LOCUS       NC_009437.1            10225 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_009437.1 Caldicellulosiruptor saccharolyticus DSM 8903, complete
            sequence.
ACCESSION   NC_009437
VERSION     NC_009437.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:29:42
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 579681
            Orig. end    :: 589906
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10225
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[584681:584906](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5225
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10225
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10225
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             464..952
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 85.4; E-value: 4.2e-26)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_543"
                     /transl_table=11
                     /translation="VNLSKKILGQIAENMLSIFPMITKNILKKDEFTEKYGLPPRFIHI
                     LHVVDSFGPMSISELARRLSISAPNMTPVLDKLISEGYIDRIKDESDRRISIIKTTEKG
                     KWLLELHMQWVNQNLGKSLEKLSEDEIEELWYLLKRLKKLVVKMISTGQQKGDEEINV"
     PFAM_domain     590..748
                     /aSDomain="MarR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01047.24"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_543_0010"
                     /evalue="2.80E-15"
                     /label="ctg1_543"
                     /locus_tag="ctg1_543"
                     /protein_end="95"
                     /protein_start="42"
                     /score="56.0"
                     /tool="antismash"
                     /translation="IHILHVVDSFGPMSISELARRLSISAPNMTPVLDKLISEGYIDRI
                     KDESDRRI"
     CDS             945..2681
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     262.8; E-value: 4e-80)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 360; E-value:
                     3.8e-109)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_544"
                     /transl_table=11
                     /translation="MFKLFRYLRPYTWAVVLAPLFMLLEVVMDLMQPRFLERIIDVGLK
                     NGDMAYIFRTGLLMILAALIGMVGGGGCVVFSSIASQNFAFDLRNDLFKKIMAFSFKNI
                     DRFKPETLITRLTNDVMQMQNVVMMSLRIVVRAPLLFIGGLVMAVMINPKLSIILFIAI
                     PFVILIFYFMVKKSFPLFSTLQKKIDRVNAVMRENLLGARLVKAFVRHEHEKSRFLKAN
                     QDLLNISFQAFGLIVITMPLFVFVMNMSMVGVVWFGAVQIKAANMQVGELMAFINYTLQ
                     ILFSLMMIGNIFLFITRASASAERINEVLNCEIDIKNKDGAITTPIKEGKVEFRNVTFY
                     YNEEEKSPAIDGISFVAKPGEVVGIIGTTGSGKSTLVSLIPRLYDATEGEVLIDGINVK
                     DYDVTVLRKNISMVLQDTVLFTGTIKDNIAWGNEDASMEEIIEAAKVAQAHDFIMSFEK
                     GYDTEVSERGVNLSGGQKQRISIARAILKKPKILILDDCTSAVDMATEKRIQAALKEYI
                     KGTTTFIIAQRISSIKHADKILVMDGGRIVAQGTHEELLKSCPIYQEIYQTQMGEGEKE
                     IA"
     PFAM_domain     990..1799
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_544_0011"
                     /evalue="4.40E-44"
                     /label="ctg1_544"
                     /locus_tag="ctg1_544"
                     /protein_end="285"
                     /protein_start="15"
                     /score="151.3"
                     /tool="antismash"
