LOCUS       NC_022567.1            20258 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_022567.1 Adlercreutzia equolifaciens DSM 19450, complete
            sequence.
ACCESSION   NC_022567
VERSION     NC_022567.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:48:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 359837
            Orig. end    :: 380095
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..20258
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[369837:370095](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10258
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..20258
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..20258
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2936..3553
                     /locus_tag="ctg1_222"
                     /transl_table=11
                     /translation="MTQLAICTDLDRCVGCLACSVSCKVVNGVPIGNFWNKTLRVGPTP
                     KEGGSGQYPDVETYFLNVQCQHCENPQCVEVCPTEASHKLPDGTIQIDKSKCIGCQFCV
                     MSCPYGVRYLNEEEGVVEKCTLCQQRTAQGELPQCVSQCCGMARWYGDAEQGIESFEGP
                     RGERLGDFVNDFTEDQVYKLTDVGNGPSMFYIMRNIKWQGVE"
     PFAM_domain     3104..3391
                     /aSDomain="Fer4_11"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13247.8"
                     /description="4Fe-4S dicluster domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_222_0051"
                     /evalue="6.00E-23"
                     /label="ctg1_222"
                     /locus_tag="ctg1_222"
                     /protein_end="152"
                     /protein_start="56"
                     /score="81.0"
                     /tool="antismash"
                     /translation="ETYFLNVQCQHCENPQCVEVCPTEASHKLPDGTIQIDKSKCIGCQ
                     FCVMSCPYGVRYLNEEEGVVEKCTLCQQRTAQGELPQCVSQCCGMARWYGD"
     CDS             3557..4426
                     /locus_tag="ctg1_223"
                     /transl_table=11
                     /translation="MEIQIPLVIFTSFLAWAAGIFGTQCILALQKRGGAVQLPALICSA
                     VVLVVGGIAVVFHLTHPFNLFNGFGHITSGITQELVAIVLLAVVMVLFFLMLRRSEDDT
                     VPQWLAVVGIVVVLVLIVAMGHSYMMPSLPAWDTVLQLLSLLGAACVMGPATVAFIGAA
                     RGIEIEGIGLLAVIGAAVNAVLSVAYMFAMEASSATFQSFQYYFDPTHPNVAMANPANV
                     SLFTGDSMTALVIAAIALVVALIGALAGKKQGAWKVWGAVVAIAGLVCAVALRVMMYTM
                     GETLFMLY"
     PFAM_domain     3566..4168
                     /aSDomain="DmsC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04976.14"
                     /description="DMSO reductase anchor subunit (DmsC)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_223_0052"
                     /evalue="3.20E-05"
                     /label="ctg1_223"
                     /locus_tag="ctg1_223"
                     /protein_end="204"
                     /protein_start="3"
                     /score="23.6"
                     /tool="antismash"
                     /translation="QIPLVIFTSFLAWAAGIFGTQCILALQKRGGAVQLPALICSAVVL
                     VVGGIAVVFHLTHPFNLFNGFGHITSGITQELVAIVLLAVVMVLFFLMLRRSEDDTVPQ
                     WLAVVGIVVVLVLIVAMGHSYMMPSLPAWDTVLQLLSLLGAACVMGPATVAFIGAARGI
                     EIEGIGLLAVIGAAVNAVLSVAYMFAMEASSATFQSFQ"
     CDS             4493..5359
                     /locus_tag="ctg1_224"
                     /transl_table=11
                     /translation="MRGIYKRAALALAAGALVVGLAGCAAESAPVSDPSKGDNTQLAYT
                     GAESADEQSFDTVTFGSYQGQDITWLKLAEENGKTLLISEQVLDAVPYDDSTEAYQWSV
                     QSPRPQKDIEWATSSIRTWLNGEFLKAAFSADEQGAIAATTLTDAKNNVSHTAATAADP
                     SVHAAEETTDQVFLLSLAEAKQYFANNAARVAHPTDYAVRQGVYVGVASNDEQPDGAAA
                     WWLRSNGYYAGYASVVTDDGYVHGDGYRMAGELHDGFDDHGSELKSTLGGNIGVRPAIW
                     VETSALS"
     PFAM_domain     4721..5341
                     /aSDomain="DUF6273"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19789.1"
                     /description="Family of unknown function (DUF6273)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_224_0053"
                     /evalue="2.10E-26"
                     /label="ctg1_224"
                     /locus_tag="ctg1_224"
                     /protein_end="283"
                     /protein_start="76"
                     /score="92.9"
                     /tool="antismash"
                     /translation="NGKTLLISEQVLDAVPYDDSTEAYQWSVQSPRPQKDIEWATSSIR
                     TWLNGEFLKAAFSADEQGAIAATTLTDAKNNVSHTAATAADPSVHAAEETTDQVFLLSL
                     AEAKQYFANNAARVAHPTDYAVRQGVYVGVASNDEQPDGAAAWWLRSNGYYAGYASVVT
                     DDGYVHGDGYRMAGELHDGFDDHGSELKSTLGGNIGVRPAIWVE"
     CDS             5673..6356
                     /locus_tag="ctg1_225"
                     /transl_table=11
                     /translation="MAGGNSLTRRTLCIGVGATVAMAGLGALRYVGSEPLVRPPGGQDE
                     ENLVSRCVHCYRCIEACPEKVIVAASLDAGVLNMRTPRMEFSDCYPGQLDDFRYCDFCA
                     ERNGGVPLCAAVCPSGALQLPVDYAPETEVIGVAVLNTETCIAYRSSFCAFCHDVCIQV
                     RGEENAAIYYQNADATDALDTRLPVVDAEKCNGCGACEAVCVSAQAGSTMNASERAIVV
                     KPLEG"
     PFAM_domain     6231..6284
                     /aSDomain="Fer4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00037.29"
                     /description="4Fe-4S binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_225_0054"
                     /evalue="9.30E-05"
                     /label="ctg1_225"
                     /locus_tag="ctg1_225"
                     /protein_end="204"
                     /protein_start="186"
                     /score="22.2"
                     /tool="antismash"
                     /translation="PVVDAEKCNGCGACEAVC"
     CDS             6366..7376
                     /locus_tag="ctg1_226"
                     /transl_table=11
                     /translation="MKFKNARTAVAAVAFAALAVCLIAGVATGTWCGFGANDIAVLCPV
                     GALLSMVAAKTLIPRAVLSIVVAIALVLLLGRLFCGWICPVTLWRRVKEFFKPVKTREQ
