LOCUS       NC_009437.1            10934 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_009437.1 Caldicellulosiruptor saccharolyticus DSM 8903, complete
            sequence.
ACCESSION   NC_009437
VERSION     NC_009437.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:29:42
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 161521
            Orig. end    :: 172455
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..3066
                     /locus_tag="ctg1_167"
                     /transl_table=11
                     /translation="VIYFKLQQRYIELNAEIEDLESQKTLKLSSLNDHMQRLSQADADI
                     KRSKHQLLNSQNLIKDYIEQSRKLLESLNMQKFSNVLDIFEKGKQKSLDIIKNELARSI
                     AEIEKALKSYDTLQDVQKDLDVQLRKLDHSKNDLQKYQDELNLLILQLEGAKNLLKSKI
                     KSYFDQNQILKTELDDITLMFQLINTISQKGEYEGVKKILNDVYNRHYLSISDNLRKLE
                     FEMNLLKERIKDKKKKIEEIQSQKDKFIPSSEKQKKVRQRLLEKGVPFVPFYMAVDFKP
                     GIEERLKAVIEDALFELGILNALIVPEKYKNEIDGLLEDEKEVVLFPRPAYFSHTLNEY
                     LEVANFENAEGLINEVAAVIDSIHINPVDDGIYVCEDGWFGNGILKGKTTTHEQARYIG
                     IENRRRYKQMLISQLEEEIQSLTKELEEKKAETNFLKSQLEVLELEKKNFPTSADIDTA
                     FDMIDGVEKNISKLQIEIEALEERIKELTNKQNLLKYEISLIATKLSLPTSKEVFAKAK
                     QDANALSSLLLRVETEALHKQEIEKTQESLNRLYEQIKESVDTLNGDVHRISKKLEVLK
                     LQKEEIEKRLSSEDAQRLFDEQRRAFERLENIPAERKRLSEKLFEVTSQKAAAEQKLEF
                     SKQELKSIESEYELASATFKIELGFGFVFKGIEFEDDKKLLEFARSKEGELKEYSQKDF
                     SSILQRLMSIHYTTQIQLAELGANLVDWKDDKTTYKRYLWTCRKEGRFLSLYQFMDEIA
                     AEIAEKKNLITESERELFEEVLAKNIGFKISRKIMLAQDWVKKMNELMANLSTSSALTF
                     RLSWEQKRQEAEDELSTGELVKLLSKDPLAATDEDRNKIAMHFRSRIEKAKKYQEDPEN
                     FATLYEIIKEILDYRQWFEFRLYYQKVGESRKELTNNAFDKFSGGEKALSIHVPLLAAL
                     CAKYQSAANFAPRIIALDEAFAGVDENNIENMFDLIEKLEFDYIMNSQVLWGDYKTVPG
                     LCIYELLRENNQPSVLKVKYIWNGYKKVLVEV"
     protocluster    1..10934
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[166178:168383](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4658..6862
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10934
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10934
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     2641..2901
                     /aSDomain="SbcCD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13558.8"
                     /description="Putative exonuclease SbcCD, C subunit"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_167_0001"
                     /evalue="2.00E-22"
                     /label="ctg1_167"
                     /locus_tag="ctg1_167"
                     /protein_end="967"
                     /protein_start="880"
                     /score="79.3"
                     /tool="antismash"
                     /translation="EILDYRQWFEFRLYYQKVGESRKELTNNAFDKFSGGEKALSIHVP
                     LLAALCAKYQSAANFAPRIIALDEAFAGVDENNIENMFDLIE"
     CDS             3063..4331
                     /locus_tag="ctg1_168"
                     /transl_table=11
                     /translation="MTKDKIFDECVEYFSQPGLKRALELIHKKYRSLGRFSGKIILENP
                     SEEEKEALSRHLRRVLRGEKVVIDVKDFAVTKFQDTKFSELDFKTILSAVLKKEVITKK
                     EEKELEKERVLNFFESLSAHFDNDENAAVVLNVFKENFKSFESFYKKYSQKEFLEIIKK
                     VIEAILKRPQTPETLAIFATRVTGNPHFFDDEQDAGKIFLKLLSIINGREFPQNAEEKS
                     ELLFDNNILIDELSNWCLLYNIGGYIENGKEDKGLKYFSNQKKPIILPLYTIKDYRGFF
                     AYSNKLVVVENPAVFSAIVQRVPAISAVCTNGHLRLSAKIIIGSIAKTNIPLLYSGDFD
                     PEGLLIADKVIQNFGARPLCMDENHYLLALSENKIDERRLEMLKNVKSAQLQSVCQKME
