRKSFPLFLKECEFRFNFGTPSRQLKILQDWCGI"
     PFAM_domain     complement(319..720)
                     /aSDomain="DDE_Tnp_IS1595"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12762.9"
                     /description="ISXO2-like transposase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1727_0090"
                     /evalue="2.80E-23"
                     /label="ctg1_1727"
                     /locus_tag="ctg1_1727"
                     /protein_end="200"
                     /protein_start="66"
                     /score="82.7"
                     /tool="antismash"
                     /translation="VEPDESDFGGWRKGRCGRGAAGKVVVFDILKRNGRVYTVVVNNAK
                     SETLLPVIKKKIMPDSIVYTDSLSSCDKLDVSGFIYYRINHSKEFADRQNHINGIENFW
                     NQAKRVLRKYNGIDRKSFPLFLKECEFRFN"
     CDS             complement(1462..2427)
                     /locus_tag="ctg1_1728"
                     /transl_table=11
                     /translation="MSYTQLTQGERYHIQYLSRHCTVTEIAKQLNRHKSTISREIRRHR
                     TQGQQYSAEKAQRQSRTIKQRKRQPYKLDSQLIQHIDTLIRRKLSPEQVCAYLCKHHQI
                     TLHHSTIYRYLRQDKSNGSTLWQHLRICSKPYRKRYGSTWTRGKVPNRVGIENRPAIVD
                     QKSRIGDWEADTIVGKGQKSALLTLVERVTRYTIICKLDSLKAEDTARAAVRALKAHKD
                     RVHTITMDNGKEFYQHTKITKALKAETYFCRPYHSWEKGLNENTNGLIRQYFPKQTDFR
                     NISDREIRRVQDELNHRPRKTLGYETPSVLFLNLFQPLIH"
     PFAM_domain     complement(1660..1917)
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1728_0093"
                     /evalue="3.00E-10"
                     /label="ctg1_1728"
                     /locus_tag="ctg1_1728"
                     /protein_end="256"
                     /protein_start="170"
                     /score="40.4"
                     /tool="antismash"
                     /translation="WEADTIVGKGQKSALLTLVERVTRYTIICKLDSLKAEDTARAAVR
                     ALKAHKDRVHTITMDNGKEFYQHTKITKALKAETYFCRPYH"
     PFAM_domain     complement(2083..2322)
                     /aSDomain="HTH_32"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13565.8"
                     /description="Homeodomain-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1728_0092"
                     /evalue="1.70E-09"
                     /label="ctg1_1728"
                     /locus_tag="ctg1_1728"
                     /protein_end="115"
                     /protein_start="35"
                     /score="38.3"
                     /tool="antismash"
                     /translation="TISREIRRHRTQGQQYSAEKAQRQSRTIKQRKRQPYKLDSQLIQH
                     IDTLIRRKLSPEQVCAYLCKHHQITLHHSTIYRYL"
     PFAM_domain     complement(2296..2424)
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1728_0091"
                     /evalue="1.40E-10"
                     /label="ctg1_1728"
                     /locus_tag="ctg1_1728"
                     /protein_end="44"
                     /protein_start="1"
                     /score="40.9"
                     /tool="antismash"
                     /translation="SYTQLTQGERYHIQYLSRHCTVTEIAKQLNRHKSTISREIRRH"
     CDS             complement(2799..3221)
                     /locus_tag="ctg1_1729"
                     /transl_table=11
                     /translation="MRPIFLSFVLLPILITACSTPDKSARWENIGTISNGNIHTYINKD
                     SVRKNGNLMIFQDKKVVTNLKQERFANTPAYKTAIAEWEIHCNNKTYRLSSLQLFDTKN
                     TEISTQNYTASSLRPMSILSGTLTEKQYETVCGKKL"
     CDS             complement(3656..4243)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 100.2;
                     E-value: 1.8e-30)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_1730"
                     /transl_table=11
