GCF_000478885.1_ASM47888v1_genomic - 3 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_022567.1

Region	Type	From	To
Region 1	NRPS	65,579	118,816
Region 2	RRE-containing	359,838	380,095
Region 3	betalactone	1,197,201	1,221,159

NC_022567.1 - Region 1 - NRPS

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Location: 65,579 - 118,816 nt. (total: 53,238 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001806.1	0.23	NRP	tolaasin A	Pseudomonas tolaasii
BGC0000412.1	0.23	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000410.1	0.22	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000396.1	0.22	NRP	nodularin	Nostoc sp. 73.1
BGC0001699.1	0.21	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0001758.1	0.21	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.21	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001185.1	0.21	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001833.1	0.21	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000460.1	0.21	NRP	vulnibactin	Vibrio vulnificus CMCP6

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001806.1	0.56	NRP	tolaasin A	Pseudomonas tolaasii
BGC0000412.1	0.56	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000410.1	0.55	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000396.1	0.54	NRP	nodularin	Nostoc sp. 73.1
BGC0001699.1	0.54	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0001758.1	0.54	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.54	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001185.1	0.53	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001833.1	0.53	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000460.1	0.53	NRP	vulnibactin	Vibrio vulnificus CMCP6

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 65578 - 118816:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys - cys) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_70

Search NORINE for peptide: strict or relaxed

AMP-binding (533..923): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg1_71

Search NORINE for peptide: strict or relaxed

AMP-binding (724..1095): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLSmIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

AMP-binding (2050..2421): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLSmIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

ctg1_74

Search NORINE for peptide: strict or relaxed

AMP-binding (17..418): X

NRPSPredictor2: dhb, sal

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: dhb, sal
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PLPthGsLtK
Nearest Stachelhaus code:: sal
Stachelhaus code match:: 60% (weak)

NC_022567.1 - Region 2 - RRE-containing

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Location: 359,838 - 380,095 nt. (total: 20,258 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

Reference	RRE-containing	Similarity score	Type	Compound(s)	Organism
BGC0000774.1		0.13	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000774.1		0.42	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NC_022567.1 - Region 3 - betalactone

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Location: 1,197,201 - 1,221,159 nt. (total: 23,959 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000904.1	0.21	Other	FR-900098	Streptomyces rubellomurinus
BGC0001859.1	0.20	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000779.1	0.19	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.17	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0000259.1	0.17	Polyketide	prodigiosin	Serratia marcescens
BGC0001897.1	0.16	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001137.1	0.15	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000805.1	0.14	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672
BGC0000774.1	0.14	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0001925.1	0.14	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000904.1	0.54	Other	FR-900098	Streptomyces rubellomurinus
BGC0001859.1	0.52	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000779.1	0.50	Saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0000780.1	0.49	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0000259.1	0.49	Polyketide	prodigiosin	Serratia marcescens
BGC0001897.1	0.46	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001137.1	0.44	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000805.1	0.44	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672
BGC0000774.1	0.44	Saccharide	lipopolysaccharide	Xanthomonas campestris pv. campestris
BGC0001925.1	0.43	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names