                     ELQLAGYQERIVDRIVEKLKVNI"
     PFAM_domain     3171..3794
                     /aSDomain="DUF3323"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11796.10"
                     /description="Protein of unknown function N-terminus
                     (DUF3323)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_168_0002"
                     /evalue="3.60E-32"
                     /label="ctg1_168"
                     /locus_tag="ctg1_168"
                     /protein_end="244"
                     /protein_start="36"
                     /score="112.1"
                     /tool="antismash"
                     /translation="SGKIILENPSEEEKEALSRHLRRVLRGEKVVIDVKDFAVTKFQDT
                     KFSELDFKTILSAVLKKEVITKKEEKELEKERVLNFFESLSAHFDNDENAAVVLNVFKE
                     NFKSFESFYKKYSQKEFLEIIKKVIEAILKRPQTPETLAIFATRVTGNPHFFDDEQDAG
                     KIFLKLLSIINGREFPQNAEEKSELLFDNNILIDELSNWCLLYNI"
     PFAM_domain     3867..4316
                     /aSDomain="DUF2399"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09664.12"
                     /description="Protein of unknown function C-terminus
                     (DUF2399)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_168_0003"
                     /evalue="2.90E-24"
                     /label="ctg1_168"
                     /locus_tag="ctg1_168"
                     /protein_end="418"
                     /protein_start="268"
                     /score="85.7"
                     /tool="antismash"
                     /translation="LPLYTIKDYRGFFAYSNKLVVVENPAVFSAIVQRVPAISAVCTNG
                     HLRLSAKIIIGSIAKTNIPLLYSGDFDPEGLLIADKVIQNFGARPLCMDENHYLLALSE
                     NKIDERRLEMLKNVKSAQLQSVCQKMEELQLAGYQERIVDRIVEKL"
     CDS             4658..6862
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 335.1; E-value:
                     1.4e-101)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_169"
                     /sec_met_domain="TIGR01193 (E-value: 1.5e-215, bitscore:
                     715.2, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.6e-39, bitscore:
                     131.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKRYYCVKQHDITDCAAASLATICLQYGKEVSIARIREMAGTDR
                     FGTTAYGVVKAAEKLGFEAKAVRAETKEAIFEKIPLPCIAHVLIDGKLFHYVVIHEIRK
                     ERIVIADPARGIVKLNPEEFFKLWTGILIFLVPNERFKKGKQEGVLKKFFKLLRPQKNL
                     ILNIFAVSVVYTLLGIAAAFYYKFLMDDVIPNLLKNTLHVIATGAILITIFKVILGAFR
                     VRLLIHLSQRLDIKLMLGYYEHVIELPMSFFGSRKIGEIISRFMDASKIRDAVSGATLT
                     LMIDSIMAVVGAIILYLQNSTLFFIALVMVLLYAAVVFGFNRALREANRQEMEDNAILT
                     SYLVESLNGIEVVKAFNIEEDVNFKTESKFVKLLKDVFKVANLNNLQSNISSAIAAVGV
                     MVILWVGAHKVINGQMSIGELFTFNALLAYFVDPIKNLIGLQPMLQTAIVAAERLSEIL
                     ELESEFQEDEDRKLSPSLKGDIEIEGLNFRYGTRQLVLRDINLKIRRGEKIAIVGESGS
                     GKTTLAKLLLGFYDYESGEIRINGYNLKDINKRHLREKIAYISQDIFLFSGTIFENLVL
                     GNRDLKMEEVIEVSKLTTLDEFVTKLPLRYNTMIEENGANLSGGQKQLIAITRALLKNP
                     EIIIMDEATSNLDSVTEQAIGKVIEKVCEGITTIIIAHRLSTILKCDRVVVMHEGRIVE
                     VGTHEELMAKKGYYYNLWREQLMGLEQKGLLGLVGSAAGG"
     PFAM_domain     4670..5074
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_169_0004"
                     /evalue="2.40E-38"
                     /label="ctg1_169"
                     /locus_tag="ctg1_169"
                     /protein_end="139"
                     /protein_start="4"
                     /score="131.1"
                     /tool="antismash"
