LOCUS       NC_016603.1            10864 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_016603.1 Acinetobacter pittii PHEA-2 chromosome, complete genome.
ACCESSION   NC_016603
VERSION     NC_016603.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:52:56
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 615539
            Orig. end    :: 626403
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10864
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[620539:621403](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5864
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10864
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10864
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             612..929
                     /locus_tag="ctg1_581"
                     /transl_table=11
                     /translation="MNKMHVTLAVIIGLIVGGVIGALGYSKTAARYDAMTTACVMVNQA
                     VEHGILKPEQVKELGELTGQSLKKDYESVASKFKFSEKQLGNASEGSNCSQFIVGVNTA
                     Q"
     CDS             1548..2006
                     /locus_tag="ctg1_582"
                     /transl_table=11
                     /translation="MPKYLAVAEKVYKNIKKDSLFTDDITQNLNCLISQIRKAIKGTEF
                     KLKFNYIDFEENLTKPLSECKVQIDLSVMPKFTNEGEYLLWLAGFIERITEGGKPKLPP
                     ISHFLPPGFKMSKDSLPVTVAPPKEEHADMIINYFKSEDFIKTNKTPS"
     CDS             2319..2663
                     /locus_tag="ctg1_583"
                     /transl_table=11
                     /translation="MNENAELIKYIDVAENVYERVYENNQVSNNLIVNLNRIMAEIKKQ
                     AAEKNLRLKYNSIDFEYCLSLPIADRDIKIDLSLIPHFEHRDECILWLTNFIGKISVPK
                     KMTRQKLSFH"
     CDS             2784..3728
                     /locus_tag="ctg1_584"
                     /transl_table=11
                     /translation="MKTFALTFAVLASLSTYGLANDSTGYVGTGGIQYLKNSQIAMQSE
                     DLFISKKLIKVDYLYKNLSNKDVTETILFPLPRIDNFFEADFAHTEQLLKSFKIVVDGK
                     NIKPEMHVRTFIQKDEKSPLIDATDEFKQCGFSEQEMLNPWTRTNYDYEYYVDKLKQCN
                     KPQIQKILANFKKDDVIPWSSQVVYSWKQTFKANSLTKIHHEYKPLVGGSVALYPDEYN
                     QQFCMDKQFKQGLKKASAENSPFSALGYILTTGANWAKPIENFKLTIERDKDELVSFCW
                     DGPVKKISPTQFQMTKTKFVPKKDLDIIFVRVR"
     PFAM_domain     2841..3707
                     /aSDomain="DUF4424"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14415.8"
                     /description="Domain of unknown function (DUF4424)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_584_0051"
                     /evalue="1.90E-75"
                     /label="ctg1_584"
                     /locus_tag="ctg1_584"
                     /protein_end="308"
                     /protein_start="19"
                     /score="254.1"
                     /tool="antismash"
                     /translation="ANDSTGYVGTGGIQYLKNSQIAMQSEDLFISKKLIKVDYLYKNLS
                     NKDVTETILFPLPRIDNFFEADFAHTEQLLKSFKIVVDGKNIKPEMHVRTFIQKDEKSP
                     LIDATDEFKQCGFSEQEMLNPWTRTNYDYEYYVDKLKQCNKPQIQKILANFKKDDVIPW
                     SSQVVYSWKQTFKANSLTKIHHEYKPLVGGSVALYPDEYNQQFCMDKQFKQGLKKASAE
                     NSPFSALGYILTTGANWAKPIENFKLTIERDKDELVSFCWDGPVKKISPTQFQMTKTKF
                     VPKKDLDI"
     CDS             complement(3857..4459)
                     /locus_tag="ctg1_585"
                     /transl_table=11
                     /translation="MKNFIYGLSQYYQKLGKTLQHADGIAALALRLYLVPIFWMAGTNK
                     LMHFNDIVEWFGNSDGGLGLPFPYVMALLATTAELVGAILLTFGLLTRLISIPLIITML
                     VAIFTVHIPNGWQAIADPNAPFANMQVLASAEKLEKAREILQTYGNYDWLTSSGSFVIL
                     NNGIEFAATYLVMLLALLVLGGGRYFSLDYWIKKKLL"
     PFAM_domain     complement(4127..4381)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_585_0052"
