LOCUS       NZ_CP039266.1          10225 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP039266.1 Lactobacillus crispatus strain DC21.1 chromosome,
            complete genome.
ACCESSION   NZ_CP039266
VERSION     NZ_CP039266.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:16:26
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1811068
            Orig. end    :: 1821293
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10225
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1816068:1816293](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5225)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10225
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10225
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(674..901)
                     /locus_tag="ctg1_1736"
                     /transl_table=11
                     /translation="MKNTVISIIMIIVIVITLCWLVTIPQVMRNKTSDGYQLRFIRKST
                     KVYPHFWQAYWRQLLLNILDVLAFFGDNYS"
     CDS             complement(1051..1152)
                     /locus_tag="ctg1_1737"
                     /transl_table=11
                     /translation="MLEKAKKQFTGAVIFSVIALIVAIFSITGNGTT"
     CDS             complement(1171..1593)
                     /locus_tag="ctg1_1738"
                     /transl_table=11
                     /translation="MNNEKFARENKRIIEGMGIGALVGPILALVMMYVKTAGSPQPFQI
                     IMSMGAGLAFGLMIGGIMSASLVLNKTVTSKIPWQKKVLKLAPQVIGTGVVVAAASVVI
                     TLVTNWGSVDIVKTIFSTDTLWQFFDGVLLGLITIR"
     CDS             complement(1627..1821)
                     /locus_tag="ctg1_1739"
                     /transl_table=11
                     /translation="MLYLIYIVLGLLIVLAVNYAVTAFLAVHDLLENREKDQLSFTDAF
                     KKYFAKNNNIPTKFSDLFN"
     CDS             complement(1954..2163)
                     /locus_tag="ctg1_1740"
                     /transl_table=11
                     /translation="MIEVTLDFMLLKRKMSSKELAEKVGITPANLSILKTGKAHGVRFD
                     TLSKICEVLDCQPGDLLVYKKDEE"
     PFAM_domain     complement(1963..2148)
                     /aSDomain="HTH_26"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13443.8"
                     /description="Cro/C1-type HTH DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1740_0001"
                     /evalue="1.40E-21"
                     /label="ctg1_1740"
                     /locus_tag="ctg1_1740"
                     /protein_end="67"
                     /protein_start="5"
                     /score="76.8"
                     /tool="antismash"
                     /translation="LDFMLLKRKMSSKELAEKVGITPANLSILKTGKAHGVRFDTLSKI
                     CEVLDCQPGDLLVYKKD"
     CDS             complement(2178..2717)
                     /locus_tag="ctg1_1741"
                     /transl_table=11
                     /translation="MKKFILNLLTVFAWIYQIICVIGIIMWIVMGGVILFGIKNPDFRA
                     GFESSMYVKGVSVDSYVGVLIVMLLLMILMSIAAFLICRYARLIVKNIKQEVYFADSNL
                     NLLKKLLISVAGYTIISIIDFIMLMTHRAWFIKYANNVLYPSGVTTGLLFLAVLYVVYL
                     VFKYGMKVQEDADSII"
     CDS             complement(3566..4600)
                     /locus_tag="ctg1_1742"
                     /transl_table=11
                     /translation="MTNSNSSISKHYHQLNSEQRGQIQALLDSGITSCTAIAQEVGCHK
