LOCUS       NZ_CP027793.1          10951 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP027793.1 Prescottella equi strain DSSKP-R-001 chromosome,
            complete genome.
ACCESSION   NZ_CP027793
VERSION     NZ_CP027793.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:27:47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4964689
            Orig. end    :: 4975640
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10951
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[4969689:4970640](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5951
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..10951
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10951
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="16"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             1014..1487
                     /locus_tag="ctg1_4628"
                     /transl_table=11
                     /translation="MADRDRDTLGKPRNARPRDRLGRPLEWGEEGFPTMPDDLDLDPGE
                     AITEAQRLLDHDLPFHAHEVLESAWKKAPHEERGLWQGLAQLAVAVTHQMRGNPAGAVS
                     LLRQGRHRIVPFEDDPPHALDITGLVAWADHLIVELDRDTQPDTIPVPRLRMP"
     PFAM_domain     1155..1328
                     /aSDomain="DUF309"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03745.16"
                     /description="Domain of unknown function (DUF309)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4628_0709"
                     /evalue="7.10E-20"
                     /label="ctg1_4628"
                     /locus_tag="ctg1_4628"
                     /protein_end="105"
                     /protein_start="47"
                     /score="70.6"
                     /tool="antismash"
                     /translation="TEAQRLLDHDLPFHAHEVLESAWKKAPHEERGLWQGLAQLAVAVT
                     HQMRGNPAGAVSL"
     CDS             1487..2149
                     /locus_tag="ctg1_4629"
                     /transl_table=11
                     /translation="MTHPGQMTVLPMFPLGAALLPGERLPLHVFEPRFQALVRDCLTAT
                     EGPVFGTVLIARGHEVGGGDVRNDVGTAVRIVSHVGIGDGRYALDCVGEERIRIVRWLG
                     DDPYPRAEIEPWPVEASSRVSDDQLQHLTDKITELYILLTRIRELRDDPPPAPPRLFDV
                     LERPGDHLYALASWVPMGAADKYAVLSAQTADDRHRALTDAIDNAREIAEFRLSGRR"
     PFAM_domain     1511..2095
                     /aSDomain="LON_substr_bdg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02190.18"
                     /description="ATP-dependent protease La (LON)
                     substrate-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4629_0710"
                     /evalue="1.60E-22"
                     /label="ctg1_4629"
                     /locus_tag="ctg1_4629"
                     /protein_end="203"
                     /protein_start="8"
                     /score="80.5"
                     /tool="antismash"
                     /translation="VLPMFPLGAALLPGERLPLHVFEPRFQALVRDCLTATEGPVFGTV
                     LIARGHEVGGGDVRNDVGTAVRIVSHVGIGDGRYALDCVGEERIRIVRWLGDDPYPRAE
                     IEPWPVEASSRVSDDQLQHLTDKITELYILLTRIRELRDDPPPAPPRLFDVLERPGDHL
                     YALASWVPMGAADKYAVLSAQTADDRHRALTD"
     PFAM_domain     2211..2630
                     /aSDomain="Polyketide_cyc2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10604.11"
                     /description="Polyketide cyclase / dehydrase and lipid
                     transport"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4630_0711"
                     /evalue="2.00E-11"
                     /label="ctg1_4630"
                     /locus_tag="ctg1_4630"
                     /protein_end="140"
                     /protein_start="0"
                     /score="44.5"
                     /tool="antismash"
                     /translation="MIHVRHKAVAVVPVDLAFAHIDDYRNVPDWMFGISRFVPIGDLDQ
                     GLGATYDATMQLGPKALKSTVEVTEWERDRLITLSSVSGFGNRSSWMFTPVGDDRTELS
                     VDFGYELPGGLAGKALGRLIEPFVTTAIKQTETNLR"