                     /evalue="1.90E-20"
                     /label="ctg1_585"
                     /locus_tag="ctg1_585"
                     /protein_end="111"
                     /protein_start="26"
                     /score="73.4"
                     /tool="antismash"
                     /translation="ALALRLYLVPIFWMAGTNKLMHFNDIVEWFGNSDGGLGLPFPYVM
                     ALLATTAELVGAILLTFGLLTRLISIPLIITMLVAIFTVH"
     CDS             4623..4931
                     /locus_tag="ctg1_586"
                     /transl_table=11
                     /translation="MNKLNSMTSVAALLALSVAGATQVAVAATHTTTEAHATKAADGKC
                     GEAKCGANKMKNHEKSAEAKCGADKKAADGKCGATKKAADGKCGADKKVADGKCGAK"
     CDS             5001..5864
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_587"
                     /sec_met_domain="DUF692 (E-value: 1.3e-102, bitscore:
                     340.4, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMDLSGVGLGLRRDFIDSFLDAKTCPDFIEVAPENWLGFGGRHAK
                     LLAQCVEKAPLICHGLSLSIGGPHPLNLEFIGKIKSFLEQYDVSIYSEHLSYTNDGGYL
                     YDLLPIPMTEAAVKYVAERILRVQDILGRRLVIENVSTYLMPNAQMSEAEFIREVLQYA
                     DCDLLLDVNNVYVNSINHGSDAFGFIRDMPKERIRYLHIAGHEQVQKNLLIDTHGAEVC
                     DRVWELLRYTYQLCGIKPTLLERDFNIPSWHELEEELAKIKLIQQQESGYEGKSNILPN
                     HATSVL"
     PFAM_domain     5016..5798
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_587_0053"
                     /evalue="1.50E-99"
                     /label="ctg1_587"
                     /locus_tag="ctg1_587"
                     /protein_end="266"
                     /protein_start="5"
                     /score="332.6"
                     /tool="antismash"
                     /translation="GVGLGLRRDFIDSFLDAKTCPDFIEVAPENWLGFGGRHAKLLAQC
                     VEKAPLICHGLSLSIGGPHPLNLEFIGKIKSFLEQYDVSIYSEHLSYTNDGGYLYDLLP
                     IPMTEAAVKYVAERILRVQDILGRRLVIENVSTYLMPNAQMSEAEFIREVLQYADCDLL
                     LDVNNVYVNSINHGSDAFGFIRDMPKERIRYLHIAGHEQVQKNLLIDTHGAEVCDRVWE
                     LLRYTYQLCGIKPTLLERDFNIPSWHELEEELAKIKLIQ"
     CDS             5815..6570
                     /locus_tag="ctg1_588"
                     /transl_table=11
                     /translation="MKGNQTSFQTMQRQFCDWIRDPDLEIPQALPVQRMQIYRDLLFNN
                     VSSFINLVYPVARAMLPELKWQQVLSEFFQKAECHSPLYNDISLEFREYLTEQQHPILQ
                     EYPWLAELLQFEWIELYLDTVEIEDVVLHENYAWQLSTQVWVLVYQYPVYTWTTLMIPE
                     QVEPMPGAIMVWRDEQDKVCIEQLSPLFAMVIEQLTQNVKLTDQDIHTLIQSVLTDLSE
                     HDIYLQIQELKAMLTRMRLIQVPHDFKEV"
     PFAM_domain     5845..6099
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_588_0054"
                     /evalue="1.30E-19"
                     /label="ctg1_588"
                     /locus_tag="ctg1_588"
                     /protein_end="95"
                     /protein_start="10"
                     /score="70.3"
                     /tool="antismash"
                     /translation="MQRQFCDWIRDPDLEIPQALPVQRMQIYRDLLFNNVSSFINLVYP
                     VARAMLPELKWQQVLSEFFQKAECHSPLYNDISLEFREYL"
     CDS             6573..7193
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 111.3;
                     E-value: 6.6e-34)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_589"
                     /transl_table=11
                     /translation="MTSAVASDHEEIEDQLHNPAFLQDLRQQMIKFAFLQLSSLPQAED
                     VVQEALTSAFQHLDSFKGRAAFKTWIFAILKNKIIDVIRQKSRLVAMTELFKDEESELS
                     IDALFDASGHWHKYEAPQAWQSPEEMMEQADFWIIFEACLNHLPAKYAQVFMMREVIEL
                     SSNEICSKLELSISNFNVLMYRSRTRLRECLENKWLLKEDCSC"
     aSDomain        6618..7178
                     /aSDomain="TIGR02943"
                     /aSTool="tigrfam"