                     /translation="MPLPDLTDAELIESRKLLLHFARLQLPDHPDLAEDLVQETLLSAY
                     SAGDSFQGRALVNSWLFAILKNKIIDALRQIGRQRKVFTTLDDELLDEAFESHFSQNGH
                     WTPEGQPQHWNTPEKSLNNNEFQKILQSCLYNLPENTARVFTLKEILGFSSDEIQQMCG
                     ISTSNYHTIMHRARESLRQCLQIKWFNQENPK"
     aSDomain        complement(3665..4228)
                     /aSDomain="TIGR02943"
                     /aSTool="tigrfam"
                     /description="Sig70_famx1: RNA polymerase sigma-70 factor,
                     TIGR02943 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1730_0033"
                     /evalue="4.60E-86"
                     /identifier="TIGR02943"
                     /label="ctg1_1730"
                     /locus_tag="ctg1_1730"
                     /protein_end="193"
                     /protein_start="5"
                     /score="285.4"
                     /tool="antismash"
                     /translation="LTDAELIESRKLLLHFARLQLPDHPDLAEDLVQETLLSAYSAGDS
                     FQGRALVNSWLFAILKNKIIDALRQIGRQRKVFTTLDDELLDEAFESHFSQNGHWTPEG
                     QPQHWNTPEKSLNNNEFQKILQSCLYNLPENTARVFTLKEILGFSSDEIQQMCGISTSN
                     YHTIMHRARESLRQCLQIKWFNQEN"
     aSDomain        complement(3692..4201)
                     /aSDomain="TIGR02937"
                     /aSTool="tigrfam"
                     /description="sigma70-ECF: RNA polymerase sigma factor,
                     sigma-70 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1730_0034"
                     /evalue="7.90E-25"
                     /identifier="TIGR02937"
                     /label="ctg1_1730"
                     /locus_tag="ctg1_1730"
                     /protein_end="184"
                     /protein_start="14"
                     /score="85.3"
                     /tool="antismash"
                     /translation="RKLLLHFARLQLPDHPDLAEDLVQETLLSAYSAGDSFQGRALVNS
                     WLFAILKNKIIDALRQIGRQRKVFTTLDDELLDEAFESHFSQNGHWTPEGQPQHWNTPE
                     KSLNNNEFQKILQSCLYNLPENTARVFTLKEILGFSSDEIQQMCGISTSNYHTIMHRAR
                     ESLRQCL"
     PFAM_domain     complement(3704..3859)
                     /aSDomain="Sigma70_r4_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08281.14"
                     /description="Sigma-70, region 4"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1730_0095"
                     /evalue="9.00E-10"
                     /label="ctg1_1730"
                     /locus_tag="ctg1_1730"
                     /protein_end="180"
                     /protein_start="128"
                     /score="38.2"
                     /tool="antismash"
                     /translation="ILQSCLYNLPENTARVFTLKEILGFSSDEIQQMCGISTSNYHTIM
                     HRARESL"
     PFAM_domain     complement(4013..4201)
                     /aSDomain="Sigma70_r2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04542.16"
                     /description="Sigma-70 region 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1730_0094"
                     /evalue="2.80E-11"
                     /label="ctg1_1730"
                     /locus_tag="ctg1_1730"
                     /protein_end="77"
                     /protein_start="14"
                     /score="43.1"
                     /tool="antismash"
                     /translation="RKLLLHFARLQLPDHPDLAEDLVQETLLSAYSAGDSFQGRALVNS
                     WLFAILKNKIIDALRQIG"
     CDS             complement(4265..5011)
                     /locus_tag="ctg1_1731"
                     /transl_table=11
                     /translation="VQPETSAQYQHRFAQAIRGGEAADGLPQDRLNVYIRLIRNNIHSF
                     IDRCYTETRQYFDSEEWSRLKEGFVRDAHAQTPYFQEIPGEFLQYCQSLPLSDGILALM