                     /translation="VLAPLFMLLEVVMDLMQPRFLERIIDVGLKNGDMAYIFRTGLLMI
                     LAALIGMVGGGGCVVFSSIASQNFAFDLRNDLFKKIMAFSFKNIDRFKPETLITRLTND
                     VMQMQNVVMMSLRIVVRAPLLFIGGLVMAVMINPKLSIILFIAIPFVILIFYFMVKKSF
                     PLFSTLQKKIDRVNAVMRENLLGARLVKAFVRHEHEKSRFLKANQDLLNISFQAFGLIV
                     ITMPLFVFVMNMSMVGVVWFGAVQIKAANMQVGELMAFINYTLQILFS"
     PFAM_domain     1995..2441
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_544_0012"
                     /evalue="8.00E-35"
                     /label="ctg1_544"
                     /locus_tag="ctg1_544"
                     /protein_end="499"
                     /protein_start="350"
                     /score="120.4"
                     /tool="antismash"
                     /translation="DGISFVAKPGEVVGIIGTTGSGKSTLVSLIPRLYDATEGEVLIDG
                     INVKDYDVTVLRKNISMVLQDTVLFTGTIKDNIAWGNEDASMEEIIEAAKVAQAHDFIM
                     SFEKGYDTEVSERGVNLSGGQKQRISIARAILKKPKILILDDCTS"
     CDS             2674..4521
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     309.2; E-value: 3.3e-94)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 381.1; E-value:
                     1.5e-115)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_545"
                     /transl_table=11
                     /translation="LPEERKGSASSFQPPAFAPGPGPGRHPAHRFTSKSAKPKDLKYTL
                     RRLWGYFSSYKIALLGVFLLITISSFISIVSPLLVQKAIDRYIIPRKFTGLVNIIFAMI
                     VLYILNSLFAYFQGYSMMKISQKVVFNMRNDMFSKLQRLPIKIFDTRAHGDLMSRLTND
                     IDVVNNTINASVTSIFSSVITLVGSVIVMLTISPILTVCTLLVVPLMFVLTNWIANYTK
                     EYFSQNQKLLGKLNGVIEEDITGQKVIKVFTREEKEINKFIDINRQLTSVGIKAQILSG
                     VIPPLMNMLNNFAFIIVAAVGGYLALKSAVSVGSIASFVQYARQFVRPLNELANQFNQL
                     QSAFAAAERVFEIMDEEEEKEDEKDAIELTNIKGEVEFRNVWFSYKEGEPVLKDVSFHA
                     KPGQMIALVGPTGAGKTTIVNLLTRFYDIDRGEILIDGINIRKIKRESLRKSLGIVLQD
                     TYLFSEPVMENIRYGKLTAKDDEVIKAAKIANAHEFIKHLPHGYKTVLTDGGADLSQGQ
                     RQLLALARTILSDPAILILDEATSNIDTRTEKHVEEAMLKLMQGRTSFVIAHRLSTIRN
                     ADLILVINNGQVVEQGTHEELLQKRGFYYNLYMSQFAVV"
     PFAM_domain     2854..3663
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_545_0013"
                     /evalue="1.10E-56"
                     /label="ctg1_545"
                     /locus_tag="ctg1_545"
                     /protein_end="330"
                     /protein_start="60"
                     /score="192.6"
                     /tool="antismash"
                     /translation="GVFLLITISSFISIVSPLLVQKAIDRYIIPRKFTGLVNIIFAMIV
                     LYILNSLFAYFQGYSMMKISQKVVFNMRNDMFSKLQRLPIKIFDTRAHGDLMSRLTNDI
                     DVVNNTINASVTSIFSSVITLVGSVIVMLTISPILTVCTLLVVPLMFVLTNWIANYTKE
                     YFSQNQKLLGKLNGVIEEDITGQKVIKVFTREEKEINKFIDINRQLTSVGIKAQILSGV
                     IPPLMNMLNNFAFIIVAAVGGYLALKSAVSVGSIASFVQYARQFVRPL"
     PFAM_domain     3847..4296
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_545_0014"
                     /evalue="3.20E-33"
                     /label="ctg1_545"
                     /locus_tag="ctg1_545"
                     /protein_end="541"
                     /protein_start="391"
                     /score="115.2"
                     /tool="antismash"