                     STISREIRRGSVLQRDSSYVLYEHYYADTAQIYHEKRRRNCYKRNPLQHYAVFFRMLSR
                     RFKAKFDATSIDEFVGEFHRIMPNYPCPSTPTVYRYIDQGLLDISNIDLPMKLKRRRNK
                     RHHSHGGHAPHKKNLGNSIEQRPKEVENRKVPLHWEGDLVKSVRRKNQPALMTLTERTT
                     RFEVVIKIPDYRASTCQRLLQKEIDRHPNWFKSITFDNGSEFVDMTKIKGCQIYFAHPY
                     SPWERGTNENCNGLLRQFFPKGKSMKDKSAAYVQQATDAINRKHRRILQYHTAEELFKQ
                     YVPS"
     PFAM_domain     complement(4436..4570)
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1742_0002"
                     /evalue="2.10E-12"
                     /label="ctg1_1742"
                     /locus_tag="ctg1_1742"
                     /protein_end="55"
                     /protein_start="10"
                     /score="46.7"
                     /tool="antismash"
                     /translation="HYHQLNSEQRGQIQALLDSGITSCTAIAQEVGCHKSTISREIRRG
                     "
     CDS             complement(4758..4997)
                     /locus_tag="ctg1_1743"
                     /transl_table=11
                     /translation="MNAIILIAVTLIISIVLIALVKTIKNKSNGQYTYRHHVMKIEDNK
                     RKLCTETVRVESFTTAFLLNIIDVVTYAFILLWP"
     CDS             complement(5001..5225)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1744"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 9.3e-12,
                     bitscore: 42.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVEVLNEEELTTVVGGTHSKGFHPSKGMKCLSGLTTGFGIGLM
                     RGSAFGAAWGLAKASVLYCGLGPRPQKVY"
     PFAM_domain     complement(5061..5225)
                     /aSDomain="Bacteriocin_IIc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10439.11"
                     /description="Bacteriocin class II with double-glycine
                     leader peptide"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1744_0003"
                     /evalue="2.20E-06"
                     /label="ctg1_1744"
                     /locus_tag="ctg1_1744"
                     /protein_end="55"
                     /protein_start="0"
                     /score="27.7"
                     /tool="antismash"
                     /translation="MSKVEVLNEEELTTVVGGTHSKGFHPSKGMKCLSGLTTGFGIGLM
                     RGSAFGAAWG"
     CDS             complement(5477..5710)
                     /locus_tag="ctg1_1745"
                     /transl_table=11
                     /translation="MRGKIMKTIIFLIIGILLIIGGIWTFISAKHWLHNIQKKGTDNGF
                     ILMEIGSGFIFSILILGLGISYFSQAIIAWIK"
     CDS             complement(5746..5949)
                     /locus_tag="ctg1_1746"
                     /transl_table=11
                     /translation="MILSIKKKTNFESDSLGVFLPLVMASAYVTNNNSIGYSNLATIAV
                     GIFIPVYFLGKAFNLYHRKNKK"
     CDS             complement(6021..6425)
                     /locus_tag="ctg1_1747"
                     /transl_table=11
                     /translation="MTKKQIMIRSIIAGCLYLVLDIALSVVLKEPVTTIYVLETIFESI
                     LFAVFMIWLLKTNKDSKKINSNGSFLKYFSIGMIGSWIILTIMLFLQVGNRISKVMVDN
                     TALLIGIYLVVGIICGLALYFVFRIACRRQ"
     CDS             complement(6599..6811)
                     /locus_tag="ctg1_1748"
                     /transl_table=11
