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Overview
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1.11

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP102267.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | cyclic-lactone-autoinducer | 658,396 | 678,262 |
Region 2 | lanthipeptide-class-ii,ranthipeptide | 882,849 | 919,539 | ruminococcin A | RiPP:Lanthipeptide | 14%
Region 3 | cyclic-lactone-autoinducer | 1,137,263 | 1,161,913 |
Region 4 | cyclic-lactone-autoinducer | 1,215,123 | 1,232,905 |
Region 5 | cyclic-lactone-autoinducer | 1,315,798 | 1,334,601 |
Region 6 | cyclic-lactone-autoinducer | 1,465,855 | 1,484,523 |
Region 7 | NRPS | 1,897,541 | 1,946,525 | dipeptide aldehydes | NRP | 82%
Region 8 | cyclic-lactone-autoinducer | 2,164,991 | 2,185,560 |
Region 9 | lanthipeptide-class-ii | 2,189,388 | 2,211,015 | xantholipin | Polyketide | 6%
Region 10 | ranthipeptide | 2,715,265 | 2,736,853 |
Region 11 | lanthipeptide-class-ii | 3,300,589 | 3,323,282 |

NZ_CP102267.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 658,396 - 678,262 nt. (total: 19,867 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000780.1 |  | 0.17 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000528.1 |  | 0.16 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000783.1 |  | 0.16 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000522.1 |  | 0.15 | RiPP | lacticin Z | Lactococcus lactis
BGC0000928.1 |  | 0.15 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.15 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000883.1 |  | 0.14 | Other | arginomycin | Streptomyces arginensis
BGC0000243.1 |  | 0.13 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000550.1 |  | 0.13 | RiPP | salivaricin G32 | Streptococcus salivarius

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000780.1 |  | 0.48 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000616.1 |  | 0.46 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000528.1 |  | 0.46 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000783.1 |  | 0.46 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000522.1 |  | 0.46 | RiPP | lacticin Z | Lactococcus lactis
BGC0000928.1 |  | 0.45 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.45 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000883.1 |  | 0.43 | Other | arginomycin | Streptomyces arginensis
BGC0000243.1 |  | 0.42 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000550.1 |  | 0.42 | RiPP | salivaricin G32 | Streptococcus salivarius

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP102267.1 - Region 2 - lanthipeptide-class-ii,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 882,849 - 919,539 nt. (total: 36,691 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000528.1 |  |  | 0.44 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.1 |  |  | 0.40 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000626.1 |  |  | 0.38 | RiPP | thuricin | Bacillus thuringiensis
BGC0000521.1 |  |  | 0.36 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0001787.1 |  |  | 0.36 | RiPP | suicin 3908 | Streptococcus suis
BGC0000547.1 |  |  | 0.34 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000561.1 |  |  | 0.34 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000498.1 |  |  | 0.33 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000616.1 |  |  | 0.33 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000486.1 |  |  | 0.32 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.1 |  | 0.68 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.1 |  | 0.66 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000516.1 |  | 0.66 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.1 |  | 0.64 | RiPP | thuricin | Bacillus thuringiensis
BGC0001787.1 |  | 0.64 | RiPP | suicin 3908 | Streptococcus suis
BGC0000547.1 |  | 0.62 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000521.1 |  | 0.61 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0001660.1 |  | 0.61 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000599.1 |  | 0.61 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001929.1 |  | 0.61 | RiPP | WGK | Streptococcus ferus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_785 - Putative Class II

ctg1_784 leader / core peptide
  MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS - QFC Dhb Dha DhbKECNWGDhbIMFVC C
allorf_0889319_0889417 leader / core peptide
  MIRSSIIFFVLNKLQGS - CQVDhaVRFLDhaEKYIIL
allorf_0904958_0905074 leader / core peptide
  LKLISHVLPMSKEIKKSAKKTINMVVNAM - DhbWYKEC DhbNDhb

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_784 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 2127.9 Da
  Molecular weight: 2129.5 Da
  Number of bridges: 4
allorf_0889319_0889417 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 0
  Monoisotopic mass: 1761.0 Da
  Molecular weight: 1762.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1780.1 Da N = 1
allorf_0904958_0905074 - Class II
  Cleavage pHMM score: -4.50
  RODEO score: 0
  Monoisotopic mass: 1090.5 Da
  Molecular weight: 1091.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1109.2 Da N = 1
    1127.2 Da N = 2