                     /translation="LKDVSFHAKPGQMIALVGPTGAGKTTIVNLLTRFYDIDRGEILID
                     GINIRKIKRESLRKSLGIVLQDTYLFSEPVMENIRYGKLTAKDDEVIKAAKIANAHEFI
                     KHLPHGYKTVLTDGGADLSQGQRQLLALARTILSDPAILILDEATS"
     CDS             5001..5225
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_546"
                     /sec_met_domain="Bacteriocin_IId (E-value: 1.3e-29,
                     bitscore: 99.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLFVAATLGIPETLATTIVNIILTGSTIVSIILALTSILTAGVSA
                     VILAGGWTAFINLVKSKVAQLGLRGAILW"
     aSDomain        5007..5222
                     /aSDomain="TIGR03651"
                     /aSTool="tigrfam"
                     /description="circ_ocin_uber: circular bacteriocin,
                     circularin A/uberolysin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_546_0002"
                     /evalue="1.80E-26"
                     /identifier="TIGR03651"
                     /label="ctg1_546"
                     /locus_tag="ctg1_546"
                     /protein_end="74"
                     /protein_start="2"
                     /score="90.2"
                     /tool="antismash"
                     /translation="FVAATLGIPETLATTIVNIILTGSTIVSIILALTSILTAGVSAVI
                     LAGGWTAFINLVKSKVAQLGLRGAILW"
     PFAM_domain     5013..5222
                     /aSDomain="Bacteriocin_IId"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09221.12"
                     /description="Bacteriocin class IId cyclical
                     uberolysin-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_546_0015"
                     /evalue="2.60E-15"
                     /label="ctg1_546"
                     /locus_tag="ctg1_546"
                     /protein_end="74"
                     /protein_start="4"
                     /score="56.4"
                     /tool="antismash"
                     /translation="AATLGIPETLATTIVNIILTGSTIVSIILALTSILTAGVSAVILA
                     GGWTAFINLVKSKVAQLGLRGAILW"
     CDS             5374..7125
                     /locus_tag="ctg1_547"
                     /transl_table=11
                     /translation="VARFLKIYFLLIQEELSKKYKRIAKIFNLKRWEIIYILLKILSLV
                     FFYYVVSMMLKISNNYNKNMECLIFLLVYLLINLNLFYNVSISRLQQKSEFELLCIYLP
                     NKEIAFKMFFLYPYFSRQIEIVLMKFLIIILTLLHNMTWLLVFYVFIEVLFLLIYCLKY
                     ILNSNTTYRIYFSFLFLRSCATLIVFFMAKFGIQFIYDLRAVINKYKALKVPLEKILIN
                     LDNIMNNHFNKKYYYYVHKVEDLSNVVNNMSENYKTYIAAVIIEIIICFIIFYILRKNP
                     TKSKRLFYYKKRRSINSIVKSIFCYLFCRYAKPKINNNSLKAGFYKDMCLFINYLKNLE
                     PNKIIECLFPYELFFATGVSIAVAGTIQSFYVSIIIHFICIYLIMYGYIGTCNFMIEDL
                     FKFNYDKKISLAIYCSEDFRFWDGLMIPKIKVLFVFSALPILISSLLITLIFLYSLKLK
                     AVFLLFNILIILFAMKHAIVQLIKPYYLYFTKNIQHLLTYGETENNGFIMATLKAPITI
                     VRYYLLFIPNCLLVVNSIFSLLNGIEWLYCYIAVCFCYVSSLCIGVGKVDNYAKKRKIK
                     DSYNKDY"
     CDS             7079..7627
                     /locus_tag="ctg1_548"
                     /transl_table=11
                     /translation="MQKKEKLRIVIIKTIKEIKPLFLIALMFFGLSLSVGILIGYNKDI
                     EINLTKLTFLDIFKNNILTCSKALLFGIISFGIGTTFYVIYNGITLGYILASVYNSYGW