                     /translation="MYHLIYLVIGILLIIGGVFTFRHTQGYLKLNTTSKAVQNNQWRGF
                     ALWFGYIGAGILTLIGVIMILVSLF"
     CDS             complement(6835..7644)
                     /locus_tag="ctg1_1749"
                     /transl_table=11
                     /translation="MKIMANYPIIVCDDDHDLANQLATNINSSIQNLSDDNSSYSELKE
                     RVTFVANDFAQAVGYIVANDIKNGIYFLDIELSQQSEAKNGVDLAEFIKKQDENAQIIF
                     VTAYEKYAPLTYRRRIGAIDYISKNLSSDEIIQRLEETLRGAIDNLTNMIKYGNRNFKY
                     KIGRNVFKVSENEVIYIENSTMQHKVHMVTDHGDVEFKGNISQVAKDADFLVKVSQSTL
                     INPNNIQAIDTHNKLIIFDENNAITYSRSYRKVIKQLMTKFEAIDVI"
     PFAM_domain     complement(6865..7140)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1749_0005"
                     /evalue="9.90E-14"
                     /label="ctg1_1749"
                     /locus_tag="ctg1_1749"
                     /protein_end="260"
                     /protein_start="168"
                     /score="51.5"
                     /tool="antismash"
                     /translation="VFKVSENEVIYIENSTMQHKVHMVTDHGDVEFKGNISQVAKDADF
                     LVKVSQSTLINPNNIQAIDTHNKLIIFDENNAITYSRSYRKVIKQLM"
     PFAM_domain     complement(7228..7620)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1749_0004"
                     /evalue="2.30E-10"
                     /label="ctg1_1749"
                     /locus_tag="ctg1_1749"
                     /protein_end="139"
                     /protein_start="8"
                     /score="40.7"
                     /tool="antismash"
                     /translation="IIVCDDDHDLANQLATNINSSIQNLSDDNSSYSELKERVTFVAND
                     FAQAVGYIVANDIKNGIYFLDIELSQQSEAKNGVDLAEFIKKQDENAQIIFVTAYEKYA
                     PLTYRRRIGAIDYISKNLSSDEIIQRL"
     CDS             complement(7628..8971)
                     /locus_tag="ctg1_1750"
                     /transl_table=11
                     /translation="VFLLALCLNIFYILVDIWSFFRISGIKIKVDFYFYLFLLLIFVVG
                     VIDFIWNISFISDALEMILFYLFFKKYGDIELILGSGIIVGILDLIFSIITTIIMKVTM
                     LNSNLNVELAFGLITLILMVFFVKRFGNKFKIYLSNQNKNIFLGVLIYLYVSSAGVSFL
                     YLLDKRITPFTLFFTIFVIVQSVFAIGVYGEMVYVQNKLLTQRKQQEIRQKQRQLEEYA
                     DYLEKSEDDLRAFRHDYKNILNSLKVSAQEGNVQEVIQKLDKYTETNLNSDALLKYKDV
                     NHIHIKSIKSIIISKLTEMYNLNIPYNFECRSGVKKLPANIDELDLVRILGIAFDNAIE
                     ESKIIKDMAEKNKSPEYEEIQIMAYSDGPDNFEFEIRNRVRKDQKISTSKIQEQGFTTK
                     KGHQGYGLANIRKLEEKNPDMSVSYMVQDGWFDFYMVIDMEDGDEDNG"
     PFAM_domain     complement(7661..8005)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1750_0006"
                     /evalue="7.10E-12"
                     /label="ctg1_1750"
                     /locus_tag="ctg1_1750"
                     /protein_end="437"
                     /protein_start="322"
                     /score="45.2"
                     /tool="antismash"
                     /translation="DELDLVRILGIAFDNAIEESKIIKDMAEKNKSPEYEEIQIMAYSD
                     GPDNFEFEIRNRVRKDQKISTSKIQEQGFTTKKGHQGYGLANIRKLEEKNPDMSVSYMV
                     QDGWFDFYMVI"
     CDS             complement(8978..9112)
                     /locus_tag="ctg1_1751"
                     /transl_table=11
