LOCUS       NC_014391.1            11785 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_014391.1 Micromonospora aurantiaca ATCC 27029, complete sequence.
ACCESSION   NC_014391
VERSION     NC_014391.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:56:55
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2949891
            Orig. end    :: 2961676
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11785
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[2954891:2956676](-)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6785)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
     cand_cluster    1..11785
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11785
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="siderophore"
                     /region_number="7"
                     /rules="IucA_IucC"
                     /tool="antismash"
     CDS             56..865
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 186.1; E-value:
                     1.3e-56)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2586"
                     /transl_table=11
                     /translation="VRADGLSGSDLRLGYHGTTVVHDAAITLRPAAVTALVGPNGSGKS
                     TLLRGLARLHPLEHGEIVLADGTPARALSARDFARRVTLLAQSRPTPSGVTVRDVVGYG
                     RHPYRQRWRANDLDGPAAIDRAMRVTGVDGMAGRPVDELSGGELQRVWLATCLAQDTAI
                     LLLDEPTTFLDLRYQVEILDLMRELADTAGVAVGVVLHDLNQAAAVADQVVLLHEGRVR
                     GAGTPHEVFTEEALTEAYGIRVEVSVDPVTNLLSTRPVGRHTTRVSA"
     PFAM_domain     122..565
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2586_0437"
                     /evalue="7.40E-24"
                     /label="ctg1_2586"
                     /locus_tag="ctg1_2586"
                     /protein_end="170"
                     /protein_start="22"
                     /score="84.9"
                     /tool="antismash"
                     /translation="DAAITLRPAAVTALVGPNGSGKSTLLRGLARLHPLEHGEIVLADG
                     TPARALSARDFARRVTLLAQSRPTPSGVTVRDVVGYGRHPYRQRWRANDLDGPAAIDRA
                     MRVTGVDGMAGRPVDELSGGELQRVWLATCLAQDTAILLLDEPT"
     CDS             894..1883
                     /gene_functions="transport (smcogs) SMCOG1033:iron compound
                     ABC transporter, periplasmic (Score: 203.6; E-value:
                     5.6e-62)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2587"
                     /transl_table=11
                     /translation="MLRTRLTLLVAAAASALLIAGCGTTEEPAAAPSPSDAASTGPVTV
                     TDSRGKTITLKSPATKVVGLEWGEVEMLVGLGVMPVGVADPKGYATWVTAAPLDASVKD
                     VGTRGEPSVDSIVALQPDLVVMEAERGSAVVTQLEKYVPVLVTKGSDASDNIGRMRADL
                     KMIATATGRTAQADKLLADFDAALADGKKKIADAGAAGKQFAIADGWKEGSTVSIRMFG
                     QGALVSQLGIQLGLKNAWTGKTDEMWGLGQTDVEGMTVLKGQDVHFFYNASDGTDVFAD
                     GLAGNAIWRSLPFVQQNKLHKMPNGIWTFGGTLSAKQYIDELVKVYTA"
     PFAM_domain     1077..1805
                     /aSDomain="Peripla_BP_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01497.20"
                     /description="Periplasmic binding protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2587_0438"
                     /evalue="3.10E-18"
                     /label="ctg1_2587"
                     /locus_tag="ctg1_2587"
                     /protein_end="304"
                     /protein_start="61"
                     /score="66.2"
                     /tool="antismash"
                     /translation="VVGLEWGEVEMLVGLGVMPVGVADPKGYATWVTAAPLDASVKDVG
                     TRGEPSVDSIVALQPDLVVMEAERGSAVVTQLEKYVPVLVTKGSDASDNIGRMRADLKM
                     IATATGRTAQADKLLADFDAALADGKKKIADAGAAGKQFAIADGWKEGSTVSIRMFGQG
                     ALVSQLGIQLGLKNAWTGKTDEMWGLGQTDVEGMTVLKGQDVHFFYNASDGTDVFADGL
                     AGNAIWRSLPFVQQNKLHKMP"
     CDS             1889..3991
                     /gene_functions="transport (smcogs) SMCOG1011:transport
                     system permease protein (Score: 284; E-value: 2.3e-86)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2588"