                     /translation="YYCVKQHDITDCAAASLATICLQYGKEVSIARIREMAGTDRFGTT
                     AYGVVKAAEKLGFEAKAVRAETKEAIFEKIPLPCIAHVLIDGKLFHYVVIHEIRKERIV
                     IADPARGIVKLNPEEFFKLWTGILIFLVPNE"
     aSDomain        4685..6793
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_169_0001"
                     /evalue="2.30E-215"
                     /identifier="TIGR01193"
                     /label="ctg1_169"
                     /locus_tag="ctg1_169"
                     /protein_end="712"
                     /protein_start="9"
                     /score="715.2"
                     /tool="antismash"
                     /translation="QHDITDCAAASLATICLQYGKEVSIARIREMAGTDRFGTTAYGVV
                     KAAEKLGFEAKAVRAETKEAIFEKIPLPCIAHVLIDGKLFHYVVIHEIRKERIVIADPA
                     RGIVKLNPEEFFKLWTGILIFLVPNERFKKGKQEGVLKKFFKLLRPQKNLILNIFAVSV
                     VYTLLGIAAAFYYKFLMDDVIPNLLKNTLHVIATGAILITIFKVILGAFRVRLLIHLSQ
                     RLDIKLMLGYYEHVIELPMSFFGSRKIGEIISRFMDASKIRDAVSGATLTLMIDSIMAV
                     VGAIILYLQNSTLFFIALVMVLLYAAVVFGFNRALREANRQEMEDNAILTSYLVESLNG
                     IEVVKAFNIEEDVNFKTESKFVKLLKDVFKVANLNNLQSNISSAIAAVGVMVILWVGAH
                     KVINGQMSIGELFTFNALLAYFVDPIKNLIGLQPMLQTAIVAAERLSEILELESEFQED
                     EDRKLSPSLKGDIEIEGLNFRYGTRQLVLRDINLKIRRGEKIAIVGESGSGKTTLAKLL
                     LGFYDYESGEIRINGYNLKDINKRHLREKIAYISQDIFLFSGTIFENLVLGNRDLKMEE
                     VIEVSKLTTLDEFVTKLPLRYNTMIEENGANLSGGQKQLIAITRALLKNPEIIIMDEAT
                     SNLDSVTEQAIGKVIEKVCEGITTIIIAHRLSTILKCDRVVVMHEGRIVEVGTHEELMA
                     KKGYYYNLW"
     PFAM_domain     5150..5956
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_169_0005"
                     /evalue="1.10E-48"
                     /label="ctg1_169"
                     /locus_tag="ctg1_169"
                     /protein_end="433"
                     /protein_start="164"
                     /score="166.4"
                     /tool="antismash"
                     /translation="LNIFAVSVVYTLLGIAAAFYYKFLMDDVIPNLLKNTLHVIATGAI
                     LITIFKVILGAFRVRLLIHLSQRLDIKLMLGYYEHVIELPMSFFGSRKIGEIISRFMDA
                     SKIRDAVSGATLTLMIDSIMAVVGAIILYLQNSTLFFIALVMVLLYAAVVFGFNRALRE
                     ANRQEMEDNAILTSYLVESLNGIEVVKAFNIEEDVNFKTESKFVKLLKDVFKVANLNNL
                     QSNISSAIAAVGVMVILWVGAHKVINGQMSIGELFTFNALLAYFVDP"
     PFAM_domain     6143..6592
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_169_0006"
                     /evalue="4.50E-36"
                     /label="ctg1_169"
                     /locus_tag="ctg1_169"
                     /protein_end="645"
                     /protein_start="495"
                     /score="124.5"
                     /tool="antismash"
                     /translation="LRDINLKIRRGEKIAIVGESGSGKTTLAKLLLGFYDYESGEIRIN
                     GYNLKDINKRHLREKIAYISQDIFLFSGTIFENLVLGNRDLKMEEVIEVSKLTTLDEFV
                     TKLPLRYNTMIEENGANLSGGQKQLIAITRALLKNPEIIIMDEATS"
     CDS             6859..7242
                     /locus_tag="ctg1_170"
                     /transl_table=11
                     /translation="MREVIYDFGELKESKLLYESEIPRYGLFITYILLALVIGLVLWSV
                     VGKIDINVKVQGIIRPWEDEAKVISYVGGKVKEVFVKEGEYIKKGEVLFKIDDEEYVNK
                     RDFLKRDLSRILCFHFIAYIVEL"
     PFAM_domain     7060..7194
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_170_0007"
                     /evalue="3.30E-10"
                     /label="ctg1_170"
                     /locus_tag="ctg1_170"
                     /protein_end="112"
                     /protein_start="67"
                     /score="39.7"