                     LPIIRYILPHAIFEITGFLLFSSLGYYPLKVVYVISKNSTNQQRHSYIYLRGVLFLIFL
                     ATVLVACAAIIESLVSYYA"
     PFAM_domain     7154..7615
                     /aSDomain="SpoIIM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01944.19"
                     /description="Stage II sporulation protein M"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_548_0016"
                     /evalue="1.50E-22"
                     /label="ctg1_548"
                     /locus_tag="ctg1_548"
                     /protein_end="179"
                     /protein_start="25"
                     /score="80.4"
                     /tool="antismash"
                     /translation="LMFFGLSLSVGILIGYNKDIEINLTKLTFLDIFKNNILTCSKALL
                     FGIISFGIGTTFYVIYNGITLGYILASVYNSYGWLPIIRYILPHAIFEITGFLLFSSLG
                     YYPLKVVYVISKNSTNQQRHSYIYLRGVLFLIFLATVLVACAAIIESLVS"
     CDS             7665..8303
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 125.4; E-value:
                     4.8e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_549"
                     /transl_table=11
                     /translation="MAYLQIENLRYSYDGNKYILRNFNLSINKNEVIKIIGPNGSGKTT
                     FLKILMGIIDDENLVYAAYLNGKQVKFSDIKFKFSYVPDRIYLLENLSGFKNIKFFSYI
                     FNENEYTKKVYEFCNLLNMDMYLKQPILEYSAGMKQKLFIAMMLAKNAELYLMDEPFNS
                     LDKESKVALANIICEMKKQDKSFLIVSHSDNDKLMYDKIIDFGFLQKAN"
     PFAM_domain     7722..8150
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_549_0017"
                     /evalue="2.10E-21"
                     /label="ctg1_549"
                     /locus_tag="ctg1_549"
                     /protein_end="162"
                     /protein_start="19"
                     /score="76.9"
                     /tool="antismash"
                     /translation="LRNFNLSINKNEVIKIIGPNGSGKTTFLKILMGIIDDENLVYAAY
                     LNGKQVKFSDIKFKFSYVPDRIYLLENLSGFKNIKFFSYIFNENEYTKKVYEFCNLLNM
                     DMYLKQPILEYSAGMKQKLFIAMMLAKNAELYLMDEPFN"
     CDS             8325..8513
                     /locus_tag="ctg1_550"
                     /transl_table=11
                     /translation="MSNKKIWLYIIGVILIILSAVIAKVFFNVKSIKAAIIIFILLFVW
                     HGWFQAELLKIGRKIKR"
     CDS             8953..9615
                     /locus_tag="ctg1_551"
                     /transl_table=11
                     /translation="MEYLKPSNLLNLVISPTKVFQKVKEKPDFLILIFFIPIIAALTTL
                     FLPKISDEAMLEYVKKITEDPQVQEATLKTLKFTKSPIYLAGTTFLHTIISFFIASFVL
                     LIIVRLAGGEIDYKRALTIVAVANLVMIPYYIFYVIYARVVNLNILDIQMNFKYFIRTY
                     LHVFAIWRYVLIGIGVFAACELNTAKSIIVSIVYSAVTLIMPIVSMFTQNFMKFGGR"
     PFAM_domain     8983..9573
                     /aSDomain="Yip1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04893.19"
                     /description="Yip1 domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_551_0018"
                     /evalue="3.50E-18"
                     /label="ctg1_551"
                     /locus_tag="ctg1_551"
                     /protein_end="207"
                     /protein_start="10"
                     /score="66.2"
                     /tool="antismash"
                     /translation="NLVISPTKVFQKVKEKPDFLILIFFIPIIAALTTLFLPKISDEAM