                     /transl_table=11
                     /translation="MTAPAPPGPATRPAPVGPPPARRSRVAGAFALAAALLVAITAVHL
                     TQGTSSVGALDLLRLLTGGDDETARVLVASRLPRLLTGLAVGVALGFAGAALQSTTRNP
                     LASPDTLAVNAGAHLAIVSTAAFGIALPALPAGGLAFCGGLAAASLVMLLSAGGQAATT
                     RLILAGSATAMALSSLTMLLMLLFEQATIGLFAWGNGSLVQGDLVAFTQLAPVIGVAAL
                     VLVALGHRLDLLALGDDTATVLGLNVRRTRLTVVLLAVLLSAAAVTLAGPIGFVGLGAP
                     VIVRLLGRWVPEVHRHRILMPLSGIVGVVIVLGSDVLLRAVLGGQAGVDVPTGVVTTLF
                     GAVLLVWLARRHRDAGPTRQAPGGHAAVRSRGFVATVVAVCAVVVTAALVLGMLAGDTW
                     VLLGDIVNWVQGRTGPAYTFVLDARWPRVAAALLAGAALALAGTTVQAVCRNPLAEPGI
                     LGITGGAGIGAVSLLTFAPMAGVLALSGAAGLGAVVAFALVYGLARRRGLNSDRLVLIG
                     FAVWQGGTAIITFIVVSSDPWNTGKALTWLSGSTYGRTAPQVLPVAIALLIALPVVAAV
                     RRELDLLALDDDTPRVLGVRLERARLVALGLAALLTATAVSAVGVIGFVGLVAPHAARA
                     LVGGRHTRVLPVAVLLGATLVSLADTLGRSVIAPAQVPAGLVTAMIGTPYFVWLLWRSR
                     AAAAAR"
     PFAM_domain     1994..2941
                     /aSDomain="FecCD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01032.20"
                     /description="FecCD transport family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2588_0439"
                     /evalue="6.90E-64"
                     /label="ctg1_2588"
                     /locus_tag="ctg1_2588"
                     /protein_end="351"
                     /protein_start="35"
                     /score="215.9"
                     /tool="antismash"
                     /translation="LLVAITAVHLTQGTSSVGALDLLRLLTGGDDETARVLVASRLPRL
                     LTGLAVGVALGFAGAALQSTTRNPLASPDTLAVNAGAHLAIVSTAAFGIALPALPAGGL
                     AFCGGLAAASLVMLLSAGGQAATTRLILAGSATAMALSSLTMLLMLLFEQATIGLFAWG
                     NGSLVQGDLVAFTQLAPVIGVAALVLVALGHRLDLLALGDDTATVLGLNVRRTRLTVVL
                     LAVLLSAAAVTLAGPIGFVGLGAPVIVRLLGRWVPEVHRHRILMPLSGIVGVVIVLGSD
                     VLLRAVLGGQAGVDVPTGVVTTLFGAVLLVWLARR"
     PFAM_domain     3044..3964
                     /aSDomain="FecCD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01032.20"
                     /description="FecCD transport family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2588_0440"
                     /evalue="4.00E-84"
                     /label="ctg1_2588"
                     /locus_tag="ctg1_2588"
                     /protein_end="692"
                     /protein_start="385"
                     /score="282.4"
                     /tool="antismash"
                     /translation="TAALVLGMLAGDTWVLLGDIVNWVQGRTGPAYTFVLDARWPRVAA
                     ALLAGAALALAGTTVQAVCRNPLAEPGILGITGGAGIGAVSLLTFAPMAGVLALSGAAG
                     LGAVVAFALVYGLARRRGLNSDRLVLIGFAVWQGGTAIITFIVVSSDPWNTGKALTWLS
                     GSTYGRTAPQVLPVAIALLIALPVVAAVRRELDLLALDDDTPRVLGVRLERARLVALGL
                     AALLTATAVSAVGVIGFVGLVAPHAARALVGGRHTRVLPVAVLLGATLVSLADTLGRSV
                     IAPAQVPAGLVTAMIGTPYFVWLLWR"
     CDS             4037..4939
                     /gene_functions="other (smcogs) SMCOG1200:vibriobactin
                     utilization protein ViuB (Score: 272.2; E-value: 6.5e-83)"
                     /gene_kind="other"
                     /locus_tag="ctg1_2589"
                     /transl_table=11
                     /translation="MTSTLAVAPWRVFTVEVRALRRLGPSFLRVTLTGPDLDRFADNGY
                     DQRIKLALPPVDGAPGELPDGPDWFPRWRELPDALRSPIRTYTVRAVRPEAYEVDVDMA
                     LHGDGGPATRWARRARLGDRIAVVGPDAGWDGPHGGVEFQPPAGATLLLAGDETAAPAI
                     CAILERLPAEARGHALVEVPETGDELPCRAPAGVTVTWLPRDGAPHGSRLTPAVTGLAG
                     RLVPVPVAVAAAPLTEVDVDRDILWEVPERPDGAALYAWLAGEAAVIRGLRRHLVTERG
                     MDRRAVAFMGYWRAGRAEN"
     PFAM_domain     4085..4432
                     /aSDomain="FAD_binding_9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08021.13"
                     /description="Siderophore-interacting FAD-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2589_0441"