                     /tool="antismash"
                     /translation="VISYVGGKVKEVFVKEGEYIKKGEVLFKIDDEEYVNKRDFLKRDL
                     "
     CDS             complement(7195..8424)
                     /gene_functions="other (smcogs) SMCOG1130:transposase
                     (Score: 276.9; E-value: 3.5e-84)"
                     /gene_kind="other"
                     /locus_tag="ctg1_171"
                     /transl_table=11
                     /translation="MEKNEIFETAKNMAIEQVLNMYCSKDDPTRPALKQLLENLLDCFM
                     LSERTVYLAKNENDKGNGFYGRKLATPVGSLEISVPRTRSGNFRPSILPDRYKRVDSSY
                     TDLLMSLVANGYSESSLVQTLKSMNLPYSEDEIEKIKNDLKNELQLFKQRELPESAFAL
                     IIDGYHCEIKDNSKVKQATCYVVLGIDLKGKKDIFGIYTFFGKENKADWMRVFDDLITR
                     GLKKVLIVVSDDFPGIIDAVRLAYPLADHQLCFVHLQRNVRKHMAKDDASVFNKELDKL
                     RTSSADFDEAISKFKLLCEQYSSKYPRFIKGICEKAEFYLAHMRYPEDLRKYIYTTNAV
                     ESVNSMIEKIRINSGGYFQSVEVLEINIYLQRENLRRGKWKNGVPILKKCSYNILQLYN
                     IRYEMETQNS"
     PFAM_domain     complement(7378..8364)
                     /aSDomain="Transposase_mut"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00872.20"
                     /description="Transposase, Mutator family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_171_0008"
                     /evalue="5.90E-67"
                     /label="ctg1_171"
                     /locus_tag="ctg1_171"
                     /protein_end="349"
                     /protein_start="20"
                     /score="226.3"
                     /tool="antismash"
                     /translation="MYCSKDDPTRPALKQLLENLLDCFMLSERTVYLAKNENDKGNGFY
                     GRKLATPVGSLEISVPRTRSGNFRPSILPDRYKRVDSSYTDLLMSLVANGYSESSLVQT
                     LKSMNLPYSEDEIEKIKNDLKNELQLFKQRELPESAFALIIDGYHCEIKDNSKVKQATC
                     YVVLGIDLKGKKDIFGIYTFFGKENKADWMRVFDDLITRGLKKVLIVVSDDFPGIIDAV
                     RLAYPLADHQLCFVHLQRNVRKHMAKDDASVFNKELDKLRTSSADFDEAISKFKLLCEQ
                     YSSKYPRFIKGICEKAEFYLAHMRYPEDLRKYIYTTNAVESVNSMIEK"
     CDS             8539..9576
                     /locus_tag="ctg1_172"
                     /transl_table=11
                     /translation="LKELRNSIEKGESLRNKNNAYYLRYLSYSYEINKLRKAAEEARVQ
                     REYSIMDFKKQIESLDEKIKSIDKFENMLREIKGVVNKGEHIKIEKYDIGYLEFILSEI
                     EAYNQQVKTKSDGSNIQKKILISKIDSKLDELRQSKSEMILQKQKIEGQLRVLNISCDD
                     TKEEIEKYKFDVLQQIDNELDNLSSEIKNLKISLEETERLIESCSIRAEKDGYVEYSAN
                     LLKGAVVNNGAEIGRIVGSQARGFKVVGYIPNTKGSSIEIGQRAKVKIAGADGLKVLEG
                     KVVRASQDIKIASQSGQGFYEVEVEVKKVPKGINLRAGQACEMSIVVEQERLIEWVLEK
                     SGLRF"
     CDS             9652..9843
                     /locus_tag="ctg1_173"
                     /transl_table=11
                     /translation="MVNESVFKNGYFVELNSYEMEFVNGGLDKALSRITLIKDLYEFAK
                     ELWDFGRGFADGWRDATR"
     CDS             9882..10073
                     /locus_tag="ctg1_174"
                     /transl_table=11
                     /translation="MNKFIQINKNELIKINGGAEEDYKFGYSVGYHLGKAYKWIANLIE
                     SIFYTLNGIPVSDLYYRG"
     CDS             10212..10934
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_175"
                     /sec_met_domain="Abi (E-value: 3.4e-21, bitscore: 72.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQAKEKKRSILKYISLLFVSSIVLPLIFQAVIYNVKVKYNILLF
                     YIFTYTCVFSFFAIFCRDEVMDLIKCSYIVIKNKIKIRNILLLFLFGSLSSIIIQIIIY
                     LFNMYLLHIRDVNSIGGYEKEIKNLIESNNMPNIIILLTIVFFSGILSPVIEEIIFRGL
