Select genomic region:
Overview
5.1
5.2
7.1
7.2
7.3

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_ACSH02000004 (original name was: NZ_ACSH02000004.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 5.1 | T1PKS | 112,205 | 157,112 |
Region 5.2 | lanthipeptide-class-ii | 232,872 | 255,472 |

NZ_ACSH02000002 (original name was: NZ_ACSH02000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 7.1 | siderophore | 65,566 | 78,211 |
Region 7.2 | NRPS | 309,082 | 352,942 | amonabactin P 750 | NRP | 42%
Region 7.3 | terpene | 536,200 | 557,126 | carotenoid | Terpene | 25%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 5.1 | T1PKS | 112,205 | 157,112 |
Region 5.2 | lanthipeptide-class-ii | 232,872 | 255,472 |
Region 7.1 | siderophore | 65,566 | 78,211 |
Region 7.2 | NRPS | 309,082 | 352,942 | amonabactin P 750 | NRP | 42%
Region 7.3 | terpene | 536,200 | 557,126 | carotenoid | Terpene | 25%

No secondary metabolite regions were found in these records:
  NZ_ACSH02000008 (original name was: NZ_ACSH02000008.1)
  NZ_ACSH02000007 (original name was: NZ_ACSH02000007.1)
  NZ_ACSH02000006 (original name was: NZ_ACSH02000006.1)
  NZ_ACSH02000005 (original name was: NZ_ACSH02000005.1)
  NZ_ACSH02000003 (original name was: NZ_ACSH02000003.1)

Compact view
c00005_NZ_ACSH.. - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 112,205 - 157,112 nt. (total: 44,908 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.32 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001831.1 |  | 0.24 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001897.1 |  | 0.21 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001343.1 |  | 0.21 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000044.1 |  | 0.21 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001591.1 |  | 0.19 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.19 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001264.1 |  | 0.19 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.19 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001273.1 |  | 0.19 | Polyketide | asperlactone | Aspergillus ochraceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.65 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001831.1 |  | 0.58 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001897.1 |  | 0.54 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001343.1 |  | 0.53 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000044.1 |  | 0.53 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001591.1 |  | 0.52 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.52 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001264.1 |  | 0.52 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.52 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001273.1 |  | 0.51 | Polyketide | asperlactone | Aspergillus ochraceus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 112204 - 157112:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg5_127: pk
  CAL_domain (66..536): pk
  minowa: Acetyl-CoA
  Prediction, score:
    Acetyl-CoA: 17.3
    NH2: 16.2
    AHBA: 10.6
    shikimic_acid: 10.4
    fatty_acid: -0.8
ctg5_129: mal
  PKS_AT (643..934): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 62.5%
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 115.4
    Methylmalonyl-CoA: 70.4
    Methoxymalonyl-CoA: 66.9
    Malonyl-CoA: 66.9
    Isobutyryl-CoA: 49.2
    Ethylmalonyl-CoA: 44.5
    Propionyl-CoA: 43.0
    2-Methylbutyryl-CoA: 36.0
    Acetyl-CoA: 31.8
    CHC-CoA: 29.9
    trans-1,2-CPDA: 28.6
    Benzoyl-CoA: 14.5
    3-Methylbutyryl-CoA: 14.2
    inactive: 8.9

c00005_NZ_ACSH.. - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 232,872 - 255,472 nt. (total: 22,601 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.35 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000626.1 |  | 0.28 | RiPP | thuricin | Bacillus thuringiensis
BGC0000500.1 |  | 0.27 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000521.1 |  | 0.26 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000528.1 |  | 0.25 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000517.1 |  | 0.25 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000563.1 |  | 0.25 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000516.1 |  | 0.25 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000503.1 |  | 0.24 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0001787.1 |  | 0.23 | RiPP | suicin 3908 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.68 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000626.1 |  | 0.62 | RiPP | thuricin | Bacillus thuringiensis
BGC0000500.1 |  | 0.61 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000521.1 |  | 0.60 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000528.1 |  | 0.58 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000517.1 |  | 0.58 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000563.1 |  | 0.58 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000516.1 |  | 0.58 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000503.1 |  | 0.57 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0001787.1 |  | 0.57 | RiPP | suicin 3908 | Streptococcus suis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg5_226 - Putative Class II

ctg5_222 leader / core peptide
  VVCHLDQLLAEREMTLAA - LADQVGVDhbVANLDhaVLKNNRAKAVRFDhbDhbLVALCDALDCQPGDLFDhbAE
ctg5_223 leader / core peptide
  MNASTAVLDSTILDELDKELEAQIIKELEPEMFG - LDhaRLLGNNGRWCDhbIDhbKECMPDhaCN
ctg5_224 leader / core peptide
  MNQQPSNHDRVQNYSQDELRAMIENEEAVDGG - DhbHPDhaDhbLIPIDhaIALCPDhbDhbRCDhaRRC
ctg5_225 leader / core peptide
  MKKYTKQEWAYTTIGLALGVAVALSLGQGNYMMGA - LDhaAFFGICGYLLARKDhaARKQ
allorf_235152_235298 leader / core peptide
  VCVVARAWHAYGGVVAAA - CVAVPVVGVLDhaWDhaDhaGCGADhbPDhaLAPNREDhaIA
allorf_237797_238033 leader / core peptide
  MAVAGSRLAMRWGCKFGGLGFAGA - VMPWDhaWFFYKDhaQPDhbKPAADhaLGIRFPELEFRFWAFPVPGPMGAAFLKLQLDhaDhbCEA
allorf_238090_238173 leader / core peptide
  VGVCAGSSNFA - CDGGGEGDhbLAAYRIDhbI

