LOCUS       c00003_NZ_VXKG..       10837 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_VXKG01000003.1 Ewingella americana strain CCUG 14506T
            contig_0000003, whole genome shotgun sequence.
ACCESSION   NZ_VXKG01000003
VERSION     NZ_VXKG01000003
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:07:37
            Original ID  :: NZ_VXKG01000003.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 103458
            Orig. end    :: 114295
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10837
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[108458:109295](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5837
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10837
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10837
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             744..2051
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 171.3; E-value: 7.5e-52)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_92"
                     /transl_table=11
                     /translation="MTWWPRSLLSRLLIIVLLGLLLANALTLSLLMYERISSARSVMLG
                     NLEYDVATSVAILDRLPAAERPAWLSMLGRGNYHYLLSAGQSGEYPTTWRSQDTAKSLE
                     QALGANYHLSINAIAGKQEQLQAHLTLKDGQPLTIDVMPRPTPIANWLPFVLCVQLVLL
                     LICSWFAVRQAVRPLTVFTKAIESLDPTSLSASTMVESGPAEVRYAARAFNAMQARIKG
                     YLKERAQILAAISHDLQTPITRMKLRAEMADQPELRDKLLLDLEEMTHLVREGIAYARA
                     SENLEEKLSRIDLNAFIDSLVCDYLDVGKNVTFTPAGQAVALVTHPQALRRILTNLIDN
                     ALKFAGSAELRLSLGESGAVEIVIADNGPGIPPEELESVLQPFYRVESSRNRDTGGTGL
                     GLAIAQQLVNQLKGKLQLANRQPQGLQVKIHFPLTE"
     PFAM_domain     1722..2045
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_92_0001"
                     /evalue="1.40E-23"
                     /label="ctg3_92"
                     /locus_tag="ctg3_92"
                     /protein_end="434"
                     /protein_start="326"
                     /score="83.6"
                     /tool="antismash"
                     /translation="PQALRRILTNLIDNALKFAGSAELRLSLGESGAVEIVIADNGPGI
                     PPEELESVLQPFYRVESSRNRDTGGTGLGLAIAQQLVNQLKGKLQLANRQPQGLQVKIH
                     FPLT"
     CDS             2213..2482
                     /locus_tag="ctg3_93"
                     /transl_table=11
                     /translation="MKLFRTVILPLSLLIAAAAATPAFAAKEVNNAQGLVKIGTVSDSS
                     SNALSLSELNDNLSMKADKAGASAYRIIAAGGNNSYYGVAEIYR"
     PFAM_domain     2315..2479
                     /aSDomain="DUF1471"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07338.15"
                     /description="Protein of unknown function (DUF1471)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_93_0002"
                     /evalue="4.40E-16"
                     /label="ctg3_93"
                     /locus_tag="ctg3_93"
                     /protein_end="89"
                     /protein_start="34"
                     /score="58.7"
                     /tool="antismash"
                     /translation="LVKIGTVSDSSSNALSLSELNDNLSMKADKAGASAYRIIAAGGNN
                     SYYGVAEIYR"
     CDS             2638..3405
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_94"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.5e-18, bitscore:
                     61.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPLHKTFLAMTVAGLMTGFSAHAEQVHTIVLVHGAFADGTASWE
                     QVIPALQSRHYEIITAQIPLTSLKDDVEVTERAIARAKGDVILVGHSWGGTVITQAGNN
                     PRVKGLVYINAFAPSAGQSTADLVKSFPAPPGSAKIVKGADGFLSLPTSAIASDFAQDA