                     /evalue="2.00E-35"
                     /label="ctg1_2589"
                     /locus_tag="ctg1_2589"
                     /protein_end="132"
                     /protein_start="16"
                     /score="121.7"
                     /tool="antismash"
                     /translation="VRALRRLGPSFLRVTLTGPDLDRFADNGYDQRIKLALPPVDGAPG
                     ELPDGPDWFPRWRELPDALRSPIRTYTVRAVRPEAYEVDVDMALHGDGGPATRWARRAR
                     LGDRIAVVGPDA"
     PFAM_domain     4487..4924
                     /aSDomain="SIP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04954.15"
                     /description="Siderophore-interacting protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2589_0442"
                     /evalue="2.20E-40"
                     /label="ctg1_2589"
                     /locus_tag="ctg1_2589"
                     /protein_end="296"
                     /protein_start="150"
                     /score="137.9"
                     /tool="antismash"
                     /translation="LLLAGDETAAPAICAILERLPAEARGHALVEVPETGDELPCRAPA
                     GVTVTWLPRDGAPHGSRLTPAVTGLAGRLVPVPVAVAAAPLTEVDVDRDILWEVPERPD
                     GAALYAWLAGEAAVIRGLRRHLVTERGMDRRAVAFMGYWRAG"
     CDS             complement(5001..6785)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2590"
                     /sec_met_domain="IucA_IucC (E-value: 1.5e-77, bitscore:
                     259.0, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VNASASVDHLTPEAWATANRLLVRKALAEFAHERLITPEPDGPGR
                     WLVRSDDGSVEYRFAAQRLALDHWEVDAGSIVRRRDGAELPPDAVDLCVELRSALGLTD
                     AILPVYLEEITSTLAGTAYKLAKPTLSAAELAAAGFQAIETGMTEGHPCFVANNGRIGF
                     GVHEYHAYAPEAAAPVRLLWLAAHRDHTTFTCADDLDYDTLVRAELGEQTIAGFTATLT
                     GLGLDPADYLFVPVHPWQWWNKLAVTFAGEVAARRLVCLGEGPDEYLAQQSIRTFFNVT
                     DPAKHYVKTALSVLNMGFMRGLSAAYMEATPAINDWLAGLIEGDPVLKRTGLSIIRERA
                     AIGYRHRQYEAATDRYSPYRKMLAALWRESPVPGLEPGRRLATMASLLHLDRDGRSLAA
                     ALIDESGLAPADWLRRYLDAYLVPLLHSLYAHDLAFMPHGENVILVLHDGVVERVVFKD
                     IAEEIVVMNPEADLPERVRRIRAAIPEDEKILSIFTDVFDCFLRHLSAALHTRGVLDQD
                     EFWRTVAACAADYAATVPHLADRMRRHDLFAPEFTLSCLNRLQLRNNQQMVDLSDPSAA
                     LQFAGTLVNPLAPYAPRD"
     PFAM_domain     complement(5085..5555)
                     /aSDomain="FhuF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06276.14"
                     /description="Ferric iron reductase FhuF-like transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2590_0444"
                     /evalue="1.50E-40"
                     /label="ctg1_2590"
                     /locus_tag="ctg1_2590"
                     /protein_end="567"
                     /protein_start="410"
                     /score="139.4"
                     /tool="antismash"
                     /translation="DWLRRYLDAYLVPLLHSLYAHDLAFMPHGENVILVLHDGVVERVV
                     FKDIAEEIVVMNPEADLPERVRRIRAAIPEDEKILSIFTDVFDCFLRHLSAALHTRGVL
                     DQDEFWRTVAACAADYAATVPHLADRMRRHDLFAPEFTLSCLNRLQLRNNQQM"
     PFAM_domain     complement(5619..6368)
                     /aSDomain="IucA_IucC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04183.14"
                     /description="IucA / IucC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2590_0443"
                     /evalue="1.80E-79"
                     /label="ctg1_2590"
                     /locus_tag="ctg1_2590"
                     /protein_end="389"
                     /protein_start="139"
                     /score="266.8"
                     /tool="antismash"
                     /translation="FQAIETGMTEGHPCFVANNGRIGFGVHEYHAYAPEAAAPVRLLWL
                     AAHRDHTTFTCADDLDYDTLVRAELGEQTIAGFTATLTGLGLDPADYLFVPVHPWQWWN
                     KLAVTFAGEVAARRLVCLGEGPDEYLAQQSIRTFFNVTDPAKHYVKTALSVLNMGFMRG
                     LSAAYMEATPAINDWLAGLIEGDPVLKRTGLSIIRERAAIGYRHRQYEAATDRYSPYRK
                     MLAALWRESPVPGLEPGRRLATMASLLH"