                     DFEYTQLLAEVAQIPDIPDIHYSNDSKYTPSPAAFIRQYRYDVTDDLHEAETALLIWRN
                     AEDDVMYQTLDGFDMMLLEIMGSSALSFDTLAQTLVEFMPEDDNWKNILLGKWSGWTEQ
                     RIIIPSLSAISENMEGNSPGQNHLST"
     PFAM_domain     complement(4739..4990)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1731_0096"
                     /evalue="1.10E-17"
                     /label="ctg1_1731"
                     /locus_tag="ctg1_1731"
                     /protein_end="91"
                     /protein_start="7"
                     /score="64.1"
                     /tool="antismash"
                     /translation="QYQHRFAQAIRGGEAADGLPQDRLNVYIRLIRNNIHSFIDRCYTE
                     TRQYFDSEEWSRLKEGFVRDAHAQTPYFQEIPGEFLQYC"
     CDS             complement(5001..5843)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1732"
                     /sec_met_domain="DUF692 (E-value: 7.5e-137, bitscore:
                     451.8, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQHAGLGYRRDLAEDFLSLSENSPICFIEAAPENWLKMGGWARK
                     QFDRVAERLPLALHGLSMSLGGQAPLDTDLIDGIKEMMRRYDCTFFSDHLSYCHDGGHL
                     YDLLPLPFTEEMVHHTARRIREVQDRLGCRIAVENTSYYLHSPLAEMNEVEFLNAVARE
                     ADCGIHLDVNNIYVNAVNHGLLSPEAFLKNVDADRVCYIHIAGHDVETPELLIDTHGAA
                     VLPTVWDLLELAYAKLPTIPPTLLERDFNFPPFAELEAEVAKIADYQTRAGKEYRRAA"
     PFAM_domain     complement(5037..5831)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1732_0097"
                     /evalue="7.40E-99"
                     /label="ctg1_1732"
                     /locus_tag="ctg1_1732"
                     /protein_end="269"
                     /protein_start="4"
                     /score="330.3"
                     /tool="antismash"
                     /translation="AGLGYRRDLAEDFLSLSENSPICFIEAAPENWLKMGGWARKQFDR
                     VAERLPLALHGLSMSLGGQAPLDTDLIDGIKEMMRRYDCTFFSDHLSYCHDGGHLYDLL
                     PLPFTEEMVHHTARRIREVQDRLGCRIAVENTSYYLHSPLAEMNEVEFLNAVAREADCG
                     IHLDVNNIYVNAVNHGLLSPEAFLKNVDADRVCYIHIAGHDVETPELLIDTHGAAVLPT
                     VWDLLELAYAKLPTIPPTLLERDFNFPPFAELEAEVAKIADYQ"
     CDS             complement(5958..6266)
                     /locus_tag="ctg1_1733"
                     /transl_table=11
                     /translation="MNKNIAAALAGALSLSLAAGAVAANKPASNATGVHKSAHGSCGAS
                     KSAEGSCGAAGSKAGEGKCGEGKCGATVKKTHKHTKASKAKAKSAEGKCGEGKCGSK"
     CDS             complement(6340..6789)
                     /locus_tag="ctg1_1734"
                     /transl_table=11
                     /translation="MKIGTTWQTASAMLVLRLFAAYEFLESGLQKWNGENWFSEINDQF
                     PFPFNLLPDALNWNLAMYAELLLPVLLLLGLATRLSALGLMVVTAVAWAAVHAGSGYNV
                     CDNGYKMALIYIVVLIPLLFQGAGGWSLDTLLKKRFCPQCRLKQD"
     PFAM_domain     complement(6496..6756)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1734_0098"
                     /evalue="6.60E-22"
                     /label="ctg1_1734"
                     /locus_tag="ctg1_1734"
                     /protein_end="98"
                     /protein_start="11"
                     /score="78.0"
                     /tool="antismash"
                     /translation="AMLVLRLFAAYEFLESGLQKWNGENWFSEINDQFPFPFNLLPDAL
                     NWNLAMYAELLLPVLLLLGLATRLSALGLMVVTAVAWAAVHA"
     CDS             7131..8024
                     /locus_tag="ctg1_1735"
                     /transl_table=11
                     /translation="MVTFSKIRPLLAIAAAALLAACGTAGNNAARKPVQTAKPAAVVGL
                     ALGGGASKGFAHVGIIKVLKENGIPVKVVTGTSAGSIVGSLFASGMSPDRLELEAEILG
                     KTDLVDLTLSTSGFIKGEKLQNYINRKVGGRQIQQFPIKFAAVATDFETGKAVAFNQGN