                     /description="Sig70_famx1: RNA polymerase sigma-70 factor,
                     TIGR02943 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_589_0024"
                     /evalue="9.00E-74"
                     /identifier="TIGR02943"
                     /label="ctg1_589"
                     /locus_tag="ctg1_589"
                     /protein_end="202"
                     /protein_start="15"
                     /score="245.3"
                     /tool="antismash"
                     /translation="LHNPAFLQDLRQQMIKFAFLQLSSLPQAEDVVQEALTSAFQHLDS
                     FKGRAAFKTWIFAILKNKIIDVIRQKSRLVAMTELFKDEESELSIDALFDASGHWHKYE
                     APQAWQSPEEMMEQADFWIIFEACLNHLPAKYAQVFMMREVIELSSNEICSKLELSISN
                     FNVLMYRSRTRLRECLENKWLLKE"
     aSDomain        6633..7154
                     /aSDomain="TIGR02937"
                     /aSTool="tigrfam"
                     /description="sigma70-ECF: RNA polymerase sigma factor,
                     sigma-70 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_589_0025"
                     /evalue="1.80E-26"
                     /identifier="TIGR02937"
                     /label="ctg1_589"
                     /locus_tag="ctg1_589"
                     /protein_end="194"
                     /protein_start="20"
                     /score="90.7"
                     /tool="antismash"
                     /translation="FLQDLRQQMIKFAFLQLSSLPQAEDVVQEALTSAFQHLDSFKGRA
                     AFKTWIFAILKNKIIDVIRQKSRLVAMTELFKDEESELSIDALFDASGHWHKYEAPQAW
                     QSPEEMMEQADFWIIFEACLNHLPAKYAQVFMMREVIELSSNEICSKLELSISNFNVLM
                     YRSRTRLRECL"
     PFAM_domain     6636..6836
                     /aSDomain="Sigma70_r2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04542.16"
                     /description="Sigma-70 region 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_589_0055"
                     /evalue="2.90E-13"
                     /label="ctg1_589"
                     /locus_tag="ctg1_589"
                     /protein_end="88"
                     /protein_start="21"
                     /score="49.5"
                     /tool="antismash"
                     /translation="LQDLRQQMIKFAFLQLSSLPQAEDVVQEALTSAFQHLDSFKGRAA
                     FKTWIFAILKNKIIDVIRQKSR"
     PFAM_domain     6990..7142
                     /aSDomain="Sigma70_r4_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08281.14"
                     /description="Sigma-70, region 4"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_589_0056"
                     /evalue="2.80E-09"
                     /label="ctg1_589"
                     /locus_tag="ctg1_589"
                     /protein_end="190"
                     /protein_start="139"
                     /score="36.6"
                     /tool="antismash"
                     /translation="FEACLNHLPAKYAQVFMMREVIELSSNEICSKLELSISNFNVLMY
                     RSRTRL"
     CDS             7187..7366
                     /locus_tag="ctg1_590"
                     /transl_table=11
                     /translation="MLTCRQATQLLSEKQDRPLLLREQSGLQLHLLACRSCRRYSKQIK
                     TISQLSKAFKNLDG"
     PFAM_domain     7196..7300
                     /aSDomain="zf-HC2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13490.8"
                     /description="Putative zinc-finger"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_590_0057"
                     /evalue="4.10E-05"
                     /label="ctg1_590"
                     /locus_tag="ctg1_590"
                     /protein_end="38"
                     /protein_start="3"
                     /score="23.8"
                     /tool="antismash"