                     TPEAQNIVGITQVPIRASSFDEKVTKAAWETKPSWFLVGSKDRMINPDLERAMAKKIHA
                     HVTELPVSHVPMLYDPKNVARTIFKAVNITSGN"
     PFAM_domain     2725..3366
                     /aSDomain="Abhydrolase_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12697.9"
                     /description="Alpha/beta hydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_94_0003"
                     /evalue="2.90E-16"
                     /label="ctg3_94"
                     /locus_tag="ctg3_94"
                     /protein_end="243"
                     /protein_start="29"
                     /score="60.8"
                     /tool="antismash"
                     /translation="IVLVHGAFADGTASWEQVIPALQSRHYEIITAQIPLTSLKDDVEV
                     TERAIARAKGDVILVGHSWGGTVITQAGNNPRVKGLVYINAFAPSAGQSTADLVKSFPA
                     PPGSAKIVKGADGFLSLPTSAIASDFAQDATPEAQNIVGITQVPIRASSFDEKVTKAAW
                     ETKPSWFLVGSKDRMINPDLERAMAKKIHAHVTELPVSHVPMLYDPKNVAR"
     CDS             3426..4616
                     /gene_functions="other (smcogs) SMCOG1241:lipoprotein dsbF
                     (Score: 121.8; E-value: 4e-37)"
                     /gene_kind="other"
                     /locus_tag="ctg3_95"
                     /transl_table=11
                     /translation="MPILIAYLGGMLTLLSPCTLPVIPLLFAGAGSNKRHFAALLVGMV
                     LTFTLVALLATASSEWVVHASKYGRWLALGLLAITALSLISERFAQKIAQPAVRLGSLL
                     DSRSRQQRGITSALLAGGAVGLLWAPCAGPILGAILSTTMLNGASGQSGLLLLAYGSGC
                     ATMLALLWFCGDKLLTRLRAKMALTLRFRQMAGVMMLASVVFIASGATSLLDTNSAVGQ
                     QLEQHLLTLKPSPAKRVILQPVDIQAPSSQMPSLNGAITWLNSPALTPEQLKGKVVLID
                     FWTFDCINCQHSIPYVREWAEKYQSQGLVVIGIHTPEYPWEKNIDAVKQALNKWNIKYP
                     VAVDNNYAIWNAFGNQYWPAHYYFDAKGQLRYQNFGEGNYQQQEKVINALLAEAKA"
     PFAM_domain     3441..4028
                     /aSDomain="DsbD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02683.17"
                     /description="Cytochrome C biogenesis protein transmembrane
                     region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_95_0004"
                     /evalue="4.20E-12"
                     /label="ctg3_95"
                     /locus_tag="ctg3_95"
                     /protein_end="201"
                     /protein_start="5"
                     /score="46.5"
                     /tool="antismash"
                     /translation="AYLGGMLTLLSPCTLPVIPLLFAGAGSNKRHFAALLVGMVLTFTL
                     VALLATASSEWVVHASKYGRWLALGLLAITALSLISERFAQKIAQPAVRLGSLLDSRSR
                     QQRGITSALLAGGAVGLLWAPCAGPILGAILSTTMLNGASGQSGLLLLAYGSGCATMLA
                     LLWFCGDKLLTRLRAKMALTLRFRQMAGVMMLA"
     PFAM_domain     4236..4541
                     /aSDomain="AhpC-TSA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00578.23"
                     /description="AhpC/TSA family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_95_0005"
                     /evalue="4.40E-12"
                     /label="ctg3_95"
                     /locus_tag="ctg3_95"
                     /protein_end="372"
                     /protein_start="270"
                     /score="46.1"
                     /tool="antismash"
                     /translation="EQLKGKVVLIDFWTFDCINCQHSIPYVREWAEKYQSQGLVVIGIH
                     TPEYPWEKNIDAVKQALNKWNIKYPVAVDNNYAIWNAFGNQYWPAHYYFDAKGQLRY"
     CDS             4716..4982
                     /locus_tag="ctg3_96"
                     /transl_table=11
                     /translation="MKRIAMSAIALSLISFSAASLAAEATGPNLERCFGVAKAADNDCK