                     AGQAVRASAAIPNVFQPVIIGRHTYVDGGLSQPVPVSAARRQGANFVIAVDISARPGKN
                     ISQGFFSYLDQTLNVMSVSALQNELGQADVVIKPQVLDLGAVGGFDQKKRAIRLGEEAA
                     RAALPEIKRKLAAYRY"
     PFAM_domain     7263..7736
                     /aSDomain="Patatin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01734.24"
                     /description="Patatin-like phospholipase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1735_0099"
                     /evalue="1.90E-25"
                     /label="ctg1_1735"
                     /locus_tag="ctg1_1735"
                     /protein_end="202"
                     /protein_start="44"
                     /score="90.3"
                     /tool="antismash"
                     /translation="LALGGGASKGFAHVGIIKVLKENGIPVKVVTGTSAGSIVGSLFAS
                     GMSPDRLELEAEILGKTDLVDLTLSTSGFIKGEKLQNYINRKVGGRQIQQFPIKFAAVA
                     TDFETGKAVAFNQGNAGQAVRASAAIPNVFQPVIIGRHTYVDGGLSQPVPVSAA"
     CDS             8127..9230
                     /locus_tag="ctg1_1736"
                     /transl_table=11
                     /translation="MEAEVINQLNNTLNDLEKRSEDIRVYMDYQGKKDRLEEVVGLSED
                     PELWNDPKRAQEIGKERKILEGIVLTLDNIASGIEDNRMLIEMTVEENDEEGFAAVQED
                     VAGLEKQMADLEFKRMFNQPADPNNCFIDITAGAGGTEAEDWAGMLFRMYSRYAERKGF
                     KIEILEEDDGEIAGINRATIRVEGEYAYGLLRTETGVHRLVRYSPFDSNNKRHTSFASV
                     FVYPEIDDSIEIEINPADLRIDTYRASGAGGQHINKTDSAVRITHEPTGIVVQCQNDRS
                     QHANKAAAMEMLKSKLYELEMRKRNEEKQALEEGKSDVGWGSQIRSYVLDSSRIKDLRT
                     GYEVGNTKAVLDGDLDGFIEASLKQGV"
     aSDomain        8145..9221
                     /aSDomain="TIGR00020"
                     /aSTool="tigrfam"
                     /description="prfB: peptide chain release factor 2"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1736_0035"
                     /evalue="3.20E-160"
                     /identifier="TIGR00020"
                     /label="ctg1_1736"
                     /locus_tag="ctg1_1736"
                     /protein_end="365"
                     /protein_start="6"
                     /score="530.9"
                     /tool="antismash"
                     /translation="NQLNNTLNDLEKRSEDIRVYMDYQGKKDRLEEVVGLSEDPELWND
                     PKRAQEIGKERKILEGIVLTLDNIASGIEDNRMLIEMTVEENDEEGFAAVQEDVAGLEK
                     QMADLEFKRMFNQPADPNNCFIDITAGAGGTEAEDWAGMLFRMYSRYAERKGFKIEILE
                     EDDGEIAGINRATIRVEGEYAYGLLRTETGVHRLVRYSPFDSNNKRHTSFASVFVYPEI
                     DDSIEIEINPADLRIDTYRASGAGGQHINKTDSAVRITHEPTGIVVQCQNDRSQHANKA
                     AAMEMLKSKLYELEMRKRNEEKQALEEGKSDVGWGSQIRSYVLDSSRIKDLRTGYEVGN
                     TKAVLDGDLDGFIEASLKQ"
     PFAM_domain     8223..8792
                     /aSDomain="PCRF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03462.20"
                     /description="PCRF domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1736_0100"
                     /evalue="3.40E-56"
                     /label="ctg1_1736"
                     /locus_tag="ctg1_1736"
                     /protein_end="222"
                     /protein_start="32"
                     /score="190.2"
                     /tool="antismash"
                     /translation="KDRLEEVVGLSEDPELWNDPKRAQEIGKERKILEGIVLTLDNIAS
                     GIEDNRMLIEMTVEENDEEGFAAVQEDVAGLEKQMADLEFKRMFNQPADPNNCFIDITA
                     GAGGTEAEDWAGMLFRMYSRYAERKGFKIEILEEDDGEIAGINRATIRVEGEYAYGLLR
                     TETGVHRLVRYSPFDSNNKRHTSFASV"
     PFAM_domain     8814..9143
                     /aSDomain="RF-1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00472.22"