                     /translation="CRQATQLLSEKQDRPLLLREQSGLQLHLLACRSCR"
     CDS             7458..8369
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 150; E-value: 1.6e-45)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_591"
                     /transl_table=11
                     /translation="VNLKNLEAFYWVVTLKSFNKAATKLQTTQPAVSQKITSLENELGF
                     KVLDRSYRQLKPTHKGLTLFKYAEKFMRLETDLVAELTENQHLTGTIRLGVSETIVYTW
                     LVEYIEKVQQEFPKISVEIVVDLTPNLQEGVRTGDLDMAFLLGPTLAFECIEQALCDFE
                     LSFLASPSFKGGVAQMSFKTLMSHTILTYPKITYPYKELKARMKEQGIDEPLSITSYSL
                     ATLLRLAEQGLGIAVVPTLTALKEITDGRLEILNTPIQLKTFHFTSIYIQGNDVALKEK
                     LTEVAVKVSECAMKRLNEQIKK"
     PFAM_domain     7464..7640
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_591_0058"
                     /evalue="1.80E-15"
                     /label="ctg1_591"
                     /locus_tag="ctg1_591"
                     /protein_end="61"
                     /protein_start="2"
                     /score="56.7"
                     /tool="antismash"
                     /translation="LKNLEAFYWVVTLKSFNKAATKLQTTQPAVSQKITSLENELGFKV
                     LDRSYRQLKPTHKG"
     PFAM_domain     7713..8252
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_591_0059"
                     /evalue="1.30E-29"
                     /label="ctg1_591"
                     /locus_tag="ctg1_591"
                     /protein_end="265"
                     /protein_start="85"
                     /score="103.2"
                     /tool="antismash"
                     /translation="QHLTGTIRLGVSETIVYTWLVEYIEKVQQEFPKISVEIVVDLTPN
                     LQEGVRTGDLDMAFLLGPTLAFECIEQALCDFELSFLASPSFKGGVAQMSFKTLMSHTI
                     LTYPKITYPYKELKARMKEQGIDEPLSITSYSLATLLRLAEQGLGIAVVPTLTALKEIT
                     DGRLEILNTPIQLKTFH"
     CDS             8736..9968
                     /locus_tag="ctg1_592"
                     /transl_table=11
                     /translation="MSLLKSSFLSDRQWAIVASIFMMATSAMGPGFLTQTAVFTVKLGA
                     AFGFAILVSILIDYVVQQNIWRVVTLTQMRASDIANKALPGSGYLLAFLVILGGFFFSV
                     GNIAGAALGLNALFGLDTKWGGILSGALAILIFASRKATLAMDKSMIVLGLLKILLIII
                     VAVIVMPPVGQAVHQTFAPDQIDFAIITTIVGGTVGGYICYAGAHRLLDKGAVGPENID
                     EVAKAATKGIVVVGIMRYVLFLAFLGVVVSGATIDLASHDANPAAQAFQYAAGTFGFKL
                     FGLIFWAAGISSTIGAAYTSVSFFTAFKKNLTPKQTNYTTITFIALALLLYVLLGATPA
                     GLLIFVGGFNGLVLPIGLTIFVYVAACRKDLMGNYNYPKWLLILGGLTCLLTWWMGYMS
                     FTTVFNYLTKL"
     PFAM_domain     8865..9863
                     /aSDomain="Nramp"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01566.20"
                     /description="Natural resistance-associated macrophage
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_592_0060"
                     /evalue="1.10E-23"
                     /label="ctg1_592"
                     /locus_tag="ctg1_592"
                     /protein_end="376"
                     /protein_start="43"
                     /score="83.9"
                     /tool="antismash"
                     /translation="GAAFGFAILVSILIDYVVQQNIWRVVTLTQMRASDIANKALPGSG
                     YLLAFLVILGGFFFSVGNIAGAALGLNALFGLDTKWGGILSGALAILIFASRKATLAMD
                     KSMIVLGLLKILLIIIVAVIVMPPVGQAVHQTFAPDQIDFAIITTIVGGTVGGYICYAG
                     AHRLLDKGAVGPENIDEVAKAATKGIVVVGIMRYVLFLAFLGVVVSGATIDLASHDANP
                     AAQAFQYAAGTFGFKLFGLIFWAAGISSTIGAAYTSVSFFTAFKKNLTPKQTNYTTITF
                     IALALLLYVLLGATPAGLLIFVGGFNGLVLPIGLTIFVYVAACRKDLMGNYN"
     CDS             10003..10767
                     /locus_tag="ctg1_593"
                     /transl_table=11
                     /translation="MFVDLNSDLGESFGSWKMGNDDQILPVVTSANIACGFHAGEPLGI
