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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NC_009922.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | cyclic-lactone-autoinducer | 265,624 | 283,120 |
Region 2 | cyclic-lactone-autoinducer | 472,905 | 492,638 |
Region 3 | ranthipeptide | 1,809,541 | 1,830,905 |
Region 4 | cyclic-lactone-autoinducer | 2,383,898 | 2,404,604 |

NC_009922.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 265,624 - 283,120 nt. (total: 17,497 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.17 | RiPP | circularin A | Clostridium beijerinckii
BGC0000294.1 |  | 0.16 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000617.1 |  | 0.16 | RiPP | coagulin | Bacillus coagulans
BGC0000928.1 |  | 0.15 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.15 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000571.1 |  | 0.15 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000554.1 |  | 0.15 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000883.1 |  | 0.15 | Other | arginomycin | Streptomyces arginensis
BGC0000584.1 |  | 0.15 | RiPP | colicin V | Escherichia coli
BGC0002009.1 |  | 0.15 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.48 | RiPP | circularin A | Clostridium beijerinckii
BGC0000294.1 |  | 0.47 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000617.1 |  | 0.46 | RiPP | coagulin | Bacillus coagulans
BGC0000928.1 |  | 0.46 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.46 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000571.1 |  | 0.46 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000554.1 |  | 0.45 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000883.1 |  | 0.45 | Other | arginomycin | Streptomyces arginensis
BGC0000584.1 |  | 0.45 | RiPP | colicin V | Escherichia coli
BGC0002009.1 |  | 0.45 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_009922.1 - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 472,905 - 492,638 nt. (total: 19,734 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001122.1 |  | 0.05 | NRP, Polyketide | dihydroisoflavipucine, isoflavipucine | Aspergillus terreus NIH2624
BGC0000495.1 |  | 0.04 | RiPP | actagardine | Actinoplanes garbadinensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001122.1 |  | 0.24 | NRP, Polyketide | dihydroisoflavipucine, isoflavipucine | Aspergillus terreus NIH2624
BGC0000495.1 |  | 0.19 | RiPP | actagardine | Actinoplanes garbadinensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_009922.1 - Region 3 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,809,541 - 1,830,905 nt. (total: 21,365 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.18 | Other | nucleocidin | Streptomyces calvus
BGC0000599.1 |  | 0.14 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001887.1 |  | 0.13 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000684.1 |  | 0.11 | Terpene | asperthecin | Aspergillus nidulans FGSC A4
BGC0001144.1 |  | 0.08 | Polyketide | neosartoricin B | Trichophyton tonsurans CBS 112818
BGC0001860.1 |  | 0.07 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.07 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.1 |  | 0.07 | RiPP | GE2270A | Nonomuraea sp. WU8817
BGC0001591.1 |  | 0.07 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.07 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.49 | Other | nucleocidin | Streptomyces calvus
BGC0000599.1 |  | 0.43 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001887.1 |  | 0.42 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000684.1 |  | 0.37 | Terpene | asperthecin | Aspergillus nidulans FGSC A4
BGC0001144.1 |  | 0.31 | Polyketide | neosartoricin B | Trichophyton tonsurans CBS 112818
BGC0001860.1 |  | 0.29 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.28 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.1 |  | 0.28 | RiPP | GE2270A | Nonomuraea sp. WU8817
BGC0001591.1 |  | 0.28 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.28 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_009922.1 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,383,898 - 2,404,604 nt. (total: 20,707 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.14 | RiPP | circularin A | Clostridium beijerinckii
BGC0000466.1 |  | 0.13 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0001540.1 |  | 0.13 | Other | CC-1065 | Streptomyces zelensis
BGC0000486.1 |  | 0.08 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001536.1 |  | 0.06 | NRP | brevicidine | Brevibacillus laterosporus
BGC0000132.1 |  | 0.04 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0001555.1 |  | 0.04 | RiPP | colicin V | Escherichia coli chi7122
BGC0001088.1 |  | 0.04 | NRP, Polyketide | albicidin | Xanthomonas albilineans
BGC0000379.1 |  | 0.03 | NRP | glycinocin A | Streptomyces viridochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.43 | RiPP | circularin A | Clostridium beijerinckii
BGC0000466.1 |  | 0.42 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0001540.1 |  | 0.41 | Other | CC-1065 | Streptomyces zelensis
BGC0000486.1 |  | 0.32 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001536.1 |  | 0.24 | NRP | brevicidine | Brevibacillus laterosporus
BGC0000132.1 |  | 0.20 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0001555.1 |  | 0.19 | RiPP | colicin V | Escherichia coli chi7122
BGC0001088.1 |  | 0.18 | NRP, Polyketide | albicidin | Xanthomonas albilineans
BGC0000379.1 |  | 0.15 | NRP | glycinocin A | Streptomyces viridochromogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names