                     AGAGTTCAGTSKIDYQKDAYKMVPQGTCTSIQTPKGHGSLTEG"
     PFAM_domain     4806..4967
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_96_0006"
                     /evalue="2.90E-23"
                     /label="ctg3_96"
                     /locus_tag="ctg3_96"
                     /protein_end="84"
                     /protein_start="30"
                     /score="81.8"
                     /tool="antismash"
                     /translation="ERCFGVAKAADNDCKAGAGTTCAGTSKIDYQKDAYKMVPQGTCTS
                     IQTPKGHGS"
     CDS             5001..5837
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_97"
                     /sec_met_domain="DUF692 (E-value: 7.7e-92, bitscore: 302.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTITQLGAGLGLKPEHYQQALKSPADVWFEVHSENYLMAGGPRR
                     EWLEAIRQQHAISLHGVSLSLAADAPPDAALLSRLKMLVDEVKPALVSEHLAWSQWDGA
                     YYPDLLPVPRTSQVMRRLIDNIDRVQDALGRQISLENPTHYLHMPEHEWDDIAFLHEVS
                     CATGCGLLLDINNVWLSAHNLGFDAAAWLDGFPADHVTEIHLAGFSSDEGGSSLLIDSH
                     DNPVSDDVWALYQRLIQRIGARPTLIERDDKLPEFAVLLQEQQRAQGILHTYGGLR"
     PFAM_domain     5022..5813
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_97_0007"
                     /evalue="3.50E-95"
                     /label="ctg3_97"
                     /locus_tag="ctg3_97"
                     /protein_end="271"
                     /protein_start="7"
                     /score="318.3"
                     /tool="antismash"
                     /translation="GAGLGLKPEHYQQALKSPADVWFEVHSENYLMAGGPRREWLEAIR
                     QQHAISLHGVSLSLAADAPPDAALLSRLKMLVDEVKPALVSEHLAWSQWDGAYYPDLLP
                     VPRTSQVMRRLIDNIDRVQDALGRQISLENPTHYLHMPEHEWDDIAFLHEVSCATGCGL
                     LLDINNVWLSAHNLGFDAAAWLDGFPADHVTEIHLAGFSSDEGGSSLLIDSHDNPVSDD
                     VWALYQRLIQRIGARPTLIERDDKLPEFAVLLQEQQRAQGIL"
     CDS             5834..6586
                     /locus_tag="ctg3_98"
                     /transl_table=11
                     /translation="MSGELARYHQAFIRALYDENSNELAHLQQQPGFMVYRNSVLKGCI
                     DALQANFPSVASLTGEDFFREMARQYALVEPPREGMLIRYGEFFPAFIATYLPAADLGY
                     LADVARLDWLWLEMFCAESAACLAVQALAELPPESVGELVLSLRDAVRWHWHPSLPVFT
                     LWHFNRYHTAPPENIQWQGEGALLVMRQQGIEAEPISRGGAAFLAACRDGANLNAASER
                     ALHAEPTFDIGPFFTRLLHLGVFAATAH"
     PFAM_domain     5855..6112
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_98_0008"
                     /evalue="2.90E-19"
                     /label="ctg3_98"
                     /locus_tag="ctg3_98"
                     /protein_end="93"
                     /protein_start="7"
                     /score="69.2"
                     /tool="antismash"
                     /translation="YHQAFIRALYDENSNELAHLQQQPGFMVYRNSVLKGCIDALQANF
                     PSVASLTGEDFFREMARQYALVEPPREGMLIRYGEFFPAFI"
     CDS             6602..7084
                     /locus_tag="ctg3_99"
                     /transl_table=11
                     /translation="MKTTDNSLNNQASSEQGLRGLWNGTWRGVQRVVSGNVLLLVARVG
                     IAAVFFLSGRTKVTGFMTLKPSTYELFKTEYALPLIPYDIAAHLATFAEHTFPVLLVLG
                     LLSRFAASGLLFMTLIIEIFVYPDAWPTHLIWGGLLLMVISRGAGKWSLDRVLGLV"
     PFAM_domain     6713..6979
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_99_0009"
                     /evalue="3.40E-16"
                     /label="ctg3_99"
                     /locus_tag="ctg3_99"
                     /protein_end="126"
                     /protein_start="37"
                     /score="59.7"
                     /tool="antismash"