                     ILQSLRQKMDSKIAIIIGALIFGLWHINLYTVLCAFLFGIILSIFYIRFNSIFVPIVIH
                     IGANVIGLINMIISLIIK"
     PFAM_domain     10635..10892
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_175_0009"
                     /evalue="3.00E-20"
                     /label="ctg1_175"
                     /locus_tag="ctg1_175"
                     /protein_end="227"
                     /protein_start="141"
                     /score="72.5"
                     /tool="antismash"
                     /translation="LTIVFFSGILSPVIEEIIFRGLILQSLRQKMDSKIAIIIGALIFG
                     LWHINLYTVLCAFLFGIILSIFYIRFNSIFVPIVIHIGANV"
ORIGIN
        1 gtgatatatt ttaagcttca gcagaggtat attgagctaa atgctgaaat tgaggattta
       61 gaaagtcaga aaactttaaa gctttcaagt ttaaatgacc acatgcaaag gctctcccag
      121 gcagatgctg acatcaagcg ttcgaaacac cagcttttaa attctcagaa tctgataaaa
      181 gactatattg agcagagcag aaagctactt gagagtttga atatgcaaaa gttttcgaat
      241 gtacttgata tttttgagaa aggtaagcaa aaaagcttag acattattaa aaatgaactg
      301 gccagatcaa tagctgagat agaaaaagct cttaaaagtt atgatacgtt acaagatgtg
      361 caaaaggact tggatgttca actaagaaaa cttgaccata gcaaaaatga tcttcaaaag
      421 tatcaagatg agttaaatct tttaattctt cagcttgaag gtgccaaaaa tcttctaaaa
      481 agcaagatca agagctattt tgaccaaaac cagattttaa aaacagagct tgatgatata
      541 actttgatgt ttcagctgat aaacacaata tcgcaaaagg gcgagtatga aggtgtaaag
      601 aagattttga atgatgtgta taacagacat tatttgtcaa tctcagataa cttgcgaaag
      661 ctcgagtttg agatgaatct actcaaagag agaattaaag acaaaaagaa aaagattgag
      721 gagattcaaa gccaaaaaga caagtttata ccatcttcag agaaacaaaa aaaggtaagg
      781 caaagacttt tagaaaaagg tgtgccattt gtgccttttt acatggcagt tgactttaaa
      841 ccgggcatag aggagagatt aaaagctgtg attgaggatg cactttttga gcttggaatt
      901 ttaaatgctc tcattgtgcc agaaaagtac aaaaatgaaa ttgatggact tttggaagat
      961 gaaaaggaag ttgtactttt tccaaggccg gcatattttt ctcacacatt aaatgagtat
     1021 cttgaggttg caaactttga aaacgcagaa ggtttgatta atgaggttgc agctgtaatt
     1081 gacagtatcc atataaatcc tgtggatgat ggaatatatg tgtgcgaaga cgggtggttt
     1141 ggaaatggca tattaaaagg gaagacaacc acacatgagc aggcaaggta tataggcatt
     1201 gagaatagac gaagatacaa acaaatgcta atttcgcagc ttgaagaaga gattcaaagc
     1261 cttacaaaag agttggaaga aaagaaagcc gagaccaatt ttctaaaatc ccagcttgag
     1321 gttttagagc tggaaaagaa aaactttcca acatctgcgg acatagacac tgcctttgac
     1381 atgatagatg gagttgagaa aaatatttca aagcttcaga ttgagattga agctcttgaa
     1441 gagagaataa aagagctgac aaataagcaa aatctgctga agtatgaaat ttcactaatt
     1501 gcaacaaagc tatcactgcc aacttcaaaa gaagtttttg caaaggcaaa acaagacgca
     1561 aatgcgttgt cgagcttact tttgcgtgtt gagactgagg cgctacacaa gcaggaaatc
     1621 gaaaaaacac aagagagtct aaacaggtta tatgaacaga taaaagaaag tgtagatact
     1681 ttaaatggcg atgttcacag gatttctaaa aagttagaag ttttaaaact tcagaaagag
     1741 gagattgaaa aaaggctttc gagcgaggat gctcaaagac tttttgatga gcaaagaaga
     1801 gcatttgaga ggcttgagaa cataccagct gagagaaaaa gacttagtga aaagcttttt
     1861 gaggtgactt cccaaaaagc agcggctgaa caaaaacttg aattttcaaa acaggaactt
     1921 aagtcaatcg aaagtgagta tgaattagca tcagccacgt ttaagataga acttggattt
     1981 ggttttgttt tcaaagggat agaatttgaa gatgacaaaa agcttttaga gtttgcaagg
     2041 tcaaaggaag gtgagctaaa agagtattct cagaaggatt tttcttcgat acttcagagg
     2101 cttatgtcca tccattacac aacacagatt cagcttgcag agcttggagc aaaccttgtt
     2161 gattggaagg acgacaaaac aacctacaag aggtatttgt ggacttgcag aaaagaggga
     2221 agatttcttt cgctttacca gttcatggat gaaattgcag cagagattgc tgagaaaaag
     2281 aacttaataa cagagagcga aagagagctt tttgaagaag ttttggcaaa gaacataggt