                     LKTVRKAVELGVTIGAHVSYPDLVGFGRRNMDLSRDELIADVLYQISALDGLAKVAGSK
                     VQYVKPHGALYNTIAHDQAQAAAVIDAIKMYNPELVLVALAGSNLVEQARAAGLKVVSE
                     AFADRAYNSDGSLVSRRLEGAVLHDSAFVASRVVSMLKNGGVESIDGVFTPIQADTICL
                     HGDTDGALEMSAAIKAELVKNNIEIRPFVNKA"
     PFAM_domain     10009..10722
                     /aSDomain="LamB_YcsF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03746.18"
                     /description="LamB/YcsF family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_593_0061"
                     /evalue="1.40E-98"
                     /label="ctg1_593"
                     /locus_tag="ctg1_593"
                     /protein_end="240"
                     /protein_start="2"
                     /score="329.4"
                     /tool="antismash"
                     /translation="VDLNSDLGESFGSWKMGNDDQILPVVTSANIACGFHAGEPLGILK
                     TVRKAVELGVTIGAHVSYPDLVGFGRRNMDLSRDELIADVLYQISALDGLAKVAGSKVQ
                     YVKPHGALYNTIAHDQAQAAAVIDAIKMYNPELVLVALAGSNLVEQARAAGLKVVSEAF
                     ADRAYNSDGSLVSRRLEGAVLHDSAFVASRVVSMLKNGGVESIDGVFTPIQADTICLHG
                     DTDGALEMSAAIKAEL"
ORIGIN
        1 ctttttaggc tgtgcagtat gctatttttt tattaaagaa cacgggatta ataaagctta
       61 tcaagaagaa atttataaat tcttttttaa agccgagttt gaatcttcaa aaaaataccc
      121 ttggttagaa aagcctttag ttaaaaagac attggtctca attacatttg ctatatgttt
      181 gattatggga gtttttcact ttattgatga tgatatttct cagcacagac ctagacgtaa
      241 aggtggactt atagcattta gttataatta cagagtgggg gtgatgttct gggaaatagc
      301 agtcagctta tttagtattt tcccgatttt ttattttggc ttgttattct tatatatcat
      361 taattatttt ttccgcgggt taggtacggg taaggtggtt attcctttag aagtgccaag
      421 caaaaaacga aagagaacta gaaaggtctg atatttttct tttgaactgg ttaaacacat
      481 ttcacgtaat atatcaataa atgtgacaga atctaacttt ttaaaacctg taaatacgac
      541 tatcctaact ggacttgagc acatcctttt gaagtgttcg tcttttggtt agatttttag
      601 gtatttaaaa aatgaataag atgcacgtaa ctttagcggt cattattggt ttaattgttg
      661 gtggtgtaat cggtgctctt ggttactcta aaactgctgc gcgttatgac gcgatgacga
      721 cagcatgtgt catggtaaac caagcagttg aacatggcat cttgaaacca gaacaggtga
      781 aagagcttgg tgagctcaca ggccaaagcc ttaaaaaaga ttatgagtca gttgcctcta
      841 aatttaaatt ctctgaaaaa caattaggca atgcatctga aggctctaat tgtagtcagt
      901 ttattgttgg ggtaaatacc gcacaataac cattaagaag cccacagtaa gtgggctttt
      961 tttataatgt ttagttaggg cagctacaag atcaacagaa catattgtct acagactgct
     1021 ataataatgc tcaccccaaa atttaagcta agcttgctct aaaggcaggc ttttgtatgt
     1081 gtaatcaagt ctgttaggaa atatgaaacg ctatttaaaa caaactgaat cgactacgtc
     1141 taattggaca acagagcaag actgtttctt gatagaaaat aattctctct caatttacga
     1201 gctcatcgag catttacctt tttctgaaga agaaatacga gtgcgtaggg ctgttttagg
     1261 gctggtaaga cgagataagc aaatgaaaac atattagttt taccaaatgg tcaaaactaa
     1321 tgtgaaagta aatatttcta attatctcta ttcaagcatt cgttttgcgg atgagttatc
     1381 aaaaccataa tttttttaag tgtttttata gtgcaattta cataaagtac taattactta
     1441 caaaccactc taataaggct acctttaatt acaatacttt aagcataatc aaagacagaa
     1501 aacattcata gatcagaact ttataacaat agtacggaga gaggttaatg ccaaagtatc
     1561 tagctgtagc cgaaaaggtt tataaaaata ttaaaaagga tagcttattc actgatgaca
     1621 ttactcagaa ccttaactgt ttaattagtc agattcgaaa agccatcaaa ggaacggagt
     1681 ttaagctcaa gttcaactat atagactttg aagaaaactt aacgaaaccg ttaagtgaat
     1741 gcaaagttca aattgatctg agtgttatgc caaagttcac aaatgaaggt gaatatcttc
     1801 tctggttagc tggttttatt gagcgaatca cagaaggagg taaacctaag ttgccaccaa
     1861 tttcgcactt tttaccacca ggttttaaga tgtcgaaaga ttcgttgcca gtaactgttg
     1921 ctcctccaaa agaagagcat gcggacatga ttattaatta ttttaaatct gaggatttta