     aSDomain        2211..2642
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_4630_Polyketide_cyc2.1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="6.70E-16"
                     /label="ctg1_4630_Polyketide_cyc2.1"
                     /locus_tag="ctg1_4630"
                     /protein_end="144"
                     /protein_start="0"
                     /score="50.8"
                     /tool="antismash"
                     /translation="MIHVRHKAVAVVPVDLAFAHIDDYRNVPDWMFGISRFVPIGDLDQ
                     GLGATYDATMQLGPKALKSTVEVTEWERDRLITLSSVSGFGNRSSWMFTPVGDDRTELS
                     VDFGYELPGGLAGKALGRLIEPFVTTAIKQTETNLRKQIE"
     CDS             2211..2657
                     /NRPS_PKS="Domain: Polyketide_cyc2 (0-144). E-value:
                     6.7e-16. Score: 50.8. Matches aSDomain:
                     nrpspksdomains_ctg1_4630_Polyketide_cyc2.1"
                     /NRPS_PKS="type: other"
                     /locus_tag="ctg1_4630"
                     /transl_table=11
                     /translation="MIHVRHKAVAVVPVDLAFAHIDDYRNVPDWMFGISRFVPIGDLDQ
                     GLGATYDATMQLGPKALKSTVEVTEWERDRLITLSSVSGFGNRSSWMFTPVGDDRTELS
                     VDFGYELPGGLAGKALGRLIEPFVTTAIKQTETNLRKQIESLGL"
     CDS             complement(2659..3633)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 169.5; E-value: 1.6e-51)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4631"
                     /transl_table=11
                     /translation="MRTRETTIIRHWKVSWRAWLVFWIARIFVKPLFAAWPTTDRGIAA
                     LGHLEKVVDRLPKPKGVTIEPMTLGGVPSELISHHRKAADSLAGATVLYFHGGGFVFCG
                     LATHRSLCAVLAARAGVPVISVEYRQLPYGGIGTSIHDAMAAYTDLLGRAEDPTKIILA
                     GDSAGGYLAMKVAELAATRGMVTPAAVIGYSPLLNLALEKHDPDYMRRDAYLPMSQVEA
                     LKDRWAGGPEPIAGADSPIEADPRVYPPVFFSVAQYELMRPDVEAMTGMLEDVGQAVET
                     HVWSGQIHAYPVMGTVLTEATMTIAFSLDFARRALGYRGRHSA"
     PFAM_domain     complement(2761..3360)
                     /aSDomain="Abhydrolase_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07859.15"
                     /description="alpha/beta hydrolase fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4631_0712"
                     /evalue="3.00E-38"
                     /label="ctg1_4631"
                     /locus_tag="ctg1_4631"
                     /protein_end="291"
                     /protein_start="91"
                     /score="131.9"
                     /tool="antismash"
                     /translation="VLYFHGGGFVFCGLATHRSLCAVLAARAGVPVISVEYRQLPYGGI
                     GTSIHDAMAAYTDLLGRAEDPTKIILAGDSAGGYLAMKVAELAATRGMVTPAAVIGYSP
                     LLNLALEKHDPDYMRRDAYLPMSQVEALKDRWAGGPEPIAGADSPIEADPRVYPPVFFS
                     VAQYELMRPDVEAMTGMLEDVGQAVETHVWSGQIHAY"
     misc_feature    complement(3466..3468)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(3718..4869)
                     /locus_tag="ctg1_4632"
                     /transl_table=11
                     /translation="VPVANDLPLRDVYAEPTLADVLPSALSSLGAPGEANRLDIPESDR
                     TVVLLIDGLGWNLLRRNLDAAPFLNGIEGRPIRAGFPTTTATSLASFGTGLPSGRHGIT
                     GYVSDVAEAGGPFNWLRWQRVGDHRDLLAQVMPERIQPSPTVFERATAADVIATTVLPR
                     EFAGSGLTRAALRGGRFVGTVAYGDLLHSTVHAATAGERTLVYCYLSQIDTLGHVYGPG
                     SDPWVAQLTIVDRFVEDLVAHLGPDVNLLVTADHGMVPVDPSHRVDFDKEPALSSGVVA
                     LTGEARCRYVHTEPGRAAGVLSRWRELLGSRAWVGTRDDVAAAGLLGPNPTPAALRRVG
                     DVVMIAHGATAVVRSEAEPRMSMLAGQHGALTDDELLIPLLQV"
     PFAM_domain     complement(3763..4734)
                     /aSDomain="Phosphodiest"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01663.24"
                     /description="Type I phosphodiesterase / nucleotide
                     pyrophosphatase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4632_0713"
                     /evalue="4.10E-29"
                     /label="ctg1_4632"
