GCF_000590555.1_ASM59055v1_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_022198.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	betalactone	621,495	648,500
Region 2	terpene	1,005,578	1,025,704	SF2575	Polyketide:Type II + Saccharide:Hybrid/tailoring	6%
Region 3	terpene,T1PKS,NRPS	1,488,186	1,556,538	carotenoid	Terpene	14%
Region 4	T1PKS	1,902,144	1,947,042

NC_022198.1 - Region 1 - betalactone

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Location: 621,495 - 648,500 nt. (total: 27,006 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000649.1	0.18	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000928.1	0.16	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.16	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000528.1	0.15	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001387.1	0.15	Other	nucleocidin	Streptomyces calvus
BGC0000597.1	0.15	RiPP	SWA-2138	Streptomyces sp. e14
BGC0002000.1	0.15	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000805.1	0.15	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672
BGC0000559.1	0.14	RiPP	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000506.1	0.14	RiPP	entianin	Bacillus subtilis subsp. spizizenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000649.1	0.49	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000928.1	0.47	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.47	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000528.1	0.46	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001387.1	0.45	Other	nucleocidin	Streptomyces calvus
BGC0000597.1	0.45	RiPP	SWA-2138	Streptomyces sp. e14
BGC0002000.1	0.44	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000805.1	0.44	Saccharide	moenomycin	Streptomyces viridosporus ATCC 14672
BGC0000559.1	0.44	RiPP	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000506.1	0.44	RiPP	entianin	Bacillus subtilis subsp. spizizenii

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_022198.1 - Region 2 - terpene

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Location: 1,005,578 - 1,025,704 nt. (total: 20,127 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000643.1	0.18	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.17	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0001579.1	0.17	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000563.1	0.16	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001660.1	0.16	RiPP	mathermycin	Marinactinospora thermotolerans
BGC0001551.1	0.16	RiPP	citrulassin E	Streptomyces glaucescens
BGC0000539.1	0.16	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000521.1	0.16	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001210.1	0.16	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000501.1	0.16	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000643.1	0.49	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.49	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0001579.1	0.48	RiPP	duramycin	Streptomyces cinnamoneus
BGC0000563.1	0.47	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001660.1	0.47	RiPP	mathermycin	Marinactinospora thermotolerans
BGC0001551.1	0.47	RiPP	citrulassin E	Streptomyces glaucescens
BGC0000539.1	0.47	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000521.1	0.47	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001210.1	0.46	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000501.1	0.46	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_022198.1 - Region 3 - NRPS,T1PKS,terpene

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Location: 1,488,186 - 1,556,538 nt. (total: 68,353 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001636.1	0.57	NRP	KK-1	Curvularia clavata
BGC0001591.1	0.54	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.54	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000513.1	0.53	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001343.1	0.51	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000351.1	0.51	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001399.1	0.50	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001525.1	0.50	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0001526.1	0.49	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0000412.1	0.49	NRP	pyochelin	Pseudomonas aeruginosa PAO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.66	Terpene	carotenoid	Myxococcus xanthus
BGC0000647.1	0.65	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000650.1	0.62	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000637.1	0.61	Terpene	carotenoid	Corynebacterium glutamicum
BGC0001903.1	0.59	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0001399.1	0.58	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000643.1	0.57	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000644.1	0.57	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000634.1	0.56	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000225.1	0.56	Polyketide	frenolicin B	Streptomyces roseofulvus

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 1488185 - 1556538:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 1503789 - 1550576:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 1510991 - 1556538:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1413

Search NORINE for peptide: strict or relaxed

AMP-binding (41..479): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: vLaFiGGaaK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 50% (weak)

ctg1_1446

PKS_AT (527..807): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 36.5
Methoxymalonyl-CoA: 32.1
Methylmalonyl-CoA: 29.3
Propionyl-CoA: 14.8
CHC-CoA: 13.7
Benzoyl-CoA: 11.6
inactive: 10.1
fatty_acid: 10.1
trans-1,2-CPDA: 8.7
Ethylmalonyl-CoA: 7.0
Isobutyryl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -1.7

ctg1_1447

Search NORINE for peptide: strict or relaxed

AMP-binding (567..968): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLwNMSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

NC_022198.1 - Region 4 - T1PKS

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Location: 1,902,144 - 1,947,042 nt. (total: 44,899 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.24	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.21	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.21	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.21	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000044.1	0.21	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001281.1	0.19	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0001264.1	0.19	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.19	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001276.1	0.19	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.58	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.54	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001161.1	0.54	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.54	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000044.1	0.53	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001281.1	0.52	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0001264.1	0.51	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.51	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001276.1	0.51	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 7, location 1902143 - 1947042:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1799

PKS_AT (655..948): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: fatty_acid

Prediction, score:

fatty_acid: 114.9
Methylmalonyl-CoA: 73.6
Malonyl-CoA: 70.7
Methoxymalonyl-CoA: 67.1
Propionyl-CoA: 46.0
Ethylmalonyl-CoA: 42.9
CHC-CoA: 40.1
trans-1,2-CPDA: 39.2
Isobutyryl-CoA: 34.0
Acetyl-CoA: 33.1
2-Methylbutyryl-CoA: 32.2
inactive: 15.9
Benzoyl-CoA: 13.6
3-Methylbutyryl-CoA: 0.0

ctg1_1800

CAL_domain (65..534): pk

minowa: NH2

Prediction, score:

NH2: 14.1
AHBA: 8.5
shikimic_acid: 7.9
Acetyl-CoA: 0.0
fatty_acid: -2.0