LOCUS       NZ_KI260438.1          11988 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_KI260438.1 Ruminococcus callidus ATCC 27760 Scaffold5, whole
            genome shotgun sequence.
ACCESSION   NZ_KI260438
VERSION     NZ_KI260438.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:22:47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11988
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11988
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2149:3018]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2150..3018
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..11988
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11988
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             3..89
                     /locus_tag="ctg132_1"
                     /transl_table=11
                     /translation="HENGVGMLIYSYLLFEEGCGMIKRKRGK"
     CDS             91..792
                     /locus_tag="ctg132_2"
                     /transl_table=11
                     /translation="MLRIAVIDDDKTLLCDMHKLFDRFIIAYDFDFTVEYFSSCEDIYA
                     KFKAGEKYDLLFLDIEFPEMKGTEFGLQLRRQMKNYDTQIVFISTIRDYAMELFKIRPI
                     AFLIKPITYEDLCKCLQDYMLDYSNSDSFLEYISENTKHKIKLKEVSYLESNGKKVIFH
                     TKTEEFAVNGKISSIIEGNGSKFLCISRGVYVNIKHIIKATSKEVTLEDGTSLFISRGQ
                     QSIVRDRLSEL"
     PFAM_domain     100..450
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_2_0001"
                     /evalue="2.30E-12"
                     /label="ctg132_2"
                     /locus_tag="ctg132_2"
                     /protein_end="120"
                     /protein_start="3"
                     /score="47.2"
                     /tool="antismash"
                     /translation="IAVIDDDKTLLCDMHKLFDRFIIAYDFDFTVEYFSSCEDIYAKFK
                     AGEKYDLLFLDIEFPEMKGTEFGLQLRRQMKNYDTQIVFISTIRDYAMELFKIRPIAFL
                     IKPITYEDLCKCL"
     PFAM_domain     517..780
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_2_0002"
                     /evalue="4.40E-12"
                     /label="ctg132_2"
                     /locus_tag="ctg132_2"
                     /protein_end="230"
                     /protein_start="142"
                     /score="46.2"
                     /tool="antismash"
                     /translation="HKIKLKEVSYLESNGKKVIFHTKTEEFAVNGKISSIIEGNGSKFL
                     CISRGVYVNIKHIIKATSKEVTLEDGTSLFISRGQQSIVRDRL"
     CDS             808..2019
                     /locus_tag="ctg132_3"
                     /transl_table=11
                     /translation="METSLYLVSNVIRIYAISIFLDSFFGNLKCKRIIKIIAYISYYFI
                     GSLVWIISQNTNINLVINTAAIILISILYRATWKKRVFSAIWVCAVGMFIDWIAFSILG
                     NSQFVQSGFLQYVLLLDLAFLFRHLYHRHIEYSSKSPYFLLILLVSLGTIAVGILTVND
                     SSKHDIIVAIILLLINLINFYTYHLEQDRLKNKHMVELIQASNDAYQNQLKIMETSQRE
                     MRYLRHDMQKHLNTMRRMLQEKEYAEVQEYLTTIENAIIVKEEYSKTGNRDVDSLINYE
                     LALASDLGTAIMCRIDLPAELNISSFDMTVILGNLLDNAIEALRQSENKRLLLSMKLTR
                     GIVRIDIENSYNPKQKKKADQKQHGIGLLSVSHTLEKYHGDLKHYVEDNNKYHTTVTMF
                     NGTE"
     PFAM_domain     1720..1998
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_3_0003"
                     /evalue="6.40E-19"
                     /label="ctg132_3"
                     /locus_tag="ctg132_3"
                     /protein_end="397"
                     /protein_start="304"
                     /score="67.8"
                     /tool="antismash"