                     /locus_tag="ctg1_4632"
                     /protein_end="369"
                     /protein_start="45"
                     /score="102.4"
                     /tool="antismash"
                     /translation="TVVLLIDGLGWNLLRRNLDAAPFLNGIEGRPIRAGFPTTTATSLA
                     SFGTGLPSGRHGITGYVSDVAEAGGPFNWLRWQRVGDHRDLLAQVMPERIQPSPTVFER
                     ATAADVIATTVLPREFAGSGLTRAALRGGRFVGTVAYGDLLHSTVHAATAGERTLVYCY
                     LSQIDTLGHVYGPGSDPWVAQLTIVDRFVEDLVAHLGPDVNLLVTADHGMVPVDPSHRV
                     DFDKEPALSSGVVALTGEARCRYVHTEPGRAAGVLSRWRELLGSRAWVGTRDDVAAAGL
                     LGPNPTPAALRRVGDVVMIAHGATAVVRSEAEPRMSMLAGQHG"
     CDS             5001..5951
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4633"
                     /sec_met_domain="AfsA (E-value: 6.1e-20, bitscore: 69.3,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVQALSFESTVPRRFVHRQSVSEVYLTDGIPVGEAGRFRLGAQWP
                     RQHAFYRTCTDRYDTMLLGETVRQCAIYLGHMHYAVPLGHLFTMQTMRIEAHLDRLTIG
                     SSAAGVVMNAQVTEHARRGSRLSAFSVDVDFLVDDTPAGHGMAVAGVLTPDDYARIRWS
                     SDRAPTVGRIPQPLPVLQSAVCVPDDRAVVLGVHPSGDIGRWLLRVDPTHPVLFDHPSD
                     HVPGVVVLEAARQSARLRLGWSCADVESLELRFRRFLELDEPTTVTTELRPGEDGCVDV
                     EFSQWGEIKASGTIRLAVPLPTVEPAHAFVGLHRV"
     PFAM_domain     5043..5435
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4633_0714"
                     /evalue="1.50E-19"
                     /label="ctg1_4633"
                     /locus_tag="ctg1_4633"
                     /protein_end="145"
                     /protein_start="14"
                     /score="70.4"
                     /tool="antismash"
                     /translation="FVHRQSVSEVYLTDGIPVGEAGRFRLGAQWPRQHAFYRTCTDRYD
                     TMLLGETVRQCAIYLGHMHYAVPLGHLFTMQTMRIEAHLDRLTIGSSAAGVVMNAQVTE
                     HARRGSRLSAFSVDVDFLVDDTPAGHG"
     PFAM_domain     5583..5891
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4633_0715"
                     /evalue="3.60E-15"
                     /label="ctg1_4633"
                     /locus_tag="ctg1_4633"
                     /protein_end="297"
                     /protein_start="194"
                     /score="56.2"
                     /tool="antismash"
                     /translation="GVHPSGDIGRWLLRVDPTHPVLFDHPSDHVPGVVVLEAARQSARL
                     RLGWSCADVESLELRFRRFLELDEPTTVTTELRPGEDGCVDVEFSQWGEIKASGTIRL"
     CDS             complement(5921..6601)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 86.4; E-value: 5.6e-26)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_4634"
                     /transl_table=11
                     /translation="VSDGEAKREGIGTVLKQERAFETRNEIIWAAATRFDETGYERASL
                     TEIVELTGFTKGALYFHFKSKDDLAVAIIEEQHAISMNAVAAIRATEAPALEQLVMLAY
                     EMGRQIVEDPVVRAGIRLTLEMSAAAGPTAPYLDWIDGLREVFQAAIEEGDIADTVDSA
                     ELARYFVSAFTGVQMVSNVLTGRADLDARLDQMVSFVLASVVAPRRRHKIDRYVHTRWS
                     PTNA"
     PFAM_domain     complement(6383..6523)
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4634_0716"
                     /evalue="7.40E-12"
                     /label="ctg1_4634"
                     /locus_tag="ctg1_4634"
                     /protein_end="73"
                     /protein_start="26"
                     /score="45.0"
                     /tool="antismash"
                     /translation="IIWAAATRFDETGYERASLTEIVELTGFTKGALYFHFKSKDDLAV
                     AI"
     CDS             6772..7587
                     /NRPS_PKS="Domain: NAD_binding_4 (20-126). E-value:
                     1.1e-08. Score: 26.3. Matches aSDomain:
                     nrpspksdomains_ctg1_4635_NAD_binding_4.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 69.2;
                     E-value: 6.7e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4635"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.3e-09, bitscore:
                     35.7, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPESPIPGVRYVLSDIGVPSTLHSALDGVDAIVHAASYTGPDETL
                     CRRINYEGTRNLLAAAEARSIDVVVTLSTIGVYGAGPFRDVVEDTREPNPVTVLSATRA
                     AADRMVRAQGGIVVRPGFVQGEGDRWFLPGLRHILARMGAWIDDGAALLSVISVDELGE
                     LIARLALTSSDADRGALFHAASPEPMSVFDIATRTATDGLPTTSCSFPTALAGAGAAGL
                     TDRHVDLVGRDHTIDGTKLRRRCERPTLRATSELPIRPRDTTRSANLKP"
     PFAM_domain     6802..7188
                     /aSDomain="3Beta_HSD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01073.21"
                     /description="3-beta hydroxysteroid dehydrogenase/isomerase
                     family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4635_0717"
                     /evalue="8.90E-12"
                     /label="ctg1_4635"
                     /locus_tag="ctg1_4635"
                     /protein_end="139"
                     /protein_start="10"
                     /score="44.7"
                     /tool="antismash"
                     /translation="YVLSDIGVPSTLHSALDGVDAIVHAASYTGPDETLCRRINYEGTR
                     NLLAAAEARSIDVVVTLSTIGVYGAGPFRDVVEDTREPNPVTVLSATRAAADRMVRAQG
                     GIVVRPGFVQGEGDRWFLPGLRHIL"
     aSDomain        6832..7149
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_4635_NAD_binding_4.1"
                     /evalue="1.10E-08"
                     /label="ctg1_4635_NAD_binding_4.1"
                     /locus_tag="ctg1_4635"
                     /protein_end="126"
                     /protein_start="20"
                     /score="26.3"
                     /tool="antismash"
                     /translation="TLHSALDGVDAIVHAASYTGPDETLCRRINYEGTRNLLAAAEARS
                     IDVVVTLSTIGVYGAGPFRDVVEDTREPNPVTVLSATRAAADRMVRAQGGIVVRPGFVQ
                     GE"
     CDS             7622..8629
                     /locus_tag="ctg1_4636"
                     /transl_table=11
                     /translation="MARPVRVVVLGSGSWGTTVAKLAAHNTPTLLWSRNPETADEINTE
                     HRNSRYLGEHELPESLRATSDILEAANEADVLVVGVPSHAIRSTLNLISNEVRAWVPVL
                     SLAKGLEPGTRQRPTEVISECLPGHPVGLLAGPNIAREIADGLAAASVVATQDEDVATA
                     LQPLFASKVFRVYRNTDVLGCELGGVLKNIVAIASGMADGLGVGDNTRAMVLARGLAEM
                     TRLGEAMGANPRTFAGLTGVGDLIATCMSPASRNRRVGEAIARGLTVDEAVEKLGQVAE
                     GVKTAPTVMELARDYHVEMPIAAEVEAVVAGRKTPEDAYRGLRKVQPGGEDEVA"
     PFAM_domain     7640..8101
                     /aSDomain="NAD_Gly3P_dh_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01210.25"
                     /description="NAD-dependent glycerol-3-phosphate
                     dehydrogenase N-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4636_0718"
                     /evalue="8.00E-47"
                     /label="ctg1_4636"
                     /locus_tag="ctg1_4636"
                     /protein_end="160"
                     /protein_start="6"
                     /score="159.2"
                     /tool="antismash"
                     /translation="VVVLGSGSWGTTVAKLAAHNTPTLLWSRNPETADEINTEHRNSRY
                     LGEHELPESLRATSDILEAANEADVLVVGVPSHAIRSTLNLISNEVRAWVPVLSLAKGL
                     EPGTRQRPTEVISECLPGHPVGLLAGPNIAREIADGLAAASVVATQDEDV"
     PFAM_domain     8159..8581
                     /aSDomain="NAD_Gly3P_dh_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07479.16"
                     /description="NAD-dependent glycerol-3-phosphate
                     dehydrogenase C-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4636_0719"
                     /evalue="3.10E-52"
                     /label="ctg1_4636"
                     /locus_tag="ctg1_4636"
                     /protein_end="320"
                     /protein_start="179"
                     /score="176.7"
                     /tool="antismash"
                     /translation="DVLGCELGGVLKNIVAIASGMADGLGVGDNTRAMVLARGLAEMTR
                     LGEAMGANPRTFAGLTGVGDLIATCMSPASRNRRVGEAIARGLTVDEAVEKLGQVAEGV