                     /translation="LLLVARVGIAAVFFLSGRTKVTGFMTLKPSTYELFKTEYALPLIP
                     YDIAAHLATFAEHTFPVLLVLGLLSRFAASGLLFMTLIIEIFVY"
     CDS             7326..9347
                     /locus_tag="ctg3_100"
                     /transl_table=11
                     /translation="MQSLVEIYDLQQQVKEKISQKKYQDIEALFAPLSRKDLQNVLQFP
                     FIFNSQVEGLDSILSQLQEWQQETPHSYYPYVFFASFWFITAANQRGKQTIDRVTPAQR
                     QNCSAANDQFFYWALKTLEFNPQCETAYTMLLEASGYFGMPEWLDFLVTKPIRYSCESY
                     NEEAVKFVSSFTTYSIPHGSININLPSPSEEEERFIPLYWLRRILAIAPDHMISRKVVI
                     KLLSPRWYGGEKYEDIDYFLASDYCSSLSELDIKILKREKEYDQLTSYNTLPLLNYRKE
                     LKRRASNFIDLINSPLTKDETSRTLLEYVYFCNHVLETDPKAKQSAKDDMVESVYQSLH
                     HIVKLASPWFLFYQSEEIFNQLISFMKIYEFDDKSHVFDDIARQTQFRNLTSPIDVLYS
                     TFAANFTLANISLFTQRESLERYYMLAEKNFDYYIFRLHIFMLCKMGYASSIKPVLERF
                     AIENMTTSASLLFYEIYHGNVPGMAGMLSIHPDENKEREFLDIAVKQGSTHAILIKSRD
                     LESLIERSTKPSVKSELALERERLLKQNIQLGDAVSQYDYACSLISSSEEQQIIKGLFI
                     EAPKVLAESRVRLDQLAYIAYLYAFCAFNGRGMRKNIFVMDFWMNMALAWYPDLEYQDF
                     YTTAKHAVGIKPFYNSALKKGRGKIPEEMKKIMNSVAQ"
     PFAM_domain     7362..8084
                     /aSDomain="DUF4034"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13226.8"
                     /description="Domain of unknown function (DUF4034)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_100_0010"
                     /evalue="9.20E-23"
                     /label="ctg3_100"
                     /locus_tag="ctg3_100"
                     /protein_end="253"
                     /protein_start="12"
                     /score="81.1"
                     /tool="antismash"
                     /translation="QVKEKISQKKYQDIEALFAPLSRKDLQNVLQFPFIFNSQVEGLDS
                     ILSQLQEWQQETPHSYYPYVFFASFWFITAANQRGKQTIDRVTPAQRQNCSAANDQFFY
                     WALKTLEFNPQCETAYTMLLEASGYFGMPEWLDFLVTKPIRYSCESYNEEAVKFVSSFT
                     TYSIPHGSININLPSPSEEEERFIPLYWLRRILAIAPDHMISRKVVIKLLSPRWYGGEK
                     YEDIDYFLASDYCSSLSEL"
     CDS             9361..9474
                     /locus_tag="ctg3_101"
                     /transl_table=11
                     /translation="MTTLPIVIFIVLVYMIIRIRSFRAKKRITSIMLPRRK"
     CDS             complement(9769..10653)
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 212.4; E-value: 1.5e-64)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_102"
                     /transl_table=11
                     /translation="MRIFIRVVERGSMSAAARDLGIGQPAVSERIEKLEAHLGTRLLRR
                     NTRNMSLTHSGNLFYERSKTAIQAAEHALLVNEENQSLQGKIRIAAPYSAGESLLMPAI
                     LRLQDQHPSLQVDVIFNDNVIDPVTEGVDLSLRLGDLSEGFFVARPLGIVRRVLLASPA
                     LLAKMGDPQSPDELAGYPFAAVSGIFANNRIQLLSSENQLMNVPIDVRFRATHWRSVFT
                     YLLAGHAIGVLQYPVCRNEIEKSELIPLLSHFQLPSFNAYLLHPPTVMMSYETRICASL
                     LEGYLKDSLLEMS"
     PFAM_domain     complement(9850..10413)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_102_0012"
                     /evalue="3.00E-29"
                     /label="ctg3_102"
                     /locus_tag="ctg3_102"
                     /protein_end="268"
                     /protein_start="80"
                     /score="102.0"
                     /tool="antismash"
                     /translation="QSLQGKIRIAAPYSAGESLLMPAILRLQDQHPSLQVDVIFNDNVI
                     DPVTEGVDLSLRLGDLSEGFFVARPLGIVRRVLLASPALLAKMGDPQSPDELAGYPFAA
                     VSGIFANNRIQLLSSENQLMNVPIDVRFRATHWRSVFTYLLAGHAIGVLQYPVCRNEIE