     CDS             complement(6782..7378)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     139.9; E-value: 2.4e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2591"
                     /transl_table=11
                     /translation="MSARMTAFTRVDDALGEFTLRPLDPDADAALLHRWVTHPKSAFWL
                     MQDADVDAVAAEYRRIADHPHHDAYLGSWRGAPAFLAERYDPARVELVGLYDPEPGDVG
                     MHFLCAPADTPVHGFTRAVITTVMAWLFADPATRRVVVEPDVRNTAVHALNAAVGFTVV
                     GPIRKPEKEALLSVCTRDQFRVATGVPTGEEGAPA"
     PFAM_domain     complement(6881..7309)
                     /aSDomain="Acetyltransf_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13523.8"
                     /description="Acetyltransferase (GNAT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2591_0445"
                     /evalue="6.90E-52"
                     /label="ctg1_2591"
                     /locus_tag="ctg1_2591"
                     /protein_end="166"
                     /protein_start="23"
                     /score="175.1"
                     /tool="antismash"
                     /translation="DPDADAALLHRWVTHPKSAFWLMQDADVDAVAAEYRRIADHPHHD
                     AYLGSWRGAPAFLAERYDPARVELVGLYDPEPGDVGMHFLCAPADTPVHGFTRAVITTV
                     MAWLFADPATRRVVVEPDVRNTAVHALNAAVGFTVVGPI"
     CDS             complement(7375..8661)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 411.5;
                     E-value: 5.8e-125)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2592"
                     /transl_table=11
                     /translation="MSTHDFIAVGLGPYNLGLACLTAPIDDLDGLFLEARDSFDWHPGM
                     LLESTRLQTPFIADLVTLADPTSPYSFLSYLKETGRLYPFYIRESFFPLRAEYNDYCRW
                     AAGKLPNLRFRHSVTAVEYDESDDRYVVHADTPDGPVTHRARHLVLGTGTPPYLPPACA
                     GLGGDMIHNSRYLEHREALRAKDSITVVGSGQSAAEIYHDLLCDIDTYGYQLTWVTRSP
                     RFFPLEYTKLTLEMTSPDYVDYFHALPEPTRYALEAAQKPLFKGINADLINDIYDLLYA
                     KSLHGPAPTRLLTNTELVEAAYTDGRYRLGLRHTEQDRAFTLDTEGLVLATGYHYRVPE
                     FLAPVRDRLRFDAHGRFDVARNYSIDHTGRGVFLQNGGTHTHSITSPDLGMGPYRNSWL
                     IREMTGREHYPVEKTIAFQEFGAPAGVPA"
     PFAM_domain     complement(7657..8655)
                     /aSDomain="K_oxygenase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13434.8"
                     /description="L-lysine 6-monooxygenase (NADPH-requiring)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2592_0446"
                     /evalue="2.00E-123"
                     /label="ctg1_2592"
                     /locus_tag="ctg1_2592"
                     /protein_end="335"
                     /protein_start="2"
                     /score="411.9"
                     /tool="antismash"
                     /translation="THDFIAVGLGPYNLGLACLTAPIDDLDGLFLEARDSFDWHPGMLL
                     ESTRLQTPFIADLVTLADPTSPYSFLSYLKETGRLYPFYIRESFFPLRAEYNDYCRWAA
                     GKLPNLRFRHSVTAVEYDESDDRYVVHADTPDGPVTHRARHLVLGTGTPPYLPPACAGL
                     GGDMIHNSRYLEHREALRAKDSITVVGSGQSAAEIYHDLLCDIDTYGYQLTWVTRSPRF
                     FPLEYTKLTLEMTSPDYVDYFHALPEPTRYALEAAQKPLFKGINADLINDIYDLLYAKS
                     LHGPAPTRLLTNTELVEAAYTDGRYRLGLRHTEQDRAFTLDTEGLVLATGYH"
     CDS             complement(8690..10246)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 370.2;
                     E-value: 2.3e-112)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2593"
                     /transl_table=11
                     /translation="MSSIGSPTGAAPADTGSAAATARGHLFNAGSLGRYRDVLARGVDR
                     VARRVGEADRPFTGVTPDELAPLIGAIDLDRPLGDTDAALDELHDVWLRDAVYFHHPRY
                     LAHLNCPVVIPALLGEAVLSAVNSSLDTWDQSAGATLMERRLIEWTAGRIGLGATADGV
                     FTSGGTQSNLQAMLLAREEAYRTVVGGGATGRPDRPEVLSRLRILTSAAGHFSVQKAAK
                     LLGLAADAVLTVPTDATRRMRTDELARTIDSCHRDGQVVMAVVATAGTTDFGTVDPLPE
                     IADICAAAGVWLHVDAAYGCGLLVSPTRRHLLDGIERAASVTVDYHKSFFQPVSSSALL
                     VRDGRVLRHATWHADYLNPVRAVEQGLPNQVDKSIQTTRRFDACKLWLTLRIMGPDAIG
                     TLFDQVVDLAAQAWRRLDADPRFEVAAPSQLSTVVFRYRPSGLAPDLVDEANLHARDAL