                     KTAPTVMELARDYHVEMPIAAEVEAVVAGRKTPEDAY"
     CDS             8719..10254
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 451.8; E-value: 5.5e-137)"
                     /gene_kind="other"
                     /locus_tag="ctg1_4637"
                     /transl_table=11
                     /translation="MGSSVSESVRHTRVLIVGAGFAGLGMALQLTRRGRRDFLILEQAD
                     AVGGTWRQNTYPGCECDIPSVLYSYSFAPKTDWTSSHAGQPEILDYLIELTERHGLRDR
                     LQFGTEVAGAQWDETGCRWHVFDKSGREFVAQYLVVASGALNVPRIPRIPGAETFAGAS
                     MHSAAWRNDVDLTGKRVALIGTGASGIQLAPHLAERAAELTVFQRTPAWILPRRRFRTA
                     VAASRRSTLARNLFRAATYWGGEALGVGLGRPRLLEHTQNRALAHLRKQVHNAVLRDAL
                     TPDYRIGCKRILRSNDFYPTLARPNTTLVTDPITAIHPSGIETADGTRHDVDVIVYATG
                     FRVAGALNRMNLVGRGGVSLLERWQQDGVRTHLGVTMSGMPNAFFLSGPNTGLGHNSVI
                     VMIEAQIAHALDAMRLAEESGAGTVEVRAAAQDAFDSSLRERLSRGVWSTGGCASWYLD
                     ARGSNHALWPGTSWDYRRRTRVVDPADYQLLRAESHRGLTTPKNGWTRSDARC"
     PFAM_domain     8755..9366
                     /aSDomain="FMO-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00743.21"
                     /description="Flavin-binding monooxygenase-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4637_0720"
                     /evalue="3.80E-14"
                     /label="ctg1_4637"
                     /locus_tag="ctg1_4637"
                     /protein_end="216"
                     /protein_start="12"
                     /score="52.1"
                     /tool="antismash"
                     /translation="RVLIVGAGFAGLGMALQLTRRGRRDFLILEQADAVGGTWRQNTYP
                     GCECDIPSVLYSYSFAPKTDWTSSHAGQPEILDYLIELTERHGLRDRLQFGTEVAGAQW
                     DETGCRWHVFDKSGREFVAQYLVVASGALNVPRIPRIPGAETFAGASMHSAAWRNDVDL
                     TGKRVALIGTGASGIQLAPHLAERAAELTVFQRTPAWILPR"
ORIGIN
        1 ccgtgcttgg cggacgtgta gttcgacgtc ccggggctgg ccttgatgcc ggccgccgag
       61 ctgacgacga tgatcgagcc gccgcgaccg ccgtcgatca tcgcgggaac cgcagccttc
      121 agggtgcgcc acacgccgtt gaggttgatg tcgatcatcg tggtccactg ctcctcgggc
      181 atctcccaga agcggttcca cgtcgagatg ccggcgttcg cgaccacgat gtcgagacgg
      241 ccgaatcgcg caacaccggc gtcgacggcg gcctgcaggt cggactggtc gcggacgtcg
      301 ccgatcgcgg tgacgatctc gcggccctcg gcgcgcacga ggcgggcggt ctcctcgaga
      361 tcctcgggcg tggccgccgg gtagccgacg tcgtcggaca cggacgcgca gatgtcgagc
      421 gcgatgatgt ccgcgccttc ctgtgcgaag cgcaccgcgt ggttgcgccc ctgtccgcgt
      481 gccgcgcctg tgatgaaggc aaccttgttc tcgagcagtg ccatgcgaat ccctccggat
      541 ccctcgtcgt gcagtatctc cgcagattaa ggcagtgatt gagcctcgtt cggggcgctt
      601 tccggtgacc gggaccacaa ccgattcgac ccccgatccg gcgggtggtc gaggcacccc
      661 gaaacgtcgt gtaggctgaa cataccgacg cggggtggag cagctcggta gctcgctggg
      721 ctcataaccc agaggtcgca ggttcaaatc ctgtccccgc tacaaatgaa agacccggta
      781 tcgcaccagc gataccgggt cttttctttt gtccacgacg ccgccgccgg cgtcacaccg
      841 gttttcggaa caacacacac gaaatgcacg ccgaatcggt gtgtgttgcc gacagaaagg
      901 gtgtggcgcc gcggcctcgg cgcgccggca ctccaccgcc cgacccgaga cgattccggg
      961 caacccgaag ctgcccctcc cccggtaccc ctgtcggcgg ctagattgct tctatggccg
     1021 accgcgatcg ggacaccctc ggtaagccgc gcaacgcccg gccccgggat cgtctggggc
     1081 gcccgctcga gtggggcgag gaagggtttc cgacgatgcc cgacgacctg gacctcgatc
     1141 ccggcgaggc gatcaccgag gcgcagcgcc tgctcgatca cgacctgccg ttccacgcgc
     1201 acgaggtgct cgagtccgcc tggaagaagg cgccgcacga ggagcgcgga ctgtggcagg
     1261 gcctggccca gctcgcggtg gcggtaaccc atcagatgcg cggcaacccg gccggcgccg
     1321 tctccctgct caggcagggc cgacaccgca tcgtcccgtt cgaggacgac ccgccgcacg
     1381 cgctcgacat caccggcctg gtcgcgtggg ccgatcacct catcgtcgaa ctcgatcgag
     1441 acacgcaacc cgacacgatc ccggttcccc gactccggat gccctgatga ctcatcctgg
     1501 tcaaatgacc gttctgccga tgttccccct cggcgccgca ctgctgcccg gggaacggct
     1561 cccgctgcac gtgttcgagc cccggttcca ggcgctcgtc cgcgactgtc tcactgccac
