Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
2.1
3.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_FWWX01000004 (original name was: NZ_FWWX01000004.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene | 138,233 | 157,909 | belactosin A / belactosin C | Other | 8%
Region 1.2 | NRPS-like | 627,843 | 670,986 |
Region 1.3 | terpene | 774,656 | 793,240 |
Region 1.4 | T3PKS | 996,680 | 1,037,735 |
Region 1.5 | betalactone | 1,683,335 | 1,708,369 |
Region 1.6 | terpene | 2,710,659 | 2,731,606 |
Region 1.7 | redox-cofactor | 2,817,487 | 2,840,226 |

NZ_FWWX01000003 (original name was: NZ_FWWX01000003.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS-like | 51,077 | 93,812 |

NZ_FWWX01000002 (original name was: NZ_FWWX01000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | terpene | 95,705 | 116,826 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene | 138,233 | 157,909 | belactosin A / belactosin C | Other | 8%
Region 1.2 | NRPS-like | 627,843 | 670,986 |
Region 1.3 | terpene | 774,656 | 793,240 |
Region 1.4 | T3PKS | 996,680 | 1,037,735 |
Region 1.5 | betalactone | 1,683,335 | 1,708,369 |
Region 1.6 | terpene | 2,710,659 | 2,731,606 |
Region 1.7 | redox-cofactor | 2,817,487 | 2,840,226 |
Region 2.1 | NRPS-like | 51,077 | 93,812 |
Region 3.1 | terpene | 95,705 | 116,826 |

No secondary metabolite regions were found in these records:
  NZ_FWWX01000001 (original name was: NZ_FWWX01000001.1)

Compact view
c00001_NZ_FWWX.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 138,233 - 157,909 nt. (total: 19,677 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000683.1 |  | 0.31 | Terpene | avermitilol | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000674.1 |  | 0.23 | Terpene | (-)-δ-cadinene | Streptomyces clavuligerus ATCC 27064
BGC0001206.1 |  | 0.17 | Other | indolmycin | Streptomyces griseus subsp. griseus
BGC0000706.1 |  | 0.17 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001458.1 |  | 0.16 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0000665.1 |  | 0.16 | Terpene, Alkaloid | xiamycin | Streptomyces sp. HKI0576
BGC0000666.1 |  | 0.16 | Terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0000286.1 |  | 0.16 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000595.1 |  | 0.15 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.15 | RiPP | SLI-2138 | Streptomyces lividans TK24

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000683.1 |  | 0.65 | Terpene | avermitilol | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000674.1 |  | 0.56 | Terpene | (-)-δ-cadinene | Streptomyces clavuligerus ATCC 27064
BGC0001206.1 |  | 0.49 | Other | indolmycin | Streptomyces griseus subsp. griseus
BGC0000706.1 |  | 0.48 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001458.1 |  | 0.47 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0000665.1 |  | 0.47 | Terpene, Alkaloid | xiamycin | Streptomyces sp. HKI0576
BGC0000666.1 |  | 0.46 | Terpene | xiamycin A | Streptomyces sp. SCSIO 02999
BGC0000286.1 |  | 0.46 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0000595.1 |  | 0.45 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.45 | RiPP | SLI-2138 | Streptomyces lividans TK24

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_FWWX.. - Region 2 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 627,843 - 670,986 nt. (total: 43,144 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.33 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.32 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001444.1 |  | 0.30 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.30 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001516.1 |  | 0.29 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.28 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001184.1 |  | 0.27 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.27 | Other | bacilysin | Bacillus sp. CS93
BGC0001940.1 |  | 0.25 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000679.1 |  | 0.25 | Terpene | diazepinomicin | Micromonospora sp. M42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.66 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.66 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001444.1 |  | 0.64 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.64 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001516.1 |  | 0.63 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.61 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001184.1 |  | 0.61 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.61 | Other | bacilysin | Bacillus sp. CS93
BGC0001940.1 |  | 0.59 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000679.1 |  | 0.59 | Terpene | diazepinomicin | Micromonospora sp. M42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 627842 - 670986:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_612: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (26..434): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      nVWlwnvevK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      30% (weak)
ctg1_619: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (103..542): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      m-wgGtTafK
    Nearest Stachelhaus code:
      dhpg
    Stachelhaus code match:
      30% (weak)