                     AASGAALVAGTKVDGAHHLKLTLLNPETTVDDVAHVLDLIADHAAWYARTAAAAELSCP
                     V"
     PFAM_domain     complement(8933..9955)
                     /aSDomain="Pyridoxal_deC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00282.21"
                     /description="Pyridoxal-dependent decarboxylase conserved
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2593_0447"
                     /evalue="1.50E-63"
                     /label="ctg1_2593"
                     /locus_tag="ctg1_2593"
                     /protein_end="438"
                     /protein_start="97"
                     /score="214.9"
                     /tool="antismash"
                     /translation="YFHHPRYLAHLNCPVVIPALLGEAVLSAVNSSLDTWDQSAGATLM
                     ERRLIEWTAGRIGLGATADGVFTSGGTQSNLQAMLLAREEAYRTVVGGGATGRPDRPEV
                     LSRLRILTSAAGHFSVQKAAKLLGLAADAVLTVPTDATRRMRTDELARTIDSCHRDGQV
                     VMAVVATAGTTDFGTVDPLPEIADICAAAGVWLHVDAAYGCGLLVSPTRRHLLDGIERA
                     ASVTVDYHKSFFQPVSSSALLVRDGRVLRHATWHADYLNPVRAVEQGLPNQVDKSIQTT
                     RRFDACKLWLTLRIMGPDAIGTLFDQVVDLAAQAWRRLDADPRFEVAAPSQLSTVVFRY
                     R"
ORIGIN
        1 gcttgacagc gtgatcgttg attaggttag cctaacctcc gtgacgagca gaacggtgcg
       61 agccgacggc ttgagcggca gcgacctgcg gctgggctac cacggcacga cggtggtgca
      121 cgacgccgcc atcacgctgc ggcccgcggc ggtgaccgcg ttggtcggcc cgaacggcag
      181 cggcaagtcg acgctgctgc gcgggctggc ccgcctgcac ccgctggaac acggcgagat
      241 cgtgctggcc gacggcacgc cggcccgggc gctgtccgcc cgggacttcg cccgccgggt
      301 cacgctgctc gcgcagagcc gccccacccc cagcggggtg acggtgcggg acgtggtcgg
      361 gtacggccgg cacccgtacc ggcagcggtg gcgcgcgaac gacctcgacg gaccggccgc
      421 gatcgaccgg gccatgcggg tgacgggcgt cgacggcatg gccggccggc cggtcgacga
      481 gctgtccggc ggcgagctgc aacgggtctg gctggccacg tgcctggccc aggacaccgc
      541 gatcctgctg ctggacgagc cgaccacgtt cctggacctg cgctaccagg tggagatcct
      601 cgacctgatg cgcgaactcg ccgacaccgc cggcgtcgcc gtcggtgtgg tgctgcacga
      661 cctcaaccag gccgccgccg tcgccgacca ggtggtgctc ctgcacgaag gccgggtccg
      721 cggcgccggc acgccgcacg aggtgttcac cgaggaggcg ctcaccgagg cgtacggcat
      781 ccgcgtcgag gtgagcgtcg acccggtcac caacctgctc tccactcgtc ccgtcggccg
      841 gcacacgacc cgcgtctccg cctgaccgac tcctgcacac agaagagaaa ccgatgctgc
      901 gtacccgtct gaccctgctc gtcgccgccg cggcgagcgc gctgctgatc gccggctgcg
      961 gcaccaccga ggagcccgcc gccgcaccgt ccccctccga cgccgcgtcc accggcccgg
     1021 tcaccgtcac cgacagccgg ggcaagacca tcaccctcaa gagccccgcc accaaggtcg
     1081 tcggcctgga gtggggcgag gtggagatgc tcgtcggcct cggcgtgatg ccggtcggcg
     1141 tggccgaccc gaaggggtac gccacctggg tgaccgccgc cccgctcgac gcgagcgtca
     1201 aggacgtcgg cacccggggt gagccgagcg tcgactccat cgtcgccctc cagccggacc
     1261 tcgtggtgat ggaggccgag cgcggctccg ccgtcgtcac ccagctggag aagtacgtcc
     1321 cggtgctggt caccaagggc agcgacgcct ccgacaacat cggccggatg cgcgcggacc
     1381 tgaagatgat cgccaccgcg accggccgta ccgcgcaggc ggacaagctg ctcgccgact
     1441 tcgacgccgc gctcgccgac ggcaagaaga agatcgccga cgccggggcg gccggtaagc
     1501 agttcgccat cgccgacggc tggaaggagg gcagcaccgt ctcgatccgg atgttcggcc
     1561 agggcgcgct cgtctcccag ctcggcatcc agctcggcct caagaacgcc tggaccggca
     1621 agaccgacga gatgtggggc ctgggccaga ccgacgtcga gggcatgacc gtcctcaagg
     1681 gccaggacgt gcacttcttc tacaacgcct cggacggcac cgacgtgttc gccgacggcc
     1741 tcgccggcaa cgcgatctgg cgttccctgc cgttcgtcca gcagaacaag ctgcacaaga
     1801 tgcccaacgg catctggacc ttcggcggca cgctgtccgc caagcagtac atcgacgagc
     1861 tggtcaaggt ctacacggct tgagcgcgat gaccgccccc gccccgccgg ggccggccac
     1921 ccggccggcc ccggtcgggc cgccgcccgc ccggcgcagc cgggtggccg gcgcgttcgc
     1981 cctcgccgcc gcgctgctcg tcgcgatcac cgcggtgcac ctcacccagg gcacctcctc
     2041 ggtgggggcg ctggacctgc tccggctgct caccggcggc gacgacgaga ccgcccgggt
     2101 gctcgtcgcc tcccgcctgc cccggctgct caccggcctg gccgtcggcg tcgcgctcgg
     2161 cttcgccggc gcggcgttgc agtcgaccac ccgcaacccg ctcgcctcgc cggacacgct