     1621 cgagggtccc gtcttcggca ctgtgctcat cgcgcgtggc cacgaggtgg gcggtggtga
     1681 cgtccgcaac gacgtcggca ccgcggtgcg gatcgtctcc cacgtcggca tcggcgacgg
     1741 acggtacgcg ttggactgcg tcggcgagga gcgcatccgg atcgtgcgat ggctcggcga
     1801 cgacccgtat ccgcgcgccg agatcgagcc atggccggtg gaggcgtcga gtcgcgtgtc
     1861 ggacgaccaa ctccagcacc tcaccgacaa gatcaccgag ctgtacatcc tgctgacccg
     1921 gatccgggag ttgcgcgacg atccgccgcc agcccctccg cgcctgttcg acgtgctcga
     1981 gcggcccggc gaccacctgt acgcgctcgc ctcctgggta ccgatggggg cagcggacaa
     2041 gtacgcggtg ctgtccgccc agaccgccga cgaccggcac cgggcgctga cggacgcgat
     2101 cgacaacgcc cgcgagatcg ccgagttccg actctcgggg cggcggtgac cggagtggac
     2161 cgtcggatgc actagcgtcc gacctccggg gaattcaggg gaggaaacac atgatccacg
     2221 ttcgacacaa ggccgttgcc gtcgttcccg tcgatctggc gttcgcgcac atcgacgact
     2281 atcggaacgt gcccgactgg atgttcggca tcagccgatt cgtcccgatc ggcgacctcg
     2341 accaaggtct gggcgccacg tacgacgcga cgatgcagct cggccccaag gcgctgaagt
     2401 cgacggtcga ggtcaccgag tgggagcggg atcggctcat cacgttgtcc tcggtctccg
     2461 gattcggcaa ccggtccagt tggatgttca ccccggtcgg cgacgaccgc accgagttgt
     2521 ccgtcgactt cggctacgaa ctgccgggcg ggctggccgg caaggccctg ggcaggctga
     2581 tcgagccgtt cgtcaccacc gcgatcaagc agaccgagac gaatctgcgc aagcagatcg
     2641 agtcgctggg cctgtagatc aggcggagtg ccggccgcgg taacccagtg cgcggcgggc
     2701 gaagtcgagg ctgaacgcga tcgtcatggt ggcctccgtc agcactgtgc ccatcaccgg
     2761 gtaggcgtgg atctggccac tccacacgtg cgtctcgacg gcctgtccga cgtcctcgag
     2821 catccccgtc atcgcctcca cgtcggggcg catcagctcg tactgggcga cgctgaagaa
     2881 caccggcggg tacacccgcg gatcggcctc gatgggcgaa tcggccccgg cgatcggttc
     2941 cggaccgccg gcccaccggt ccttgagcgc ctcgacctgg ctcatcggca ggtaggcgtc
     3001 gcgacgcatg tagtcggggt cgtgcttctc gagcgccagg ttgagcagcg gcgagtaccc
     3061 gatcacggcg gcgggggtca ccatgccgcg ggtcgcggcc agttcggcca ccttcatcgc
     3121 caggtagcca cccgccgagt cgcccgcgag gatgatcttc gtgggatcct cggctctgcc
     3181 gagcagatcg gtgtacgcgg ccatcgcgtc gtggatggac gtgccgatcc cgccgtacgg
     3241 cagctgccga tactcgacgg agatcaccgg gacgcctgct cgggccgcga gtaccgcaca
     3301 gaggctgcga tgagttgcca agccgcagaa gacgaatccg ccgccgtgga agtacaggac
     3361 ggtcgcaccc gcgagcgagt cggcagcctt ccggtgatgg ctgatcagtt cactcggcac
     3421 cccgccgagc gtcatcggct cgatcgtgac gcccttgggc ttgggtaacc ggtcgacgac
     3481 cttctccagg tgcccgagag ccgcgatgcc ccggtcggtg gtgggccacg ccgcgaagag
     3541 cggtttgacg aagatgcgcg cgatccagaa caccagccac gcccgccagc tcaccttcca
     3601 gtgccggatg atcgtcgtct cgcgcgtacg catcgtgccc ccagtcgtcg tccccgcggg
     3661 tggtcaggtc caccccgccc gccaccctag agtccggcgc cggaacccgc acggacatca
     3721 gacctgcagc agcgggatca ggagttcgtc gtcggtgagt gcaccgtgct ggcccgccag
     3781 catcgacatc cgcggctcgg cctcgctgcg gaccacggca gtggcgccgt gcgcgatcat
     3841 cacgacgtca cccacccggc gcagcgcggc cggggtcggg ttcggcccca gcagcccggc
     3901 ggcggcgacg tcgtcgcggg tacccaccca ggcccgcgag ccgagcagct cccgccaccg
     3961 gctcaggacg cccgcggcac gcccgggttc ggtgtgcacg taccggcagc gggcttcgcc
     4021 ggtgagggcg accaccccgc tcgacagcgc gggttccttg tcgaagtcga cgcggtgcga
     4081 cgggtcgacc ggcaccatgc cgtggtcggc ggtcaccagc aggttgacgt cgggacccag
     4141 gtgcgcgacg aggtcctcga cgaaccggtc gacgatcgtc agctgcgcca cccacgggtc
     4201 gctgccgggt ccgtacacgt ggccgagggt gtcgatctga ctcaggtagc agtagaccag
     4261 ggtccgctct cccgccgtcg cggcgtgcac cgtcgagtgc aacaggtcgc cgtacgcgac
     4321 ggtgccgacg aagcggccgc cgcgcagggc ggcacgggtg agtccgctgc cggcgaactc
     4381 gcggggcaga actgtcgtcg cgatcacgtc ggctgccgtc gcgcgctcga aaactgtggg
     4441 ggacggctgg atccgctccg gcatcacctg cgcgagcagg tcgcggtggt cgccgacccg
     4501 ctgccagcgc agccagttga acggtccacc cgcctccgcg acgtccgaga cgtaaccggt
     4561 gatgccgtgc cggcccgacg gcagtccggt gccgaacgac gccaggctcg tcgcggtggt
     4621 ggtggggaat ccggcccgga tcggtcgccc ctcgatgccg ttgaggaacg gagcggcatc
     4681 gaggttgcgg cgcagtagat tccagccgag accgtcgatc agcagaacca cggtccgatc