c00001_NZ_FWWX.. - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 774,656 - 793,240 nt. (total: 18,585 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.1 |  | 0.32 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000650.1 |  | 0.27 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000648.1 |  | 0.22 | Terpene | carotenoid | Myxococcus xanthus
BGC0001336.1 |  | 0.21 | Alkaloid | erdasporine A, erdasporine B, erdasporine C | uncultured bacterium
BGC0000640.1 |  | 0.20 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.1 |  | 0.19 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000656.1 |  | 0.19 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0001546.1 |  | 0.19 | Alkaloid | chuangxinmycin | Actinoplanes tsinanensis
BGC0001485.1 |  | 0.19 | Other | 3-demethylchuangxinmycin | Actinoplanes tsinanensis
BGC0000664.1 |  | 0.18 | Terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.1 |  | 0.66 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000650.1 |  | 0.61 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000648.1 |  | 0.55 | Terpene | carotenoid | Myxococcus xanthus
BGC0001336.1 |  | 0.54 | Alkaloid | erdasporine A, erdasporine B, erdasporine C | uncultured bacterium
BGC0000640.1 |  | 0.52 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.1 |  | 0.51 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000656.1 |  | 0.51 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0001546.1 |  | 0.51 | Alkaloid | chuangxinmycin | Actinoplanes tsinanensis
BGC0001485.1 |  | 0.51 | Other | 3-demethylchuangxinmycin | Actinoplanes tsinanensis
BGC0000664.1 |  | 0.50 | Terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_FWWX.. - Region 4 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 996,680 - 1,037,735 nt. (total: 41,056 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.30 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001938.1 |  | 0.24 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001184.1 |  | 0.22 | Other | bacilysin | Bacillus velezensis FZB42
BGC0002016.1 |  | 0.22 | Polyketide | lugdunomycin | Streptomyces sp. QL37
BGC0000888.1 |  | 0.22 | Other | bacilysin | Bacillus sp. CS93
BGC0002000.1 |  | 0.22 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0001895.1 |  | 0.22 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000236.1 |  | 0.21 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0002012.1 |  | 0.21 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001831.1 |  | 0.20 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.1 |  | 0.63 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001938.1 |  | 0.57 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001184.1 |  | 0.55 | Other | bacilysin | Bacillus velezensis FZB42
BGC0002016.1 |  | 0.55 | Polyketide | lugdunomycin | Streptomyces sp. QL37
BGC0000888.1 |  | 0.55 | Other | bacilysin | Bacillus sp. CS93
BGC0002000.1 |  | 0.55 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0001895.1 |  | 0.54 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000236.1 |  | 0.54 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0002012.1 |  | 0.53 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001831.1 |  | 0.53 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_FWWX.. - Region 5 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,683,335 - 1,708,369 nt. (total: 25,035 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.21 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001783.1 |  | 0.15 | Other | streptonigrin | Streptomyces flocculus
BGC0000261.1 |  | 0.15 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0001706.1 |  | 0.14 | Terpene | nodulisporic acid F | Hypoxylon pulicicidum
BGC0001936.1 |  | 0.14 | Terpene | nodulisporic acid F | Hypoxylon pulicicidum
BGC0000259.1 |  | 0.14 | Polyketide | prodigiosin | Serratia marcescens
BGC0001844.1 |  | 0.14 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002009.1 |  | 0.14 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0001220.1 |  | 0.14 | NRP | aculeacin A | Aspergillus japonicus
BGC0001758.1 |  | 0.14 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.53 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001783.1 |  | 0.45 | Other | streptonigrin | Streptomyces flocculus
BGC0000261.1 |  | 0.45 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0001706.1 |  | 0.44 | Terpene | nodulisporic acid F | Hypoxylon pulicicidum
BGC0001936.1 |  | 0.44 | Terpene | nodulisporic acid F | Hypoxylon pulicicidum
BGC0000259.1 |  | 0.43 | Polyketide | prodigiosin | Serratia marcescens
BGC0001844.1 |  | 0.43 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002009.1 |  | 0.43 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0001220.1 |  | 0.43 | NRP | aculeacin A | Aspergillus japonicus
BGC0001758.1 |  | 0.43 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_FWWX.. - Region 6 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,710,659 - 2,731,606 nt. (total: 20,948 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001746.1 |  | 0.32 | Terpene | pristinol | Streptomyces pristinaespiralis ATCC 25486
BGC0000683.1 |  | 0.31 | Terpene | avermitilol | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000674.1 |  | 0.23 | Terpene | (-)-δ-cadinene | Streptomyces clavuligerus ATCC 27064
BGC0000678.1 |  | 0.18 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000843.1 |  | 0.17 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate | Streptomyces clavuligerus ATCC 27064
BGC0001909.1 |  | 0.16 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0000723.1 |  | 0.11 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0001749.1 |  | 0.10 | Polyketide | epipyriculol | Pyricularia oryzae 70-15
BGC0001480.1 |  | 0.09 | Other | tundrenone | Methylobacter tundripaludum 21/22