                     KSELIPLLSHFQLPSFNAYLLHPPT"
     PFAM_domain     complement(10486..10653)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_102_0011"
                     /evalue="5.20E-19"
                     /label="ctg3_102"
                     /locus_tag="ctg3_102"
                     /protein_end="56"
                     /protein_start="0"
                     /score="68.0"
                     /tool="antismash"
                     /translation="MRIFIRVVERGSMSAAARDLGIGQPAVSERIEKLEAHLGTRLLRR
                     NTRNMSLTHSG"
ORIGIN
        1 gtttacgtgg atcatattga ccatattctg atcgtggatg atgaccgcga tattcgtgac
       61 cttatcgccg attacctgca aaaggccggg ctgcgcacca gcgtggcggc caatggcaag
      121 cagatgcgcg ccttgctgga aacccagccg gtggacctga ttgtgttgga tatcatgatg
      181 ccgggcgatg acggtctggt gctgtgccgc gagttgagca gcggcaagca tcgcactatt
      241 ccggtcctga tgctgaccgc ccgccatgag gaaactgacc ggattttggg attggaaatg
      301 ggcgcggacg actatctggt gaagcctttt gtcgcccgtg aactgctggc gcgcatcaag
      361 gcgattttgc gccgtgcgcg catgatgcca ccaaacctgc aagtgaccga agcagggcgt
      421 ttactctcct ttggcgtgtg ggatctggac acgtcggcgc gccatctggt ggctgccgac
      481 ggcactatcg tggcgctcag cggcgcggaa tatcggctgc tgcgggtgtt tctcgaccat
      541 ccccagcgcg tgctaaaccg cgaccaactg ctcaatctga cccaaggccg cgacgccgag
      601 ttgttcgagc gctcaatcga tttgctggtc agccgcctgc gtctgcgact taacgatgac
      661 gctcgcgaac cggcctacat caaaaccatg cgcagcgaag gctacgtttt ctccatgccg
      721 gtggtgatta aagaggcacg cgaatgacgt ggtggccgcg ctctctgctt tcccgcctgc
      781 tgattatcgt gctgctcggc ctgctgctgg ctaacgccct gacgctgagc ttattgatgt
      841 atgaacgcat tagcagtgcg cgctcggtga tgctgggtaa cctcgaatat gacgtggcga
      901 ccagcgtggc gatcctcgac cggctgcccg ccgccgagcg cccggcctgg ttgagcatgc
      961 tcgggcgcgg gaactaccat tatttgctta gcgccggtca gtccggcgag tacccgacga
     1021 cgtggcgttc acaggatacc gccaagtcgc tggagcaggc gctgggtgcc aattatcacc
     1081 tgtcgatcaa tgctattgcg ggcaagcagg agcagctaca ggcgcacctc accttgaaag
     1141 acggccagcc gctgaccatt gatgtcatgc cgcgcccgac gcctatcgcc aactggctgc
     1201 ccttcgtgct ctgcgtgcag ctggtcctgc tgctgatttg ttcgtggttc gccgtgcgtc
     1261 aggcggtgcg gcctttgacc gtttttacca aggcgattga gtcactcgac ccgacctcgc
     1321 tgtctgctag caccatggtg gagagcggac ccgccgaggt gcgctacgcc gcgcgggctt
     1381 ttaacgccat gcaggccaga attaaaggtt atttgaagga gcgggcgcag attctggcgg
     1441 ccatctccca cgacttgcag acgccaatca cgcggatgaa attacgtgcc gaaatggccg
     1501 accagcccga gctgcgcgac aagctgctgt tggatctcga ggagatgact catctggtgc
     1561 gcgaggggat cgcctatgcc cgcgcgtcag aaaatcttga agagaagttg agtcgaatcg
     1621 acctcaatgc ctttatcgac agtctggtgt gcgactatct cgacgtgggg aaaaacgtca
     1681 ctttcacccc cgccgggcag gccgtggcgc tggtcactca cccacaggcg ctgcggcgta
     1741 ttctgaccaa cctgattgat aacgcgctga agtttgccgg tagtgccgag ctgcggctta
     1801 gcctcggcga gagtggagcg gtggagattg tgattgctga caacgggccg ggcattccgc
     1861 cagaagagct ggagtccgtg ctgcaacctt tctatcgggt cgaaagctcg cgcaatcgcg
     1921 atactggcgg cacaggttta ggcttggcta tcgcccagca gttggtcaat cagctgaagg
     1981 gtaaactgca attagccaac cgccagccac agggtttgca ggtcaagatc catttccctc
     2041 tcactgaata attgttttct tatgtatcag cgccgcccgg cgctatacag gaaaacaaat
     2101 ctaccgttaa ttgaaacagc ccacatacat ttatacgttt aaataagtca tccgccgaga
     2161 cagggtccgg cggaaataaa cttaacctaa ccgatatatt gtgaggctta ttatgaaact
     2221 cttccgcacc gttattctgc cactctcttt gcttattgcc gccgctgccg ctacacctgc
     2281 ctttgccgcc aaagaagtca acaacgcaca gggcttggtg aaaattggca ccgtttctga