     4741 ggactcgggt atgtccagcc ggttcgcctc gccgggcgcg cccagcgagg acagcgccga
     4801 cggtaggacg tcggcgagcg tgggctcggc gtacacgtcg cgcagaggta ggtcgttcgc
     4861 caccggcact cgctatcgtc tcgaagatcg ggttcgcttc gtacccctcc gactctaggc
     4921 ggatcatccg tgggtcgagg tacgaaaatt tcgacccaaa tcgctcatgc caggcgattt
     4981 cccccgctac tgtccgtgag atggtgcagg cgttgagctt tgaatcgacg gtgccgcgac
     5041 ggttcgtaca tcgtcaatcc gtgtccgagg tctacctgac ggacggtatc cccgtcgggg
     5101 aggccggccg gtttcggctg ggcgcccaat ggccgcgaca acacgccttc taccgaacgt
     5161 gcaccgaccg ctacgacacg atgctgctcg gcgagaccgt tcgccagtgc gccatctatc
     5221 tcggacacat gcactacgcc gtacccctgg ggcacctctt cacgatgcag acgatgcgca
     5281 tcgaggcaca cctcgaccgg ttgaccatcg ggtcgtcggc ggcgggggtc gtcatgaacg
     5341 cccaggtcac cgagcacgcg cggcggggca gtcgcttgtc ggcgttcagt gtcgacgtgg
     5401 acttcctcgt cgacgacacg ccggcgggac acggcatggc cgttgccggt gtcctcaccc
     5461 cggacgacta cgcccgcatc cggtggagca gtgaccgggc cccgacggtg gggcgcatcc
     5521 cgcagccgct tcccgtgctg cagtccgccg tatgtgttcc cgacgaccgc gcggtcgtgc
     5581 tcggtgtcca tccgtcgggc gacatcggtc gctggctgct gcgggtggat ccgacgcatc
     5641 cggtgctgtt cgaccatccc tccgaccacg ttccgggcgt ggtggtgctc gaggcggccc
     5701 gccagagcgc gcgcctacgg ctcggatggt cgtgcgccga tgtggaatcg ctcgaactgc
     5761 ggttccgtcg gttcctggag ttggacgaac cgacaacggt gaccaccgaa ctccggcccg
     5821 gagaggacgg ctgtgtcgac gtcgagttct cgcagtgggg cgagatcaag gcgtcgggca
     5881 ccatccgcct ggcggtgcct ctgccgaccg tcgaaccggc tcacgcgttc gtcgggctcc
     5941 accgggtatg aacgtaccgg tcgatcttgt gacgccggcg gggtgcgacc accgaggcca
     6001 gcacgaacga caccatctga tcgagtcgcg catcgagatc cgcgcggccc gtgagcacgt
     6061 tcgacaccat ctggacgccg gtgaaagccg agacgaagta ccgcgcgagt tccgcggaat
     6121 cgacggtgtc ggcgatgtcg ccctcttcga tcgcggcctg gaacacctca cgaagaccgt
     6181 cgatccagtc caggtacggc gccgtcggtc cggccgccgc gctcatctcc aacgtcaggc
     6241 ggataccggc ccgcaccacg gggtcctcga cgatctgccg ccccatctcg tacgcgagca
     6301 tcaccaactg ctcgagcgcc ggagcctcgg tcgcgcggat cgcggccacc gcgttcatcg
     6361 agatcgcatg ctgttcctcg atgatcgcga cggccagatc gtccttcgat ttgaagtgga
     6421 agtacaacgc gcccttggtg aagcccgtca gttcgacgat ctcggtgagg ctggctcgtt
     6481 cgtaaccggt ctcgtcgaac cgagtggctg cggcccagat gatctcgttc ctcgtctcga
     6541 aagccctctc ctgcttgagc actgtgccga tcccctctcg cttcgcctcc ccatcggaca
     6601 caccactgct gcgctcgccg ctccctccgg cgccgcccag tgatgccacg cgacgaaacg
     6661 ggcggacacc gtccccacat cgccctggtc ggtgcgtccg gtttcatcgg cggtgccact
     6721 ctacgggcac ttgccgcgtc tgacggcgaa gtcaccgcag cagtgcggcg aatgccggag
     6781 tcaccgatcc caggtgtccg atatgtcctg tccgacatag gcgttccgtc cactttgcac
     6841 tcagcgctcg acggtgtcga cgccatcgtc cacgccgcga gctacaccgg tccggacgag
     6901 accctgtgcc ggcgaatcaa ctacgagggc acccggaatc tgctcgcggc agccgaggcc
     6961 cggtcgatcg atgtcgtcgt caccctcagc accatcggcg tctacggagc gggtccgttt
     7021 cgggacgtcg tcgaggacac ccgcgagccg aatccggtca ccgtgctcag tgccacccga
     7081 gcggcagccg accggatggt ccgcgcccag ggcggcatcg tcgtccgacc cggattcgtc
     7141 caaggcgagg gcgatcgctg gttccttccg gggcttcgac acatcctcgc ccgcatgggg
     7201 gcctggatcg acgacggcgc cgcactcctc tcggtcatct ccgtcgacga actcggcgaa
     7261 ctgatcgccc gtctcgctct caccagctcg gacgccgacc ggggcgcact gttccatgcc
     7321 gcgtcaccgg aaccgatgtc ggtgttcgac attgcgactc gaacggccac cgacggccta
     7381 cccaccacca gttgttcgtt cccgacggcg ctcgccggcg ccggtgcggc aggcctcacc
     7441 gatcggcacg tcgacctcgt cgggcgcgac cacacgatcg acgggacgaa actgcggcgg
     7501 cgttgcgagc gacccaccct tcgggccacc tcggagttgc cgattcgccc acgcgacacc
     7561 acccgcagtg ccaacctgaa gccatgagtc cccggaacgc cccagtacga ggtgatcact
     7621 gatggcccga cccgtccgcg tcgtcgttct cggctccgga tcctggggca ccacggtcgc
     7681 caaactcgcg gcccacaaca cgcccacgtt gctgtggtcg cgtaaccccg agacggccga
     7741 cgagatcaac accgaacacc gcaattcgcg ttacctcggc gagcacgagc tgccggagag
     7801 cctgcgggcg acgtccgaca ttctcgaggc cgcgaacgag gccgacgtgc tggtggtggg