                     LEYVKKITEDPQVQEATLKTLKFTKSPIYLAGTTFLHTIISFFIASFVLLIIVRLAGGE
                     IDYKRALTIVAVANLVMIPYYIFYVIYARVVNLNILDIQMNFKYFIRTYLHVFAIWRYV
                     LIGIGVFAACELNTAKSIIVSIVYSAVTLIMPIV"
ORIGIN
        1 cgccaattac aagtgagaat atcataagca ttatgtactg cctgtcaatt ctgccgctat
       61 ttagaacttt gaatatgccc tgaagcaccc ccgatattcc gatgaagatg acagatagcg
      121 atattgcctg cataattgta gatttgaacc tttctgggat tccaaacttt aacacaagcc
      181 ccaaaatcga gcctacaatt acagcagcag cgtttacaat agtcccaaga cctatcattt
      241 tgtcagctcc ttcataaaaa ttttgctgat ggtcaggtaa atgtgttata atagttatgt
      301 aaaaataact atttcatatt aatcatataa ggtttcaata aaagtcgatt atatttttat
      361 aataattttt gaaacttctt tatgttaaaa taacattttt tttggatatt atattatttt
      421 tcaattgcaa tttcaaattt ttttaaaaag gtggtgcaca agagtgaatc tctctaaaaa
      481 aattttaggt caaatagctg aaaatatgtt atctatattt ccgatgataa caaaaaacat
      541 tttaaaaaag gacgaattta ctgaaaagta tgggctccca ccacgattta tccatatttt
      601 gcatgtcgta gatagttttg gaccaatgag tatatctgag cttgcaagaa ggctttctat
      661 ctctgcaccc aacatgacac cagttttaga caaacttatt tcagaagggt atatagatag
      721 gataaaagat gaatcagaca ggagaatttc cataatcaaa acgacagaaa aaggcaaatg
      781 gttgcttgaa cttcatatgc aatgggtaaa tcaaaacctg ggaaaaagtc ttgaaaagct
      841 ttctgaggac gagatcgagg aactttggta tttgctaaaa aggctaaaaa agcttgtggt
      901 gaaaatgata agtacaggtc agcaaaaggg ggatgaagaa attaatgttt aagcttttta
      961 gatatttaag accctataca tgggcagtgg tattggctcc gctttttatg cttttagagg
     1021 ttgtgatgga cctcatgcag ccaaggtttt tggagagaat aatagatgtt ggactcaaaa
     1081 acggggatat ggcatacatt ttcagaaccg ggcttttgat gattttggca gcgttaatag
     1141 gaatggttgg cggtggcgga tgtgttgtgt tttcaagcat tgcaagccaa aactttgcat
     1201 ttgatttaag aaatgacctg ttcaagaaga taatggcatt ttcgttcaaa aacattgaca
     1261 ggttcaaacc agaaactctt atcacaaggc ttacaaacga tgtcatgcaa atgcaaaatg
     1321 ttgtcatgat gtctttgaga attgttgtaa gagctccact tcttttcatt ggcgggcttg
     1381 tgatggcagt tatgataaat ccaaagcttt ccatcatttt atttattgca attccctttg
     1441 taattttaat attttacttt atggtcaaaa agagttttcc actgttttca actcttcaaa
     1501 agaaaataga tagggtcaat gcagttatgc gtgagaattt actaggagct cgacttgtaa
     1561 aggcatttgt caggcatgaa catgaaaagt caaggttttt aaaggcaaat caagaccttt
     1621 tgaatatatc attccaagcc tttggactga ttgtaattac aatgccactt tttgtgtttg
     1681 taatgaacat gagtatggta ggggttgtat ggtttggggc agttcagata aaagcagcca
     1741 atatgcaggt tggtgagctt atggcattta taaactacac attgcaaatt ctattttcgt
     1801 tgatgatgat aggcaatatc tttttgttca ttacaagggc cagtgcgtct gctgagagaa
     1861 taaatgaggt tttgaattgt gagattgaca tcaagaacaa agatggggcg attacaactc
     1921 ctataaaaga aggaaaggta gaatttagaa atgtcacatt ttattacaat gaagaagaaa
     1981 aaagccctgc tattgatgga atctcttttg ttgcaaagcc aggtgaagtt gttgggataa
     2041 taggtacaac aggttcagga aaatcaactt tagtaagtct tatcccaaga ctttacgatg
     2101 ctacagaagg cgaggttttg attgacggaa taaatgttaa agactatgat gtgaccgttt
     2161 tgagaaagaa tatcagcatg gtattgcagg atactgtact tttcacaggg actataaaag
     2221 ataacattgc atggggaaat gaagatgcat caatggaaga gataatagag gcagcaaaag
     2281 ttgcccaggc tcatgacttt ataatgagtt ttgaaaaggg ttatgacaca gaggtatctg
     2341 agcgaggtgt gaatctctcc ggtggacaaa aacagagaat ctctattgcg agggctatct
     2401 taaaaaagcc aaagatactc attttagatg actgcacatc agctgttgac atggcgacag