     2341 cagcagcagt aatgcacttt cattatctga attaaatgac aatctttcga tgaaagcgga
     2401 caaagccggg gccagcgcgt atcgcattat cgccgccggt ggcaataaca gttattacgg
     2461 cgtcgctgaa atataccgtt aattgtgtat ctcattattt attacgtcat ccagatacat
     2521 agacataaga atccgctacc agaccgaaac atgccagata cataacaact ttagtcttgt
     2581 tatgtcggga agctcatccc gcccacgtca cttggtctgg tatttcagga gaaaatgatg
     2641 aagccgctac acaaaacgtt tttggcaatg accgtcgccg gtctgatgac cggcttttcc
     2701 gcccacgcgg agcaggttca caccattgtt ctggtccacg gcgctttcgc cgacggcact
     2761 gccagctggg agcaggtgat ccccgcgcta cagtcgcgcc attacgaaat tatcaccgcg
     2821 caaatcccgc tgacctcgct gaaagatgat gtcgaagtga ctgaacgcgc cattgcccgc
     2881 gccaaaggcg acgtgattct ggtcggccac tcgtggggcg gcacggtcat cacccaggct
     2941 ggcaacaacc cgcgcgtcaa agggctggtg tacatcaacg ccttcgcgcc gtctgccggg
     3001 cagtccaccg ccgacttggt gaaaagcttc ccagcacctc cgggcagcgc aaaaattgtg
     3061 aaaggggctg acggcttcct cagcctgcca accagcgcca tcgccagcga ctttgcacag
     3121 gacgccacgc cagaggcgca gaacatagtg ggcattactc aggtgccaat ccgcgcctca
     3181 agttttgatg aaaaagtcac taaagccgcg tgggaaacca agcccagctg gttcttggtc
     3241 ggcagcaagg atcggatgat caatcccgac ttggagcgcg cgatggcgaa gaaaatccac
     3301 gcccacgtga ccgaattgcc ggtgagccac gttccgatgc tgtatgaccc aaaaaacgtc
     3361 gcccgcacaa ttttcaaagc ggtgaatatc acttcgggta actagcccgt ggtcagggag
     3421 ttctcatgcc aattctgatt gcttatctgg gcggaatgct cactttgtta agcccgtgca
     3481 cgctgccggt gatcccgctg ttattcgccg gagcgggcag caataaacgc catttcgcgg
     3541 ccttgctcgt cggcatggta ctgaccttca cgctggtggc tctgctggca acggcgagca
     3601 gcgagtgggt ggttcatgcc agcaaatatg gccgctggct ggcgctgggg ttattggcta
     3661 tcaccgcgct gtcgcttatc tctgaacgtt ttgctcagaa gattgcgcag cccgcggtgc
     3721 gccttggctc actgctggat agccgcagcc gccagcagcg gggtatcacc agcgcgctgc
     3781 tggccggggg agcagtcggg ctgttatggg caccctgcgc ggggccgatt ctgggggcga
     3841 tcctcagtac caccatgctt aacggagcat cagggcagag tgggttactg ctgctggcct
     3901 atggcagcgg ctgcgcgacc atgctggcct tactgtggtt ttgcggtgac aagctgctca
     3961 ccagactgcg agccaaaatg gcactcactc tgcgttttcg ccagatggcc ggggtgatga
     4021 tgctggcctc ggtggtgttt atcgcctcgg gagctaccag tttgctggat accaatagcg
     4081 ccgttggaca gcagttggag cagcatctgc tgaccctcaa gccttcaccg gccaagagag
     4141 tgattctaca acccgttgat attcaggcac cttccagcca aatgccgtct ctcaatggcg
     4201 ccataacgtg gctgaactcc ccggcactca cgccggagca gttaaaaggc aaagtggtgt
     4261 taatcgactt ctggaccttc gactgcatta actgccagca cagtattcct tacgtccgcg
     4321 agtgggctga gaaatatcag tcgcaggggc tggtggtgat tggtattcac accccggaat
     4381 atccgtggga gaagaatatc gatgccgtaa aacaagcgct gaataaatgg aatattaagt
     4441 acccggtcgc ggttgataat aattacgcca tctggaatgc cttcggtaac caatattggc
     4501 ccgcgcatta ttatttcgat gccaaaggac aattacgtta tcagaacttc ggagaaggta
     4561 attatcagca gcaagagaaa gtcatcaacg cattattagc cgaagctaag gcttaattta
     4621 ataaggaggt aatgtcacat tagataatct cactgtgtta atgctgtgtc tgacatcatt
     4681 tatttaattt aactttcaac tttctggagc tttatatgaa acgtattgct atgtccgcta
     4741 ttgccttatc tctgatctct ttcagcgccg cgtctttagc tgctgaagcc actggcccta
     4801 atttagagcg ctgttttggt gtggcaaaag cggcggataa cgactgcaag gccggggcgg
     4861 gcaccacctg cgccgggact tccaaaatcg attaccagaa agacgcctac aagatggttc
     4921 cgcaaggcac ctgcacctcc atccagacac caaaaggcca cggttcactg accgaaggct
     4981 aagccaagag ggccaccacc atgacgacaa taactcaact gggtgccggg ctggggctga
     5041 agccggaaca ttaccagcag gcgcttaaaa gtccggcgga cgtttggttt gaagtccaca
     5101 gtgaaaatta tctcatggcc ggtggcccac gcagggagtg gctggaggcg attcgccagc