                     EAEALSQANQALAAEEIAALKEASATHDCAACGACHAKRNAPLDSRHAVLGGALLTTAV
                     FGFPVFCLVCPVGLTFAAVALLVSLFGSGDLNWSLLFVPAMLVIELVFLRKWCGRFCPI
                     SAFMSLFSRFSRTGMPVIDNERCLETAKGTACSRCATACTFDVNLRHPDLGELPLHDCA
                     RCGDCIDACPTSAISFRAVSGKPVPFVDAFASTRSGGKAKAPAAPALDDLEPEEA"
     PFAM_domain     6546..6629
                     /aSDomain="Fer4_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12801.9"
                     /description="4Fe-4S binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_226_0055"
                     /evalue="2.00E-06"
                     /label="ctg1_226"
                     /locus_tag="ctg1_226"
                     /protein_end="88"
                     /protein_start="60"
                     /score="27.7"
                     /tool="antismash"
                     /translation="AVLSIVVAIALVLLLGRLFCGWICPVTL"
     PFAM_domain     6951..7067
                     /aSDomain="Fer4_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12801.9"
                     /description="4Fe-4S binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_226_0056"
                     /evalue="6.60E-04"
                     /label="ctg1_226"
                     /locus_tag="ctg1_226"
                     /protein_end="234"
                     /protein_start="195"
                     /score="19.7"
                     /tool="antismash"
                     /translation="WSLLFVPAMLVIELVFLRKWCGRFCPISAFMSLFSRFSR"
     CDS             7521..8051
                     /locus_tag="ctg1_227"
                     /transl_table=11
                     /translation="MVNKTFIPEGEAVPASQIGATLEALAATIAARRDADEASYTYRLL
                     TGNVDDVLKKVMEESGEVALAAKDVEGWATSSLAAAVALEATEAGGTTTGAETADDGAD
                     FPLSVQLPPEYGEAVDHLRYEAADVVYHLLVVLERYGITLDEFAAELNNRMTEGERPHG
                     AVRLHDEFVRRGK"
     PFAM_domain     7587..7982
                     /aSDomain="PRA-PH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01503.19"
                     /description="Phosphoribosyl-ATP pyrophosphohydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_227_0057"
                     /evalue="7.30E-09"
                     /label="ctg1_227"
                     /locus_tag="ctg1_227"
                     /protein_end="154"
                     /protein_start="22"
                     /score="36.0"
                     /tool="antismash"
                     /translation="EALAATIAARRDADEASYTYRLLTGNVDDVLKKVMEESGEVALAA
                     KDVEGWATSSLAAAVALEATEAGGTTTGAETADDGADFPLSVQLPPEYGEAVDHLRYEA
                     ADVVYHLLVVLERYGITLDEFAAELNNR"
     CDS             8167..9594
                     /locus_tag="ctg1_228"
                     /transl_table=11
                     /translation="MARLFGTDGVRGIANVELTCEMAYRLGQAAAIYLGKTIVVGRDTR
                     RSGDMLGAALSAGIMSAGGTVLEAGIIPTPGVALLVREMRAAGGAVISASHNPPEYNGI
                     KFFDAQGFKLPDAVEDEIEAFIVNGGLEGEVAAAEEAAWSAAQAAAPDAPADATSYLAS
                     EIKMPAGAEVGVVIPLENACDIYIDHAARSIEDQGISFKGLRIALDTGHGASSLTSPEA
                     LRRLGAEVIVINDDFDGMDINVQCGSTHLEPLRALMAETGADVGIAHDGDADRVMLMAP
                     DGTEIDGDMVEAVCALDMRERGVLAGDTVVSTVMCNFGFVRAMKEMGINVVQTKVGDRY
                     VLEAMREHGYSIGGEQSGHMILLDHNSTGDGLMTACQFLAAVIRSGKPVGEAIQVMEKM
                     PQTLINVRVNDKHAVEDSAEVAAAVASAEEALGEDGRVLLRPSGTEPVVRVMVEAVDPA
                     AAQAHAEAIAAVVEACA"
     PFAM_domain     8173..8544
                     /aSDomain="PGM_PMM_I"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02878.18"
                     /description="Phosphoglucomutase/phosphomannomutase,
                     alpha/beta/alpha domain I"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_228_0058"
                     /evalue="9.90E-41"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="126"
                     /protein_start="2"
                     /score="138.8"
                     /tool="antismash"
                     /translation="RLFGTDGVRGIANVELTCEMAYRLGQAAAIYLGKTIVVGRDTRRS
                     GDMLGAALSAGIMSAGGTVLEAGIIPTPGVALLVREMRAAGGAVISASHNPPEYNGIKF
                     FDAQGFKLPDAVEDEIEAFI"
     PFAM_domain     8719..9015
                     /aSDomain="PGM_PMM_II"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02879.18"
                     /description="Phosphoglucomutase/phosphomannomutase,
                     alpha/beta/alpha domain II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_228_0059"
                     /evalue="1.90E-17"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="283"
                     /protein_start="184"
                     /score="63.9"
                     /tool="antismash"
                     /translation="IYIDHAARSIEDQGISFKGLRIALDTGHGASSLTSPEALRRLGAE
                     VIVINDDFDGMDINVQCGSTHLEPLRALMAETGADVGIAHDGDADRVMLMAPDG"
     PFAM_domain     9025..9360
                     /aSDomain="PGM_PMM_III"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02880.18"
                     /description="Phosphoglucomutase/phosphomannomutase,
                     alpha/beta/alpha domain III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_228_0060"
                     /evalue="3.40E-31"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="398"
                     /protein_start="286"
                     /score="107.9"
                     /tool="antismash"
                     /translation="DGDMVEAVCALDMRERGVLAGDTVVSTVMCNFGFVRAMKEMGINV
                     VQTKVGDRYVLEAMREHGYSIGGEQSGHMILLDHNSTGDGLMTACQFLAAVIRSGKPVG
                     EAIQVMEK"
     PFAM_domain     9373..9579
                     /aSDomain="PGM_PMM_IV"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00408.22"
                     /description="Phosphoglucomutase/phosphomannomutase,
                     C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_228_0061"