     2461 aaaaaagaat ccaagcagcc ttgaaagaat atatcaaagg gaccactaca tttataattg
     2521 ctcagagaat ctcttctata aaacatgcag acaaaatttt ggtgatggat ggtggaagga
     2581 ttgtagccca gggtacacat gaagaacttc taaagagctg cccaatttat caggagattt
     2641 accagactca aatgggagag ggggaaaaag aaattgcctg aagaaagaaa agggtctgca
     2701 tcttcttttc agccgcctgc ctttgcgccc gggcctggcc ctggaagaca tcctgcccac
     2761 aggtttacaa gcaaaagtgc caagccaaag gatttaaaat atacactcag aaggctatgg
     2821 ggttatttta gcagttataa aattgctctt ttgggtgtgt ttttgctaat aacaattagc
     2881 tcgtttatct caatagtttc gccgctttta gtacaaaaag ccatagatag gtatataatc
     2941 cccagaaaat ttacagggct tgtaaatata atctttgcaa tgattgtttt atatatttta
     3001 aactcgctct ttgcatattt tcaaggctat agcatgatga aaatttcaca gaaagttgtt
     3061 ttcaatatgc gaaatgatat gttttcaaag cttcaaagac ttcctataaa aatctttgac
     3121 acacgcgctc atggtgattt gatgagcagg cttacaaacg atatagatgt tgtcaacaac
     3181 accatcaatg caagtgtcac ttccattttc tcaagcgtaa ttacacttgt gggctctgtc
     3241 attgttatgt tgacaataag ccccatttta acagtttgta ctctgcttgt tgtgcctctt
     3301 atgttcgttt taacaaactg gattgctaat tacacaaaag agtacttttc acaaaaccaa
     3361 aaactacttg gaaaactcaa tggggttatt gaagaggaca tcacaggcca aaaagtgata
     3421 aaggtgttca caagagagga aaaggagata aacaagttta ttgatataaa caggcagctg
     3481 acatcggttg gaataaaagc tcagattcta tctggggtaa ttccaccgct tatgaatatg
     3541 ctcaacaact ttgcttttat aattgttgca gcagtaggtg ggtatttagc gctaaaaagt
     3601 gctgtttcag taggcagtat tgcaagcttt gtccagtatg caagacagtt tgtacgtcct
     3661 ttaaatgagc ttgcgaacca gttcaaccag cttcaatctg cctttgctgc agcagaaaga
     3721 gtatttgaaa taatggatga ggaagaagaa aaagaagatg aaaaagatgc aattgagctt
     3781 acaaatatca agggtgaggt tgaatttagg aacgtgtggt tttcttacaa agaaggtgaa
     3841 cctgttttaa aagatgtaag ctttcatgca aaaccggggc agatgatagc cttggtaggt
     3901 ccaactggtg ctggcaaaac tacaattgtc aatttgctta caaggtttta tgatattgac
     3961 agaggtgaga ttctcattga tgggattaat ataaggaaga taaaaagaga gtctttgaga
     4021 aaaagccttg ggattgtgct tcaggacaca taccttttct ctgagcctgt tatggaaaat
     4081 attcgttatg gaaagctcac agcaaaagac gacgaagtta taaaagcagc taaaattgca
     4141 aatgctcatg agtttataaa acatctgcca cacggctaca aaacagtgct aacagatggc
     4201 ggggcagacc ttagccaagg acagagacag cttttggctt tagcccggac aatcttatct
     4261 gaccctgcaa tactcatctt agatgaggcg acaagcaata tcgacacaag gacagaaaag
     4321 catgtagaag aggcaatgct aaagctcatg caaggtcgaa caagctttgt catcgctcac
     4381 agactctcta ctatcagaaa tgctgatttg attttggtta taaacaatgg tcaagttgtt
     4441 gaacagggaa cgcatgaaga gcttttgcaa aagagaggat tttattataa cctttatatg
     4501 agtcagtttg cggtggtgta gagttgttag tttgaaaata aagcttgaag tcaaaaactt
     4561 ttaaagatta ctgaacaagt tgacttatgg ctttttcttt ctaaacgcag aaaccatata
     4621 ttttaactgt ttgcaggttt ggctttttaa actcaagaaa attagagaaa ttttaagcta
     4681 tttaaagaaa aatgtatctt cagctcaaaa tttggctgaa aaaaaaaaaa cggcattgac
     4741 agagtgaaaa tgcataagat aaaatttgca tggaagtttc aagaaaaagt ttacagaaaa
     4801 aatagtttga gaacaaaatg ctctaaataa gagaataaag aaactgagat actaaaatat
     4861 caagtggatg gagaaatgag gagaaaataa ttaagaaaaa cgtactcttt tattaaaaac
     4921 ttaaaaaagt attaaacgct ccacttggag cgtttagcac aaaactctaa aaaatcgaaa
     4981 agaggggagg tggacagaaa atgctatttg tagctgcaac attaggaatt cctgaaactc