     1981 ttaaaaccaa taaaactcct tcataaaaga atatagaagt aaacgtccac cttacttcta
     2041 tatgctgctg gttttaactc agcgaccgcc ttctggggcg gttttttttg tttaaaaaat
     2101 tgctcataac ttaatttttc ttatgttgaa attctaattt aaaagaatat taaatgtgta
     2161 taaatgtgca aatatctggc tattttttat aaataacaat accttaatta tattatttga
     2221 taaagaaaaa tatacatttt tcacataagc catgtgccaa gtaacgcaat taaacattta
     2281 gctgtacata atctttaaaa aaagagagtg taaataagat gaatgaaaat gcagagctta
     2341 taaaatacat tgacgttgct gaaaacgtct atgaacgtgt ctatgagaat aatcaagttt
     2401 ccaataattt gattgttaac cttaaccgca ttatggcgga aatcaaaaaa caggccgcag
     2461 aaaaaaatct gagattaaaa tataactcga tcgactttga atattgcttg agtttgccta
     2521 tagcagatcg ggatataaaa attgatctca gtttgattcc tcactttgaa catcgtgatg
     2581 aatgcatttt atggctaacc aactttattg gaaaaattag tgtgcctaaa aagatgacga
     2641 gacaaaagct aagttttcat taaagttttt agatttaaag cgatataagt cattattaaa
     2701 aaactaactg cctttatgct taaacagtta tgctttatta cagatcgata tttcataatt
     2761 agaaaatgac agagcgcttt aaaatgaaaa cgtttgcatt aacctttgct gttttagctt
     2821 cgctatctac ctatggtcta gccaatgact ctacgggtta cgtgggtaca ggtgggattc
     2881 aatatctcaa aaactcacag attgccatgc aaagtgaaga tctattcatc agtaaaaaac
     2941 tgattaaggt cgactatctt tataaaaact taagcaataa agacgtaacg gaaacgatct
     3001 tatttccgtt accacgcatt gataattttt ttgaggctga ttttgctcac accgaacagc
     3061 ttttaaaaag ttttaaaatt gtggtggatg gtaaaaatat aaagccggag atgcatgtca
     3121 gaacctttat tcaaaaagat gaaaaatcgc ccctgattga tgctacggat gagtttaaac
     3181 agtgcggttt tagtgaacaa gagatgctaa acccatggac tcgcactaac tatgattatg
     3241 aatattatgt agacaagcta aaacaatgta ataagccgca aatacagaaa attttagcta
     3301 attttaaaaa agatgacgtg atcccgtggt catctcaagt ggtttatagt tggaagcaga
     3361 ctttcaaagc caatagtttg actaagattc atcatgaata taaacctttg gtcggtggct
     3421 ctgtagctct ctatccagat gagtataacc agcaattttg tatggataaa caatttaagc
     3481 agggcttaaa aaaagccagt gcagaaaatt cgccgtttag tgctttgggc tatattttaa
     3541 cgacgggtgc aaattgggca aagccaattg aaaactttaa gctcaccatt gagcgtgata
     3601 aggatgaact ggtttcattt tgttgggatg ggccagttaa aaaaattagt ccaactcaat
     3661 ttcaaatgac caagactaag tttgtaccta aaaaagacct agatattatt tttgtgagag
     3721 ttagataact tcatacaatc ttctagtttg accaaattgc ctcaacattg attgtgtgtc
     3781 atgaaccaga catggcacac aataagaaaa agatgcccta tgttgctgtc agtaggattc
     3841 ttggcgtaat gagtaattag agcagcttct ttttaatcca ataatctaaa ctgaaataac
     3901 ggccgcctcc aagaacaagc agtgcgagaa gcatgactaa atacgtagcg gcaaactcaa
     3961 ttccattatt taaaattaca aacgaaccac tagacgtgag ccagtcgtaa ttgccgtagg
     4021 tttgtaatat ttcacgagct ttctctaact tttcagccga ggccaagacc tgcatgtttg
     4081 caaagggtgc atttggatca gcaatcgctt gccatccatt tggtatatgg acagtaaata
     4141 tggcaactaa catcgtaata atgaggggaa tactaattaa acgcgttagc aaaccaaatg
     4201 ttaataatat tgcacctact agttcagccg ttgttgcaag taatgccatt acatacggaa
     4261 agggaagtcc taaacctcca tctgagttgc caaaccattc tacaatatca ttgaagtgca
     4321 ttaatttatt tgtgcctgcc atccaaaata taggaactaa atacaatcga agagccagag
     4381 ctgcgatgcc gtccgcatgt tgtagagttt tacccagttt ttgataatat tgagataagc
     4441 cataaataaa attcttcatg ataatttcac atccgatgcg attgaatatt aattagtcgg
     4501 ataaagactg tatttcttac ataaaaaaaa ttttatttac ggtgtaataa aaaaggattt
     4561 ggtccgtcta actatacgta caaatgtaca aaccgagaat ttatctttaa aggaatacta
     4621 acatgaataa gctcaattca atgacttcag tggcggcatt attagcacta tcagttgctg
     4681 gcgctacaca agtggcggta gcagcaaccc atacaacaac cgaagcacat gcaaccaaag
     4741 cagcagatgg aaaatgcggt gaagcaaaat gcggtgctaa caaaatgaaa aaccatgaaa
     4801 agtctgccga agcaaaatgt ggtgcagata aaaaagcagc agatggaaaa tgtggagcaa
     4861 ctaaaaaagc agcggacggc aagtgcggtg cagataaaaa agtcgctgac ggtaagtgcg
