GCF_016728665.1_ASM1672866v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP068161.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	siderophore	882,061	894,613	coelichelin	NRP	27%
Region 2	T1PKS	1,017,377	1,062,380
Region 3	terpene	1,082,276	1,103,211
Region 4	linaridin	1,273,998	1,295,308
Region 5	NRPS	1,529,422	1,573,054	streptobactin	NRP	17%

NZ_CP068161.1 - Region 1 - siderophore

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Location: 882,061 - 894,613 nt. (total: 12,553 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.38	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.28	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.26	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.1	0.25	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.1	0.25	Other	desferrioxamine	Streptomyces argillaceus
BGC0000295.1	0.22	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001713.1	0.21	Other	ochrobactin	Ochrobactrum anthropi
BGC0001499.1	0.19	Other	aerobactin	Pantoea ananatis
BGC0000939.1	0.18	Other	aerobactin	Grimontia hollisae
BGC0000947.1	0.17	Other	vibrioferrin	Vibrio alginolyticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.70	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.61	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.59	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.1	0.59	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.1	0.59	Other	desferrioxamine	Streptomyces argillaceus
BGC0000295.1	0.55	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001713.1	0.53	Other	ochrobactin	Ochrobactrum anthropi
BGC0001499.1	0.51	Other	aerobactin	Pantoea ananatis
BGC0000939.1	0.49	Other	aerobactin	Grimontia hollisae
BGC0000947.1	0.48	Other	vibrioferrin	Vibrio alginolyticus

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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NZ_CP068161.1 - Region 2 - T1PKS

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Location: 1,017,377 - 1,062,380 nt. (total: 45,004 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.24	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.21	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.21	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.21	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000044.1	0.20	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001264.1	0.19	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.19	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0000138.1	0.19	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001897.1	0.19	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.58	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.54	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.54	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.54	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000044.1	0.53	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001264.1	0.52	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.52	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0000138.1	0.51	Polyketide	rimocidin	Streptomyces diastaticus
BGC0001897.1	0.51	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 1017376 - 1062380:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_951

PKS_AT (650..953): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: fatty_acid

Prediction, score:

fatty_acid: 93.5
Methoxymalonyl-CoA: 75.8
Malonyl-CoA: 73.2
Methylmalonyl-CoA: 72.7
trans-1,2-CPDA: 44.7
Ethylmalonyl-CoA: 44.2
Propionyl-CoA: 42.1
Isobutyryl-CoA: 35.3
2-Methylbutyryl-CoA: 28.0
Acetyl-CoA: 22.6
Benzoyl-CoA: 12.1
CHC-CoA: 9.4
inactive: 7.4
3-Methylbutyryl-CoA: 0.0

ctg1_952

CAL_domain (200..528): pk

minowa: NH2

Prediction, score:

NH2: 57.2
Acetyl-CoA: 16.7
fatty_acid: 13.0
shikimic_acid: 0.0
AHBA: 0.0

NZ_CP068161.1 - Region 3 - terpene

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Location: 1,082,276 - 1,103,211 nt. (total: 20,936 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.1	0.25	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000637.1	0.17	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.1	0.17	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000666.1	0.14	Terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0000636.1	0.14	Terpene	carotenoid	Brevibacterium linens
BGC0001928.1	0.14	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000665.1	0.13	Terpene, Alkaloid	xiamycin	Streptomyces sp. HKI0576
BGC0000503.1	0.09	RiPP	cinnamycin	Streptomyces cinnamoneus
BGC0000874.1	0.07	Other	blasticidin S	Streptomyces griseochromogenes
BGC0001510.1	0.07	Other	anisomycin	Streptomyces hygrospinosus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.1	0.58	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000637.1	0.49	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.1	0.48	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000666.1	0.43	Terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0000636.1	0.43	Terpene	carotenoid	Brevibacterium linens
BGC0001928.1	0.43	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000665.1	0.42	Terpene, Alkaloid	xiamycin	Streptomyces sp. HKI0576
BGC0000503.1	0.34	RiPP	cinnamycin	Streptomyces cinnamoneus
BGC0000874.1	0.29	Other	blasticidin S	Streptomyces griseochromogenes
BGC0001510.1	0.29	Other	anisomycin	Streptomyces hygrospinosus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP068161.1 - Region 4 - linaridin

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Location: 1,273,998 - 1,295,308 nt. (total: 21,311 nt) Show pHMM detection rules used

linaridin: (cypemycin or cypI)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.1	0.18	Other	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001210.1	0.17	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000521.1	0.17	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001137.1	0.16	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000249.1	0.16	Polyketide	nogalamycin	Streptomyces nogalater
BGC0000539.1	0.16	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000626.1	0.16	RiPP	thuricin	Bacillus thuringiensis
BGC0001222.1	0.15	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.15	RiPP	gassericin A	Lactobacillus gasseri
BGC0000514.1	0.14	RiPP	gallidermin	Staphylococcus gallinarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.1	0.50	Other	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001210.1	0.48	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000521.1	0.48	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001137.1	0.47	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000249.1	0.47	Polyketide	nogalamycin	Streptomyces nogalater
BGC0000539.1	0.47	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000626.1	0.46	RiPP	thuricin	Bacillus thuringiensis
BGC0001222.1	0.45	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.45	RiPP	gassericin A	Lactobacillus gasseri
BGC0000514.1	0.44	RiPP	gallidermin	Staphylococcus gallinarum

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NZ_CP068161.1 - Region 5 - NRPS

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Location: 1,529,422 - 1,573,054 nt. (total: 43,633 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.34	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001399.1	0.26	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001132.1	0.24	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001131.1	0.24	NRP	ambactin	Xenorhabdus miraniensis
BGC0001825.1	0.23	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001149.1	0.23	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001833.1	0.23	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.23	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844.1	0.23	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758.1	0.23	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.67	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001399.1	0.59	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001131.1	0.57	NRP	ambactin	Xenorhabdus miraniensis
BGC0001825.1	0.56	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001149.1	0.56	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001833.1	0.56	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.56	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844.1	0.56	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758.1	0.56	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 5, location 1529421 - 1573054:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1397

Search NORINE for peptide: strict or relaxed

AMP-binding (29..433): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: tMPAQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

ctg1_1399

Search NORINE for peptide: strict or relaxed

AMP-binding (399..764): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHMSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)