     5041 ttgctacaac tatcgtaaat attatactta ctggatccac aatagtttca attatattag
     5101 ctttaacatc tattcttaca gctggggtta gtgctgttat cttggcaggt ggctggacag
     5161 cttttattaa cctagttaaa agtaaggtcg cacaacttgg gttgagggga gctatattat
     5221 ggtaaagttt tagtgattag ttttttcaaa ctcttttgca aggggtcagc ttaaatcata
     5281 aagacgaccc cttgcattaa taattttatc acaaagttaa attttttaat tgaagatttt
     5341 ttaagagctc gaaattgata agagggggtt aaagtggcaa ggtttttgaa aatatatttt
     5401 ttgcttatcc aagaagaatt atcgaaaaaa tataaaagaa ttgctaaaat ttttaattta
     5461 aaaagatggg agattattta tattctgtta aaaatattaa gccttgtctt tttctattac
     5521 gtagtaagta tgatgttaaa gatttcgaat aattataaca aaaatatgga atgtttaatc
     5581 tttttattgg tttatttatt gataaactta aatttgtttt ataatgttag cataagtagg
     5641 ttacaacaga aatcagaatt tgagttatta tgtatatatt taccaaacaa ggaaatagca
     5701 tttaagatgt tttttctgta tccctacttt tcgagacaaa ttgaaattgt tttaatgaag
     5761 tttctcataa taattttaac cttattacat aatatgactt ggcttttagt gttttatgta
     5821 tttattgaag tacttttttt gttaatttac tgtttaaaat atattttaaa cagtaatact
     5881 acatatagaa tttatttttc atttcttttt ttgagaagtt gcgcaacgtt aattgtattt
     5941 tttatggcta aatttggaat tcaatttatc tatgatttac gtgcagttat aaataaatat
     6001 aaagctttaa aagtaccttt agaaaagata ttaattaacc tcgataatat tatgaataat
     6061 cattttaaca aaaagtatta ttactatgtt cataaagtag aagatttgtc taatgtagtt
     6121 aataatatgt cagaaaatta caaaacatac atagcagctg taataataga aattattatt
     6181 tgctttataa tattttatat attgaggaag aatcctacaa aatctaaaag gcttttctat
     6241 tataaaaaaa gaagaagtat taatagtata gtaaaaagca tattttgtta cttattttgt
     6301 agatatgcta aaccaaaaat aaataacaat tcattaaaag ctggatttta taaggatatg
     6361 tgcttgttta taaattatct caaaaattta gagccaaata aaattataga atgtcttttc
     6421 ccatatgaat tattctttgc aacaggtgtg agtatagcag tagcaggaac aattcagagt
     6481 ttttatgttt ccataattat tcattttata tgtatttatc ttattatgta tggatatata
     6541 ggaacatgca atttcatgat tgaagactta tttaaattta attatgacaa aaaaataagt
     6601 ttagcaatat actgtagcga agattttaga ttttgggatg gactaatgat accgaagatt
     6661 aaagttctat ttgttttttc tgctttaccg atactgatta gttcgttatt aataacacta
     6721 atatttttgt atagtttgaa attaaaggca gtttttcttt tgttcaatat tttaataatt
     6781 ttgtttgcaa tgaagcatgc gatagttcaa ttaataaaac cttattactt atatttcaca
     6841 aaaaacatac aacatttact cacatatggt gaaacagaaa ataatgggtt tattatggct
     6901 acgcttaaag ctccaattac aattgtaaga tactatttat tatttatacc aaattgctta
     6961 ttggtggtta actcaatatt ttctttactt aatggtattg aatggttgta ttgttatata
     7021 gctgtttgtt tttgttatgt ttcaagtcta tgtatagggg ttgggaaggt tgataattat
     7081 gcaaaaaaaa gaaaaattaa ggatagttat aataaagact attaaagaga ttaaaccctt
     7141 atttttaatt gcacttatgt tttttggact ttctttaagt gtagggattc ttataggcta
     7201 taataaagat attgaaataa atttaactaa attgacgttt ttagatatat ttaaaaataa
     7261 tatattaact tgctcaaagg ctttactttt tggtattata tcatttggga tagggacaac
     7321 gttttacgtt atatataatg gaattacttt gggctatatt cttgcaagtg tttataatag
     7381 ttatggatgg ctaccaatta ttagatacat attgccacat gctatatttg agattaccgg
     7441 gtttttactt ttttcgtcgt taggttatta tcctttgaaa gttgtttatg taatttcaaa
     7501 aaattcaacg aatcaacaaa gacactcata catatattta agaggagttc tttttttaat
     7561 ttttttggca actgttcttg tagcttgtgc cgcaattatc gaatctcttg tatcttatta