                     /evalue="4.60E-17"
                     /label="ctg1_228"
                     /locus_tag="ctg1_228"
                     /protein_end="471"
                     /protein_start="402"
                     /score="62.1"
                     /tool="antismash"
                     /translation="LINVRVNDKHAVEDSAEVAAAVASAEEALGEDGRVLLRPSGTEPV
                     VRVMVEAVDPAAAQAHAEAIAAVV"
     CDS             10001..10258
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_229"
                     /sec_met_domain="PF05402 (E-value: 4.6e-06, bitscore: 23.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.7e-07,
                     bitscore: 27.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTRSLAPGAYLARSGQGVSLYDADGKCFAMNKMGGSILALALTG
                     LSAEGIADALRHYFNGTPTQSRDEVAAWLDEMEASGFLNS"
     CDS             10884..11741
                     /locus_tag="ctg1_230"
                     /transl_table=11
                     /translation="MPELRFCLKDCTDGLGAKPWHILHDGKEGTKSSMLAERHRSLLNY
                     PRGSFVRIAEGLFVCSPELVFVQMASCLSFGELLALGYELCGCYPRSTQKSVPLVRRPL
                     TTPNRLMAYAARLNGAKGAKLARAVAKQVRAKSGSVMETELAAIAFTAEVYGGLGIAEA
                     LINAPVALSEEARRVARTDWVVLDFYWPKAHFGIEYNGRTAHASADQQDRDSRKRDGLM
                     VDGIETATMTNSQFQNVTECTALLDRVSGRAGKKRRKRRAAHADAHRKLRRQVSKFHQQ
                     HFPF"
     CDS             12179..13606
                     /locus_tag="ctg1_231"
                     /transl_table=11
                     /translation="VTTRDDNIVAEEARAIEVGEETGAGAPGASGGSGRGRRDTWATHT
                     GFILACVGSAVGMANIWLFPYRVAQLGGAAFLIPYLIFVALLGFTGVIGEMSFGRAMGA
                     GPMGAFGRAMEMRGVRHGERIGKIIGLVPTLGSLAIAIGYAVVLGWACNYFVASLDGEL
                     MAQTDMGAFFGAIASDFGNVGFHLLGLALTFGIMILGISRGIERVNKVLMPTFFVLFVI
                     IAIRVATLPGAAAGYEYLLVPRWEALLNPTTWVYALGQAFFSLSLAGCGTLVYGSYLKR
                     DVDVVDAAKNVAIFDTIAGLVAACVVVPAVFAFGLDVSSGPPLLFITLAQVFQEMPFGN
                     IFAVILFAAVAFAAITSLMNLFEAPVEALQAQLGLSRAVSVGIVAVIAVAVGLFLENGS
                     SVSDWMDVISIYVIPVGAFLAAVMFFWVCPRGFAKKQAEMGRKKPLGRWFDFMTRCVFV
                     IITALVIVLGIFYGGIG"
     PFAM_domain     12290..12667
                     /aSDomain="SNF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00209.20"
                     /description="Sodium:neurotransmitter symporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_231_0062"
                     /evalue="4.70E-21"
                     /label="ctg1_231"
                     /locus_tag="ctg1_231"
                     /protein_end="163"
                     /protein_start="37"
                     /score="75.2"
                     /tool="antismash"
                     /translation="RDTWATHTGFILACVGSAVGMANIWLFPYRVAQLGGAAFLIPYLI
                     FVALLGFTGVIGEMSFGRAMGAGPMGAFGRAMEMRGVRHGERIGKIIGLVPTLGSLAIA
                     IGYAVVLGWACNYFVASLDGEL"
     PFAM_domain     12713..13582
                     /aSDomain="SNF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00209.20"
                     /description="Sodium:neurotransmitter symporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_231_0063"
                     /evalue="2.30E-28"
                     /label="ctg1_231"
                     /locus_tag="ctg1_231"
                     /protein_end="468"
                     /protein_start="178"
                     /score="99.3"
                     /tool="antismash"
                     /translation="DFGNVGFHLLGLALTFGIMILGISRGIERVNKVLMPTFFVLFVII
                     AIRVATLPGAAAGYEYLLVPRWEALLNPTTWVYALGQAFFSLSLAGCGTLVYGSYLKRD
                     VDVVDAAKNVAIFDTIAGLVAACVVVPAVFAFGLDVSSGPPLLFITLAQVFQEMPFGNI
                     FAVILFAAVAFAAITSLMNLFEAPVEALQAQLGLSRAVSVGIVAVIAVAVGLFLENGSS
                     VSDWMDVISIYVIPVGAFLAAVMFFWVCPRGFAKKQAEMGRKKPLGRWFDFMTRCVFVI
                     ITALVIVLG"
     CDS             13614..13853
                     /locus_tag="ctg1_232"
                     /transl_table=11
                     /translation="VNRVLTYEQETEMRCRRAREEALEQGIEQGIEQGIEQGMDRLGAL
                     VGRLIDAGRLDDAKRASEDADYREALLAEFGLQN"
     CDS             14441..15166
                     /locus_tag="ctg1_233"
                     /transl_table=11
                     /translation="MKQFVAEESFWELFPEAQIGIVVAHNMKPTAEVAPADAAAIARAL
                     AEANGKADQHLESNTISQNEVVAVWREAYQKFKTKKGARCSIENLLKRVLKGNPVGSIT
                     PSVDIYNTVSLTHALPVGGEDIDAMAGDIRLGITEGGDAFRPLGEEEDAPTLEGELCYR
                     DDAGAICRCWNWRDGERTALTDDSKKAFLIIESVDPDRADDLAAATDQLAAMVQQYLGA
                     DIFAKQIITRDNPTMVIDE"
     PFAM_domain     14651..15082
                     /aSDomain="B3_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03483.19"
                     /description="B3/4 domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_233_0064"
                     /evalue="1.90E-19"
                     /label="ctg1_233"
                     /locus_tag="ctg1_233"
                     /protein_end="214"
                     /protein_start="70"
                     /score="70.1"
                     /tool="antismash"
                     /translation="REAYQKFKTKKGARCSIENLLKRVLKGNPVGSITPSVDIYNTVSL
                     THALPVGGEDIDAMAGDIRLGITEGGDAFRPLGEEEDAPTLEGELCYRDDAGAICRCWN
                     WRDGERTALTDDSKKAFLIIESVDPDRADDLAAATDQLAA"
     CDS             15212..15577
                     /locus_tag="ctg1_234"
                     /transl_table=11
                     /translation="VVARPALSGKGRLVSWLVLVASGCMESVWAIALGKSEGFTHLGPT
                     IVFVVALVLSMLGLSFAVKTLPTGTAYAVWVGIGAALTVIYGMVTGSEPANLARILLIA
                     GLVGCVIGLKLVDGSTD"
     PFAM_domain     15254..15523
                     /aSDomain="Multi_Drug_Res"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00893.21"