BGC0001768.1 |  | 0.09 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001746.1 |  | 0.65 | Terpene | pristinol | Streptomyces pristinaespiralis ATCC 25486
BGC0000683.1 |  | 0.65 | Terpene | avermitilol | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000674.1 |  | 0.57 | Terpene | (-)-δ-cadinene | Streptomyces clavuligerus ATCC 27064
BGC0000678.1 |  | 0.50 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000843.1 |  | 0.48 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate | Streptomyces clavuligerus ATCC 27064
BGC0001909.1 |  | 0.47 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0000723.1 |  | 0.38 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0001749.1 |  | 0.35 | Polyketide | epipyriculol | Pyricularia oryzae 70-15
BGC0001480.1 |  | 0.34 | Other | tundrenone | Methylobacter tundripaludum 21/22
BGC0001768.1 |  | 0.32 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_FWWX.. - Region 7 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,817,487 - 2,840,226 nt. (total: 22,740 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.21 | Other | bacilysin | Bacillus sp. CS93
BGC0000602.1 |  | 0.21 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001184.1 |  | 0.18 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000466.1 |  | 0.18 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0001889.1 |  | 0.16 | RiPP | fusilassin | Thermobifida fusca YX
BGC0000228.1 |  | 0.16 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001634.1 |  | 0.16 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001645.1 |  | 0.15 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001176.1 |  | 0.15 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001222.1 |  | 0.15 | RiPP | acidocin B | Lactobacillus acidophilus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.54 | Other | bacilysin | Bacillus sp. CS93
BGC0000602.1 |  | 0.53 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001184.1 |  | 0.50 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000466.1 |  | 0.49 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0001889.1 |  | 0.47 | RiPP | fusilassin | Thermobifida fusca YX
BGC0000228.1 |  | 0.47 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001634.1 |  | 0.46 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001645.1 |  | 0.46 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001176.1 |  | 0.46 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001222.1 |  | 0.45 | RiPP | acidocin B | Lactobacillus acidophilus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_FWWX.. - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 51,077 - 93,812 nt. (total: 42,736 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001444.1 |  | 0.27 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.27 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001895.1 |  | 0.25 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000343.1 |  | 0.24 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001723.1 |  | 0.23 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000886.1 |  | 0.22 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000723.1 |  | 0.22 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0000194.1 |  | 0.21 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000888.1 |  | 0.21 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.21 | Other | bacilysin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001444.1 |  | 0.60 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.60 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001895.1 |  | 0.58 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000343.1 |  | 0.57 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001723.1 |  | 0.56 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000886.1 |  | 0.55 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000723.1 |  | 0.55 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0000194.1 |  | 0.54 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000888.1 |  | 0.54 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.54 | Other | bacilysin | Bacillus velezensis FZB42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 51076 - 93812:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_70: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (15..459): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      pfviaGGPLK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      50% (weak)

c00003_NZ_FWWX.. - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 95,705 - 116,826 nt. (total: 21,122 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.17 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.17 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001197.1 |  | 0.17 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000513.1 |  | 0.17 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001551.1 |  | 0.16 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000539.1 |  | 0.16 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000294.1 |  | 0.16 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000500.1 |  | 0.16 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.49 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.48 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001197.1 |  | 0.48 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000513.1 |  | 0.48 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001551.1 |  | 0.47 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0000504.1 |  | 0.47 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000501.1 |  | 0.47 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000539.1 |  | 0.47 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000294.1 |  | 0.47 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000500.1 |  | 0.46 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names