                     /description="RF-1 domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1736_0101"
                     /evalue="1.10E-41"
                     /label="ctg1_1736"
                     /locus_tag="ctg1_1736"
                     /protein_end="339"
                     /protein_start="229"
                     /score="141.5"
                     /tool="antismash"
                     /translation="DSIEIEINPADLRIDTYRASGAGGQHINKTDSAVRITHEPTGIVV
                     QCQNDRSQHANKAAAMEMLKSKLYELEMRKRNEEKQALEEGKSDVGWGSQIRSYVLDSS
                     RIKDLR"
     CDS             complement(9123..9719)
                     /locus_tag="ctg1_1737"
                     /transl_table=11
                     /translation="MPSEPYFRFQTAFACRMHTGRAVSRVLSRTVIPLGIPLPVCSSNL
                     PERSAGSVIAFCLVLLRMGFGLPHIVTKCAVRPYRTFSPLPVLPKQPSAVLLSVPLSVA
                     LPRPAVNRHSTLRSPDFPPRMPYAIRGDCLPVPCAARIITRNAKMPSETVQVSDGIQPK
                     LHALFQAGFDKAVQIAIQYGFGVADFVACTQVFDT"
ORIGIN
        1 gccgcttgtg tcaggctttg caaacgcctt tggtctcgac ttcgtgcaac cgcgcaggca
       61 aacgcgcgtg tcggacggag agggaagtca gaaggcaatt cggacgcgat gtgtggattg
      121 ttggtgggag aatcggcagg cagaaatcgc cgagtcagat tattgacggg gaaacaggta
      181 aacgtttgcg ttagatatgg gtacttgaat gaaaactttt ttgcatacac aaagaaaaaa
      241 ttttggggct gtactagatt agccctaaat cccacaccaa tcctgtagga tttttagctg
      301 ccgggacggt gtgccgaagt taaatcgaaa ttcgcattct ttcaagaaca gcgggaaaga
      361 tttgcgatcg attccattgt attttcgcaa gacacgtttt gcctgattcc aaaaattctc
      421 aatgccgtta atgtggttct gacggtctgc aaattccttg gaatggttga tgcggtaata
      481 aatgaaaccg ctcacgtcca acttgtcgca gctgctcaga ctatcggtat aaacaatact
      541 gtccggcatg attttctttt tgatgacagg gagtaacgtt tcagacttgg cattgtttac
      601 gacaacggta tagacccgtc cgttgcgttt cagaatgtcg aagacaacca cttttcctgc
      661 cgcaccacga ccacatctgc ctttacgcca cccgccgaaa tcgctttcgt ccggctcgac
      721 aggatcctca aaaacctcat cggcagccag ggccaaatga tggttgataa ccgtgcggat
      781 tttacggtag aacagtgctg ccgaattggg atggataccc aaaatatcgg cggcagaacg
      841 ggcggtaact tccagcacaa aaaaacggag cagttctttc tgtacttttt tctttaattt
      901 gcagtgcgtt atcttcatat ttcgagggta acatatctgc taatctagta cagcccctaa
      961 atttttcgga tggtatttct ctgcatgatt gttattgcac agagataaag gtagaaggac
     1021 gcaacgtcta ctttgatttt gaggacggtt ttgtcgttcc ggacaataat ccgaacaatc
     1081 aagcgggcaa gcatctgaaa acagattttt cccgtgttgt tttaacccat aaaaatgaaa
     1141 acggcgaaga tgattatttg gtcgatattt ttgaagacat cgttttttta gggaaacgtt
     1201 tgtttacggt cagaaaattt cttgattttt ctgaattgct tgagatggtt aatacacaag
     1261 gttattttct tgagtttctg tatttgtata gtggattaaa tttaaaccag tacagcgttg
     1321 cctcgccttg ccgtactatc tgtactgtct gcggcttcgt cgccttgtcc tgatttttgt
     1381 taatccacta tatgagtgta tcggtgtcaa aacaagcgat tattttttag aggctcttgg
     1441 attcggattt caagtgcaac actagtgtat tagtggttgg aacagattca agaataaaac
     1501 acttggcgtt tcgtagccaa gtgtttttct tggtcggtgg ttcaactcat cttgaaccct
     1561 gcgtatctcc cgatcactga tgttacggaa atcggtttgt ttggggaagt attgccggat
     1621 gagtccgttg gtgttctcat tcagcccttt ctcccaagaa tggtaagggc gacaaaaata
     1681 agtctccgct ttcaatgctt tggttatttt ggtgtgttgg tagaactctt tgccgttatc
     1741 catggtgatg gtgtgcaccc tgtctttatg tgcctttaat gccctaacag ctgcccgggc
     1801 agtgtcttcg gctttgaggc tatccaattt gcagatgatg gtgtagcggg taacgcgttc
     1861 gaccaaggtc aataatgcgc ttttctgtcc tttgccgaca atggtgtcgg cttcccaatc
     1921 gccgatacgg gatttctggt cgacgatagc gggtcggttt tctatgccga cacggttggg
     1981 gactttgcct ctggtccatg tgctgccgta gcgtttgcgg tagggtttgc tgcatattct
     2041 gagatgttgc cacaacgtgc tgccgttgct tttgtcttgg cgaaggtagc ggtaaatggt