                     /description="Small Multidrug Resistance protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_234_0065"
                     /evalue="8.50E-22"
                     /label="ctg1_234"
                     /locus_tag="ctg1_234"
                     /protein_end="104"
                     /protein_start="14"
                     /score="77.6"
                     /tool="antismash"
                     /translation="SWLVLVASGCMESVWAIALGKSEGFTHLGPTIVFVVALVLSMLGL
                     SFAVKTLPTGTAYAVWVGIGAALTVIYGMVTGSEPANLARILLIA"
     CDS             15658..16986
                     /locus_tag="ctg1_235"
                     /transl_table=11
                     /translation="MVDGISIREAASELGVSVQTVHNRIKSGALDGEKTNTGWRVSARS
                     VEAAKKTPPRKGRPWHGETYLLMNGPYEVMTFTYRRETDSFAPGEVVDAERAPLGTVTR
                     EGRGKASGLKTWWQHRSIPGSRAGMDEKLRSLGLEEPSQIPFRNLGLSLSDRYWIRPAD
                     HALRWEDVNYFQNDFGGAEGDWDEWLAEVGLSSPDNTSEGVLPKRWLCRGSERILLKGH
                     IPWTDQQVYNEAVATALHGRLLAPGDYVPYEVQRTEALGVVSACPCFLSPHEEYVPMSL
                     VLEAERRRKGETPYDTVVRACVNRGIPLKTAETQLAKMIVCDSVMANIDRHLRNFGLVR
                     NIDDLRWRFAPIFDTGNSLWYDKDEGAVARGDYAFSSHPFSDMPNRQLMYAAELGWFDA
                     GKLEGFADEACEILAEGDLCRWRLDYLREGIRQRIGAVRGLLV"
     PFAM_domain     16549..16752
                     /aSDomain="HipA_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07804.14"
                     /description="HipA-like C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_235_0066"
                     /evalue="1.30E-07"
                     /label="ctg1_235"
                     /locus_tag="ctg1_235"
                     /protein_end="365"
                     /protein_start="297"
                     /score="31.7"
                     /tool="antismash"
                     /translation="VVRACVNRGIPLKTAETQLAKMIVCDSVMANIDRHLRNFGLVRNI
                     DDLRWRFAPIFDTGNSLWYDKDE"
     CDS             complement(17003..18454)
                     /locus_tag="ctg1_236"
                     /transl_table=11
                     /translation="MKLLEEGVFPVRFLGFGFFWAWLFIAGLSPSPLFGSPLCVGGIPF
                     ELFELLMRCAMLAISLTLSCVIATDRGKYCFLALGAVAGIAVTPLLLWGGSEEAHSVAA
                     LLTAMTEVSLFLMWLSFFGAMRLGDTLTLLVISYGVGALLFLVALMGGERTLLGASIVF
                     PLLSAAALVFSSRLISRRGGTALFDNESTEPLKDEALSEETSIRNVTKSIPALKMTLAL
                     VCYSLAFSLLAAMAFSGSFALPASYLAEPVCIVVLAGVYILYAQFAKDAAKPYVLYRAV
                     APSMGLGFALLAISGGESIAGEGMVMIGYLLFEVLALNDYCNIVKANDASLFRTMAIGR
                     LAISVGMLAGWTAGFFSGSVSVAALAVFGMTIVLITATLVFTDRDRMPLVSIADDRAIS
                     EDRDLRLDKSTALASFAAECKLSKRETEVFDYLIAGRTTSYVAERLFVAESTVRAHVYN
                     IYQKADVHSRMELMDAFDAFWAKHS"
     PFAM_domain     complement(17036..17194)
                     /aSDomain="GerE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00196.21"
                     /description="Bacterial regulatory proteins, luxR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_236_0067"
                     /evalue="5.00E-15"
                     /label="ctg1_236"
                     /locus_tag="ctg1_236"
                     /protein_end="473"
                     /protein_start="420"
                     /score="54.9"
                     /tool="antismash"
                     /translation="LSKRETEVFDYLIAGRTTSYVAERLFVAESTVRAHVYNIYQKADV
                     HSRMELMD"
     CDS             18713..19408
                     /locus_tag="ctg1_237"
                     /transl_table=11
                     /translation="MEDAPELFVTPESEQSEAVAVSGNVQALLDLMARNPLHREIYLQI
                     IEFCEVRRLLGDVEAMVADCSGFSLTAQTPFRLIANVVDNGGIHWYEVDAQGDEITEER
                     RANLTDDEADDLVEGFALEASDAGREVLERMAPERRLRDLFDKAPGRLSTYLDIIDFCG
                     EPQTFKAIEALVHQTDAGALIGASGQPLQPSYFVDMLERSGGLVWDKGWKATGKGSALA
                     KQLRPALAV"
ORIGIN
        1 gcgcatccgc tcctgctgcc gcggctgcgg caaggtggag tgcggcgtgt gggtgtacgt
       61 gcaggacggc aaggtcattc gcaccgaggg cgacgaggac tgcttcctca ccatgggcaa
      121 ccactgctcc aagggccagg cgtccattca ggcggcctac caccccgacc gcatcaagta
      181 ccccatgaag cgcacgaacc ccaagggcga cgacgatccc ggctgggtgc gcatttcctg
      241 ggacgaggcc taccagacca tcgccgacaa cattctggag atcaccgaga agtacggcaa
      301 cgagtccacc ttcacctggt gcggcacggg ccgtcagtgg tgcatgcagt ccgacgccgg
      361 catggcgctg cttctgttcg gcacgccgaa catcgtggcc gcctaccagg tgtgcaaggg
      421 cccgcgccac ttcgccagcc gtatcgacaa cgtgcaggcc tggtcgtggt ccgagctgat
      481 caaccactcc acgaagttcg tgcagtgggc caccgagcag tcgcagtcga actacgacga
      541 cgccgcccgc accgtggtgg acgtcgcccg ttgcgccgac gccttcatct cggtggaccc
      601 gcgccagacg aacctgggac gtaccgccaa gtactggctg ccgctgcgcc ccggcaccga
      661 caacgcgctg gcgctcggct ggtgccacct catcctgaag aacgacctgt gcgactggca
      721 gttcctgaaa cgttggtcga actcgccgtt catcgtggtg ccggacatgg acccgaccgg
      781 ctacgaggag cacgtgcaga acggcggcta cccctacgcc taccagaccc gcctgctcac
      841 cgaggccgac atcgacccga ccatggtgga ctgggagatc gaaggcgacg gcgacccgca
      901 gcgctacctc gtcttcgatc agctgaacaa ccgctggacc tactggcagg cgcacccgga
      961 ggtgggcgag gcccactggg agggcgagaa ttggcagaag tccacgagct acttcgacca
     1021 ggatctctcc cgtctgcgcg acgacgagtc gaagaagccc ggcaaggtgt acgacctctc
     1081 cgagttcaac ccgctcatcg acccggccat gtacggcgaa ttcgatgtga agctgaagga
     1141 cggcaccacc cataagggac gccctgtgtg ggatatttgg gccgagtacc tggagggctt
     1201 cacccccgag aaggtgagcg agatcaccga ggtggacgcg cagctgctga ccgacgcctg
     1261 cctggagtgg gccacccgcg acgatccgcg catccccaac ggcggcatca actacggcct
     1321 ggccatcgag catcacggca tgtccacgca gaactgtcgc gccatcatgg ccgcctgcgc
     1381 catggtgggc gccatcgaca cccccggcgg ccagcgcggc gccaccaacg gctggaccac
     1441 ccagtcgggc cccacgtcca tgtaccctgg cgccgacggc ggctcgaacc ccgcctcctt
     1501 cgtgcgcgcg ccgttcttcg ggctgtacaa ccgcatcgcc ggctacgaga agttccccat
     1561 gctgtactgg tacgccgtgt gggccgactg caactcggtc atggagtaca tgcaccgcga