     4921 gcgctaagta aacaatctga tcatggatga tgtcggcctt ctagtaagtg ccgacatcgt
     4981 ttccaaaagg agaaatcacc atgatggatt tgtcaggcgt agggctgggt ttaaggcgtg
     5041 attttataga ttcgtttttg gatgcaaaaa catgtcccga ttttatcgaa gttgctcctg
     5101 aaaactggct aggttttggt ggtcgacatg cgaaattact cgcacagtgt gttgaaaaag
     5161 ccccattaat ttgtcacggc ctgtcattgt ctattggcgg tcctcatcca ctcaatcttg
     5221 aatttattgg caaaataaaa agctttttag aacaatatga tgtctcgatt tattctgaac
     5281 atttaagtta tacaaatgat gggggctatc tatatgattt gttgccaatc cccatgaccg
     5341 aagcggctgt taaatatgtc gctgaacgta ttttacgtgt tcaagatatt ttaggaagaa
     5401 gattagtcat agagaatgtt tctacttatt taatgcccaa tgcccaaatg agtgaggcgg
     5461 aatttattcg tgaagttctt caatatgcag actgtgattt gcttctggat gtaaataatg
     5521 tctatgtcaa cagtattaac catggtagtg acgcatttgg atttattcgg gacatgccaa
     5581 aagaacgcat ccgttactta catattgctg ggcatgaaca agttcagaaa aatttattaa
     5641 ttgatacgca tggtgcagag gtttgcgacc gtgtttggga gctattgaga tatacctacc
     5701 aattatgtgg aataaaacca actttattgg aacgtgactt taatattccg tcatggcatg
     5761 aattagaaga ggaacttgcc aaaattaaac ttattcaaca acaggagagt ggctatgaag
     5821 ggaaatcaaa catccttcca aaccatgcaa cgtcagtttt gtgactggat tagagatcct
     5881 gatttggaaa tacctcaagc acttcctgtt caaagaatgc aaatttatcg ggatttactt
     5941 tttaataatg ttagttcatt tattaactta gtttatccgg tagctcgtgc gatgttgcca
     6001 gagttaaagt ggcaacaagt actctcggag ttttttcaaa aagctgagtg tcactcacct
     6061 ttatacaatg atatctcttt agagtttaga gagtatttaa cagagcaaca gcatcccata
     6121 ttgcaagaat acccatggtt ggctgagtta ttgcagtttg aatggattga attgtattta
     6181 gatactgttg aaattgaaga tgtcgttttg catgaaaatt acgcttggca attaagcacc
     6241 caagtatggg tattggttta tcaatatccc gtttatacgt ggacaacttt aatgattcca
     6301 gaacaggtcg agcctatgcc tggagcaatt atggtctggc gagatgaaca agacaaagta
     6361 tgtattgaac agctttcgcc tttgtttgct atggtgattg aacagttgac tcaaaatgta
     6421 aagttaactg accaagatat tcatacactc attcaatctg tactcaccga tttgtctgaa
     6481 catgatattt atctgcaaat tcaagaacta aaagcaatgt taactcgaat gcgattgatt
     6541 caagttccgc atgattttaa agaggtataa ggatgacttc agccgtggca tcagatcatg
     6601 aagaaataga agatcagttg cataatccag cctttttaca agacttaaga cagcaaatga
     6661 taaagtttgc ttttttacag ttgtcttcgc ttcctcaagc tgaagatgtg gtgcaagaag
     6721 cattaacgag tgcttttcaa catttagatt catttaaagg gcgggctgca ttcaaaacgt
     6781 ggatattcgc gattttaaaa aataaaatta ttgatgtgat tcggcaaaag tcacgtttgg
     6841 tcgcaatgac agaattattt aaagatgagg aaagtgaact gagtattgat gcactgtttg
     6901 atgcttctgg acattggcac aaatatgaag cgcctcaagc atggcaaagc cctgaagaaa
     6961 tgatggagca ggcagatttc tggataattt ttgaagcttg tttaaatcat ttacctgcca
     7021 aatatgctca agtttttatg atgagagagg tgatagagct gagttctaat gagatttgta
     7081 gcaagttgga attgtctatc tcaaacttta atgtgttgat gtatcggagt cgtaccagac
     7141 tacgtgaatg tttagaaaat aaatggttat tgaaggagga ttgttcatgc tgacatgtcg
     7201 acaagccact caactgttgt ctgaaaagca agatagaccg ttgttattac gtgagcaaag
     7261 tggtttacaa ctgcatttat tggcgtgccg ctcatgccgc cgttattcaa aacagatcaa
     7321 aacaattagt cagctttcta aagcatttaa aaatttagat ggctaatttt atttaaaaat
     7381 ttatttattg ctagcctaat cacgctaaca actcccatac tataaaagta aaggagtttt
     7441 ttaagacagg atgaaacgtg aatttaaaga atcttgaagc attttattgg gttgtgactt
     7501 taaagagctt caataaggcc gcgactaaat tacaaaccac ccagcctgcg gtttctcaaa
     7561 aaatcacatc tcttgaaaat gaattaggct ttaaagtttt agatcgaagt tatcggcagc
     7621 ttaaaccaac acacaaaggc ttaactttat ttaagtacgc cgaaaaattt atgcgactag
     7681 agaccgatct ggtggctgaa ctgactgaaa atcaacacct gactggcacc attcgtttag
     7741 gcgtttccga aactattgtc tatacgtggc tcgttgaata tatcgaaaag gttcagcaag
     7801 agttcccaaa aatttcagta gaaattgtgg tagaccttac gcctaactta caagaaggcg
     7861 ttcggacagg tgacttagac atggcttttt tacttgggcc aactttagct tttgagtgta