     2101 gctgtggtgg agcgtgatct ggtggtgttt gcacaggtag gcgcatactt gttcgggact
     2161 gagtttgcgg cggataaggg tgtcgatgtg ctgaatcagc tgcgaatcga gcttataggg
     2221 ttgtcgctta cgctgtttga tagtccggct ttgccgctgg gctttttcgg cgctgtattg
     2281 ctgcccttgg gtgcggtgcc gtctgatttc gcggctgatg gtgcttttat ggcggttaag
     2341 ctgtttggcg atttcggtga cggtgcagtg gcgggacagg tattggatgt ggtatcgttc
     2401 gccttgggtc agttgcgtgt agctcatggc aatctttctt gcaggaaagg ccgtatgcta
     2461 ccgcatactg gcctttttct gttagggaaa gttgcacttc aaatgcgaat ccgccgctgt
     2521 gttgattacg ggacggagcc gggaatgtaa gaaatgcttt atcaaaatta tgggggtaag
     2581 cagttttgtg tatcaatgga acaatttacg ttttgataat gaaattgtat agcaggttta
     2641 tatttcggat ggaagctggt ttaaaaaaat aatgtggata acttcgagga taacttttcg
     2701 gagaaatggc aaaatgccgt ccgaaatgct gatatttcag tatttcagac ggcattttta
     2761 tgataaggtt tgtgggtaag tttgtgtata agttgcaatc agagtttttt tccgcatacg
     2821 gtttcatatt gtttttcggt taatgtcccg gacaggatgc tcatcgggcg gagggaagag
     2881 gctgtgtagt tttgtgtgga aatttccgtg ttttttgtat caaacaactg tagcgaactt
     2941 aagcggtatg ttttgttgtt gcagtggatt tcccactcgg caatggcagt cttgtatgcg
     3001 ggggtgttgg caaaacgttc ttgttttaga ttggtaacaa cttttttatc ttggaaaatc
     3061 atcagatttc cgttttttct cacgctgtct ttattgatat atgtatgaat attgccgttt
     3121 gagattgtgc cgatattttc ccatcgggca gacttgtccg gtgtgctgca ggcggttatc
     3181 aaaataggga gtaaaacgaa agataggaag attgggcgca ttagggtttc cttaatcatt
     3241 gaaatctgct cattcagaaa gaacgggttg ggcgggaggg gtagcgccgt ctgtgaaata
     3301 aggcaaataa agcaaattga tgcagccttc gtgttttgcg tatttatata ttccgtatgg
     3361 aggaatatgc tgcttttgaa gcgtgtatta tggatgaact gccgataaca gtaaatcggt
     3421 ttgatttttt tccgtcagct tatgccgtct gaagcctttt cagacggcat ttattttgaa
     3481 gttctggttg tttttgccag tgatattttg atggtttgaa gctgtctttt atattctcgg
     3541 caatgtgggc agaacagcag gtgtgtgtat atggaaatct tctcgcccgg ggtggtttcc
     3601 cggtcctgat gtttggaaag aagcagggcg atatcgcggc attttttcat aacgtttact
     3661 tcgggttttc ttggttgaac catttgattt gcaggcattg gcgcaatgat tctcgggcgc
     3721 ggtgcataat ggtgtggtag ttggacgtgc tgataccgca catttgttgt atttcgtcgg
     3781 atgaaaaacc gagtatttcc ttcagggtaa atacccgtgc ggtgttttca ggcaagttgt
     3841 ataggcagct ttgcagaatt ttttggaatt cgttgttgtt taatgatttt tccggagtgt
     3901 tccaatgttg cggctgccct tccggcgtcc aatgcccgtt ttgggaaaaa tggctttcaa
     3961 atgcttcatc cagtagctcg tcatccagtg tggtaaagac tttcctctgc cttccgattt
     4021 gacgtaatgc gtcaataatt ttgtttttca atatggcaaa aagccagctg ttgacaagtg
     4081 ccctgccttg aaaactgtcg cctgcgctgt atgcggacag caatgtttcc tgcactaaat
     4141 cttcagccaa atcagggtgg tcgggcaact gaagccgcgc aaaatgcaga agcagtttac
     4201 gcgactctat taattcggca tcggtcaggt cgggtagcgg catagtatcg ggaacaaggt
     4261 aattttatgt ggatagatgg ttttggcccg gggaattgcc ttccatattt tcggatatgg
     4321 cggacaagga ggggatgata atcctttgtt cagtccagcc tgaccatttc ccaagcaaaa
     4381 tatttttcca attatcgtcc tcaggcataa attcgacaag ggtttgggcg agggtgtcaa
     4441 acgaaagcgc ggaggaaccc attatttcta gcagcatcat atcgaagccg tccaatgttt
     4501 ggtacatcac atcatcttcg gcgtttcgcc atattaacaa ggctgtttcc gcttcatgca
     4561 aatcatcggt aacatcatat cgatattgcc ggataaaggc cgcaggggag ggtgtgtatt
     4621 tgctgtcatt tgaataatga atgtcgggaa tatccggaat ttgagcaact tctgccagca
     4681 attgggtata ttcaaaatcc atcagtgcca aaatgccgtc tgaaagcggc aggctttggc
     4741 aatattgtag gaactcgccg gggatttctt gaaaataggg cgtttgggcg tgcgcgtcgc
     4801 ggacgaaacc ttctttcaga cggctccatt cttcgctgtc aaagtattgc cgcgtttcgg
     4861 tatagcagcg gtcgataaag ctgtggatat tgttgcgtat caggcggata tagacgttca
     4921 gtcggtcttg cggcagaccg tctgcggctt cgcccccgcg tatggcttgg gcgaaacggt
     4981 gctggtattg ggcggaggtt tcaggctgca cggcggtatt cctttccggc acgcgtttga