     2221 cgccgtcaac gcgggcgccc acctggcgat cgtctccacc gccgcgttcg ggatcgcgct
     2281 gcccgcgctg cccgcgggcg ggctggcgtt ctgcggcggc ctcgccgccg cctccctggt
     2341 catgctgctc tcggccggcg gtcaggccgc caccacccgg ctcatcctcg ccggctcggc
     2401 caccgcgatg gcgctctcct cgctgaccat gctgctcatg ctgctgttcg agcaggccac
     2461 catcggcctg ttcgcctggg gcaacggctc gctcgtgcag ggcgacctgg tcgcgttcac
     2521 ccagctcgcc cccgtgatcg gggtcgccgc gctggtgctc gtggccctcg ggcaccggct
     2581 ggacctgctg gccctcggcg acgacaccgc caccgtgctc gggctcaacg tgcgccgtac
     2641 ccggctgact gtcgtgctgc tggccgtgct gctctccgcc gcggcggtca ccctggccgg
     2701 cccgatcggc ttcgtcggcc tcggcgcgcc ggtgatcgtc cggctgctcg gccggtgggt
     2761 gcccgaggtg caccggcacc gcatcctgat gccgctgtcc ggcatcgtcg gcgtggtcat
     2821 cgtgctcggc tccgacgtgc tgctgcgcgc cgtgctcggc gggcaggccg gagtcgacgt
     2881 gccgaccggc gtggtgacca cgctcttcgg cgcggtgctg ctggtctggc tggcccgccg
     2941 ccaccgcgac gccggaccga cccggcaggc gccgggcggc cacgccgcag tccgctcccg
     3001 cggcttcgtc gccaccgtcg tcgcggtctg cgcggtcgtc gtcaccgccg cgctggtgct
     3061 cggcatgctc gccggtgaca cgtgggtgct gctcggggac atcgtcaact gggtgcaggg
     3121 ccgcaccgga ccggcgtaca cattcgtgct ggacgcccgc tggccgcggg tcgccgcggc
     3181 gctgctggcc ggcgccgcgc tggccctggc cggcaccacc gtgcaggcgg tgtgccggaa
     3241 cccgctggcc gaaccgggca tcctcggcat caccggcggt gccggcatcg gcgcggtgtc
     3301 gctgctgacg ttcgcgccga tggccggcgt gctcgccctg tccggcgccg ccggtctcgg
     3361 cgcggtcgtc gcgttcgcgc tggtctacgg cctggcccgg cggcgggggc tcaactccga
     3421 ccggctggtg ctgatcgggt tcgcggtctg gcagggcggt acggcgatca tcacgttcat
     3481 cgtggtgtcg tccgacccgt ggaacaccgg caaggcgctg acctggctgt ccggctccac
     3541 ctacgggcgt accgcaccgc aggtgctgcc ggtggcgatc gcgctgctga tcgcgctgcc
     3601 ggtggtcgcc gccgtgcgcc gcgagctgga cctgctcgcg ctcgacgacg acacgccccg
     3661 ggtgctcggc gtccggctgg aacgtgcccg gctggtcgcg ctcggcctgg cggcgctgct
     3721 caccgcgacc gccgtgtcgg cggtcggcgt gatcggcttc gtcggcctgg tcgcgccgca
     3781 cgcggcccgg gcgctcgtcg gcgggcggca cacccgcgtc ctgccggtcg cggtgctgct
     3841 cggcgccacc ctggtcagcc tcgccgacac gctcggccgc agcgtcatcg ctcccgccca
     3901 ggtccccgcc ggtctggtca ccgccatgat cggcaccccg tacttcgtct ggttgctgtg
     3961 gcgttcccgc gccgcggcag ccgcccgtta gcccgttcac cgacgcagcc cccaccggcc
     4021 gtgagaggaa tgacgcatga ccagcaccct ggccgtcgcg ccctggcgag tcttcaccgt
     4081 cgaggtccgc gcgctacgcc ggctcggccc gtccttcctg cgggtgacgc tcaccggccc
     4141 ggacctggac cggttcgccg acaacgggta cgaccagcgg atcaagctgg ccctgccgcc
     4201 ggtcgacggc gcgccggggg agctgcccga cgggccggac tggttcccgc ggtggcgtga
     4261 gctgccggac gcgctgcgca gcccgatccg cacgtacacg gtccgcgccg tccggccgga
     4321 ggcgtacgag gtggacgtgg acatggcgct gcacggcgac ggcggcccgg ccacccggtg
     4381 ggcccggcgg gcgcgtctcg gcgaccggat cgccgtcgtc ggcccggacg ccgggtggga
     4441 cggcccgcac ggcggggtcg agttccagcc gccggccggc gcgacgctgc tgctggccgg
     4501 cgacgagacc gccgcgccgg cgatctgcgc gatcctggag cggttgcccg ccgaggcgcg
     4561 cgggcacgcg ctggtggagg tgccggagac cggcgacgag ctgccctgcc gggcgccggc
     4621 cggcgtcacc gtgacctggc tgccccgcga cggcgccccg cacggcagcc ggctcacccc
     4681 ggccgtgaca ggtctggccg ggcggctggt gccggtaccg gtcgcggtgg ccgccgcgcc
     4741 gctgaccgag gtggacgtgg accgggacat cctctgggag gtgccggagc ggcccgacgg
     4801 cgcggcgctc tacgcctggc tggccgggga ggcggcggtg atccgcggcc tgcgccggca
     4861 cctggtcacc gagcggggca tggaccggcg cgcggtggcg ttcatgggct actggcgggc
     4921 cggtcgcgcg gagaactgat cgtccccacc accgacggaa gcgggccggc gcgatgcgcc
     4981 ggcccgcttc cgtcatgcca tcagtcgcgc ggtgcgtacg gggcgagcgg gttgaccagc
     5041 gtgccggcga actgcaacgc ggcggacggg tcggacaggt ccaccatctg ctggttgttg
     5101 cgcagctgga gccggttgag gcaggacagc gtgaactccg gcgcgaacag gtcgtgccgg
     5161 cgcatccggt cggccaggtg cggcaccgtg gcggcgtagt cggcggcgca tgcggcgacg
     5221 gtgcgccaga actcgtcctg gtcgaggacg ccccgggtgt gcagggcggc gctcaggtgc
     5281 cgcaggaagc agtcgaacac gtcggtgaag atggacagga tcttctcgtc ctcggggatc
     5341 gcggcccgga tccgccgcac ccgctccggc aggtccgcct ccgggttcat caccacgatc
