GCF_018368635.1_ASM1836863v1_genomic - 3 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

c00007_NZ_JAGZ.. (original name was: NZ_JAGZDX010000003.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 7.1	ranthipeptide	81,798	103,405

c00009_NZ_JAGZ.. (original name was: NZ_JAGZDX010000004.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 9.1	RRE-containing	326,434	346,697	kijanimicin	Polyketide	4%

c00011_NZ_JAGZ.. (original name was: NZ_JAGZDX010000005.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 11.1	ladderane,NRPS	1	73,407	heme D1	Other	11%

Region	Type	From	To	Most similar known cluster	Similarity
Region 7.1	ranthipeptide	81,798	103,405
Region 9.1	RRE-containing	326,434	346,697	kijanimicin	Polyketide	4%
Region 11.1	ladderane,NRPS	1	73,407	heme D1	Other	11%

No secondary metabolite regions were found in these records:: c00001_NZ_JAGZ.. (original name was: NZ_JAGZDX010000007.1); c00002_NZ_JAGZ.. (original name was: NZ_JAGZDX010000008.1); c00003_NZ_JAGZ.. (original name was: NZ_JAGZDX010000010.1); c00004_NZ_JAGZ.. (original name was: NZ_JAGZDX010000011.1); c00005_NZ_JAGZ.. (original name was: NZ_JAGZDX010000001.1); c00006_NZ_JAGZ.. (original name was: NZ_JAGZDX010000012.1); c00008_NZ_JAGZ.. (original name was: NZ_JAGZDX010000013.1); c00010_NZ_JAGZ.. (original name was: NZ_JAGZDX010000014.1); c00012_NZ_JAGZ.. (original name was: NZ_JAGZDX010000009.1); c00013_NZ_JAGZ.. (original name was: NZ_JAGZDX010000002.1); c00014_NZ_JAGZ.. (original name was: NZ_JAGZDX010000006.1)

Compact view

c00007_NZ_JAGZ.. - Region 1 - ranthipeptide

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Location: 81,798 - 103,405 nt. (total: 21,608 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.18	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000560.1	0.15	RiPP	subtilomycin	Bacillus subtilis
BGC0000466.1	0.14	NRP	yatakemycin	Streptomyces sp. TP-A2060
BGC0001607.1	0.14	Other	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0001120.1	0.13	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001391.1	0.12	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.1	0.12	RiPP	SmbA, SmbB	Streptococcus mutans
BGC0000608.1	0.12	RiPP	nocathiacin	Actinokineospora fastidiosa
BGC0000807.1	0.12	Saccharide	phosphonoglycans	Stackebrandtia nassauensis DSM 44728
BGC0000539.1	0.12	RiPP	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.49	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000560.1	0.46	RiPP	subtilomycin	Bacillus subtilis
BGC0000466.1	0.44	NRP	yatakemycin	Streptomyces sp. TP-A2060
BGC0001607.1	0.43	Other	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0001120.1	0.41	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001391.1	0.41	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.1	0.41	RiPP	SmbA, SmbB	Streptococcus mutans
BGC0000608.1	0.40	RiPP	nocathiacin	Actinokineospora fastidiosa
BGC0000807.1	0.40	Saccharide	phosphonoglycans	Stackebrandtia nassauensis DSM 44728
BGC0000539.1	0.39	RiPP	nukacin ISK-1	Staphylococcus warneri

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00009_NZ_JAGZ.. - Region 1 - RRE-containing

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Location: 326,434 - 346,697 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001410.1	0.17	Saccharide	polysaccharide A	Bacteroides fragilis
BGC0000868.1	0.16	Other	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001588.1	0.16	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0000732.1	0.15	Saccharide	capsular polysaccharide	Raoultella planticola
BGC0000733.1	0.15	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0001589.1	0.15	Saccharide	exopolysaccharides	Burkholderia cenocepacia J2315
BGC0000794.1	0.15	Saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000730.1	0.15	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000731.1	0.15	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000800.1	0.15	Saccharide	xanthan	Xanthomonas campestris

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001410.1	0.48	Saccharide	polysaccharide A	Bacteroides fragilis
BGC0000868.1	0.47	Other	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001588.1	0.46	Saccharide	exopolysaccharides	Burkholderia pseudomallei 1026b
BGC0000732.1	0.46	Saccharide	capsular polysaccharide	Raoultella planticola
BGC0000733.1	0.46	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0001589.1	0.45	Saccharide	exopolysaccharides	Burkholderia cenocepacia J2315
BGC0000794.1	0.45	Saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000730.1	0.45	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000731.1	0.45	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000800.1	0.45	Saccharide	xanthan	Xanthomonas campestris

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00011_NZ_JAGZ.. - Region 1 - NRPS,ladderane

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Location: 1 - 73,407 nt. (total: 73,407 nt) Show pHMM detection rules used

Region on contig edge.

ladderane: ladderane
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000886.1	0.40	Other	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0001575.1	0.31	NRP	dipeptide aldehydes	Ruminococcus sp. 5_1_39BFAA
BGC0000259.1	0.31	Polyketide	prodigiosin	Serratia marcescens
BGC0000812.1	0.29	Alkaloid	huperzine A	Shiraia sp. slf14
BGC0000698.1	0.29	Saccharide	hygromycin A	Streptomyces hygroscopicus
BGC0000207.1	0.28	Polyketide	chartreusin	Streptomyces chartreusis
BGC0001002.1	0.27	NRP, Polyketide	jawsamycin	Streptomyces roseoverticillatus
BGC0000308.1	0.26	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000245.1	0.25	Polyketide	medermycin	Streptomyces sp. AM-7161
BGC0000384.1	0.25	NRP	lyngbyatoxin	Lyngbya majuscula

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001897.1	0.61	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001184.1	0.61	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.60	Other	bacilysin	Bacillus sp. CS93
BGC0001197.1	0.59	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000308.1	0.59	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000253.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001723.1	0.57	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000715.1	0.57	Saccharide	actinospectacin	Streptomyces spectabilis
BGC0000859.1	0.57	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.57	Other	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 73407:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 26075 - 73407:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg11_51

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAsFLGgVyK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 70% (weak)

AMP-binding (1479..1869): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKnLGtVsK
Nearest Stachelhaus code:: asp
Stachelhaus code match:: 70% (weak)