     5041 taatcggcga ttttggcgac ttcggcttcg agttcggcaa aaggcgggaa attaaaatcg
     5101 cgttccaaca gggtgggcgg aatcgtcggc agcttggcat aggcaagttc gagcaagtcc
     5161 caaacagtcg gcaaaactgc cgcgccatgt gtatcaatca acaattccgg cgtttccacg
     5221 tcatgtccgg caatatggat atagcacacg cgatctgcgt caacgttttt caaaaaagcc
     5281 tccggcgaca acaggccgtg attgacggcg ttgacgtaga tattgttcac atccagatga
     5341 atgccgcaat cggcctcacg tgcgacggcg ttgaggaact cgacctcgtt catctcggca
     5401 agcggggaat gcagatagta ggacgtgttt tccacggcga tgcggcagcc caaacggtct
     5461 tgcacttcac ggatacgccg cgccgtatga tgcaccattt cctcggtgaa gggcagcggc
     5521 aacaaatcgt aaagatgacc gccgtcgtgg cagtagctca aatggtcgga gaaaaacgtg
     5581 caatcgtaac ggcgcatcat ttctttgatg ccgtctatca aatcagtatc cagcggtgct
     5641 tgcccgccca gcgacataga caatccgtgc aacgccagcg gcagccgttc cgccacacgg
     5701 tcaaactgtt tgcgcgccca gccgcccatt ttcagccagt tttccggtgc ggcttcgata
     5761 aagcatatcg ggctgttttc ggaaagcgag agaaagtctt ccgccaagtc gcggcggtag
     5821 cccaagcctg cgtgttgaat catattttta cccggttcgg atggcacaaa agaatgatgt
     5881 gcttgttaaa aaatctttgt ttgccgttaa aaaagccgca ttttactgaa aaacgcggct
     5941 tggtttgaag ggggggatta tttagaaccg catttgcctt cgccgcattt gccttcggca
     6001 gatttggcct tggctttaga tgctttggtg tgtttgtggg ttttttttac ggtcgcaccg
     6061 catttgccct cgccgcattt gccttcgcct gctttagaac cagccgcgcc gcacgaacct
     6121 tcggcagatt tggacgcgcc gcaagagcca tgggcggatt tatgaacgcc tgttgcgttg
     6181 cttgccggtt tgttggcagc aactgcaccg gcggccaaag acagggataa agcaccggcg
     6241 agtgcggcag caatgttttt gttcatttct atttcctttt cagaatatca agttaacgag
     6301 ataaggttgg aatgtttaaa gtcagattcc acgactgaat caatcttgct tcagacggca
     6361 ttgggggcaa aaccgttttt tcagcagcgt atccagcgac catccgcccg caccctggaa
     6421 aagcagcggg attaatacca cgatataaat taaagccatt ttataaccgt tgtcgcagac
     6481 attgtaaccc gaaccggcgt gaaccgcagc ccaagcgacg gcggtaacga ccatcagccc
     6541 taatgccgac agacgcgttg ccaaacccaa aagcaacagt acgggcagta aaagctccgc
     6601 atacatggcg agattccagt ttaacgcgtc cggcagcaag ttgaacggga atggaaactg
     6661 atcgttgatt tcggaaaacc aattctcccc gttccatttt tgcaaacccg attccaaaaa
     6721 ttcatatgcg gcaaacagac gcaaaaccag catagcggat gccgtctgcc aagttgttcc
     6781 gattttcata agtgttcctg ttttggttct gttgataccc cattagacgg attttgtcgg
     6841 aaaaactgac acccggcagc caatgattta acaagttaat gaatataaaa agaaagtatt
     6901 ttgatggaaa ggaaaggaaa aaggcgggat atttggataa cggcggtgtt gtgagataat
     6961 tcccgccttg gatagtatgc cttcaaatat aatttccgta aaggaaaaaa agaaatatta
     7021 attttgatga tgacttaaca aagcccccat ttgcttggct gtcaaagggg gttgttaaga
     7081 aaagcaatcc ctctttttga cggggtgcga tatataaagg aatggaaaat atggtaacgt
     7141 tttcaaaaat cagaccgctt ttggcaatcg ccgccgccgc gttgcttgcc gcctgcggca
     7201 cggcgggaaa taatgctgcc cgcaagccgg tgcaaaccgc caaacccgcc gcagtggtcg
     7261 gtttggcact cggtggcggc gcatctaaag gatttgccca tgtaggtatt attaaggttt
     7321 tgaaagaaaa cggtattcct gtgaaggtgg ttaccggcac atcggcaggt tcgatagtcg
     7381 gcagcctttt tgcatcgggt atgtcgcccg accgcctcga attggaagcc gaaattttag
     7441 gcaaaaccga tttagtcgat ttaaccttgt ccaccagtgg ttttatcaaa ggcgaaaagc
     7501 tgcaaaatta catcaaccga aaagtcggcg gcaggcagat tcagcagttt cccatcaaat
     7561 ttgccgctgt tgctactgat tttgaaaccg gcaaggccgt cgctttcaat caagggaatg
     7621 ccgggcaggc tgtgcgcgct tccgccgcca ttcccaatgt gttccaaccc gttatcatcg
     7681 gcaggcatac atatgttgac ggcggtctgt cgcagcccgt gcccgtcagt gccgcccggc
     7741 ggcagggggc gaatttcgtg attgccgtcg atatttccgc ccgtccgggc aaaaacatca
     7801 gccaaggctt cttctcttat ctcgatcaga cgctgaacgt aatgagcgtt tccgcgttgc
     7861 aaaatgagtt ggggcaggcg gatgtggtta tcaaaccgca ggttttggat ttgggtgcag