                     /translation="MEKKVVKKIELKEEELSKVVGGTTAFFDIKKFTHKNFTFGWWKK"
ORIGIN
        1 actgggccat tcaagacgat atgcccatca ttgatcatta cgacgtcatc gcacaattct
       61 tccacgttac gcatatcatg atcagaaaaa atgattgtag cgccttttct tttttcttcc
      121 aaaatcagct gcttcagtag atcgacatta acaggatcta gtccactgaa tggttcatct
      181 aaaataatca atttaggttg atgaattaaa gtcgcaatca tctgtacttt ttgttggtta
      241 cctttagaca aagacttaat cttatccatg gggatccctt taacagccaa acgtgataac
      301 caatcaggta attcttcttt taccttttta gccggcatac ctttaaggct agctaaaaac
      361 actacctgat cttcaatggt taacttaggc atcaaacttc gctcttcagg cagatagcca
      421 atattgtcat aatctttagc gttgaaagaa tgtccatcaa tactaatctg accgtcataa
      481 tcaacgaatt tcaaaatact atgaaagatc gtcgacttac ccgacccatt tttaccaacc
      541 agtccaagaa tacgcccatc tgacacattg aagctaacat caaacaaaac ctgtgttgac
      601 ccgaagcttt tatttaggtg ttctattttt aacataattt ttcctcaact tttctatgtt
      661 attgatcgaa tatctaagaa taattatcgc caaagaatgc aagcacatcc aaaatattca
      721 gcaacaattg acgccaatat gcttgccaaa aatgaggata taccttagta gatttcctaa
      781 taaatcttag ttgataacca tctgatgttt tgttccgcat tacctgggga atagtaacta
      841 accaacatag tgtaattact ataacaatta tcataattat agaaataact gtatttttca
      901 tggcattcat tcctttttaa cttctgctat gggaattatg tggtacatat actaataatt
      961 gtcgctatca ttttctgctt taagcttaaa atatccgata cttatatagc ctacccagat
     1021 caacaagata acaataacgg tacataattt tcaagttgta ccattaccag taatactaaa
     1081 aattgcgaca attagtgcaa taacagagaa aatcacagca ccagtgaatt gttttttagc
     1141 tttttctaac atgatctatc cctcaacttt ttatctaatg gttattagac ctagaagtac
     1201 accgtcaaag aactgccata aagtatcggt tgaaaaaatt gtttttacaa tatcaactga
     1261 cccccaattg gttactaaag taatcactac actagctgca gcaaccacta ctcctgtacc
     1321 aataacttga ggagcaagtt tcaacacttt cttctgccat ggaatctttg atgtgaccgt
     1381 tttattaagg actaaacttg cggacataat gccaccaatc attagaccga aagccaatcc
     1441 agctcccatc gacataataa tttgaaaagg ttgaggcgaa ccagcggtct taacatacat
     1501 catcacaaga gctaatattg gtccaacaag tgctccaatt cccatacctt caataattcg
     1561 tttgttttca cgggcaaatt tttcgttatt cattgttctt acctcaagga aatttgtttt
     1621 tcatttttaa ttaaacaaat ccgaaaactt agtcggaatg ttgttgttct tggcgaagta
     1681 ttttttgaat gcatccgtaa agcttaattg atctttttct ctattttcaa gcaaatcatg
     1741 aacagctaag aatgctgtaa cggcataatt aacagctaaa acaatcagta agccgagcac
     1801 aatataaatt aggtacagca tttttctttc ctccaattca gcgattatct cccaggaaat
     1861 aatcttttat ccttttaaat taatcatatc cccatcattt atgtaaaagg taaaaccgtc
     1921 caattctgtc atttttcgga ctgattttgc attttattct tcatcttttt tataaactaa
     1981 taaatcccct ggttgacaat ccaagacttc acagatcttg ctcaacgtat cgaagcgaac
     2041 gccatgcgcc tttcctgtct ttaggattga caggttagcc ggcgtgatgc caaccttctc
     2101 tgccaactcc tttgaagaca tctttcgctt caagagcata aaatctagtg tcacttcaat
     2161 catctatatc aacctttcta aataatcgag tctgcatcct cctgaacctt cattccgtac
     2221 ttgaatacca agtaaactac gtacaatact gctaggaaaa gcaagccggt tgtcacacca
     2281 cttggataaa gtacattatt cgcatattta atgaaccaag cgcggtgagt catgagcata
     2341 atgaaatcta ttattgaaat gatggtatat ccagcaactg aaattagtaa cttcttgagt
     2401 aaattcaaat tactatcagc aaagtaaact tcttgcttga tattcttaac aattaatctg
     2461 gcatatcgac agattaaaaa ggccgcaatg ctcataagga tcattaacag caacataact