     2341 tttaagattt cacgaaaaat catgcttgct caggactggg ttaaaaagat gaacgagctt
     2401 atggcaaatt tgtctacatc aagtgctctt acattccggc tctcttggga acagaaaaga
     2461 caagaggcag aggatgagct ttctacgggt gagctggtaa agcttttaag caaagaccct
     2521 cttgccgcaa cagatgaaga cagaaacaag attgcaatgc attttaggtc gcgcatagaa
     2581 aaagcaaaaa agtaccaaga agaccctgaa aattttgcaa cactctatga gataatcaaa
     2641 gagattcttg attacaggca gtggtttgag ttcagactct actaccaaaa ggtgggagaa
     2701 agcaggaaag agcttacaaa caatgcattt gacaagttct ctggtggtga aaaagcactt
     2761 tccatccatg tcccactttt ggcagcactt tgtgctaaat accaaagcgc tgcgaacttt
     2821 gcgccgcgga taattgcgct tgatgaggca tttgctggcg ttgatgagaa caacattgaa
     2881 aatatgtttg atttgattga aaagcttgaa tttgactata taatgaactc tcaggttttg
     2941 tggggagatt acaaaacagt gccaggactt tgtatatatg agcttttgag agagaacaat
     3001 cagccatctg ttctaaaagt aaagtatatc tggaacgggt acaagaaggt gttggttgag
     3061 gtatgacaaa ggataagatt ttcgatgagt gtgtagagta cttttcgcag ccaggactta
     3121 aacgtgcgct ggagcttatt cataagaaat acaggtcctt ggggcgattt tctggcaaga
     3181 ttattttgga gaatccgtct gaagaggaaa aagaggcttt gtcacgacat cttagaaggg
     3241 ttttgagagg cgagaaggtt gtcattgatg tgaaagactt tgccgtgaca aagtttcagg
     3301 acactaagtt ctcagagctt gattttaaaa ccatcttgtc agcagttttg aaaaaagagg
     3361 ttatcaccaa aaaagaagaa aaggagttag aaaaggaaag agtattgaac ttttttgaaa
     3421 gtttgtcagc acattttgac aatgatgaaa atgctgcagt ggttttaaat gtctttaaag
     3481 aaaatttcaa atcatttgaa agcttttaca aaaagtattc acaaaaagag tttttagaga
     3541 taataaaaaa ggtgatagaa gcaattttaa aaaggccaca aacccctgag actttggcta
     3601 tttttgcaac aagggttaca ggcaaccctc acttttttga cgatgagcaa gatgcaggaa
     3661 agatattttt aaaacttttg agtattataa acggtagaga gtttccccaa aatgcagagg
     3721 aaaaatcaga acttcttttt gataacaaca tcttgattga tgagctttca aactggtgcc
     3781 ttttgtataa cattggcggg tatattgaaa atggaaaaga agataaaggg ctcaagtact
     3841 ttagcaatca aaaaaaacct attatcttgc cactttatac tataaaggat tatagaggat
     3901 tttttgcata ctcaaataag cttgtggttg ttgaaaaccc tgctgtattt tctgcgattg
     3961 tgcaaagagt cccagctatt tctgctgtgt gcacaaatgg gcacctaaga ctatcagcaa
     4021 agataatcat tggaagtatc gcaaagacaa atataccttt gctgtactca ggcgactttg
     4081 acccagaggg gcttttgatt gcagacaaag taattcaaaa ctttggtgca aggccgcttt
     4141 gtatggatga aaaccactat cttttggcac tgtctgaaaa taagattgat gaaaggcgct
     4201 tagagatgtt aaagaatgta aaaagtgctc agcttcaaag tgtctgccag aagatggagg
     4261 agcttcagct tgcagggtat caggagagga ttgtggatag gattgttgag aagctaaaag
     4321 ttaatatttg acagttgccc caatcaaaca gaatatattt ctgacatcat gagatgactg
     4381 tatttttaac tatttgtaaa cttacccttg ttataaactc aagaaaattt aagaaatttt
     4441 aagctattta aagaaaagta tattctgagc tcaaaatttt gttgaaaatt ggctaaaaaa
     4501 aaagaaaaaa acgggattga cagggtgaaa atgtataaga taaaatttgc atagaaattc
     4561 caagaagaag tttacagaaa agatagttca agtacaaaat agcctaaata agagaataaa
     4621 gaaggaaaca tactaaaaaa tcaagtgtga tgaagagatg agtaaaagat actattgtgt
     4681 aaagcaacat gatataacag attgtgcagc ggcgagctta gcaacaattt gtttgcaata
     4741 tggaaaagaa gtatcgatag ccagaataag agagatggca gggacagaca ggtttggcac
     4801 cacagcatat ggagttgtaa aagcagcaga aaagcttgga tttgaagcaa aagcagtcag
     4861 agcagaaact aaggaggcaa tatttgagaa aataccactt ccgtgtatag cacatgtact
     4921 gatagatggc aagctatttc attatgttgt aatacatgag ataagaaaag aaaggatagt
     4981 aatagcagac ccggccagag gaatagttaa gctaaatcca gaagagtttt ttaaattatg
     5041 gacaggcatt ttgatatttc tcgtaccaaa tgagaggttc aagaaaggaa aacaagaggg
     5101 agttttgaaa aagtttttta agttattgag accacagaag aacttgatat tgaatatttt
     5161 tgcagtgtca gttgtatata ccttgcttgg gatagcggca gcattttatt acaagttttt