     7921 tcggcggatt cgatcagaaa aaacgcgcca tccggttggg tgaggaggca gcacgtgccg
     7981 cattgcctga aatcaaacgc aaactggcgg cataccgtta ttgacgctat gccgtccgaa
     8041 cgtgtttcca gaaggcttta tccatagaaa aaaatacccg aatcccgtac aatacgcccc
     8101 taaaattttg aaagaacaaa agaatcatgg aagccgaagt aatcaaccag ctcaacaata
     8161 ccctgaatga tttggaaaag cgcagcgaag acatccgagt ttatatggat tatcagggta
     8221 agaaagaccg attggaagaa gttgtcggtc tttccgaaga ccccgaactt tggaacgacc
     8281 cgaaacgcgc ccaagaaatc ggcaaagagc gcaaaatcct cgaaggcatc gtgttgacgc
     8341 tcgacaacat cgcttcgggc atcgaagaca accgcatgct gattgaaatg accgtcgaag
     8401 aaaacgacga agaaggtttt gccgccgtgc aggaagatgt ggcggggctg gaaaaacaga
     8461 tggcggattt ggagttcaaa cggatgttca accagcccgc cgatccgaac aactgcttta
     8521 tcgacattac cgcaggcgca ggcggtacgg aagcggaaga ctgggcgggt atgctgttcc
     8581 gcatgtacag ccgctacgcc gagcgcaaag gcttcaaaat cgaaatcctc gaagaagacg
     8641 acggcgaaat cgcgggcatc aaccgcgcga ctatccgagt ggaaggcgaa tatgcctacg
     8701 gcttgctgcg cacggaaaca ggtgttcacc gcttggtgcg ttactctccg tttgactcga
     8761 acaacaaacg ccatacctcg tttgcctccg tgttcgtcta tcccgaaatc gacgattcca
     8821 tcgaaatcga aatcaacccc gccgatttgc gcatcgacac ctatcgcgca tcgggtgcgg
     8881 gcggtcagca catcaataaa accgactccg ccgtgcgcat tacccacgag ccgacgggga
     8941 ttgtggtgca atgtcaaaac gaccgttcgc aacacgccaa caaagccgcc gcgatggaaa
     9001 tgttgaagtc caaactgtat gaattggaaa tgcgcaaacg caatgaagag aaacaggcgt
     9061 tggaagaagg taaatccgat gtaggttggg gcagccaaat ccgttcgtat gttttggatt
     9121 cctcacgtat caaagacttg cgtacaggct acgaagtcgg caacaccaaa gccgtattgg
     9181 atggcgattt ggacggcttt atcgaagcca gcctgaaaca gggcgtgtag tttaggctgt
     9241 atgccgtctg aaacctgtac cgtttcagac ggcatttttg cgtttcgtgt tataatccgc
     9301 gccgcacacg ggacgggcag acagtcgccg cgtatcgcgt aaggcatacg gggaggaaag
     9361 tccgggctcc gcagggtaga atgccggtta acggccgggc gcggtaacgc gacggaaagt
     9421 ggaacagaaa gcaaaaccgc cgatggctgc tttggcagca caggcaaggg tgaaaaggtg
     9481 cggtaagggc gcaccgcgca tttggtaaca atatgcggca ggccaaaccc cattcggagc
     9541 aagaccaaac agaacgcaat gacgctgccc gccgagcgtt cgggtaggtt gcttgagcat
     9601 accggtaacg gtatgcctag aggaatgact gtccgagaca gaacccggct taccgcccgt
     9661 ccggtgtgca tccgacacgc aaatgccgtc tgaaacctga aatatggttc agacggcatt
     9721 tttatttagg ttgtgttttt atagtggatt aacaaaaacc ggtacggcgt tgcctcgcct
     9781 tagctcaaag agaacgattc tctaaggtgc tgaagcacca agtgaatcgg ttccgtactg
     9841 tttgtactgt ctgcggcttc gtcgccttgt cctgattttt gttaatccac tatatattcc
     9901 gttgatgcag cactaattta gtcggataaa atgcctttta ctcaatagaa ccggtttccg
     9961 cccaagcgga aataaacggc tatttccctt gcaaacagac ggaatcagtc agatatttaa
    10021 atgacaatcg gcaggctgcc ttccggttgg ggggagcctg tcctgtcggg tggaaacggt
    10081 ttggtttcat tatgcggaaa aatgccgtct gaagggttca gacggcatcg gggcgggact
    10141 tagtctgtgc cttcgagcat tttgttcaat ttggggacga gcaggagcag caggaagcct
    10201 gtggctgcgc cgatgtagaa cagcagccga tagaagccga tttcgtcgcc cgcctgatag
    10261 catttttcaa acaatacgcc gcccaaagtg aagcctaatg aaaaggcaag gaaattaagg
    10321 gcgaccattt gggttttgaa taaaggcggt gcgattttgg tggagatgga cagcgcaatc
    10381 ggggaaatca tcagttcgcc tatcgtgatg gcaaggacaa tcagtgcgaa aaccgcaata
    10441 ggcatcggcg tgccggcgga aataaagggg acgaatccca aaaacgacgc gccggtaaca
    10501 aataccgcca tagcgaattt cagcggggtt ttgggctgtt tgcgccccat ttttgtccac
    10561 attgccgcca tcagtccgga aaacaggatg acccacaggc tttgcatgga atctttccag
    10621 gcgacgggca cggtaaacga accgatggtg cggttgacgg tttcgtcgaa atagacggtt
    10681 gctacggtgt aaatctgaaa ccagacggcc caaaacatac agatggtcag gaaaagcggg
    10741 atgtaggcga tgatgtgccg tttgttgtcg gaactgacgc ggggattagt cagcaggcgg
    10801 gcaaaatagg caatgacggc aaggatgacg gtagataaga gga
//