                     /translation="SSFDMTVILGNLLDNAIEALRQSENKRLLLSMKLTRGIVRIDIEN
                     SYNPKQKKKADQKQHGIGLLSVSHTLEKYHGDLKHYVEDNNKYHTTVT"
     CDS             2150..2731
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg132_4"
                     /sec_met_domain="AgrB (E-value: 1.1e-39, bitscore: 125.5,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEEASNRITVWLSKTKIISSDQEVVCKWGMTHILDTLFNIATFT
                     AIGLLFRMLPETAVFTVAYIPLRSFAGGYHAKTPFRCWVISNFLLIAALLIVRYVSHFT
                     AFFLLLTALSLLCLVVLMPVSDIHKKLSEKDRKKYRRKGLMILMVELCASAMLYYFALI
                     NFSYSIFSAWILLSIMLIGGMIKNGVQAKK"
     PFAM_domain     2165..2686
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_4_0004"
                     /evalue="2.00E-36"
                     /label="ctg132_4"
                     /locus_tag="ctg132_4"
                     /protein_end="179"
                     /protein_start="5"
                     /score="125.2"
                     /tool="antismash"
                     /translation="SNRITVWLSKTKIISSDQEVVCKWGMTHILDTLFNIATFTAIGLL
                     FRMLPETAVFTVAYIPLRSFAGGYHAKTPFRCWVISNFLLIAALLIVRYVSHFTAFFLL
                     LTALSLLCLVVLMPVSDIHKKLSEKDRKKYRRKGLMILMVELCASAMLYYFALINFSYS
                     IFSAWILLSIM"
     CDS             2863..3018
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg132_5"
                     /sec_met_domain="TIGR04223 (E-value: 4.6e-16, bitscore:
                     48.4, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKICSFITRFGGTMAALALVVATMTANSTCAWLAYQPEEPEEV
                     KMLKKD"
     aSDomain        2908..3000
                     /aSDomain="TIGR04223"
                     /aSTool="tigrfam"
                     /description="quorum_AgrD: cyclic lactone autoinducer
                     peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg132_5_0001"
                     /evalue="1.60E-13"
                     /identifier="TIGR04223"
                     /label="ctg132_5"
                     /locus_tag="ctg132_5"
                     /protein_end="46"
                     /protein_start="15"
                     /score="48.4"
                     /tool="antismash"
                     /translation="MAALALVVATMTANSTCAWLAYQPEEPEEVK"
     CDS             3233..3568
                     /locus_tag="ctg132_6"
                     /transl_table=11
                     /translation="MTKLKKVVAGILAAAAMATSVVGMSASAYSPTVSRTVGSVTGTLY
                     SDTTYGYGTTACSNQTCYVKVKHGGTTSGWANSYGYASCKNSATNGTTNAQSWHRTAST
                     SSFSLYF"
     CDS             3943..4077
                     /locus_tag="ctg132_7"
                     /transl_table=11
                     /translation="MPDYKDQIIENLQKEVEELKRIVEMQNDIIRDLREQLRKNSSNS"
     CDS             4132..5385
                     /locus_tag="ctg132_8"
                     /transl_table=11
                     /translation="LREKSGKKQGGQKGHSGTHLAVLSEPDHVINHLHADCQHCPKREI
                     CMMNSEVKEIRHEIDMIAQVDVTEHELITIPVCPICGEAKTGSFPAEIKAVVQYGQNLE
                     ALAVALNTIGAVSFNRTHDILSGVFNVPISVGTIKNMVSRCAAKVEEANTVSAEKLKSA
                     HHKHGDETGCRADGKTRWTHCLSNELYTVLFLHDKRGHIAMEEMGIIQYSGGTLVHDCW
                     APYWCFTNVKHQLCGAHLLRELKGIVENHPKQTWAKKFTTLLLNLKRAKEKAIAKGKTA
                     LHRNTLKRYSNLYDEIMRAAYEENPLPERKPGQRGRTKRGKVLCLIDRLSAHKGEVCLF
                     AHDFDVPFDNNQAERDIRNIKVKTKVSGCFRSVDGAKEYLKIMSYVSTAIKHGFTSFDA
                     IRRAVMGNSMSIFAQDSE"
     PFAM_domain     4420..5262