     5161 agcacgcaat ttctctgcac ggcgtttcgc tctctctggc cgccgatgct ccgccggacg
     5221 ccgcgctgct ctctcgccta aaaatgctgg tggacgaggt taaaccggcc ttggtttccg
     5281 agcatttggc gtggtcgcag tgggacggcg cttactaccc ggatctgctg ccggtgccgc
     5341 gcacctcgca ggtgatgcgc cggttaatcg acaatattga ccgggtgcag gacgcgctgg
     5401 gcaggcagat ttcgctggag aacccgacac actatctgca tatgccggag cacgagtggg
     5461 atgacatcgc gtttctgcac gaagtgagct gtgccacggg ctgcgggctg ctgctggata
     5521 tcaacaatgt ctggctgagt gcccacaact tggggtttga cgccgccgcg tggctcgacg
     5581 gttttccggc agaccacgtt accgagatcc atctggccgg gtttagtagc gacgaaggcg
     5641 gcagcagttt gctgatcgac agccacgaca acccggtttc cgacgatgtt tgggcgcttt
     5701 atcaacggct tattcagcgc atcggtgcgc gcccaacgct gattgaacgc gacgacaaac
     5761 taccggagtt cgcggtgtta ttacaggagc agcagcgagc acagggcatc cttcacacct
     5821 acggaggtct gcgatgagcg gcgaactggc tcggtatcat caggctttta tccgcgccct
     5881 gtatgacgag aacagcaatg aactggcgca tttacagcaa cagccggggt ttatggtcta
     5941 tcgcaacagc gtgctaaaag gctgcatcga cgcgcttcag gccaatttcc ccagcgttgc
     6001 cagcctgacc ggagaggact tcttccgcga gatggcgcgg caatacgcgc tggtggagcc
     6061 gccgagggag gggatgctga ttcgctacgg cgagttcttc ccggctttta tcgccaccta
     6121 tctgcccgcc gccgacctgg gctatctggc tgacgtggcg cgactcgact ggctgtggtt
     6181 ggagatgttt tgcgccgaat cggcagcctg tttggcggtg caggcactgg ctgagttgcc
     6241 accagagtcg gttggcgagc tggttttatc cttgcgcgac gcggtgcgct ggcattggca
     6301 cccgagcctg ccggtcttca cgctgtggca tttcaaccgt taccacactg cgccgccgga
     6361 gaatattcag tggcaaggag agggcgcgct actggtgatg cgccaacagg gtattgaggc
     6421 cgagccgata agccgtggcg gcgcggcatt tctcgctgcc tgccgcgatg gcgcgaacct
     6481 gaacgcggcg agcgaacggg cattacacgc cgaaccgaca ttcgatattg gtccattttt
     6541 cacgcgctta ctgcatctcg gcgtgttcgc cgcgacggcg cattaattct tagaggtaaa
     6601 aatgaaaacg acagataact ctttaaataa tcaggcttct tctgagcaag gtctgcgcgg
     6661 gttgtggaat gggacctggc gcggcgtgca gcgtgtggtc agtggcaacg tgctgctgct
     6721 ggtcgcccga gtgggcattg cggcggtgtt tttcctctcg gggcgcacca aagtgacggg
     6781 cttcatgacc ctcaaacctt cgacttatga gctgtttaaa accgaatacg ccttgccgct
     6841 gatcccctat gacatcgccg cgcatctggc gacctttgcc gaacacacct tcccagtgct
     6901 gctggtcctc ggcctgctct cccgcttcgc tgccagcggc ctgctgttta tgacgctgat
     6961 tattgagatc tttgtctatc ccgacgcatg gccaactcac ctgatttggg gcggattgct
     7021 gctgatggtc atctcacgcg gagccgggaa gtggtcgctg gatcgggtgc tggggttggt
     7081 ttgataaggt gctaagtgaa agtggatccg ttataaacag tagaagtaaa tagtttaggg
     7141 cggatttgag atccgcccta ccgcatttca acataagaca ttaattctcc aactccaccc
     7201 aataatttac gccagctagg gtccatgcct aaaatgcctt ctaattgtat gggtattcaa
     7261 tattcagaaa attttttttg tgctgctaca attacagcta tcttttcaga acaggacgtt
     7321 tactcatgca atccctcgtt gagatatatg acttacaaca gcaagtgaag gaaaaaataa
     7381 gccaaaaaaa atatcaagat attgaggccc tgtttgcgcc actctccaga aaggacttac
     7441 aaaatgtact tcaatttcca tttattttta attctcaggt ggaagggctg gattcaatat
     7501 tgtcacagct tcaggagtgg cagcaggaaa ccccacatag ctattaccct tatgtctttt
     7561 ttgctagttt ctggtttatt actgccgcca accagcgtgg taaacaaact atagatcgag
     7621 ttactccggc acagcgtcag aattgtagtg cggcaaatga tcaatttttt tattgggctt
     7681 tgaaaactct agagtttaat cctcagtgtg aaacagcata tacaatgctg ttagaggctt
     7741 caggatattt cggtatgccg gagtggcttg attttctagt cactaagcct attcgttatt
     7801 cttgtgaaag ctataatgaa gaagctgtga agtttgtatc ttcattcaca acctatagta
     7861 ttccacatgg ttcaattaat ataaatcttc catcacctag tgaagaagaa gagaggttta
     7921 ttccgctcta ctggttgagg agaattctgg ctattgctcc tgaccatatg atttcaagaa
     7981 aagtagtgat aaaactcttg tcgccaagat ggtatggggg agaaaaatat gaagatattg
