Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP020000.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS,hserlactone | 101,682 | 143,859 |
Region 1.2 | arylpolyene | 516,995 | 558,996 | APE Vf | Other | 45%
Region 1.3 | arylpolyene | 819,011 | 860,240 | berninamycin A | RiPP | 26%
Region 1.4 | betalactone | 1,470,206 | 1,499,286 | mycosubtilin | NRP + Polyketide | 20%
Region 1.5 | NRPS,redox-cofactor | 1,919,944 | 1,974,827 | lankacidin C | NRP + Polyketide | 13%
Region 1.6 | siderophore | 2,357,793 | 2,374,220 | staphylobactin | Other | 12%
Region 1.7 | NAPAA | 3,144,517 | 3,178,515 |
Region 1.8 | lassopeptide | 3,473,947 | 3,496,405 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS,hserlactone | 101,682 | 143,859 |
Region 1.2 | arylpolyene | 516,995 | 558,996 | APE Vf | Other | 45%
Region 1.3 | arylpolyene | 819,011 | 860,240 | berninamycin A | RiPP | 26%
Region 1.4 | betalactone | 1,470,206 | 1,499,286 | mycosubtilin | NRP + Polyketide | 20%
Region 1.5 | NRPS,redox-cofactor | 1,919,944 | 1,974,827 | lankacidin C | NRP + Polyketide | 13%
Region 1.6 | siderophore | 2,357,793 | 2,374,220 | staphylobactin | Other | 12%
Region 1.7 | NAPAA | 3,144,517 | 3,178,515 |
Region 1.8 | lassopeptide | 3,473,947 | 3,496,405 |

No secondary metabolite regions were found in these records:
  NZ_CP020001.1

Compact view
NZ_CP020000.1 - Region 1 - NRPS,hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 101,682 - 143,859 nt. (total: 42,178 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001983.1 |  |  | 0.50 | Other | triacsins | Kitasatospora aureofaciens
BGC0001831.1 |  |  | 0.47 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001343.1 |  |  | 0.46 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001458.1 |  |  | 0.43 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0000343.1 |  |  | 0.42 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000274.1 |  |  | 0.41 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0002034.1 |  |  | 0.41 | Other | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000220.1 |  |  | 0.41 | Polyketide | enterocin | Streptomyces maritimus
BGC0001185.1 |  |  | 0.40 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  |  | 0.38 | NRP | paenibactin | Paenibacillus elgii B69

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001890.1 |  | 0.65 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001615.1 |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001778.1 |  | 0.61 | Other | showdomycin | Streptomyces showdoensis
BGC0001983.1 |  | 0.61 | Other | triacsins | Kitasatospora aureofaciens
BGC0000389.1 |  | 0.60 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001343.1 |  | 0.59 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000417.1 |  | 0.58 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0002034.1 |  | 0.58 | Other | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0001185.1 |  | 0.58 | NRP | bacillibactin | Bacillus velezensis FZB42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 101681 - 143859:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_95: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (38..443): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ayyaSAHmVK
    Nearest Stachelhaus code:
      pip
    Stachelhaus code match:
      50% (weak)
ctg1_103: pk
  CAL_domain (154..486): pk
  minowa: NH2
  Prediction, score:
    NH2: 123.2
    Acetyl-CoA: 59.5
    fatty_acid: 21.0
    shikimic_acid: 0.0
    AHBA: 0.0
ctg1_106: gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (486..872): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGvVWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      90% (moderate)