     5401 tcctcggcga tgtccttgaa gacgacccgc tcgaccacgc cgtcgtgcag caccaggatg
     5461 acgttctcgc cgtgcggcat gaacgccagg tcgtgggcgt acaggctgtg cagcagcggc
     5521 accaggtagg cgtccaggta gcggcgcagc cagtcggccg gcgccagccc cgactcgtcg
     5581 atcagcgcgg ccgcgagcga ccgcccgtcc cggtccaggt gcagcagaga ggccatggtg
     5641 gccagccgcc gcccgggttc cagccctggt accgggctct cccgccagag cgccgccagc
     5701 atcttccggt acggggagta cctgtcggtc gccgcctcgt actgccggtg ccggtaaccg
     5761 atggcggccc gctcccggat gatcgacagt ccggtgcgct tgagcaccgg gtcgccctcg
     5821 atcagcccgg ccagccagtc gttgatcgcg ggcgtcgcct ccatgtacgc ggcggacaac
     5881 ccgcgcatga agcccatgtt cagcaccgac agcgcggtct tcacgtagtg cttggcgggg
     5941 tcggtgacgt tgaagaaggt acggatggac tgctgcgcca ggtactcgtc cggcccctcg
     6001 ccgaggcaga ccagccggcg cgcggccacc tcaccggcga acgtgacggc gagcttgttc
     6061 caccactgcc acgggtgcac cgggacgaac aggtagtcgg ccgggtccag gcccagcccg
     6121 gtgagcgtgg cggtgaaccc ggcaatcgtc tgctcgccca gctcggcccg gaccagcgtg
     6181 tcgtagtcca ggtcgtcggc gcaggtgaac gtggtgtggt cgcggtgcgc ggcgagccag
     6241 agcagccgta ccggcgcggc ggcctccggg gcgtacgcgt ggtattcgtg cactccgaag
     6301 ccgatgcggc cgttgttggc cacgaagcag ggatgcccct cggtcatgcc ggtctcgatc
     6361 gcctggaacc cggcggcggc cagctcggcg gcgctcagtg tgggcttcgc gagcttgtac
     6421 gcggtcccgg ccagcgtgga ggtgatctcc tccaggtaga ccggcaggat cgcgtcggtg
     6481 aggccgagcg cgctgcgcag ctccacgcac aggtccacgg cgtcgggcgg cagctccgcg
     6541 ccgtcgcggc ggcgcacgat gctgcccgcg tcgacctccc agtggtccag cgccagccgc
     6601 tgcgcggcga accggtactc gacgctgccg tcgtcgctgc ggaccagcca ccgtcccggg
     6661 ccgtcgggct cgggggtgat caggcgctcg tgggcgaact cggcgagcgc cttgcgcacc
     6721 agcagccggt tggccgtcgc ccacgcctcg ggggtcaggt ggtccacgga tgcgctggcg
     6781 ttcacgccgg tgccccttcc tcgcctgtgg gcacgccggt ggcgacccgg aactggtccc
     6841 gggtgcagac gctgagcagc gcctccttct cgggcttgcg gatcgggccg acgactgtga
     6901 agccgactgc cgcgttgagc gcgtgcacgg cggtgttgcg cacgtccggc tccaccacca
     6961 cccggcgcgt cgccgggtcg gcgaacagcc aggccatcac cgtggtgatg acggcacggg
     7021 tgaagccgtg caccggcgtg tcggcgggtg cgcagaggaa gtgcatgccc acgtcgccgg
     7081 gctccgggtc gtacaggccg accagctcca cccgggccgg gtcgtaccgc tcggccagga
     7141 acgccggagc gccgcgccac gaacccaggt acgcgtcgtg gtgcggatgg tcggcgatgc
     7201 gccggtactc ggcggcgacc gcgtccacgt cggcgtcctg catgagccag aacgcggact
     7261 tgggatgggt gacccagcgg tgcagcagcg cggcgtcggc gtccgggtcc agcgggcgca
     7321 gcgtgaactc gcccagcgcg tcgtcgacgc gggtgaacgc ggtcatgcgg gcgctcatgc
     7381 cggcactccg gccggcgcgc cgaactcctg gaaggcgatg gtcttctcca ccgggtagtg
     7441 ctcccggccg gtcatctccc ggatcagcca cgagttgcgg tacggaccca tgcccaggtc
     7501 gggcgaggtg atgctgtgcg tgtgggtgcc gccgttctgg aggaacacgc cccggccggt
     7561 gtggtcgatg ctgtagttgc gggccacgtc gaagcggccg tgcgcgtcga agcggagccg
     7621 gtcgcgtacc ggcgcgagga actccggcac ccggtagtgg tagccggtgg ccagcaccag
     7681 tccttccgtg tcgagggtga acgcgcggtc ctgctcggtg tggcgcagcc cgagccggta
     7741 gcggccgtcg gtgtacgccg cctcgaccag ctcggtgttg gtcagcaggc gcgtcggcgc
     7801 cggtccgtgc aggctcttgg cgtacagcag gtcgtagatg tcgttgatca ggtcggcgtt
     7861 gatgcccttg aacagcggct tctgcgcggc ctccagcgcg tagcgggtcg gctcgggcag
     7921 cgcgtggaag tagtccacgt agtccggcga ggtcatctcc aacgtgagct tggtgtactc
     7981 cagcgggaag aaccggggcg agcgggtcac ccaggtgagc tggtagccgt acgtgtcgat
     8041 gtcgcagagc aggtcgtggt agatctccgc ggcgctctgg ccgctgccga cgaccgtgat
     8101 gctgtccttg gcccgcagcg cctcccggtg ctccaggtag cgcgagttgt ggatcatgtc
     8161 gccgcccagg ccggcgcagg cgggcggcag gtacggcggc gtgccggtgc cgagcacgag
     8221 gtgccgggcc cggtgggtga ccggcccgtc cggcgtgtcc gcgtgcacca cgtaccggtc
     8281 gtcgctctcg tcgtactcga cagcggtgac gctgtgccgg aagcgcaggt tcggcagctt
     8341 cccggcggcc cagcggcagt agtcgttgta ctcggcgcgc agtgggaaga agctctcccg
     8401 gatgtagaac gggtagagcc gtccggtctc cttgaggtag ctcaggaacg agtacggcga
     8461 ggtcgggtcc gcgagcgtga ccaggtcggc gatgaacggc gtctggagcc gggtggattc
     8521 gagcagcatg ccgggatgcc agtcgaagct gtcgcgggcc tccaggaaca ggccgtcgag
