Select genomic region:
Overview
18.1
21.1
22.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_FONL01000008 (original name was: NZ_FONL01000008.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 18.1 | RiPP-like | 19,806 | 31,743 |

NZ_FONL01000006 (original name was: NZ_FONL01000006.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 21.1 | NRPS | 1 | 37,719 |

NZ_FONL01000024 (original name was: NZ_FONL01000024.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 22.1 | ranthipeptide | 9,747 | 21,847 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 18.1 | RiPP-like | 19,806 | 31,743 |
Region 21.1 | NRPS | 1 | 37,719 |
Region 22.1 | ranthipeptide | 9,747 | 21,847 |

No secondary metabolite regions were found in these records:
  NZ_FONL01000039 (original name was: NZ_FONL01000039.1)
  NZ_FONL01000038 (original name was: NZ_FONL01000038.1)
  NZ_FONL01000037 (original name was: NZ_FONL01000037.1)
  NZ_FONL01000034 (original name was: NZ_FONL01000034.1)
  NZ_FONL01000036 (original name was: NZ_FONL01000036.1)
  NZ_FONL01000033 (original name was: NZ_FONL01000033.1)
  NZ_FONL01000032 (original name was: NZ_FONL01000032.1)
  NZ_FONL01000029 (original name was: NZ_FONL01000029.1)
  NZ_FONL01000026 (original name was: NZ_FONL01000026.1)
  NZ_FONL01000031 (original name was: NZ_FONL01000031.1)
  NZ_FONL01000023 (original name was: NZ_FONL01000023.1)
  NZ_FONL01000005 (original name was: NZ_FONL01000005.1)
  NZ_FONL01000028 (original name was: NZ_FONL01000028.1)
  NZ_FONL01000003 (original name was: NZ_FONL01000003.1)
  NZ_FONL01000013 (original name was: NZ_FONL01000013.1)
  NZ_FONL01000009 (original name was: NZ_FONL01000009.1)
  NZ_FONL01000027 (original name was: NZ_FONL01000027.1)
  NZ_FONL01000015 (original name was: NZ_FONL01000015.1)
  NZ_FONL01000025 (original name was: NZ_FONL01000025.1)
  NZ_FONL01000002 (original name was: NZ_FONL01000002.1)
  NZ_FONL01000020 (original name was: NZ_FONL01000020.1)
  NZ_FONL01000004 (original name was: NZ_FONL01000004.1)
  NZ_FONL01000010 (original name was: NZ_FONL01000010.1)
  NZ_FONL01000001 (original name was: NZ_FONL01000001.1)
  NZ_FONL01000018 (original name was: NZ_FONL01000018.1)
  NZ_FONL01000011 (original name was: NZ_FONL01000011.1)
  NZ_FONL01000030 (original name was: NZ_FONL01000030.1)
  NZ_FONL01000012 (original name was: NZ_FONL01000012.1)
  NZ_FONL01000035 (original name was: NZ_FONL01000035.1)
  NZ_FONL01000021 (original name was: NZ_FONL01000021.1)
  NZ_FONL01000007 (original name was: NZ_FONL01000007.1)
  NZ_FONL01000019 (original name was: NZ_FONL01000019.1)
  NZ_FONL01000014 (original name was: NZ_FONL01000014.1)
  NZ_FONL01000016 (original name was: NZ_FONL01000016.1)
  NZ_FONL01000022 (original name was: NZ_FONL01000022.1)
  NZ_FONL01000017 (original name was: NZ_FONL01000017.1)

Compact view
c00018_NZ_FONL.. - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 19,806 - 31,743 nt. (total: 11,938 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.1 |  | 0.23 | Other | 3-demethylchuangxinmycin | Actinoplanes tsinanensis
BGC0001546.1 |  | 0.23 | Alkaloid | chuangxinmycin | Actinoplanes tsinanensis
BGC0000554.1 |  | 0.21 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.1 |  | 0.20 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001364.1 |  | 0.18 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001660.1 |  | 0.17 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000551.1 |  | 0.17 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.16 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000600.1 |  | 0.16 | RiPP | thurincin H | Bacillus thuringiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.1 |  | 0.56 | Other | 3-demethylchuangxinmycin | Actinoplanes tsinanensis
BGC0001546.1 |  | 0.56 | Alkaloid | chuangxinmycin | Actinoplanes tsinanensis
BGC0000554.1 |  | 0.53 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.1 |  | 0.52 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001364.1 |  | 0.49 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001660.1 |  | 0.48 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000551.1 |  | 0.48 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.47 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000600.1 |  | 0.47 | RiPP | thurincin H | Bacillus thuringiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00021_NZ_FONL.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 37,719 nt. (total: 37,719 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.34 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.32 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.32 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.32 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000348.1 |  | 0.31 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001479.1 |  | 0.26 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001399.1 |  | 0.26 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000980.1 |  | 0.26 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000979.1 |  | 0.26 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0001561.1 |  | 0.25 | NRP | curacomycin | Streptomyces curacoi

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.67 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.66 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.65 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000348.1 |  | 0.65 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001479.1 |  | 0.59 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000980.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000979.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0001561.1 |  | 0.59 | NRP | curacomycin | Streptomyces curacoi

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 37719:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg21_12: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (220..613): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGAdvGEVsK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)

c00022_NZ_FONL.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 9,747 - 21,847 nt. (total: 12,101 nt) Show pHMM detection rules used
Region on contig edge.
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001484.1 |  | 0.14 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0000804.1 |  | 0.13 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001484.1 |  | 0.44 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0000804.1 |  | 0.42 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names