     1621 tgcgaacgcc ccctacgaga ttcacgcggg catgatcggc tccggcgacc atatgaacat
     1681 ggctaacgcc agctacaact gggaggccct gctcatgctg gacttcctct tcgaggcgaa
     1741 cctgtggcat tcgcccacct cgggcgcggc cgacatcctt ttgccggtgt gccactggac
     1801 cgagatgaac gcccagcgca tcgcccaggg ctccggcggc tccttcagcc tgtgcgtgcg
     1861 cgccgtcgac cctccgggag agtgcaagag cgatcctttg tacttcctgg agctcggccc
     1921 ctacttcggc gtgcccttct ccaccgatcc ggaggatccc tactgggaga agaagtcggc
     1981 cgagaccggc aagtctgtgg acctgctcgc cctggagtac gagtgcctcg acgccgagca
     2041 cggcggcggc tgcgctccct atgactcctg ggacgacttc gtggccgcct accaggagca
     2101 cggcacctgg aacatgaagg aagtgttccc ggacgactgg ggctcctacc gccgctacga
     2161 gatcggccag gcctaccgca aggcgcctca tcagcagccg acgaagctgg acatcaacat
     2221 tcccggcttc cccacgccga ccatgaagca cgagttgtgg gccaccacca tcgagtccca
     2281 cttccccgag ggctccgacg gccccgaggt gacgccgggc ttccacaccg aggcgctgcc
     2341 ctactatgtg gagggcatcc actcccgggt gcgcgacgcc gagacctacg aggagtaccc
     2401 gattctctgc attaccggcc gccgcatccc cgtgtacttc cacagcgagc atcgccagct
     2461 gccctggtgc cgcgagctgt ggccggtgcc ccgcatggag atcaaccctg agacggccgc
     2521 cgagctcggc ctggagcagg gcgactgggc ctggatcgaa agcccctggg gcaaggtgcg
     2581 ccagaccgtg gacctctact acggcatcgc gcccggcacc atcaactgcg agcatcagtg
     2641 gtggtatccg gagctggccc aggccgacaa gggcttcaaa ctgtcctgca tcaactgcat
     2701 cgtcgaccgc acggcccagg acaagtacaa cggctcgtcc acggtgcgcg gctatccggt
     2761 gaaggtgtac aaggccacgc ccgagaacag ccccttcggc aaccccgtgc cctgcggcaa
     2821 cgacggcacc gagatcatcc acgactcgtc cgatccgcgc ctgaagctgt gggccattgg
     2881 cgccgagggc attcaccccg acaagttcga cgcgtaagag aaaggagtgg gagaaatgac
     2941 acagcttgct atttgcaccg acctcgaccg gtgcgtggga tgccttgcct gcagcgtgtc
     3001 ctgcaaagtg gtcaacggcg tgcccatcgg caacttctgg aacaagaccc tgcgcgtggg
     3061 tcccaccccc aaggagggcg gttccggcca gtatccggac gttgagacct actttttgaa
     3121 cgtgcagtgc cagcactgcg agaaccccca gtgcgtggaa gtgtgcccca ccgaggcgtc
     3181 gcacaagctg cccgacggca ccatccagat tgacaagtcg aagtgcatcg gctgccagtt
     3241 ctgcgtcatg agctgcccct acggcgtgcg ctacctcaac gaggaggagg gcgtcgtgga
     3301 gaagtgcacc ctctgccagc agcgtaccgc ccaaggtgag ctgccccagt gcgtgagcca
     3361 gtgctgcggc atggcccgct ggtacggcga cgccgagcag ggcatcgagt ccttcgaggg
     3421 cccgcgcggc gagcgtctgg gcgacttcgt aaacgacttc accgaggacc aggtgtacaa
     3481 gctcaccgat gtgggcaacg gaccgagcat gttctacatc atgcgcaaca tcaagtggca
     3541 gggggtcgag tagcccatgg aaattcaaat cccgctcgtc atcttcacga gctttctggc
     3601 ctgggccgcg ggcatcttcg gcacccagtg catcctcgcg ctgcagaagc gcggcggtgc
     3661 ggtgcagctg ccggcgctca tctgctcggc tgtggtgctc gtggtgggcg gcatcgccgt
     3721 cgtgttccat ctgacccacc cgttcaacct gttcaacggg ttcgggcaca tcacctcggg
     3781 catcacccag gagctcgtcg ccattgtgct tctggcggtg gtcatggtgc tgttcttcct
     3841 gatgctgcgc cgctccgagg atgatacggt gccccagtgg ctggccgtgg tgggcatcgt
     3901 ggtggtgctc gtgctcatcg tggccatggg ccacagctac atgatgccgt cgctgcccgc
     3961 ctgggacacg gtgctgcagc tgctgtcgct tctgggcgcg gcctgcgtca tgggcccggc
     4021 caccgtggcc ttcatcggtg ccgcgcgtgg cattgaaatc gagggtatcg ggcttctcgc
     4081 ggtcatcggc gcagcggtaa acgccgtgct ttcggtggcc tacatgttcg ccatggaggc
     4141 ctcgagcgcc accttccagt ccttccagta ctacttcgac ccgacgcacc cgaatgtggc
     4201 catggccaac ccggccaacg tgtccctgtt cacgggcgac tcgatgacgg cgcttgtgat
     4261 tgcggccatt gcgctggtgg tcgcgcttat cggcgcgctt gcgggcaaga agcagggcgc
     4321 gtggaaagtt tggggtgcgg tggtcgccat cgccggtttg gtgtgcgccg tggctctgcg
     4381 cgtcatgatg tacaccatgg gagagaccct gttcatgctg tactagcggg cttcggggag
     4441 gccgccgatg cgagcctccc cacccttcga gaaatgagac aaggaggttc tcatgcgagg
     4501 aatatacaag cgggccgcac tcgcgcttgc cgctggagcg ctcgtggtag gcctcgccgg
     4561 gtgcgccgcg gagagcgcgc cggtgagcga cccttccaag ggcgataaca cccaactggc
     4621 ctataccggc gccgaatccg ccgacgagca gagcttcgat accgtcacgt tcggcagcta
     4681 tcagggtcag gacatcacct ggctcaagct cgccgaggag aacggcaaga cgctgctgat
     4741 cagcgaacag gtgctggacg ccgtgcccta tgacgattcg accgaagcgt accagtggtc
     4801 ggtgcagtcg ccacgccccc agaaggacat tgagtgggcg acgagctcga tccgcacgtg
     4861 gctgaacggc gagttcttga aggccgcctt cagcgccgat gagcagggtg ccattgccgc
     4921 cacgacgctg accgatgcga agaacaacgt gtcccacacg gcggccacgg cggctgaccc
     4981 gtcggtgcat gcggccgagg agacgactga tcaggtcttt ctgctgagcc tggccgaggc
     5041 gaagcagtac ttcgccaaca acgctgctcg tgtggcccat cctaccgact acgccgtgag
     5101 acagggcgtg tatgtgggcg tggcgagcaa cgacgagcag cccgacggcg cggcggcctg
     5161 gtggctgcgt tccaacggct actatgccgg ctacgcctcg gtggtgaccg acgacggcta
     5221 cgtgcacggc gacggctacc gcatggccgg cgagctgcac gacggcttcg acgaccacgg
     5281 ctccgagctt aagagcacgc tcggcggcaa tatcggcgtg cgtcccgcca tctgggtgga
     5341 gacgagcgcg ctttcctaga agcgtttgga atgggcggct gcgacaagcg attgcagccg
     5401 cccggttcct gttgattagt tcgggcttgg aatgatgtag ttgcgactcg ctgcgggcgg
     5461 ggccacgggg taccgcccag tcgctcagac agtcctcgat ggtatcgaag gcgttacggc
     5521 cgccttcccc ctaattcact gcgccttcga taccatctgc ggaactcgct tggtgggcgg
     5581 caccccgtgt ccccgcttgg ctcaaccacg gttgcgatat cgtcaatttg aatccgaggt
     5641 aatcgaggaa agatgagaga aggaggacaa gcatggctgg aggaaattcg ctgacgcggc
     5701 gcacgctgtg tatcggcgtg ggcgccaccg tggccatggc cgggctgggc gcgctgcgct
     5761 atgtgggcag cgagccgctc gtgcggccgc cgggaggaca ggacgaggag aacctggtgt
     5821 cccgctgcgt gcactgctac cgctgcatcg aggcgtgccc cgagaaagtg atcgtggccg
     5881 cttcgctgga tgcgggcgtg ctgaacatgc gcacgccgcg catggagttc tccgactgct
     5941 accccggtca gctggacgat tttcgctatt gcgatttctg cgccgagcgc aacggaggcg
     6001 tgcccctctg cgcggctgtg tgcccttccg gggctttgca gctgccggtc gattacgcac
     6061 ccgaaaccga ggtcattggc gtggcggtac tgaataccga aacgtgcatc gcctaccgca
     6121 gcagcttctg cgctttctgc cacgacgtgt gcatccaggt gcgtggcgag gagaatgcgg
     6181 ccatctacta ccagaacgcc gatgcgacgg atgccctgga cacgcggctg cccgtggtgg