     8581 gtcgtcgatc ggcgcggtga ggcaggccag gccgaggttg taggggccca gcccgacggc
     8641 gatgaagtcg tgggtcgaca tggggattct cgttctcctc gacggggggt cagaccgggc
     8701 aggacagctc ggcggcggcc gcggtccggg cgtaccaggc ggcgtggtcg gcgatgaggt
     8761 ccagcacgtg ggcgacgtcg tccactgtgg tctcggggtt gagcagggtg agcttcaagt
     8821 ggtgggcgcc gtcgaccttg gtgccggcga ccagggccgc gccggaggcg gcgagcgcgt
     8881 cgcgggcgtg caggtttgcc tcgtcgacca gatcgggggc gagaccggac ggccggtacc
     8941 ggaagaccac tgtgctcagc tgcgacggcg cggccacctc gaagcgcggg tcggcgtcca
     9001 gccgccgcca cgcctgcgcc gcgaggtcga cgacctggtc gaacagcgtg ccgatcgcgt
     9061 ccggtcccat gatccgcagg gtcagccaga gcttgcacgc gtcgaaccgg cgggtggtct
     9121 ggatgctctt gtcgacctgg ttcgggagcc cctgctcgac cgcgcggacc gggttgaggt
     9181 agtcggcgtg ccaggtggcg tgacgcagca cccggccgtc gcggaccagc agcgcgctgg
     9241 agctgaccgg ctggaagaac gacttgtggt agtccactgt caccgacgcg gcccgttcga
     9301 tgccgtcgag caggtgccgg cgggtgggtg agaccagcag gccgcagccg tacgcggcgt
     9361 cgacatgcag ccagaccccc gcggcggcgc agatgtcggc gatctccggc agcgggtcga
     9421 cggtgccgaa gtcggtggtg ccggcggtgg cgacgacggc catcaccacc tgaccgtcgc
     9481 ggtggcagct gtcgatcgtg cgggccagct cgtcggtgcg catccggcgg gtggcgtcgg
     9541 tgggcacggt gagcaccgcg tcggcggcca ggccgagcag cttggcggcc ttttgcacgc
     9601 tgaagtgccc ggccgcggag gtgaggatgc gtagcctgga cagcacctcc ggccggtccg
     9661 gccggccggt cgcgccgccg cccaccacag tgcggtacgc ctcctcgcgc gccagcagca
     9721 tcgcctggag gttcgactgg gtgccgccgc tggtgaagac cccgtcggcg gtggcgccga
     9781 gcccgatgcg cccggcggtc cactcgatca ggcgccgctc catcagcgtc gcaccggcgc
     9841 tctggtccca ggtgtccagt gaggagttga cggcgctgag caccgcctcg ccgagcagcg
     9901 ccgggatgac caccgggcag ttcaggtggg ccaggtagcg cgggtggtgg aagtagaccg
     9961 cgtcacgcag ccacacgtcg tgcagctcgt ccagggcggc gtcggtgtcg ccgagcggcc
    10021 ggtccaggtc gatggcaccg atgagcggcg ccagctcgtc gggcgtgacg ccggtgaacg
    10081 gccggtccgc ctcgcccacc cggcgggcga cccggtcgac gccgcgcgcc agcacgtccc
    10141 ggtaccgacc gagcgagccg gcgttgaaca ggtggccgcg tgccgtggcg gcggcgctgc
    10201 cggtgtcggc gggcgcggcg ccggtcgggc tcccgatcga actcatgcga cttcccagcg
    10261 gtcgtacgga caggacgcgc ggcgatcagc cgcggcgatc aggttaggtt aggctggcct
    10321 aactggcaag cacgactcgg ggtgctttgt cccgcatgta ccgccggttg gcgccccgcc
    10381 cgcgtcgcgg taaggtcgcc ctcggttagg ggaggttatc ctaagttgac tgtcgaacgg
    10441 aaccgtcgcc cggcgcgccg aggcggcgcg agacgatgac acacgtcgat cgcgatcagt
    10501 ggggcgtgcc ccagttgtgg gccggcgacg tcgacgcgct ggcgcgtctg caggggcgtg
    10561 tcgccgctgt cgatcgggcc tggcagatca gtgccgaacg ttggcgcgcc gagggtcgcc
    10621 tggccgccca cgtcggcccg gccgagctgg cgtgggaccg gttcgcccgc cgcgtacggc
    10681 tggacgacac cgcccggcgc tgctacgagc ggctggaccc tgacacccgg cggtgggtcg
    10741 aggcgtacgt cgacggggtc aactccggac tcgccgaggg cgccgccgcc gcgccggagt
    10801 tcgccgccac cggcaccgcg cccgaaccgt ggcacccctg gtcgccgctc ggcgtgttcc
    10861 tcgtccagca cgtgctgttc tccacgttcc cgaacaagct ctggcacgcg cacgtggccc
    10921 ggacgctcgg ccccgaggcg gccggactgt tcgcggtcga gggaccggcc tcgtccggca
    10981 gcaacgcctg ggcggtgccc gccgacccgg ccaccgggcg cggcccgctg atcgccggtg
    11041 acccgcaccg gctgctcgaa ctccccggcg tctaccagca ggtccggctg gcctgcccgg
    11101 agttcgacgt ggtcggtctg gccttccccg gcgtgccggg cgtgccgcac ttcggccaca
    11161 ccggccacgt ggcctgggcc gtcaccaacg cgatggccga ctaccaggac ctctaccgcg
    11221 aacggctgcg ccgcgacggt gaccgcgtgc tggtgcgcga cgccgacggc tggacgcccg
    11281 ccgcgcgcca cgtcgaggag atcgaggttc gcggcggcgc tccggagacg gtcgaggtga
    11341 tcgagacgcc ccgcgggccg gtgatcgacc acgaccgggt caccggcgag gcgatcgccc
    11401 tgcgcacccc gagccgggtc gaggcccggc tcggcttcga ggcgttgctg ccgctgctgc
    11461 gtgcccggcg tacgggcgac gtcgccgaag cgctgcgcca ctgggtcgag ccggtcaaca
    11521 gcgtgctcgc cgccgacacc gggggaggcg tccgccgcct ggtcgcgggc ctggtcccgg
    11581 tacgcgacga acgctgccgc cgggaacccg tgccggcctg ggagccggcc taccggtggc
    11641 ggggcgacta cctgccgctg gtcgacgagc cggtggacgg cgtggcggtg tgcgccaacg
    11701 accggcgcga cgacgtcgca gcgcacggtg ccgacttcgc cccgccgcac cgggcccgcc
    11761 ggatccgggc gctgctcgcc gacgg
//