NZ_CP020000.1 - Region 2 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 516,995 - 558,996 nt. (total: 42,002 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.29 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.28 | Other | APE Ec | Escherichia coli CFT073
BGC0001723.1 |  | 0.24 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0001591.1 |  | 0.23 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.23 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000219.1 |  | 0.22 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000234.1 |  | 0.22 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.22 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001366.1 |  | 0.22 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.62 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.61 | Other | APE Ec | Escherichia coli CFT073
BGC0001723.1 |  | 0.57 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.57 | Polyketide | griseusin | Streptomyces griseus
BGC0001591.1 |  | 0.56 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.56 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000219.1 |  | 0.56 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000234.1 |  | 0.55 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.55 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001366.1 |  | 0.55 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP020000.1 - Region 3 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 819,011 - 860,240 nt. (total: 41,230 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.21 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.19 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000906.1 |  | 0.15 | Other | heme D1 | Heliophilum fasciatum
BGC0000905.1 |  | 0.14 | Other | heme D1 | Heliobacillus mobilis
BGC0001897.1 |  | 0.14 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001987.1 |  | 0.14 | Polyketide | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000234.1 |  | 0.14 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002008.1 |  | 0.14 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001973.1 |  | 0.14 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.14 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.54 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.51 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000906.1 |  | 0.45 | Other | heme D1 | Heliophilum fasciatum
BGC0000905.1 |  | 0.44 | Other | heme D1 | Heliobacillus mobilis
BGC0001897.1 |  | 0.44 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001987.1 |  | 0.44 | Polyketide | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0000234.1 |  | 0.43 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002008.1 |  | 0.43 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001973.1 |  | 0.43 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.43 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP020000.1 - Region 4 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,470,206 - 1,499,286 nt. (total: 29,081 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000662.1 |  | 0.24 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001399.1 |  | 0.20 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000890.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000234.1 |  | 0.20 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001940.1 |  | 0.17 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001983.1 |  | 0.17 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.16 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001730.1 |  | 0.15 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000662.1 |  | 0.57 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001399.1 |  | 0.52 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000890.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000234.1 |  | 0.52 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001940.1 |  | 0.48 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001983.1 |  | 0.48 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.47 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001730.1 |  | 0.45 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP020000.1 - Region 5 - NRPS,redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,919,944 - 1,974,827 nt. (total: 54,884 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001733.1 |  |  | 0.50 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000401.1 |  |  | 0.34 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001615.1 |  |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001207.1 |  |  | 0.32 | NRP | teixobactin | Eleftheria terrae
BGC0000835.1 |  |  | 0.32 | Polyketide | simocyclinone | Streptomyces antibioticus
BGC0000527.1 |  |  | 0.31 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000292.1 |  |  | 0.31 | NRP | acetylaranotin | Aspergillus terreus NIH2624
BGC0001498.1 |  |  | 0.29 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0000939.1 |  |  | 0.29 | Other | aerobactin | Grimontia hollisae
BGC0000329.1 |  |  | 0.28 | NRP | corpeptin A, corpeptin B | Pseudomonas corrugata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000401.1 |  | 0.68 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001615.1 |  | 0.67 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001184.1 |  | 0.61 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.61 | Other | bacilysin | Bacillus sp. CS93
BGC0000410.1 |  | 0.60 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001149.1 |  | 0.60 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001833.1 |  | 0.60 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.60 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.59 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001733.1 |  | 0.59 | RiPP | PcpA | Pleurocapsa sp. PCC 7327

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 1919943 - 1974827:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 1919943 - 1967098:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1829: X - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (478..892): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DslDLGlVDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1538..1943): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg1_1834: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (36..446): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      SMACQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      100% (strong)

NZ_CP020000.1 - Region 6 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,357,793 - 2,374,220 nt. (total: 16,428 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000295.1 |  | 0.30 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001453.1 |  | 0.27 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000942.1 |  | 0.27 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000946.1 |  | 0.22 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000939.1 |  | 0.19 | Other | aerobactin | Grimontia hollisae
BGC0000943.1 |  | 0.17 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000896.1 |  | 0.14 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.14 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001587.1 |  | 0.14 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001122.1 |  | 0.11 | NRP, Polyketide | dihydroisoflavipucine, isoflavipucine | Aspergillus terreus NIH2624