     6241 atgccgagaa gtgcaacggt tgcggcgcct gcgaggccgt gtgcgtgtcg gcccaggccg
     6301 gctccaccat gaacgcctcg gagcgtgcca ttgtcgtgaa gccgctggaa gggtaggggg
     6361 tcgtcatgaa gttcaagaat gcgcgcactg cggtggccgc ggtggctttt gcggcgctgg
     6421 ccgtctgcct tattgccggc gtggccacgg gaacctggtg cggattcggg gcgaacgaca
     6481 tcgcggttct gtgcccggtg ggcgcgctgc tatccatggt ggcggccaag accctcatcc
     6541 cgcgtgcggt gctgagcatc gtggtggcca tcgccctcgt gctgcttttg ggccgcctgt
     6601 tctgcggctg gatctgcccc gtgaccctgt ggcgccgagt gaaggagttc ttcaagcccg
     6661 tgaaaacgcg cgagcaggag gcggaggccc tctctcaagc gaaccaggcc ctcgccgccg
     6721 aggagatcgc agcgctgaaa gaggcgtcgg cgactcacga ctgcgccgcc tgcggagcct
     6781 gccacgccaa gcgcaacgcg cccctggact cgcgtcatgc ggtgcttggc ggcgcgctgc
     6841 tgacgacggc cgtgttcggg ttccccgtgt tctgcctcgt gtgccccgtg ggcctcactt
     6901 tcgcagcggt ggccttgctg gtgagcctgt tcggctcggg cgatttgaac tggtcgctgc
     6961 tgttcgtgcc ggccatgctc gtcatcgagc tggtattcct gcgcaagtgg tgcggccgct
     7021 tctgtcccat ctcggcgttc atgagcctct tctcccgctt cagccgcacg ggcatgccgg
     7081 tcatcgacaa cgagcgctgc ctggagacgg ccaagggtac ggcctgcagc cgctgcgcca
     7141 cggcctgcac cttcgacgtg aacctgcgtc accccgactt gggcgagctg cccctgcacg
     7201 actgcgcccg ctgcggcgac tgcatcgacg cgtgccccac gagcgccatt tccttccgcg
     7261 ccgtcagcgg caagcctgtt cccttcgtcg acgccttcgc ctcgacgcgc tccggcggca
     7321 aggcgaaggc acccgccgcg ccggctttgg acgatttgga gccagaagaa gcataaggcg
     7381 gtaggggccc acggctcgcg ccatctattc gaaacctgtg atttttatca ggggcggctt
     7441 tcgggccgtc cctgcttttt gtggttgggt atcatggagg gaaatatcat ggtggctgcc
     7501 gagagaaagt gctgcattca atggtcaaca agacgttcat ccccgaaggc gaggcggtcc
     7561 cggcctcgca gattggcgcg acgctggagg cgctcgccgc cactatcgcc gcgcgtcgcg
     7621 acgccgacga ggcgagctac acctaccggc ttctgacggg caacgtcgac gatgtgctga
     7681 agaaagtcat ggaagagtcc ggggaggtgg ccctggccgc caaggacgta gaaggctggg
     7741 cgacgtcctc gctcgcggcg gctgtggcgt tggaggcgac tgaggctggc gggacgacta
     7801 ccggcgcgga gacggctgac gacggcgctg acttccccct ttccgtccag ctgcccccgg
     7861 agtacggcga ggcggtcgat catttgcgct acgaggccgc tgatgtggtg tatcatcttc
     7921 tcgtcgtgct ggagcgctac ggcatcacgc tcgacgagtt cgctgccgag ctgaacaatc
     7981 gcatgaccga aggagagcgg ccgcacggcg ccgttcgctt gcacgacgag ttcgtgcgtc
     8041 gcggaaagta gcgttcagct gcaggtcttg tgcggggaag agacggaaat ctcgcggcag
     8101 cctgagcgag cgaaacaata tggagaactt cgggggagcc cccgagttga aggaaagaag
     8161 gatttcatgg cccgactgtt tggaactgat ggcgtgcgcg gcattgcaaa tgtggagctg
     8221 acctgcgaga tggcctatcg tctcggccag gccgccgcca tctaccttgg caagaccatc
     8281 gttgtgggtc gcgacacgcg ccgctccggc gacatgctgg gcgcggccct ttccgcgggc
     8341 atcatgagcg cgggcggtac cgtgctcgag gccggtatca tccccacgcc gggcgtggcc
     8401 ctgctcgtgc gcgagatgcg cgcggcgggc ggcgcggtca tctccgcctc tcacaatccg
     8461 ccggagtaca acggcatcaa gttcttcgac gcccagggct tcaagctgcc cgatgccgtg
     8521 gaagacgaga ttgaggcctt catcgtcaac ggtggcttgg aaggtgaggt cgctgccgcc
     8581 gaggaagccg cctggagtgc cgctcaagcc gctgcgcccg atgctcccgc cgatgcgacg
     8641 agctatctgg cttccgagat caagatgcct gctggtgccg aggtgggtgt ggtcattccg
     8701 ctggaaaacg cttgcgacat ttacatcgac catgcggctc gttccatcga ggatcagggc
     8761 atttccttca agggcctgcg catcgctttg gatacgggcc acggtgcttc ctcgctcacg
     8821 tccccggagg ctctgcgacg cttgggcgcc gaggtgatcg tcatcaacga tgatttcgat
     8881 ggcatggaca tcaacgtgca gtgcggctcc actcatctcg agcccctgcg cgcgcttatg
     8941 gccgagacgg gtgccgacgt gggtattgca catgatggcg atgccgaccg cgtcatgctc
     9001 atggcgcccg atggcaccga gatcgacggc gatatggtgg aagcggtctg cgcgctcgat
     9061 atgcgcgagc gcggcgtgct ggccggtgac acggttgtgt ccacggtgat gtgcaacttc
     9121 ggtttcgtgc gcgccatgaa agagatgggc atcaacgtgg tgcagaccaa ggtaggcgac
     9181 cgctacgttc tggaggctat gcgcgagcac ggctactcca tcggtggcga gcagtctggc
     9241 cacatgattc tgctcgatca caactccacg ggcgacggcc tcatgacggc ctgccagttc
     9301 ttggcggcgg tcatccgttc cggcaagccc gtgggcgagg ccatccaggt catggagaag
     9361 atgccgcaga ccctgattaa cgtgcgtgtg aacgacaagc atgccgtgga ggacagcgcc
     9421 gaggtggccg ctgctgtggc ctctgctgag gaggcgctcg gcgaggacgg tcgcgtgctt
     9481 ctgcgcccga gtggcaccga gccggtggtg cgcgtgatgg tggaggcagt tgatccggcc
     9541 gccgcacaag cgcacgccga ggccatcgcc gccgtggtgg aagcctgcgc gtaaggcgaa
     9601 ggcgaccgac aggccctgtt ttcgagaaca atgcagtaaa tgccagttcg accccgtaat
     9661 ggtaagagtg tcagtcccgt ttcttaccaa agcgaggtcg aactggcatt ttcgcccctc
     9721 aatcgtctcc ccttcttgcc aaagcggggt cgaactggca tttacttggg agatttcgaa
     9781 aatgattttg ctcgtcggaa tcataaggct cgctcgatca tgttcttcta taagcgaata
     9841 gctcattgat ttcgctttgg caacagaacg cagcatcgct gttaacctgg ggttatttac
     9901 aaggagtcac cgttacactg tcgttatttc ttggtagtga tcggcgcaag agctttctgt
     9961 cctcggtcct gctttatctg ctgccgaaag gacgggcgac atgaaaacgc gatcccttgc
    10021 tcctggggcc tatctggcga gaagcggcca gggcgtctcg ctgtacgatg ccgacggcaa
    10081 gtgctttgcc atgaataaga tgggcggctc cattctcgct ttggccctca cgggcctttc
    10141 cgctgagggc atcgccgatg cgttgcgtca ttatttcaac gggactccca cccagtcccg
    10201 cgacgaggtg gcagcatggc tcgacgaaat ggaagcgagc ggtttcctga attcctagca
    10261 gttggccacc gacattgttg ccccatgtcg gccattgctt aaaagtatgc aggattttgc
    10321 gattaggaga gccatgcacg ccctttcagt cgctgcaggc tctccctatc gcaaaatcct
    10381 gcacaaatgg cgcgccgagg ctctccctat cgcaaaatct tgcacaaaag agccccaacg
    10441 gttgacgtgg caagtcattg ggccgcggta tacaaaggat atccgtaata agccaaaaac
    10501 gagtttgctt acctgggctg ccatagcggc cttgctcgtc ggggctgccg tgacgacttg
    10561 ctctgcttgg caccacgctt tttaaggatg agggcaacaa tcatgaatgg gagattcgta
    10621 aggtttctca aaagcgatga tagtattaac cgcattacgc taaagttcgc tcaatgaaag
    10681 tatacctcag ccatatcacg gccttacgct tctggcgcgc atggtctatc ctgcgccctc
    10741 tcacgttgca ggagtttcac agtacaggga aagtggcgga cgccaatctg ttcccttcga
    10801 acatctatca gacttcagcg gtgctgcgag attgcgctat aagggaatgc gacatccatg
    10861 gtctttttga cgagctgcct gagatgcccg aactgcgctt ttgcctcaaa gactgcactg