     2521 attaatactc caacatagct atcaactgat acgcctttta catacatact actttcaaat
     2581 ccagcacgaa aatctggatt ttttatgcca aataatataa caccgcccat aacgatccac
     2641 ataattattc ctattacaca gattatctgg tagatccaag caaaaactgt caataaattc
     2701 aaaataaact ttttcatttt tttatcctct caaaatctga atgattctgt atatagcact
     2761 gccaactaca cccgttactc caattactaa taatgtaatt ctaagaacac tccacgttcc
     2821 gccaaagtta gcaaacacta agattgtcat tattatcagc attccaacaa ttgagcctac
     2881 ctgtcttttc tggaagcata tctatccctc tcttccatga aactatctat ctctttctta
     2941 ttccttttta taattattgt attacgataa tttataattg caatacagaa ataaaatatt
     3001 tttttaggat aataaaaaat accaggtcag tcattaaacc aacttggtat tatgttttat
     3061 cttccaagct actgcttttt acttttcttc ttatagtaag agttcatgaa aatattcata
     3121 aagataacaa aggctacact ttcaactata ttccaaaata ctgttccaaa gcttaatgtt
     3181 ttgtactgaa aatagtccca tacaaatcct attaacagag ccaaaacacc agcgacaata
     3241 cttctgcttc gaacttgatt cttagttaaa atcttattct tcataatttt taccccatta
     3301 ttatcatatc gaaaaatagg aaatctatta accgaatttt ctatttttta atattatcta
     3361 tgtttatgtt ttttatgtct attttgtttg gcgaaatctt taacagcgcc ttctacatat
     3421 ccttttatca taccacttcc gctagggagc gcgtcaatga aacccgataa acatgatcca
     3481 cctacaccaa gccagttagt gccaccactt actttttcta attctttata attcctgaat
     3541 tgtcaaatta agtgcaacag ttaggctatg aaggaacgta ttgcttgaag agttcctctg
     3601 ctgtgtgata ttggaggatt cgacgatgtt tgcggttaat ggcatcagtt gcctgttgaa
     3661 cataagcagc tgacttatct ttcatgcttt tgcccttagg gaagaattga cgcaaaagtc
     3721 cattgcagtt ctcatttgtg cctctttccc aaggagaata tggatgagca aagtagatct
     3781 gacatccttt gattttggtc atatccacaa actcagaacc attgtcaaac gtaattgatt
     3841 taaaccaatt aggatgtctg tcaatctcct tttgaagcag tctttgacaa gtactggccc
     3901 gatagtcagg aattttgata acaacctcaa aacgagtggt tctttcagtc agcgtcatta
     3961 aggcaggttg atttttacgt ctgacgcttt taaccaaatc gccttcccag tgcaggggaa
     4021 cttttctgtt ttcaacttct ttaggccgct gttcaatcga attgccaaga ttctttttat
     4081 gcggagcatg gccaccatga ctatgatggc gtttgtttct gcgtctttta agcttcattg
     4141 gcaggtcgat attgcttata tccagcaatc cttgatcaat ataacgatag acagtgggcg
     4201 tgctaggaca tggataattt ggcataatcc tgtgaaattc accaacgaat tcatcaatgc
     4261 tggtggcatc aaatttggct ttaaagcgtc tgcttagcat tctgaaaaag acggcatagt
     4321 gttgcagtgg attacgctta tagcagtttc tgcggcgctt ttcatgataa atttgtgcag
     4381 tatcagcgta atagtgctca tacaagacat agctgctgtc tctttgcagg acactgcctc
     4441 gtctaatttc acggctgata gttgatttat gacagcctac ttcttgagcg atagcagtgc
     4501 aggaggttat gccagaatca agcagagctt gaatttgtcc acgttgttcg ctgttcaatt
     4561 gatgataatg cttggaaatg ctagaatttg agttggtcat gaagatcttc ctttcttgat
     4621 ttttggtcac ttcaagttta ggtcttcatg gcctttttgt ttaacaatta gtgttgcact
     4681 tcaattttaa atccgggatt tttttaattt taataaatct gaaatatttc aaaacaacta
     4741 tatatttatc tacgttatta aggccatagt aatataaaag catatgtaac aacatcaatt
     4801 atatttaata gaaaagctgt cgtaaaagat tcaactctca ctgtttctgt gcataatttt
     4861 cttttattat cttctatctt cataacgtga tgtctgtatg tatattgacc attactttta
     4921 ttttttattg tttttaccaa tgcaattaat acgatagaaa tgattaaagt tacagcaatt
     4981 aatattatag cattcatttt ttaatatacc ttttgaggcc gtggacctaa accacaataa
     5041 agaacactcg ctttagctag accccaagct gcaccaaatg cactgcctct catcaaccct