NZ_CP102267.1 - Region 3 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,137,263 - 1,161,913 nt. (total: 24,651 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000703.1 |  | 0.13 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001311.1 |  | 0.11 | RiPP | flavecins | Ruminococcus flavefaciens FD-1
BGC0001391.1 |  | 0.11 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000541.1 |  | 0.10 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000542.1 |  | 0.10 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000552.1 |  | 0.10 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0001618.1 |  | 0.09 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0001210.1 |  | 0.09 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.1 |  | 0.09 | RiPP | thuricin | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.46 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000703.1 |  | 0.41 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001311.1 |  | 0.37 | RiPP | flavecins | Ruminococcus flavefaciens FD-1
BGC0001391.1 |  | 0.37 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000541.1 |  | 0.36 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000542.1 |  | 0.36 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000552.1 |  | 0.36 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0001618.1 |  | 0.34 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0001210.1 |  | 0.34 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.1 |  | 0.34 | RiPP | thuricin | Bacillus thuringiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP102267.1 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,215,123 - 1,232,905 nt. (total: 17,783 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000619.1 |  | 0.06 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.06 | RiPP | gassericin-T | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000619.1 |  | 0.26 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.26 | RiPP | gassericin-T | Lactobacillus gasseri

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP102267.1 - Region 5 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,315,798 - 1,334,601 nt. (total: 18,804 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001238.1 |  | 0.14 | Other | biotin | Aspergillus nidulans
BGC0001239.1 |  | 0.14 | Other | biotin | Aspergillus nidulans
BGC0001864.1 |  | 0.14 | RiPP | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0001391.1 |  | 0.14 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000243.1 |  | 0.14 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0001311.1 |  | 0.13 | RiPP | flavecins | Ruminococcus flavefaciens FD-1
BGC0000542.1 |  | 0.13 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000541.1 |  | 0.13 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000626.1 |  | 0.13 | RiPP | thuricin | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.47 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001238.1 |  | 0.44 | Other | biotin | Aspergillus nidulans
BGC0001239.1 |  | 0.44 | Other | biotin | Aspergillus nidulans
BGC0001864.1 |  | 0.43 | RiPP | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0001391.1 |  | 0.43 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000243.1 |  | 0.43 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0001311.1 |  | 0.42 | RiPP | flavecins | Ruminococcus flavefaciens FD-1
BGC0000542.1 |  | 0.42 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000541.1 |  | 0.42 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000626.1 |  | 0.41 | RiPP | thuricin | Bacillus thuringiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP102267.1 - Region 6 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,465,855 - 1,484,523 nt. (total: 18,669 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

No matches found.

No matches found.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP102267.1 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,897,541 - 1,946,525 nt. (total: 48,985 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001575.1 |  | 0.61 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0000888.1 |  | 0.27 | Other | bacilysin | Bacillus sp. CS93
BGC0000308.1 |  | 0.25 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001538.1 |  | 0.22 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0002002.1 |  | 0.22 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0001768.1 |  | 0.22 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4
BGC0001627.1 |  | 0.22 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0001197.1 |  | 0.21 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0001479.1 |  | 0.21 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000231.1 |  | 0.21 | Polyketide | griseusin | Streptomyces griseus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001575.1 |  | 0.85 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0000888.1 |  | 0.61 | Other | bacilysin | Bacillus sp. CS93
BGC0000308.1 |  | 0.59 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001538.1 |  | 0.55 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0002002.1 |  | 0.55 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0001768.1 |  | 0.55 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4
BGC0001627.1 |  | 0.54 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0001197.1 |  | 0.54 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0001479.1 |  | 0.54 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000231.1 |  | 0.53 | Polyketide | griseusin | Streptomyces griseus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 1897540 - 1946525:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1713: X - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (20..419): X
  NRPSPredictor2: gly, ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVLtdgGIsK
    Nearest Stachelhaus code:
      aeo
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1033..1421): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAmfsGAIfK
    Nearest Stachelhaus code:
      bht
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2027..2418): X
  NRPSPredictor2: phe, trp, phg, tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAiTTGgVsK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      70% (weak)

NZ_CP102267.1 - Region 8 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,164,991 - 2,185,560 nt. (total: 20,570 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.1 |  | 0.19 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000494.1 |  | 0.16 | RiPP | uberolysin | Streptococcus uberis
BGC0000938.1 |  | 0.16 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000802.1 |  | 0.16 | Saccharide | succinoglycan | Sinorhizobium meliloti
BGC0000509.1 |  | 0.15 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0000533.1 |  | 0.15 | RiPP | mutacin III | Streptococcus mutans
BGC0000560.1 |  | 0.15 | RiPP | subtilomycin | Bacillus subtilis
BGC0000530.1 |  | 0.15 | RiPP | mutacin B-Ny266 | Streptococcus mutans N66