     7621 cgcatgaaaa attattaact tacacgttat tgaggtgaaa taaaatggct tatctacaaa
     7681 tagaaaatct cagatacagc tatgatggga ataagtatat attaagaaat tttaatttgt
     7741 ctattaataa gaatgaagta ataaaaatta taggaccgaa tggaagtggc aagactacat
     7801 ttcttaaaat tttaatggga ataattgatg atgaaaatct ggtttacgca gcctatttga
     7861 atggtaaaca agtaaaattt tccgatataa aatttaaatt ttcatatgtt cctgacagaa
     7921 tatatttact cgaaaatctt tctggcttta aaaatataaa gtttttttca tatattttca
     7981 atgaaaacga gtacacgaaa aaagtgtatg aattttgcaa tttattaaat atggatatgt
     8041 atctaaaaca acctatttta gaatattcag caggaatgaa acaaaaattg tttatagcta
     8101 tgatgctggc taaaaatgcc gagttgtatc ttatggatga gccatttaat agtttagata
     8161 aagaaagtaa agtagctttg gcaaatatta tttgtgaaat gaaaaaacag gataaatcat
     8221 ttttaattgt ttcgcattca gataatgata agttaatgta tgataaaatt attgactttg
     8281 gttttttaca aaaggctaat taattgtgtc agggagggtt taaaatgagt aacaaaaaaa
     8341 tatggttgta tattattggg gttatcttaa ttatattgag tgctgttatt gcaaaggtat
     8401 tttttaatgt taagagtatt aaagcagcaa taataatttt tattttatta tttgtttggc
     8461 atgggtggtt tcaagcagaa ttactaaaaa taggaagaaa aataaagaga taatagaaac
     8521 agtaatttgt gttcataata ttttttgtaa taaattttgt gttagctttt tgtttatatt
     8581 aatggttatc aaaagcaaaa aaagtgagta aaattgcaat tgtaatacca atatttttag
     8641 tatgtatgac attggcatca ctttttatgc aaagtgttgg tatatatggg ctaaatggat
     8701 tggtgataat tatggtactt ttgtttaaaa ggtttagcat aatttaactt cctaagcaca
     8761 attttaatta aatccttgtg atttgtagaa caagaaataa aatattttaa caaaattaaa
     8821 ggttcataaa atattgttgt tttaaactgg aaaatgaatt ataatataaa aggtggttga
     8881 tattttaata atcataagaa atagaagtaa ctgtgcaaat tttgattaaa ttaaaaagga
     8941 ggagtttaaa gtatggaata cttgaagcca tcaaatcttc tgaatcttgt tatttcacca
     9001 acaaaagtat ttcagaaagt caaagaaaag ccagactttt tgattttaat attttttata
     9061 ccgataatag cagcacttac tacgttgttt ttgcccaaaa tctcagatga agctatgtta
     9121 gagtatgtaa aaaaaatcac tgaagatccg caagtacaag aagctacttt gaaaacctta
     9181 aaatttacaa aatcacctat ttatttagca ggaacaacat ttttacatac cattatttca
     9241 ttttttattg cttcttttgt cttgctcata attgtaaggc ttgcaggtgg tgagattgat
     9301 tacaaaagag cacttacaat tgtggcagtt gcaaatcttg taatgattcc atattacatc
     9361 ttctatgtga tatatgccag ggtcgtaaat ttgaacattt tggacattca aatgaatttt
     9421 aagtatttta taagaacata cctgcatgtg tttgctatat ggcgatatgt actaattggg
     9481 attggggtgt ttgctgcctg tgaacttaac acagcaaaaa gtattattgt tagtattgtc
     9541 tatagtgcag tcacactcat aatgccgatt gtttcaatgt ttacacaaaa ctttatgaag
     9601 tttggtggca gataaaaaag gagagtattc tcacatgcaa aacactacaa aaggtctaaa
     9661 aaactggcaa aaagctgtaa ttattgtgtt acttatatta gtgggattta tattaacact
     9721 tgttttaact atgccatctg ggagcaaaaa ggatgcttca tctaagccaa ggactgcaaa
     9781 ggtacaaaag atttctttaa agcaaacact tttggtatct ggcattgtgc aaagcagcag
     9841 cacaaggaat gtcatctcga aggtaaatgg cactttagaa agagtttttg tcaaaaacgg
     9901 gcagtatgtc aaaaaaggag atttaatcgc taagatagat gacagccagg cagtttttaa
     9961 gatagaggct ttgaaaagac agcttcttga tcttgaactt caaagagaaa attttcgaag
    10021 agagcttcaa aactttactt taaaatctcc ccaggacggg tttgtgcaaa atcttacaac
    10081 aagtgaaggt atgcttgtta gtcaaggaat gcagataatg actattgttg atgactcgaa
    10141 gatgaagcta aatgtccagt ttcctgcctg gtgctatgga aaggtaaaaa gaggacagaa
    10201 ggcagaggtt gtagtggttg atctt
//