     5101 attccgaatc cagttgttaa tcctgataaa cacttcattc ctttacttgg atggaaccct
     5161 ttactatgcg ttccaccaac tacagtagtc aattcttctt cattcaaaac ttcaacttta
     5221 ctcattttta ttacctccta taatgagtaa tcaagagaaa ttcacctctt atttctttct
     5281 acattattaa agtaccatga atgaattcat ttttgagata catgactgat ttaacgtttt
     5341 ctcagaccaa ttttgcattt gcatccccaa ttcagcactt tttcaactat ctctttttga
     5401 gacgctaaga cttttacatg tgaaatctaa aaaataccga atcgtcattt tttagactga
     5461 ttcggtattt gatatattac ttaatccaag caattatagc ttgagaaaaa taactgatgc
     5521 ctaatcccaa gataaggata ctaaagataa agccactgcc aatttccatt aatataaaac
     5581 cattatccgt accctttttt tgaatattat gtaaccaatg tttagctgaa ataaaagtcc
     5641 agatacctcc aattatcaat agaattccta ttattaggaa aataatcgtc ttcataattt
     5701 tgccccgcat atcttataaa ataattttct ttcaagattt aatcttcatt tcttattttt
     5761 ccgatgataa agattgaatg ctttacctaa gaaataaact ggtataaaaa taccaactgc
     5821 aatggtagca agattagaat aacctattga attattattt gtaacataag ccgaagccat
     5881 taccaatggt aaaaaaactc ctagagaatc actttcaaag ttcgttttct tttttatact
     5941 caaaatcatc cataatataa atcctataaa agatgctatc aatggaatat acgaaaataa
     6001 aatatacatt ggtcctaacc ctattgtctt ctgcatgcta tgcgaaaaac aaaatataat
     6061 gcaagcccac aaatgattcc tacaactaaa tatattccaa tcagcaatgc tgtattatca
     6121 accataactt tactaattct attacctact tgtaagaaca gcattatagt aagaattatc
     6181 caactaccta tcatgccaat tgaaaagtat tttaagaaac tgccgttact attgatcttc
     6241 ttagaatctt tatttgtttt aagtagccaa atcatgaata ctgcaaacag gatactttca
     6301 aatatagttt caagaacata aatagttgtt actggttctt ttagaactac gcttaatgca
     6361 atatctaaaa ccaagtataa acaacctgca ataatgcttc taatcattat ctgtttttta
     6421 gtcataatga tttctccctt cagttatagt tggtcttttt atctatgagt agctactgcc
     6481 aaccttcaac aatagttaat tcaacttcat ctacagccta aaacttactt atttttgaga
     6541 tacatgactg atttaacgtt ttttcaaacc gattttgcgc ttgtatgcca acttatattt
     6601 aaaataatga aactaaaatc atgatcacac caattaaagt cagaatacct gctccaatgt
     6661 agccaaacca taaagcaaag ccacgccatt gattattttg aacagctttt gaagtcgtat
     6721 ttaatttcaa atagccttgc gtatgacgaa aagtaaaaac tccaccaata atcaacagga
     6781 tgccaattac taaataaatt aaatgataca tagtctttac ctcaattctt taccctaaat
     6841 tacatcaata gcttcaaact tagtcattaa ttgcttaata actttcctat aagacctcga
     6901 ataagtgatt gcgttatttt catcgaaaat aatcaactta ttatgggtat caatagcttg
     6961 aatattattt ggattaatca aagttgactg cgagacttta accaaaaaat ctgcatcctt
     7021 agcgacttga cttatattac ctttaaattc cacatctcca tgatccgtca ccatatgcac
     7081 cttatgctgc atggtactat tctcaatata aataacttca ttttcactaa ccttaaatac
     7141 attgcgacca atcttgtatt taaagtttcg attaccatac ttaatcatat tagttagatt
     7201 atcgatagca ccacggagtg tttcttcaag acgctgaata atctcatccg aagacaagtt
     7261 tttactaata tagtcaatcg ctccaattcg tctacgatat gtcaacggcg catacttctc
     7321 atatgcagtg acaaagataa tctgcgcatt ctcatcctgt ttcttgatga actctgctaa
     7381 gtctaccccg tttttcgctt cagattgctg gctcaattca atatcaagaa agtaaatgcc
     7441 attcttaata tcattagcta caatatagcc aaccgcttga gcaaaatcat tagctacaaa
     7501 agtcactctt tcctttaatt cactgtagct tgaattatca tctgataagt tttggattga
     7561 actattaata ttagtagcta attgattagc caaatcatga tcatcatcac aaacgataat
     7621 aggataatta gccattatct tcatcaccat cttccatatc aatcaccatg tagaagtcaa