     5221 gatggatgat gtaataccta atcttttgaa gaatacactt cacgttatag caacaggtgc
     5281 gatactgatt acaatattca aggtgatatt aggagcattc agggtaaggc ttttgataca
     5341 tttaagtcaa agattggata ttaaactgat gctggggtat tatgaacatg tgatagagct
     5401 tccgatgagc ttttttggta gcaggaagat aggagagata atttcgaggt ttatggacgc
     5461 gtcaaagata agggatgcgg tatcaggtgc gacgctgacg ctaatgatag acagcataat
     5521 ggcagtggta ggcgcaatta ttttatacct gcaaaattcc acgctgtttt ttatagccct
     5581 tgtgatggtt ttgctatatg cagcagtagt gtttggattt aacagggcat tgagggaagc
     5641 gaacaggcag gagatggaag acaatgcaat tttaacatcg tatttagtag agtcactgaa
     5701 tggaatagag gtagtaaagg catttaatat agaagaggat gtaaatttta agacagagag
     5761 caagtttgta aagcttttga aagatgtttt taaggtagcg aatttaaaca atttgcaaag
     5821 taatataagc agcgcaatag cagcggtagg agttatggta atactatggg taggtgcaca
     5881 caaggtaata aatgggcaga tgagcatagg agagttgttt acgttcaatg cactgcttgc
     5941 atactttgta gacccgataa aaaatctgat aggattgcag ccgatgttgc agacggcgat
     6001 agttgcagcc gaaaggctta gtgagatttt ggaactcgag agtgagtttc aagaagacga
     6061 agacaggaaa ttatcaccca gtttgaaggg tgatatagag atagagggtt tgaactttag
     6121 atacggtaca agacagcttg tgctgaggga tataaatctt aagataagaa gaggagagaa
     6181 gatagcgata gtaggtgaga gtggttcagg taagaccaca ttggcaaaat tgcttttagg
     6241 attttatgat tatgaaagcg gagagataag aataaatggc tataacttaa aggatataaa
     6301 caagaggcat ttgagggaga agatagcata tatatcacaa gacattttct tgttcagtgg
     6361 gacgatattt gagaatctgg tgcttggaaa cagggattta aaaatggaag aagtaattga
     6421 agtgagcaaa ttaacaacgc tggacgagtt tgtaacaaaa cttcctttga gatacaatac
     6481 catgatagaa gagaatggag ctaatttgtc aggcgggcag aaacagctaa tagcaataac
     6541 cagggcactt ttaaaaaatc ctgagataat aataatggat gaagcgacca gtaaccttga
     6601 ctctgtaacc gagcaggcga taggaaaggt aatagagaag gtatgtgagg ggataaccac
     6661 tataataata gcgcacaggc tatccactat tttgaaatgc gacagggttg tggtaatgca
     6721 tgaaggcagg atagtagaag tggggacgca tgaggaactc atggcaaaga aaggatatta
     6781 ttataacctg tggagagagc aactgatggg acttgagcaa aaaggacttt tgggtttggt
     6841 tgggagtgca gctggaggat gagagaggta atatatgatt ttggagagct caaggaaagc
     6901 aagcttttgt atgaatcaga gattccaagg tatggacttt ttattacata tattttgctt
     6961 gccttagtga taggacttgt tttgtggagt gtggtaggaa aaattgatat aaatgtgaag
     7021 gttcaaggga taataagacc ctgggaagat gaagcaaagg tgataagtta tgttggaggg
     7081 aaggtaaaag aggtttttgt aaaagaaggt gaatatataa agaaaggtga ggttctattt
     7141 aagattgatg atgaagaata tgtaaataag agagattttt tgaaacgaga cttgtcaaga
     7201 attttgtgtt tccatttcat agcgtatatt gtagagctgt aatatattgt aactacattt
     7261 tttaagaata ggtactccgt ttttccactt gccccgacgc aagttttctc tttgtaaata
     7321 tatgtttatc tctaaaactt ctacagattg aaaataacca ccggagttta ttcttatctt
     7381 ttcaatcata ctgtttacgc tttctacagc attagtagta taaatgtact ttcttaaatc
     7441 ttcaggatac ctcatatgtg caagatagaa ctctgctttt tcgcaaatac cttttatgaa
     7501 tcgaggatat tttgaggagt attgctcaca aagaagtttg aactttgaaa tagcttcgtc
     7561 aaaatcagca gaggaagttc ttagtttatc aagctctttg ttgaaaacgg aagcatcatc
     7621 ttttgccata tgttttctga cattgcgttg aaggtgaaca aaacatagtt gatggtcggc
     7681 aaggggataa gcgagtctaa cagcatcgat aatgcctgga aaatcatcgc ttacaactat
     7741 taagactttt ttaagacctc ttgtaattaa gtcgtcaaag actctcatcc aatcggcttt
     7801 gttttctttg ccgaagaaag tgtagatacc gaagatatct tttttgcctt ttaaatcaat
     7861 gccaagcacg acatagcaag tagcttgttt aacttttgag ttatctttaa tttcgcaatg
     7921 gtaaccgtca atgataagag caaaagcact ttcaggaagt tctctttgtt tgaaaagttg
     7981 aagctcgttt ttaagatcgt ttttgatttt ttcgatttcg tcttcagaat aaggcagatt
     8041 catgctttta agagtttgga caagagaact ttctgagtaa ccattggcga ctaaagacat