     7861 ggtgccgtcg cacgcgatcc gcagcacgct gaacctgatc tccaacgagg tgcgcgcgtg
     7921 ggtgccggtg ctctcgctcg cgaaaggcct cgaaccgggt acccggcagc ggcccaccga
     7981 ggtgatctcc gagtgcctgc ccggtcaccc cgtcgggctc ctcgccggcc ccaacatcgc
     8041 ccgcgagatc gccgacgggc tggccgccgc gtcggtggtc gccacacagg acgaggacgt
     8101 cgccacggcg ctgcaaccgt tgttcgcgtc caaggtgttt cgcgtctacc gcaacaccga
     8161 cgtcctcggc tgcgagctgg gcggcgtcct gaagaacatc gtggcgatcg cgtcgggcat
     8221 ggccgacggt ctgggcgtcg gcgacaacac ccgcgcgatg gttctggccc gcgggctcgc
     8281 cgagatgacc cgactcgggg aggcgatggg cgccaacccg cgcaccttcg ccggactcac
     8341 cggcgtcggc gatctcatcg ccacgtgcat gagcccggcg tcgcgcaacc ggcgtgtcgg
     8401 cgaagccatc gcccgcgggc tcaccgtcga cgaggccgtg gagaagctgg ggcaggtggc
     8461 ggagggcgtc aagaccgcgc cgacggtgat ggaactggcc cgcgactacc acgtcgagat
     8521 gccgatcgcc gccgaggtgg aggccgtcgt cgccggacgc aagacccccg aggacgccta
     8581 ccgtggcctg cggaaagtcc agccgggcgg cgaggacgag gtggcctgac ccgctcgacc
     8641 gatttgtctt gaacactgtt caagttgcac actgctgacg tcaggcggtg agggaggcgc
     8701 tgcgcggaga cctcacggat gggaagcagc gtgtcggagt cggttcgtca cacccgggtg
     8761 ctgatcgtgg gcgcgggatt cgccggactc ggcatggccc tgcaactcac gcgccgcggc
     8821 cgacgcgact tcctgatcct ggagcaggcc gacgccgtgg gcggcacgtg gcggcagaac
     8881 acctacccgg gctgcgagtg cgacatcccg tcggtgctgt actcgtattc gtttgccccc
     8941 aagacggatt ggacgtcgtc gcacgccggg caaccggaga tcctggacta cctcattgag
     9001 ctgaccgagc gccacggact gcgcgaccgt ctgcagttcg gtaccgaggt cgccggggcg
     9061 cagtgggacg agaccggctg ccgctggcat gttttcgaca agagcggacg tgagttcgtg
     9121 gcacagtacc tggtggtcgc gtcgggcgct ctcaacgtgc cgcgcatccc acgcattccc
     9181 ggcgccgaga cgttcgcggg cgcgagcatg cactcggcgg cgtggcgcaa cgacgtcgac
     9241 ctcaccggca agcgggtggc gctgatcggc accggcgcca gcgggatcca gctggcgccg
     9301 cacctcgccg aacgggcggc cgaactcacc gtcttccaac gcaccccggc ctggatcctg
     9361 ccgcgccgga ggttccgtac ggcggtcgcg gcgagccgac ggagcacgct ggcgcgcaat
     9421 ctgtttcgcg cggccaccta ctggggcggc gaggcgctcg gtgtcggcct cggccgtccc
     9481 cgactactcg agcacaccca gaaccgcgcc ctcgcacacc tgcgcaagca ggtgcacaac
     9541 gcggtgctgc gcgacgccct cacccccgac taccgcatcg gctgcaagcg gatactgcgc
     9601 tccaacgact tctatcccac gctggcccgc ccgaacacca ccctcgtcac cgacccgatc
     9661 accgcgatcc acccgagcgg catcgagacc gccgacggca cccgccacga cgtcgacgtc
     9721 atcgtgtacg ccaccgggtt ccgcgtcgcc ggcgcgctga accgcatgaa cctggtcggc
     9781 cgcggcggcg tcagcctgct cgaacgctgg cagcaggacg gcgtccgcac ccacctgggc
     9841 gtcacgatgt ccgggatgcc caacgcgttc ttcctgtccg ggcccaacac cggcctgggc
     9901 cacaactcgg tgatcgtgat gatcgaggcg cagatcgcgc acgcactcga cgcgatgcgc
     9961 ctggccgagg agagcggcgc gggcaccgtc gaggtccgcg ccgccgccca ggacgcgttc
    10021 gattcgtctc tgcgggaacg gctctcgcgc ggcgtgtgga gcaccggtgg ctgcgccagc
    10081 tggtacctcg acgcccgcgg gtccaatcac gcgctgtggc cggggacgtc ctgggactac
    10141 cggcggcgca cccgcgtcgt cgatcccgcc gactaccagc tgctccgtgc cgaatcgcat
    10201 cgcggcctga cgacgccgaa aaacggctgg acgcgctccg acgcccgttg ctagcgtgtg
    10261 cgcgaccgtg acttcacacc aggaggtgag acccatgtac gcaacgaaca tgtgggtgct
    10321 cccactcgtg tgcacggtcg ggcgattgac gtaggtgtcg ccgggagcgc cgaaattcaa
    10381 ggcactcccg aaaggccaca ccatgcactt cacttccgag acatcgtcga acggtgtcgt
    10441 cgaacgcact ttcacactgg acgagatcac cggcgcgctc tggtcgcccc gatccggggc
    10501 cggcggcggg ccactgctgc tgtcgggtca ttccggcggc atgcacaagc gagcgccggg
    10561 actggtggcc ggcgcactgc acagcgtcgc cgcccacggg ttcaccgtcg ccgccatcga
    10621 cgcacccggg cacggcgacc gcccgcgaag cgccgaggat caacggcggg tggacgcgat
    10681 ccatcgggcc cgggcggcgg gcgaacccct cgccccgatc gtcgtcgagc acaacatgtc
    10741 ggtggcggag cgcgcggtac ccgaatggca ggcgacgttg gacgcgctgc aggcgctgcc
    10801 cgagatcggt gccgaagcgc aaatcggcta cggcggaatg acgttgggcg tcacgacagg
    10861 actgttgctc gcggcagccg accgccggat cgccgcactc agcattggtg cggtgttcgt
    10921 gaacgatgcc ctgatcgagg tggcccgacg g
//