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg5_222 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 4769.5 Da
  Molecular weight: 4772.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4790.5 Da N = 1
    4808.5 Da N = 2
    4826.5 Da N = 3
ctg5_223 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 2523.2 Da
  Molecular weight: 2524.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2543.0 Da N = 1
ctg5_224 - Class II
  Cleavage pHMM score: -3.50
  RODEO score: 0
  Monoisotopic mass: 2399.3 Da
  Molecular weight: 2400.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2418.9 Da N = 1
    2436.9 Da N = 2
    2454.9 Da N = 3
    2472.9 Da N = 4
ctg5_225 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 2192.2 Da
  Molecular weight: 2193.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2211.6 Da N = 1
allorf_235152_235298 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 2818.5 Da
  Molecular weight: 2820.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2838.2 Da N = 1
    2856.3 Da N = 2
    2874.3 Da N = 3
    2892.3 Da N = 4
allorf_237797_238033 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 6069.1 Da
  Molecular weight: 6073.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6091.1 Da N = 1
    6109.1 Da N = 2
    6127.2 Da N = 3
    6145.2 Da N = 4
    6163.2 Da N = 5
allorf_238090_238173 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 1559.8 Da
  Molecular weight: 1560.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1578.7 Da N = 1

c00007_NZ_ACSH.. - Region 1 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 65,566 - 78,211 nt. (total: 12,646 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001498.1 |  | 0.18 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0000939.1 |  | 0.17 | Other | aerobactin | Grimontia hollisae
BGC0001870.1 |  | 0.16 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000783.1 |  | 0.16 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000772.1 |  | 0.16 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000774.1 |  | 0.16 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0000775.1 |  | 0.16 | Saccharide | lipopolysaccharide | Legionella pneumophila
BGC0000785.1 |  | 0.15 | Saccharide | O-antigen | Burkholderia mallei
BGC0000489.1 |  | 0.15 | RiPP | enterocin AS-48 | Enterococcus faecalis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001498.1 |  | 0.50 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0000939.1 |  | 0.48 | Other | aerobactin | Grimontia hollisae
BGC0001870.1 |  | 0.47 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0000783.1 |  | 0.47 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000772.1 |  | 0.47 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000774.1 |  | 0.46 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0000775.1 |  | 0.46 | Saccharide | lipopolysaccharide | Legionella pneumophila
BGC0000785.1 |  | 0.46 | Saccharide | O-antigen | Burkholderia mallei
BGC0000489.1 |  | 0.46 | RiPP | enterocin AS-48 | Enterococcus faecalis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
c00007_NZ_ACSH.. - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 309,082 - 352,942 nt. (total: 43,861 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001615.1 |  | 0.34 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000410.1 |  | 0.26 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001128.1 |  | 0.24 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.24 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.24 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001131.1 |  | 0.23 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001833.1 |  | 0.23 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001343.1 |  | 0.23 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000423.1 |  | 0.22 | NRP | scabichelin | Streptomyces scabiei 87.22
BGC0001844.1 |  | 0.22 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001615.1 |  | 0.67 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000410.1 |  | 0.59 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001128.1 |  | 0.57 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.57 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.57 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001131.1 |  | 0.56 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001833.1 |  | 0.56 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001343.1 |  | 0.56 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000423.1 |  | 0.56 | NRP | scabichelin | Streptomyces scabiei 87.22
BGC0001844.1 |  | 0.55 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 309081 - 352942:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg7_306: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (468..849): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHISLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg7_309: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (26..432): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      TMPaQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      90% (moderate)

c00007_NZ_ACSH.. - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 536,200 - 557,126 nt. (total: 20,927 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.31 | Terpene | carotenoid | Myxococcus xanthus
BGC0000644.1 |  | 0.24 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000645.1 |  | 0.22 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000637.1 |  | 0.22 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000650.1 |  | 0.22 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000664.1 |  | 0.20 | Terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002009.1 |  | 0.19 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000630.1 |  | 0.19 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0001456.1 |  | 0.19 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000649.1 |  | 0.18 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.64 | Terpene | carotenoid | Myxococcus xanthus
BGC0000644.1 |  | 0.58 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000645.1 |  | 0.55 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000637.1 |  | 0.55 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000650.1 |  | 0.55 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000664.1 |  | 0.53 | Terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002009.1 |  | 0.51 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000630.1 |  | 0.51 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0001456.1 |  | 0.51 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000649.1 |  | 0.50 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names