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.1 |  | 0.51 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.1 |  | 0.50 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000494.1 |  | 0.47 | RiPP | uberolysin | Streptococcus uberis
BGC0000938.1 |  | 0.46 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000802.1 |  | 0.46 | Saccharide | succinoglycan | Sinorhizobium meliloti
BGC0000509.1 |  | 0.45 | RiPP | epilancin 15x | Staphylococcus epidermidis
BGC0000533.1 |  | 0.45 | RiPP | mutacin III | Streptococcus mutans
BGC0000560.1 |  | 0.45 | RiPP | subtilomycin | Bacillus subtilis
BGC0000530.1 |  | 0.45 | RiPP | mutacin B-Ny266 | Streptococcus mutans N66

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP102267.1 - Region 9 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,189,388 - 2,211,015 nt. (total: 21,628 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001723.1 |  | 0.25 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000248.1 |  | 0.25 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000275.1 |  | 0.22 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0000228.1 |  | 0.22 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000219.1 |  | 0.21 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000231.1 |  | 0.21 | Polyketide | griseusin | Streptomyces griseus
BGC0000272.1 |  | 0.21 | Polyketide | spore pigment | Streptomyces collinus
BGC0002000.1 |  | 0.20 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000194.1 |  | 0.20 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0001897.1 |  | 0.19 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001723.1 |  | 0.59 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000248.1 |  | 0.58 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000275.1 |  | 0.56 | Polyketide | tetracenomycin C | Streptomyces glaucescens
BGC0000228.1 |  | 0.55 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000219.1 |  | 0.53 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000231.1 |  | 0.53 | Polyketide | griseusin | Streptomyces griseus
BGC0000272.1 |  | 0.53 | Polyketide | spore pigment | Streptomyces collinus
BGC0002000.1 |  | 0.52 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000194.1 |  | 0.52 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_1965 - Putative Class II

ctg1_1962 leader / core peptide
  MKTCSERNEQRINSLQLSESLEDEIKELDGKNVEAGDVIFT - DhbDDhb Dha DhaFLDhbIVC C

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_1962 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 1198.6 Da
  Molecular weight: 1199.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1217.4 Da N = 1
    1235.4 Da N = 2
    1253.4 Da N = 3

NZ_CP102267.1 - Region 10 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,715,265 - 2,736,853 nt. (total: 21,589 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.17 | Other | nucleocidin | Streptomyces calvus
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000552.1 |  | 0.16 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0001391.1 |  | 0.15 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000497.1 |  | 0.15 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000622.1 |  | 0.14 | RiPP | megacin | Bacillus megaterium
BGC0000548.1 |  | 0.13 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000294.1 |  | 0.13 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000488.1 |  | 0.13 | RiPP | circularin A | Clostridium beijerinckii
BGC0001891.1 |  | 0.13 | Other | closthioamide | Ruminiclostridium cellulolyticum H10

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.48 | Other | nucleocidin | Streptomyces calvus
BGC0000501.1 |  | 0.46 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000552.1 |  | 0.46 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0001391.1 |  | 0.46 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000497.1 |  | 0.45 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000622.1 |  | 0.44 | RiPP | megacin | Bacillus megaterium
BGC0000548.1 |  | 0.42 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000294.1 |  | 0.42 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000488.1 |  | 0.42 | RiPP | circularin A | Clostridium beijerinckii
BGC0001891.1 |  | 0.41 | Other | closthioamide | Ruminiclostridium cellulolyticum H10

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP102267.1 - Region 11 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,300,589 - 3,323,282 nt. (total: 22,694 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.1 |  | 0.24 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000554.1 |  | 0.22 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.1 |  | 0.18 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.1 |  | 0.17 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000548.1 |  | 0.16 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000539.1 |  | 0.16 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000551.1 |  | 0.16 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.15 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.1 |  | 0.58 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000554.1 |  | 0.54 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000525.1 |  | 0.49 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.1 |  | 0.48 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000548.1 |  | 0.47 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000539.1 |  | 0.47 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000501.1 |  | 0.46 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000504.1 |  | 0.46 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000551.1 |  | 0.46 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.46 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_2988 - Putative Class II

ctg1_2989 leader / core peptide
  MNEMNDKIIGNVEKELDEIEIIDTESIEEKLSFIVYG - DhbIVC C

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_2989 - Class II
  Cleavage pHMM score: -5.90
  RODEO score: 0
  Monoisotopic mass: 519.2 Da
  Molecular weight: 519.7 Da
  Number of bridges: 1