    10921 acggacttgg cgcgaaacca tggcatatcc tgcatgatgg taaagagggt acgaaaagtt
    10981 cgatgcttgc tgagcgtcat cgcagcctcc tgaattatcc aagagggtct ttcgtgcgca
    11041 tcgctgaggg gttattcgtc tgttcgccag agcttgtgtt cgttcaaatg gcctcctgcc
    11101 tttctttcgg tgagttgctt gcccttggct atgagctctg tgggtgctat ccgcgatcaa
    11161 cgcaaaagag tgttccgctg gtgcgtcgtc ctcttaccac gccgaaccgc ctgatggcct
    11221 acgcagcgcg tctgaatggt gcaaagggtg caaagctcgc gagagcggtt gcaaagcagg
    11281 tgcgggcaaa atcgggatcc gtgatggaaa ccgagcttgc cgccattgcg tttacggcgg
    11341 aggtttacgg gggtctcggt attgccgaag cgctcatcaa cgcccccgtt gccttgtcgg
    11401 aggaggcgcg ccgggttgct cgtaccgatt gggttgtgct cgatttttac tggcccaagg
    11461 cgcatttcgg cattgaatac aatgggcgta ctgcccatgc gagcgccgat cagcaggatc
    11521 gcgattctcg caagcgggat ggacttatgg ttgacggcat cgagacagct acgatgacga
    11581 attcccagtt tcagaatgtg acggaatgca cggctcttct cgatagggta tccggccgtg
    11641 cgggaaagaa gcgtcggaag cgcagggctg ctcatgcgga tgcccatcga aagttgcgac
    11701 gccaggtaag caaattccac cagcagcatt ttcctttcta agccgacgct gcacgagtcg
    11761 gctgccctcc ctccctcttc gcctttctag gttgtgcgcc tgccttccgt acgcggcagg
    11821 cacctttcgt gatgcggtga gcgagagctc gagcgggtgc aggactatgc gctgctctgg
    11881 cctcgaactt cctttttttg ctggacgaat ctccttttgc tctttttgct ggatgcgcga
    11941 ggccttgaat ttgtgcagga ttttgcgata gagagagccg ccgagggctg gctggcgatt
    12001 caaagctctc ctgatcgcaa aatcctgcac aaatggcgct cgggggactc tcttaatcgc
    12061 aaaatcctgc acgaaaaaag gaggagcgcg ggcaagattt gtccctctgg ccagaacctg
    12121 cttgttcgtg ccgcgccttt cgctatgatg gaaggcacgg aaattcaagg aggacgctgt
    12181 gacgacaaga gacgacaaca tcgttgcgga ggaagcgcgg gccatcgagg tcggtgagga
    12241 gacgggtgcg ggagcgccgg gcgcatcggg cggctcgggc cgtgggcgcc gcgatacctg
    12301 ggccacacat acgggcttca tcctcgcctg cgttggcagc gccgtgggca tggccaacat
    12361 ttggctgttt ccctatcgcg tggctcagtt gggcggcgcg gccttcctca tcccgtacct
    12421 cattttcgtg gcgctgctgg gctttacggg cgtgattgga gaaatgtcct tcggtcgggc
    12481 tatgggcgct ggccctatgg gcgcattcgg ccgcgccatg gagatgcgcg gtgtgcggca
    12541 cggcgagcgc atcggtaaga tcatcggcct cgttcccacc ttgggatcgc tcgccattgc
    12601 catcggatac gccgtggtgc tcggttgggc gtgcaactac tttgtggctt cgcttgacgg
    12661 agagcttatg gcgcagaccg acatgggagc cttcttcggc gccatcgcat cggacttcgg
    12721 caacgtgggc ttccacctgc tgggcttggc gctcaccttc ggcatcatga tcctcggcat
    12781 atcccggggt atcgagcgcg tgaacaaggt gctcatgccc acgttcttcg tgctgttcgt
    12841 catcatcgcc atccgcgtgg ccaccctgcc gggggcggca gctggctacg agtatctgct
    12901 cgtgccccgc tgggaggcgt tgctgaaccc cactacctgg gtgtacgctc tgggccaggc
    12961 attcttcagc ctatcgcttg ccgggtgcgg cacgctcgtc tacggtagtt acctcaagcg
    13021 agatgtggac gtggtggacg ccgccaagaa cgtcgccatt ttcgatacca tcgccgggct
    13081 tgtggccgcc tgcgtcgtgg tgccggcggt gttcgccttt gggctggacg tgtcttccgg
    13141 gccgccgctt ctgttcatca cgctggccca ggtcttccag gagatgccct tcggtaacat
    13201 tttcgctgtc atcttgttcg cggcggtggc gttcgctgcc atcacgagcc tcatgaactt
    13261 gttcgaggcg ccggtggagg cgctgcaggc ccagctgggg ctgtcgcgcg cggtgtcggt
    13321 gggcatcgtg gccgtgatcg ccgtggccgt gggcttgttc ctggagaacg gcagctcggt
    13381 gagcgactgg atggatgtca tttccatcta cgttattccc gtcggcgcgt ttctggcggc
    13441 cgtcatgttc ttctgggtat gccctcgcgg cttcgcgaag aagcaggccg agatgggccg
    13501 caaaaagccg ctcggccgct ggttcgattt catgacccgc tgcgttttcg tcatcatcac
    13561 cgcgctcgtc atcgtgctgg gcatcttcta cggcggcatc gggtagagag tgggtgaatc
    13621 gcgtgctgac ctatgagcag gagaccgaga tgcgctgtcg ccgggccagg gaagaggctc
    13681 tggagcaggg catcgagcag ggcatcgagc agggcatcga gcagggcatg gatcgcctag
    13741 gagctctcgt cggtcgtctt attgacgcgg gccgcctcga cgacgcaaag cgcgcctccg
    13801 aggatgctga ctaccgcgaa gcgctgcttg cagaatttgg gctgcagaat tgagagggga
    13861 gttgcagagc tccgttccag ggcaacctgt ggggaagggc tttgctcggt ctcgaaacat
    13921 aacagctgca gagattattg ccggatggaa aggtgtccgt cggccaccat ctgattggcc
    13981 ctctaatggc tatgaaatcg attggggttc ggtcgcaggc gagcgaggtc tggcgggggc
    14041 gagatattaa gaaatcgcaa taacttggca atatctcaga tatgggattt ggaaggtggc
    14101 gagcgcggga ttcctcttat cttcaggcaa tagtttggaa ggaggggaat catgataggt
    14161 ctcgatgcgt cattggcaag gacgggaatg aatatggaca cttcgctgaa gaagctgtcg
    14221 ccgctcgtgc tatcatggag ccagcttaaa gcacatagcc tgccgccggg taggcgtgaa
    14281 gcgctcgcag cgcggacatc gttaggcctt tgaagatgtt cgccccgcgg gcgctttttg
    14341 tttaggccgc cttgggcgtt cgtgcggaga tctttcgact acggccttcg gccttcgctc
    14401 aagatgacac gtccggcggc gcgagaagaa aggaagacct atgaagcagt tcgtggcgga
    14461 agagtcgttc tgggagctgt tccccgaggc ccagatcggc atcgtggtgg cccacaacat
    14521 gaagccgact gccgaggtgg cgcccgcgga tgccgccgcc attgcgcgtg ccctcgccga
    14581 ggccaacggc aaggccgatc agcatctgga gagcaacacc atctcgcaga acgaggtcgt
    14641 agctgtttgg cgcgaggcct atcagaaatt caagacgaag aagggtgcgc gctgctccat
    14701 cgagaacctg ctcaagcgcg tgctgaaggg caatcccgtg gggtccatca cgccgtcggt
    14761 ggacatctac aacacggtgt cgctcaccca cgcactgccc gtgggcggcg aggacatcga
    14821 tgccatggca ggcgatatcc gtctcggcat caccgagggc ggcgacgcgt tccgcccgct
    14881 cggcgaggaa gaggacgcgc ccacgttgga aggtgagctg tgctaccgcg acgatgccgg
    14941 tgccatctgc cgctgctgga actggcgcga cggcgaacgc actgccctga ccgacgactc
    15001 gaagaaggcc ttcctcatca tcgagtccgt ggatccggac cgcgccgacg acctcgccgc
    15061 tgccaccgat cagctggccg ccatggtgca acagtacctg ggcgccgaca tcttcgccaa
    15121 gcagatcatc acccgcgaca acccgaccat ggtgatcgac gaatagcgcg agtgcgcaga
    15181 gaagcgaaga cgcggggcgc ggacggcctg ggtggtcgcg cgccccgccc tatcgggaaa
    15241 ggggaggctg gtgagctggc tcgtgctcgt tgcatcgggg tgcatggaat cggtgtgggc
    15301 gattgccttg gggaagtcgg agggtttcac ccatctgggc cccaccatcg tgtttgtcgt
    15361 ggccctggtg ctttctatgc tggggctttc cttcgctgtg aagacgctgc caacgggcac
    15421 tgcctatgcc gtgtgggtgg gcatcggcgc ggccctcacg gtcatatacg gcatggtcac
    15481 gggttcggag cccgcgaacc tcgcccgcat cctgctcatc gccggcctcg tcggctgcgt
    15541 catcggcctc aaactcgtcg acggctcaac tgattaaaca attacacttc cattattcaa