     7681 accagccatc ttgaaccatg tatgaaactg acatatcagg attcttttct tctagttttc
     7741 taatattggc tagaccatag ccctgatgtc cttttttagt tgtaaaacct tgttcttgta
     7801 ttttgctagt agagatcttt tgatctttac gcactctatt acgaatttcg aattcaaagt
     7861 tatccggtcc atctgaataa gccataattt gaatctcttc atactccgga gatttattct
     7921 tttcagccat atcctttata atcttgcttt cttcaattgc attatcgaag gcaattccta
     7981 ggattctaac aagatccaat tcatcaatat tagccggcag tttttttaca ccacttctac
     8041 attcaaaatt ataaggaata tttaggttat acatttctgt taacttagaa ataataatac
     8101 tcttaataga tttaatatga atatgattta catctttata cttaagcaga gcatcagaat
     8161 tcaaattagt ttcagtatac ttatctagct tttgaatcac ctcttgaaca ttaccttctt
     8221 gagcactcac ctttaaagaa ttaagtatat tcttataatc gtgtctaaat gcccgtaaat
     8281 catcttcact cttttccaaa taatctgcat attcttcaag ttggcgttgt ttttgtctta
     8341 tttcttgctg ttttctttgg gtcaataact tattctgaac ataaaccatc tcaccataaa
     8401 ctccaattgc aaacacagat tgaacaataa cgaatatagt aaagaataaa gtaaatggag
     8461 ttattctctt atctaataag tataaaaaag aaacaccagc actagaaaca tacaaatata
     8521 ttaaaactcc taaaaatatg tttttatttt ggttagataa atatatttta aatttatttc
     8581 caaatcgctt tacaaaaaat accattaaaa ttaatgttat taaaccaaat gctagttcta
     8641 catttaaatt agaatttagc attgttactt tcataattat tgtagttata atactaaata
     8701 ttaaatctag aatgccaact attataccgg agcctaatat taattctata tctccatact
     8761 ttttgaaaaa taaataaaat aatatcattt ctaaagcatc agatataaaa cttatattcc
     8821 agataaagtc aatcactcct actacaaaaa taagcaacag aaataaatag aaataaaaat
     8881 ctacttttat ttttattcca gatattctaa aaaaactcca aatatcaacc aaaatataaa
     8941 atatattcaa acacagtgct aataaaaaca ctatctctta cttcttccac cacccaaatg
     9001 taaaattctt atgagtaaac ttcttaatat caaaaaatgc tgttgttcca cccacaacct
     9061 tacttaattc ttcttctttc aactcaatct ttttaacaac tttcttttcc ataattaatc
     9121 catcctttca tgaatcatcc tttacacctt aaatatagca tgatttgcct tccgatatac
     9181 aaaagatacc aaattggtca ttttttagac tgatttggta ttttggtgcc aaagcattat
     9241 tcaataaatt cttatctaac taacagcaat aatcttgccc acgttctctc ccatgaacgt
     9301 cttcctttta cctgtcatca ttaataaggc aactaccaat ggaattaaca gtataataat
     9361 cgcacttatc cagccatcag tgatcagtgg actaactatt ctcgttaatg gcgtttcgct
     9421 taaagcgatt agatcgacta gaccgtgaat cgatatactc aaccatagtt tgcctgtata
     9481 tagatagatc actgcaaata gcatccccgc accaaatgta taaactacct gctgcaatgt
     9541 cgtttctaaa tcaaacttaa taagaaaggt acttattccc aaatttccta aatggcttaa
     9601 actaaaaaga atagaactaa tcactattgc aaaaatcatc ctatacttaa aattccgcat
     9661 agcaacaagc aaaatcacta aattcaggta acgcaacgtt tcttcaaata ttcctgcttc
     9721 tattgctgcc aacacagaat ttaaagtcac ttcaaatgta ctaaaatccc actgccaaaa
     9781 acacaacaaa tcagccaagg acggtgctag agttacaaaa gaattgaaaa aagcaaacca
     9841 aacagaaaaa gttaacaaga gaattaacgc tagccattga aagtttttac ttttgcccaa
     9901 ttttagattc cattgaaatt taagctgcca tgccctagtt atgaaaaatg ccaaaataaa
     9961 agtagcaagg gcaattatta caccagacct aataattgct ttaattacac cagatgtacc
    10021 tagaaacctg ttaacattgt agctatagtt tagatacaaa atgaaaatca tgaatagtcg
    10081 catgaaccaa tttttcacta ctggaaagtt aaccactact actggaatat caaccaataa
    10141 aagtaacact acgcccacaa ttgaactaac caatactagt ggtttaacca tcaaattgag
    10201 catagaagta gtcgtgtaaa tcaaa
//