     7921 ttgaacaagc tttatgtgac tttgaactaa gtttcttggc ttcaccttca tttaaaggtg
     7981 gtgttgctca aatgtctttt aaaactttaa tgtcacatac cattttaact tatccaaaaa
     8041 ttacctatcc ctataaagaa ttgaaagcca gaatgaaaga gcaagggatt gatgaaccac
     8101 tttcaattac cagttattca ttggcaacgc tgttgcgttt agccgagcag ggtttgggta
     8161 ttgctgtggt gccgacctta acagcactaa aagaaattac tgatggccga ctagaaatat
     8221 taaatacacc tattcagtta aagacgttcc atttcacctc gatctacatt caaggaaacg
     8281 atgttgcctt aaaagagaaa ttaaccgaag ttgcggttaa ggtctctgaa tgcgctatga
     8341 aaagactcaa tgagcaaatt aaaaaataag ctgtttttgt gtgtctttta tccctatttt
     8401 ttcttattta aaaaagctgt tttgtatgta aaaccataaa agcagcttat taacttcaat
     8461 aagtaaagct tatcctgatt ttttaataat taataaatca ttaaaaatca aaaatttgaa
     8521 tttttaattt tatgtaaaaa gtcttattgt ccgtagggat tagctatgtt tttattttag
     8581 acacaagatt tgatcaccga ttgtgttaat tggggaacag ggaatctttg tcattttaaa
     8641 ggattaaaga atatcgtttg ggacaaaaaa atggtgttct tggttcaact tgaaaatagc
     8701 gttgttaagc tcaaatggat gaggaacgca ttaatatgtc tttactgaaa tcttcttttt
     8761 tatcagatcg ccaatgggcc attgtggcct cgatctttat gatggcgacc tctgcaatgg
     8821 ggcccggatt tttaacccaa actgctgtat ttacagtcaa gttaggcgcg gcatttggct
     8881 ttgccatttt agtttccatt ttgattgatt atgtggttca acaaaatatt tggcgagtgg
     8941 tgacacttac tcaaatgcgt gcatctgata ttgccaataa agcattgccg ggtagtggtt
     9001 atttactggc gtttctagtg attttgggcg ggtttttctt tagtgtcggt aacattgccg
     9061 gtgcagcttt aggtttaaat gcgctttttg gcctcgacac aaagtggggc ggtattttaa
     9121 gtggtgcttt agccattttg atttttgctt caagaaaagc aacgcttgcc atggataaaa
     9181 gcatgatcgt gttgggattg cttaaaatcc tgctgattat tatcgttgct gtcattgtga
     9241 tgcctccagt tgggcaagct gtacatcaaa cctttgctcc agatcagatc gactttgcca
     9301 ttattaccac cattgttggc ggtacggttg gtggctatat ctgttatgca ggtgcacatc
     9361 gtttactcga taaaggcgct gttggccctg aaaatattga tgaagttgct aaagctgcga
     9421 ccaagggcat tgttgtggtc ggcatcatgc gctatgtgtt gttcttggct tttttaggtg
     9481 tggtggtgag cggtgcaacg attgatttag ccagccatga cgccaatccg gcagctcaag
     9541 cattccaata tgcagcgggt acatttggtt ttaaattatt tggtttaatt ttctgggcag
     9601 cagggattag tagcaccatt ggcgcagcat atacttcagt gtcattcttt actgccttta
     9661 aaaagaactt aacaccaaaa caaaccaact atacgaccat tacctttatc gcattggctt
     9721 tattgctcta tgtgctattg ggtgcaactc cggcaggcct actcattttc gtaggtggtt
     9781 ttaacggatt ggtgttgcca attggcctta caatttttgt gtatgttgcc gcgtgccgta
     9841 aagatttaat gggtaattat aactatccaa aatggttgct tattttaggt ggattaacat
     9901 gtctgttaac gtggtggatg ggctacatgt cgtttacgac tgtgtttaac tatttgacca
     9961 agctttaagc cagacgttgt taagtaataa aggaataatg ccatgtttgt agatttaaat
    10021 agtgatttgg gtgaaagctt tggctcatgg aaaatgggta atgatgacca gattttacct
    10081 gtcgtgacca gtgccaatat tgcgtgtggc tttcatgctg gcgaaccact cggcatttta
    10141 aaaacggttc gtaaagccgt tgagcttggt gtgaccattg gcgctcacgt gtcttatcca
    10201 gaccttgtag gctttggccg ccgtaatatg gatttgtcac gtgacgaact gattgctgat
    10261 gtgctttacc aaatttctgc actcgatggc ttggctaaag tggcaggctc aaaagtgcaa
    10321 tacgttaaac cacatggcgc gctctacaac accattgcac atgaccaagc tcaggcagca
    10381 gccgtgattg atgcgattaa aatgtataac cctgaactgg tcttagtggc tttggctggg
    10441 tcgaacttag tcgaacaggc acgagctgcg ggtttaaaag ttgtatctga agcatttgca
    10501 gaccgtgctt ataacagcga tggttcattg gtgtctcgcc gtctagaagg tgcggtttta
    10561 cacgactcgg catttgttgc gagccgtgtg gtttcaatgc ttaaaaatgg tggagttgag
    10621 tcaattgacg gcgtatttac cccaattcaa gccgacacca tttgcttaca tggtgatacc
    10681 gacggtgcgc tagagatgtc ggctgccatt aaagccgagc ttgtaaaaaa caatattgaa
    10741 atccgcccat ttgtaaataa agcataagga tgagcaccat gtataaggat attaaagtcg
    10801 acccagctca gcttgaagcc gcattagatg cgcgtttaaa aatccgtgca ggttttgata
    10861 aacc
//