    15601 cctttacacc ttcgcttttc aacttttata atgtgtaaag ctgaaaggtg ggttggaatg
    15661 gtggatggaa tcagcattcg cgaggcagct tccgagctgg gcgtttccgt gcagacggtg
    15721 cataatcgca tcaagagcgg cgcgcttgac ggcgaaaaaa cgaataccgg ctggcgggta
    15781 agcgcacgtt cggtggaggc tgccaaaaag acgccgccaa gaaaaggtcg tccttggcac
    15841 ggggagacgt atctcctgat gaacggtccc tacgaggtga tgacattcac ctatcgtcgc
    15901 gaaacggact cgttcgctcc aggtgaggtc gtcgatgccg aacgcgcccc gttgggaacg
    15961 gtgacgcgag aggggcgagg aaaggcgtcc ggcctcaaga cgtggtggca gcatcgcagc
    16021 attcctggtt cccgtgcggg aatggatgag aagctgcgca gtctcggcct agaagagccc
    16081 tcccagatcc cctttcgcaa tctggggctt tcgctttctg atcgatattg gattcgcccc
    16141 gccgatcatg ctctgcgctg ggaggacgtc aactactttc agaacgattt cgggggcgct
    16201 gagggcgatt gggacgagtg gctggccgag gtggggctct cgtcgccgga caacacgtcc
    16261 gagggcgttc ttccgaagcg gtggctctgc cgggggagtg agcgaattct gctgaagggc
    16321 catatcccct ggactgacca gcaggtttac aacgaggccg tggcgaccgc tctccatggc
    16381 cgcctcctcg ctccgggcga ttacgttccc tacgaggttc agcgtacgga ggccttgggc
    16441 gtggtgagtg cgtgcccctg tttcctgtcg ccgcatgagg agtacgtgcc catgagcttg
    16501 gttctggaag ccgaacgccg cagaaagggc gagacgcctt atgacaccgt ggtacgcgct
    16561 tgcgtaaacc ggggcattcc gttgaagacc gctgaaacgc agcttgcgaa aatgatcgtg
    16621 tgcgatagcg tcatggccaa catcgatcgc catctgcgca acttcgggct tgtgcggaac
    16681 atcgatgatc ttcgttggcg gtttgcgccg atcttcgaca cgggaaacag cctgtggtac
    16741 gacaaggacg aaggtgctgt cgctcggggc gactacgcgt tctcatcgca cccgttcagc
    16801 gatatgccga atcgccagct catgtacgcg gcggaactgg gctggttcga tgcggggaaa
    16861 ctggaaggct ttgctgacga ggcctgcgag attctagccg aaggggatct gtgccgctgg
    16921 cgcctcgact acctgcgcga gggcatccgc cagcgcatcg gtgccgtgcg ggggctgctt
    16981 gtctaagtgc gggggcaaag tcttagctat gcttcgccca gaaggcgtcg aaggcgtcca
    17041 tgagttccat ccgtgaatgg acatccgcct tctgatagat attgtagacg tgtgcccgta
    17101 cggtggactc ggcaacaaaa agcctctctg caacgtagga ggtcgttctg ccggcgatga
    17161 ggtagtcgaa cacttcggtc tctcgcttcg acagcttgca ctcagctgcg aaggatgcca
    17221 aggcagtgct tttgtcgagc cgcaagtcgc gatcctcgct gatggcgcgg tcgtccgcga
    17281 tggaaaccaa gggcatgcga tcgcgatcag taaacacgag agttgcagtg atcaatacga
    17341 tagtcatgcc aaaaacagcc aaggcagcaa cggagacgct cccagagaaa aagcctgcgg
    17401 tccagccggc gagcatcccc acggaaatgg cgagccttcc tatcgccatg gttcggaaga
    17461 gtgacgcgtc gtttgccttg acaatgttgc agtagtcgtt cagggcaagt acctcgaaca
    17521 gaagatagcc tatcatcacc atcccctcgc ccgcgatgga ctctcccccc gagatggcca
    17581 gaagcgcgaa gcccaggccc atggaggggg cgacggcccg atagagcaca tagggcttag
    17641 cggcgtcctt cgcgaattgg gcatacagga tgtagacgcc tgctagcacc acaatgcaga
    17701 caggttccgc aagatagctg gctggcagtg cgaagctgcc ggagaatgcc atggccgcaa
    17761 gcagcgagaa ggcgagggag tagcagacga gcgccagcgt catcttaaga gcggggatgc
    17821 tcttggtgac gttgcggatg gatgtttcct cggacagagc ctcatccttc agtggctcgg
    17881 tactttcgtt gtcgaaaaga gcagtgcctc ctcgccgtga aatgagacga ctcgagaaaa
    17941 cgagcgcggc ggcagacagc agggggaaga cgatgctggc gcccaagagg gttcgctcac
    18001 cgcccatcag agcgacaaga aacagaagcg cgcccacgcc gtaggatatg accagcaagg
    18061 tgagggtgtc gccgagtctc atggcgccga aaaaactgag ccacattaaa aagagtgaca
    18121 cctcggtcat ggcggtcagc aaagcggcga cgctgtgggc ctcctcactt ccgccccaaa
    18181 ggaggagggg ggtaacggcg atgcccgcga cggctcctag ggcaaggaag cagtacttac
    18241 cgcgatcggt ggcgataacg catgagagcg tcagcgagat ggcgagcata gcgcagcgca
    18301 tgagaagctc gaagagctca aaggggatgc cgcccacgca aagggggctg ccgaacagag
    18361 gcgagggaga aaggccggcg atgaacagcc aggcccaaaa gaagccgaat cccaaaaacc
    18421 ttacagggaa caccccttct tcaagcagct tcattgcccc ttctctctcg ggccttttta
    18481 ccatgggtct attataaggg gcaaggtgtc gccacctagc tctcatttga cccgtttgtg
    18541 cagcgtttaa tgtctgatca gggagaatag aaaaaaataa gcggaattac ttaggtcgga
    18601 atcgctgaaa accctgcgtt ttgacgaatg gtaagcaggg ctaatcccat cgtaaggtga
    18661 cctcgttgca tggttgcgcc cagttgggcg gcacaagagc aaggagacca tcatggaaga
    18721 cgcaccggaa ttgttcgtca cgcccgaatc cgagcaatct gaagcggtgg cggtgtcagg
    18781 gaatgtccag gcactgctcg accttatggc gcgcaatcct ctgcatcggg agatctatct
    18841 ccagattatc gagttctgcg aagtgcgccg tctcttggga gatgtcgaag ccatggtggc
    18901 cgactgctcg gggttctcac ttacggcgca gacgcccttc cggcttatcg cgaatgttgt
    18961 ggacaacgga ggcatccatt ggtacgaggt ggatgcacaa ggcgatgaga tcacggagga
    19021 gcgcagggcg aatttaacgg acgatgaagc cgacgatctt gtcgagggtt ttgccctcga
    19081 agcttccgat gcgggacgtg aggtcttgga gcgcatggct cccgaacgtc gtttgcgtga
    19141 cctgttcgac aaggcgcccg gccgccttag cacctatctg gacattatcg atttctgcgg
    19201 tgagccccaa acgttcaagg ccatcgaggc gctcgtccac caaaccgacg ccggggctct
    19261 tatcggcgcg tcgggccagc cgctgcagcc gagctatttc gtggacatgc tggaacgctc
    19321 cggcggcctg gtatgggata agggatggaa ggcgacaggg aaggggagtg cgcttgcgaa
    19381 gcaattgcgg cccgcgctgg ccgtttagaa cttggtaaat gaccggaaga gagaaagcga
    19441 gaggagaaac gatgacgaat atggcgatca cgcggcgtgg cttcatgaaa gccgccgcga
    19501 ccgctacggc ggctctgggc gttgctggcg cgcctgtcct gctcgacgag gttgatcagg
    19561 cctttgccga cagtatcccc aagcgcgaga agcacaagac ggcgtgccat ggctgtacca
    19621 actgctgccc cgtttgcgtg tacaccgaag acggtgtggt ggtgaagatt gaaggagacc
    19681 ccgacggccc gctcaacaag ggcggtgtgt gcctgaagtg cctctcccaa attcagacgg
    19741 tctacagccc gcgccatgtg ttgcatccca tgaagagggt gggcgatcgg ggccagaacc
    19801 ggtgggaggc gatttcctgg gacgaggcca ccgaccttgc gggcgagcag attgcaacgg
    19861 ctgtcgaaaa gtacggcccg tactcctact ggagtgctcg cgggggtggc ggtgcctata
    19921 tcgaatggga gacgtggggt ctcgactaca cgttcggagg ctgcaactcc ctggcctctg
    19981 gtgcctgtca gtgtgctatg ccccgagatt tcgtttccac gacgtcggtt gggttcaact
    20041 gctgtgtaga tatggacaat gtcgatcgct gggtgggcgt tgtggacaac gccgagcttg
    20101 atggcaagcg gcgcgacgac accgagcgcg tattcgtgct gtggggaagc cagccccact
    20161 cctccaaggc ggcccatggc ggtcatggcc tggtagatgc gcgctctaat ctcggggtga
    20221 aatccgttgt ggtcgatcct tatctgacgg ccgaggcc
//
