GCF_000020145.1_ASM2014v1_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_010644.1

Region	Type	From	To
Region 1	terpene	19,230	38,495
Region 2	terpene	173,751	194,773
Region 3	NRPS	1,062,579	1,106,433
Region 4	T1PKS	1,174,603	1,223,629

NC_010644.1 - Region 1 - terpene

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Location: 19,230 - 38,495 nt. (total: 19,266 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.28	Terpene	carotenoid	Myxococcus xanthus
BGC0000630.1	0.20	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000656.1	0.19	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000640.1	0.19	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000634.1	0.18	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000896.1	0.17	Other	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000643.1	0.17	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000645.1	0.16	Terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001227.1	0.16	Terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000635.1	0.15	Terpene	carotenoid	Paracoccus sp. N81106

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.62	Terpene	carotenoid	Myxococcus xanthus
BGC0000630.1	0.53	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000656.1	0.51	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000640.1	0.51	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000634.1	0.49	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000896.1	0.49	Other	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000643.1	0.49	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000645.1	0.47	Terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001227.1	0.46	Terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000635.1	0.45	Terpene	carotenoid	Paracoccus sp. N81106

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_010644.1 - Region 2 - terpene

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Location: 173,751 - 194,773 nt. (total: 21,023 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.29	Terpene	carotenoid	Myxococcus xanthus
BGC0001514.1	0.13	Other	aristeromycin	Streptomyces citricolor
BGC0001940.1	0.07	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0000223.1	0.04	Polyketide	rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H	uncultured bacterium BAC AB649/1850
BGC0001114.1	0.04	NRP, Polyketide	thailanstatin A	Burkholderia thailandensis
BGC0000014.1	0.04	Polyketide	ambruticin	Sorangium cellulosum
BGC0001785.1	0.03	Polyketide	streptovaricin	Streptomyces spectabilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000648.1	0.63	Terpene	carotenoid	Myxococcus xanthus
BGC0001514.1	0.42	Other	aristeromycin	Streptomyces citricolor
BGC0001940.1	0.29	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0000223.1	0.19	Polyketide	rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H	uncultured bacterium BAC AB649/1850
BGC0001114.1	0.19	NRP, Polyketide	thailanstatin A	Burkholderia thailandensis
BGC0000014.1	0.18	Polyketide	ambruticin	Sorangium cellulosum
BGC0001785.1	0.17	Polyketide	streptovaricin	Streptomyces spectabilis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NC_010644.1 - Region 3 - NRPS

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Location: 1,062,579 - 1,106,433 nt. (total: 43,855 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001132.1	0.24	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000417.1	0.23	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001833.1	0.23	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.23	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.22	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001131.1	0.22	NRP	ambactin	Xenorhabdus miraniensis
BGC0001758.1	0.22	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.22	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001890.1	0.22	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.65	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000417.1	0.57	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001833.1	0.56	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.56	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1	0.55	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001131.1	0.55	NRP	ambactin	Xenorhabdus miraniensis
BGC0001758.1	0.55	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.55	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001890.1	0.54	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 1062578 - 1106433:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_989

Search NORINE for peptide: strict or relaxed

AMP-binding (460..850): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAmfMGGaCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

ctg1_1006

Search NORINE for peptide: strict or relaxed

AMP-binding (667..1035): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gLaFgGlPgK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 50% (weak)

NC_010644.1 - Region 4 - T1PKS

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Location: 1,174,603 - 1,223,629 nt. (total: 49,027 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.1	0.24	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000044.1	0.22	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001244.1	0.18	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.18	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.18	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.18	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001591.1	0.18	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.18	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0002009.1	0.18	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000013.1	0.17	Polyketide	alternariol	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000044.1	0.54	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001244.1	0.50	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.49	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.49	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.49	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001591.1	0.49	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.49	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0002009.1	0.49	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina
BGC0000013.1	0.48	Polyketide	alternariol	Aspergillus nidulans FGSC A4

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names