     8101 gagcaggtca gtgtatgagc tgtcaaccct tttgtagcgg tcagggagaa tggaaggtcg
     8161 aaagttacca gagcgtgtgc gaggaacaga aatttcaagg ctgccaacag gtgttgcaag
     8221 ttttctgccg taaaaaccat tgcctttatc gttttcgttt ttagcaaggt aaacagttct
     8281 ttctgataac ataaagcaat cgagcaagtt ttccaaaagc tgttttaaag ctgggcgagt
     8341 aggatcatct ttggagcaat acatatttaa tacttgctcg atagccatat ttttagcggt
     8401 ttcaaaaatt tcatttttct ccataatcgt gagcccccct ttggtgatta tttcaacact
     8461 aattatacag tggacacaat tttattttaa ctccctttga aacagcaact tagcgaatat
     8521 gagaaaagga ttgataattt gaaagaattg agaaatagca tagaaaaagg agaaagtctc
     8581 aggaataaaa ataatgcgta ctatttgaga tacttgagct atagttatga gataaacaaa
     8641 ttgagaaaag cagcagaaga agcaagagta caaagagaat acagtataat ggattttaaa
     8701 aagcagattg agagtttgga tgagaagatt aaaagtattg ataagtttga gaacatgtta
     8761 agagaaataa agggagttgt aaacaagggt gagcatatta agatagaaaa atacgacata
     8821 gggtatttgg aatttatatt gagtgaaata gaggcttaca atcagcaggt gaagacaaaa
     8881 tcggatggta gtaatataca gaagaagatt ttaatatcga aaatagattc aaaacttgat
     8941 gagctgaggc agtcaaaaag tgagatgatt ttgcagaaac agaaaataga agggcagctt
     9001 agggtactaa acatttcatg tgatgataca aaagaagaaa ttgaaaagta taagtttgat
     9061 gtgctacagc agattgataa tgagcttgat aatttaagca gtgaaataaa gaatttgaaa
     9121 ataagtttag aagaaacaga gagattgata gagagttgta gtataagagc agaaaaagat
     9181 ggttatgtag aatacagtgc aaatcttctc aagggagcgg tggtaaacaa cggagctgag
     9241 attggcagaa tagttggcag ccaagcaaga gggtttaagg ttgttggata cataccaaat
     9301 acaaaaggta gtagcataga aatagggcaa agagcaaagg taaagatagc aggagcagat
     9361 gggttaaaag tattggaagg aaaagttgta agggcatcgc aggatataaa gatagcaagc
     9421 cagagtgggc aagggtttta tgaggttgag gtagaagtaa agaaagttcc aaaaggtatt
     9481 aatttgaggg cagggcaggc atgtgagatg agcatagtgg ttgagcagga gcggttgatt
     9541 gaatgggtat tagaaaagtc gggattgagg ttttgaggtg aggcaacaac ctcttttgcg
     9601 gccgcaggag gttgggataa ataaaaaaca aaaagagagg gggaatcaaa aatggtaaat
     9661 gaaagtgttt ttaaaaatgg atattttgtt gaattaaata gttacgaaat ggaatttgtt
     9721 aatggtgggt tagataaagc ccttagtcgt attacattaa taaaagattt atatgagttt
     9781 gcaaaagagc tttgggattt tggaagagga tttgcagatg gttggcggga tgcaacccgt
     9841 taaagttagt ttttatctta aaatgaagga gggataaagt tatgaataaa tttatacaaa
     9901 taaataagaa tgaattaata aaaattaatg gtggagctga agaagattat aaatttggat
     9961 atagtgtagg atatcatttg ggaaaagctt acaaatggat agccaacctg atagaaagca
    10021 ttttctatac actaaatgga attcctgttt cagatttata ctaccgcgga tagagtttaa
    10081 aaaatattag gttaatattg gtttttaaat aaaagagtat gtgctaaagc aattgtatcc
    10141 agttttctaa aaaggaaagg gtacaattgc tttagcattt ataatgtatc taaagaaatg
    10201 agggtttatg aatggaacaa gctaaagaaa agaagaggag cattttgaaa tacataagtc
    10261 ttttatttgt atcaagtatt gtattaccat tgatatttca agcagtaatc tataatgtga
    10321 aagtaaaata taatatatta ctgttttata tattcactta tacatgcgtc ttttcgtttt
    10381 ttgctatttt ttgtagagat gaagtaatgg atttgattaa atgctcgtat atagtaatca
    10441 aaaataaaat aaagattagg aatatactgt tattattttt atttggttca ttatcgtcaa
    10501 ttataataca aatcattatt tatttattta atatgtattt gctacatatc cgcgatgtga
    10561 acagtatagg tggttatgaa aaagaaataa aaaatttaat tgaatcaaat aatatgccca
    10621 atataataat cctattgaca atagtatttt tttcagggat actctctcct gttatagagg
    10681 aaattatatt tagagggtta atacttcaaa gtttaagaca aaagatggat tccaaaattg
    10741 ctatcataat tggagcatta attttcggtt tatggcatat aaatttatat accgttttat
    10801 gtgcattttt attcggaatt atcttatcaa ttttttatat acgatttaat tcgatatttg
    10861 tgcctatagt tattcatatt ggtgctaatg ttattggtct aattaacatg ataatatcgt
    10921 taattattaa atga
//