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000295.1 |  | 0.63 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001453.1 |  | 0.61 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000942.1 |  | 0.61 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000946.1 |  | 0.55 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000939.1 |  | 0.51 | Other | aerobactin | Grimontia hollisae
BGC0000943.1 |  | 0.48 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000896.1 |  | 0.44 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.44 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001587.1 |  | 0.43 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001122.1 |  | 0.38 | NRP, Polyketide | dihydroisoflavipucine, isoflavipucine | Aspergillus terreus NIH2624

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP020000.1 - Region 7 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,144,517 - 3,178,515 nt. (total: 33,999 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and PP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001444.1 |  | 0.22 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.22 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000375.1 |  | 0.22 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000888.1 |  | 0.21 | Other | bacilysin | Bacillus sp. CS93
BGC0001399.1 |  | 0.20 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001197.1 |  | 0.20 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000761.1 |  | 0.18 | Saccharide | exopolysaccharide | Methylobacillus sp. 12S
BGC0001479.1 |  | 0.18 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001444.1 |  | 0.55 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.55 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0000375.1 |  | 0.55 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000888.1 |  | 0.53 | Other | bacilysin | Bacillus sp. CS93
BGC0001399.1 |  | 0.53 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001197.1 |  | 0.52 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000761.1 |  | 0.50 | Saccharide | exopolysaccharide | Methylobacillus sp. 12S
BGC0001479.1 |  | 0.50 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 3144516 - 3178515:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2950: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..418): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmEHNgTVtK
    Nearest Stachelhaus code:
      dab
    Stachelhaus code match:
      70% (weak)

NZ_CP020000.1 - Region 8 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,473,947 - 3,496,405 nt. (total: 22,459 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000571.1 |  | 0.32 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000580.1 |  | 0.31 | RiPP | xanthomonin I, xanthomonin II | Xanthomonas gardneri ATCC 19865
BGC0000576.1 |  | 0.31 | RiPP | rubrivinodin | Rubrivivax gelatinosus IL144
BGC0001494.1 |  | 0.27 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0000577.1 |  | 0.24 | RiPP | sphingonodin II | Sphingobium japonicum UT26S
BGC0000574.1 |  | 0.23 | RiPP | caulosegnin I, caulosegnin II, caulosegnin III | Caulobacter segnis ATCC 21756
BGC0001549.1 |  | 0.19 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001550.1 |  | 0.19 | RiPP | citrulassin D | Streptomyces katrae
BGC0000575.1 |  | 0.19 | RiPP | lariatin | Rhodococcus jostii
BGC0001356.1 |  | 0.19 | RiPP | paeninodin | Paenibacillus dendritiformis C454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000571.1 |  | 0.65 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000580.1 |  | 0.64 | RiPP | xanthomonin I, xanthomonin II | Xanthomonas gardneri ATCC 19865
BGC0000576.1 |  | 0.64 | RiPP | rubrivinodin | Rubrivivax gelatinosus IL144
BGC0001494.1 |  | 0.61 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0000577.1 |  | 0.57 | RiPP | sphingonodin II | Sphingobium japonicum UT26S
BGC0000574.1 |  | 0.56 | RiPP | caulosegnin I, caulosegnin II, caulosegnin III | Caulobacter segnis ATCC 21756
BGC0001549.1 |  | 0.51 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001550.1 |  | 0.51 | RiPP | citrulassin D | Streptomyces katrae
BGC0000575.1 |  | 0.51 | RiPP | lariatin | Rhodococcus jostii
BGC0001356.1 |  | 0.51 | RiPP | paeninodin | Paenibacillus dendritiformis C454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lassopeptide(s) for ctg1_3227 - Putative Class II

ctg1_3227 leader / core peptide / cleaved tail
  MNNNQVNNLIEDQDDVDLIFLGSVKDETK - GFDFEGTVEPRDFDKYNKDLQEIDSMP

#### Legend:

Red: Putative macrolactam
Purple: Putative cleaved off residues
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_3227 - Class II
  Cleavage pHMM score: 7.90
  RODEO score: 16
  Monoisotopic mass: 3173.4 Da
  Molecular weight: 3175.4 Da
  Number of bridges: 0