GCF_900637555.1_51726_E01_genomic - 3 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_LR134378.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	arylpolyene,RiPP-like	33,188	77,053	APE Vf	Other	25%
Region 2	NRPS,T1PKS,NRPS-like	1,916,845	1,992,767	streptobactin	NRP	11%
Region 3	terpene	2,276,976	2,298,798

NZ_LR134378.1 - Region 1 - RiPP-like,arylpolyene

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Location: 33,188 - 77,053 nt. (total: 43,866 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.42	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.39	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000840.1	0.29	Other	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000837.1	0.27	Other	APE Vf	Aliivibrio fischeri ES114
BGC0001895.1	0.27	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002000.1	0.26	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001343.1	0.25	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001723.1	0.25	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000231.1	0.25	Polyketide	griseusin	Streptomyces griseus
BGC0000839.1	0.24	Other	flexirubin	Chitinophaga pinensis DSM 2588

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.62	Other	APE Ec	Escherichia coli CFT073
BGC0001895.1	0.60	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002000.1	0.60	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002008.1	0.59	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001343.1	0.58	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000231.1	0.58	Polyketide	griseusin	Streptomyces griseus
BGC0000234.1	0.56	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000228.1	0.56	Polyketide	granaticin	Streptomyces violaceoruber
BGC0002012.1	0.55	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_LR134378.1 - Region 2 - NRPS,NRPS-like,T1PKS

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Location: 1,916,845 - 1,992,767 nt. (total: 75,923 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	1.19	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000457.1	1.13	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001561.1	1.03	NRP	curacomycin	Streptomyces curacoi
BGC0001132.1	1.03	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001479.1	1.01	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000417.1	1.00	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000979.1	1.00	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	1.00	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000901.1	0.99	Other	ferrichrome	Aspergillus niger
BGC0001128.1	0.99	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.68	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000417.1	0.65	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001615.1	0.65	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001437.1	0.65	NRP	obafluorin	Pseudomonas fluorescens
BGC0001710.1	0.65	NRP	obafluorin	Pseudomonas fluorescens
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900.1	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000348.1	0.65	NRP	ergovaline	Epichloe festucae var. lolii

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 1916844 - 1992767:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly) + (val - mal) + (ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 1916844 - 1960714:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - mal) + (gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 1922602 - 1970969:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly) + (val - mal) + (ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 1948639 - 1992767:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - mal) + (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1533

Search NORINE for peptide: strict or relaxed

AMP-binding (120..450): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: sLFsLSf-yK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 50% (weak)

ctg1_1541

Search NORINE for peptide: strict or relaxed

AMP-binding (503..908): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGMvWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)

ctg1_1542

Search NORINE for peptide: strict or relaxed

AMP-binding (202..623): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DALWmGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

PKS_AT (1514..1856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 155.8
inactive: 89.8
Methoxymalonyl-CoA: 77.8
Methylmalonyl-CoA: 66.5
Ethylmalonyl-CoA: 46.4
Propionyl-CoA: 46.0
2-Methylbutyryl-CoA: 40.2
Isobutyryl-CoA: 30.3
Acetyl-CoA: 27.7
Benzoyl-CoA: 23.6
CHC-CoA: 22.6
trans-1,2-CPDA: 17.1
fatty_acid: 11.7
3-Methylbutyryl-CoA: 0.0

ctg1_1554

Search NORINE for peptide: strict or relaxed

AMP-binding (478..890): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg1_1556

Search NORINE for peptide: strict or relaxed

AMP-binding (34..449): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PMPAQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 100% (strong)

NZ_LR134378.1 - Region 3 - terpene

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Location: 2,276,976 - 2,298,798 nt. (total: 21,823 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.25	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.1	0.19	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0001120.1	0.18	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000643.1	0.18	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.18	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.1	0.16	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000640.1	0.16	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000928.1	0.15	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.15	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001456.1	0.15	Terpene	isorenieratene	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.58	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.1	0.50	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0001120.1	0.50	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000643.1	0.49	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.49	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.1	0.47	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000640.1	0.46	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000928.1	0.46	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.46	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001456.1	0.46	Terpene	isorenieratene	Streptomyces argillaceus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names