     8041 attatttttt agcgagtgat tactgttcca gtttatccga gttagatata aaaatactta
     8101 agcgtgaaaa agagtacgac caactaacct catataatac tcttcctttg cttaattaca
     8161 gaaaagagtt aaagaggaga gcaagtaatt ttatagattt aattaattct ccgctcacca
     8221 aggatgagac ttctcggaca ttgcttgagt atgtttactt ttgtaaccat gtcttagaga
     8281 cagatccaaa ggctaaacaa agtgcaaaag atgacatggt agaaagtgtt tatcaatcgt
     8341 tacatcatat tgtaaagcta gcgtcgcctt ggttcctctt ttatcaatca gaagagattt
     8401 ttaatcaact catttcattt atgaaaattt atgaattcga tgataaatcc catgtctttg
     8461 acgacatagc tagacagaca cagttccgaa atttaacttc accgatagat gttctttata
     8521 gtactttcgc ggcaaacttc acattagcta atatttcgct tttcactcaa cgtgaaagcc
     8581 tcgaacgtta ttatatgctc gctgagaaga acttcgatta ctacattttc agactgcaca
     8641 ttttcatgct ttgcaaaatg ggatatgcct cttcaataaa accagtgttg gaaaggtttg
     8701 caatcgaaaa tatgactacc agtgcctcgt tgctgttcta tgaaatttat cacggtaacg
     8761 tccctgggat ggcaggcatg ctttcaattc atcctgacga gaataaagaa agagaatttt
     8821 tagatattgc agttaagcag ggttcaacac acgccatttt aattaaatct cgcgatttag
     8881 agagtttaat tgagcgtagt actaagccat ccgtgaagtc cgagcttgct ctcgaaagag
     8941 agagattact taaacagaac attcagttgg gagatgctgt atctcagtac gattatgcat
     9001 gcagcttaat ttcctcaagc gaagaacagc agattataaa aggtctattc attgaggccc
     9061 ccaaagttct ggccgaatcc cgagtcagat tagatcagtt agcttatatc gcttatctat
     9121 atgctttctg tgcttttaat gggcgcggga tgagaaaaaa tatattcgtt atggattttt
     9181 ggatgaatat ggcacttgca tggtatcctg accttgaata tcaagatttt tacaccacgg
     9241 caaaacatgc tgttggtata aaaccctttt acaatagtgc cctaaaaaag ggtagaggta
     9301 agatacccga ggaaatgaaa aaaataatga atagtgtggc ccaataaagg agtttttgcg
     9361 atgacaacac ttcccattgt tatctttatc gtgttggttt atatgatcat cagaattagg
     9421 agttttaggg caaaaaagcg catcacgtcg attatgttgc caagaaggaa gtaattttga
     9481 ggagactggc acgccgaatt taaaactgat ctaacgagat gtgcctagtt tccgtaggtg
     9541 tgtttttaca tcagctatcc tgttgggaaa acgactattt ttctcagcta agatatttaa
     9601 cacatggctg cgagtcatct tacggggagt agggcagtgg ttgcgggatc ggctgttggg
     9661 gttggtttga cttaaacaat gaccaagctt atcaggcgag tttctctttg ctggctttgt
     9721 tgcgaatgca aaaagtccgc tatctgccac aaacaaaaaa tatcaacctc acgacatctc
     9781 aagcagcgaa tctttgagat aaccctccag cagagaggca caaattcgtg tttcatatga
     9841 catcatgact gttggtggat gaagcaaata ggcgttaaaa gaggggagct gaaagtggct
     9901 taaaagaggt attaactcac tcttttcaat ttcgtttcta caaaccgggt attgcagaac
     9961 accaatagca tgcccagcta ataagtatgt gaagacgctt cgccagtgcg tggcccgaaa
    10021 tctaacgtcg atcggaacat tcattagttg gttttcagag ctgagtaatt gaatccggtt
    10081 gttggcaaat atgcccgaaa cagcagcaaa tggataacct gccagctcat caggagactg
    10141 cggatcgccc attttagcca gcaaagcggg agaagccagt aacactctgc gcacaatgcc
    10201 aagtggacgt gcgacaaaaa aaccttccga gagatctccc agcctcaatg ataaatccac
    10261 accttcagtg acaggatcga tgacattatc gttaaaaatc acatcaacct gtaggctagg
    10321 gtgttggtcc tgaagtcgaa gtatcgcggg catcagcagg ctttcgccag cagaataggg
    10381 cgcggcaatg cggattttgc cttgcagact ctgattctct tcattcacta aaagagcgtg
    10441 ttctgccgcc tgaatggccg ttttgctccg ctcataaaat aaattgccgc tatgcgtcag
    10501 agacatgttg cgcgtgttgc gcctcagcaa acgagtgccg agatgggctt ccagtttttc
    10561 tattctttca ctgactgcgg gttgcccaat gccaagatcg cgggccgcag ctgacatgct
    10621 gccccgctcg accaccctga taaaaatacg cattgctgag aagagatcca tttagcgatt
    10681 atattggttt tacagataaa tgtaagtgga tataggtatc tactgttttt ctgtgaaatg
    10741 ataaaaaatc cacattcggc aatatattcc attgcgctgg aatatattca attgatttaa
    10801 atgtggaaat taattatgtc agatatcaga cttttta
//