                     /aSDomain="DDE_Tnp_IS66"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03050.16"
                     /description="Transposase IS66 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_8_0005"
                     /evalue="1.80E-51"
                     /label="ctg132_8"
                     /locus_tag="ctg132_8"
                     /protein_end="377"
                     /protein_start="96"
                     /score="175.4"
                     /tool="antismash"
                     /translation="VQYGQNLEALAVALNTIGAVSFNRTHDILSGVFNVPISVGTIKNM
                     VSRCAAKVEEANTVSAEKLKSAHHKHGDETGCRADGKTRWTHCLSNELYTVLFLHDKRG
                     HIAMEEMGIIQYSGGTLVHDCWAPYWCFTNVKHQLCGAHLLRELKGIVENHPKQTWAKK
                     FTTLLLNLKRAKEKAIAKGKTALHRNTLKRYSNLYDEIMRAAYEENPLPERKPGQRGRT
                     KRGKVLCLIDRLSAHKGEVCLFAHDFDVPFDNNQAERDIRNIKVKTKVSGCFRSVDGAK
                     "
     CDS             5418..6647
                     /locus_tag="ctg132_9"
                     /transl_table=11
                     /translation="MSRIHKLIVPIMLTMNLCACGSESIQKGSNIQNFEQNHYITHANT
                     YQNGVIYTGSEGSSTAAYFLDYESMQAVPLCNKPNCAHKDTSCLAFQCVQDSIMPFVYQ
                     GMVYWFHTDSKITDSDDGRSTAYQFQTTCYCGNMTTGEVESFVEIPDVSMKDAIEFVIS
                     NHTLYIIGCDCAYQEEDGSWTEMSRIGDQYLYAINLDTADVKNYGLINDAPTASYNWTL
                     NGAMFADVELTGIYQNKLYLSYRYVDDPNDIIDYVNTGDPDSPDWSDAGTAIPWHRVNK
                     CLNLETDTIEPSEYPAADLIQDDTYIYYMDGQYHVMDADGTETVSADIPANNSRNLTFV
                     NGIFWDGPQSTCFQPKTGETHVLSETYSDTNLTVIAYYKERYIINYTDENNLIHFEAVP
                     ESDLIGGIVE"
     CDS             6644..7393
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 181.9; E-value:
                     2.5e-55)"
                     /gene_kind="transport"
                     /locus_tag="ctg132_10"
                     /transl_table=11
                     /translation="MTLVLRHCNKHYGKKHALKDFTFSFETGVYGLLGPNGAGKSTLMN
                     LITDNLKPDKDGGEILWDGQPIRKLGKSYRACLGFMPQQQELYANMTARDFLGYLSALK
                     GIPRKEAKDQIADVLEQVELSEQAAQKIGGFSGGMKQRLLIAQALLGNPSLLILDEPTA
                     GLDPKQRVIIRNLTDRLGQEKIILISTHIISDIETIADQILLLRKGTLLTHGTVSELIE
                     QVQTGEKTLENLYLQYYGGEANAAGGA"
     PFAM_domain     6695..7132
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_10_0006"
                     /evalue="5.00E-31"
                     /label="ctg132_10"
                     /locus_tag="ctg132_10"
                     /protein_end="163"
                     /protein_start="17"
                     /score="108.1"
                     /tool="antismash"
                     /translation="LKDFTFSFETGVYGLLGPNGAGKSTLMNLITDNLKPDKDGGEILW
                     DGQPIRKLGKSYRACLGFMPQQQELYANMTARDFLGYLSALKGIPRKEAKDQIADVLEQ
                     VELSEQAAQKIGGFSGGMKQRLLIAQALLGNPSLLILDEPTA"
     CDS             7374..9464
                     /locus_tag="ctg132_11"
                     /transl_table=11
                     /translation="MLRAELKKCLSFRVLWILLFCLLCINGYSQITNAYDRYYTPSEYN
                     ALYEQLNRMSLQEANAFVSAKIESASPDSDADYNGYLYYDTLEIIEGLQNYPAYLESIQ
                     TNAENMTAVSIWGGTDTFSYRNIQKTPSAYTALAGTTLVLDTSLGIEDLLSSPLTDFLA
                     VLLLFFCVCRIFLRDREQGILPLLYATPNGRLRLMSCKLGIAVLCAIGLVLLFYGEIAL
                     ISCNLYGLGDLSRPIQCIYGYETCNLPVSVGTYISIYLLFKMAAYAVFAVLFGFFCTIA
                     KNNLMVYGASIGVVGISYLLYAKISVLSPISLLHFWNPIQFLQGKEILGTYTNVNCFGY
                     PISLKISACVVIGLWLFLFIGSSFIVFTHAGNLQYRSFSVRHKLHIRFRVHQKFWYTCY
                     RILILQKGLLVVFLLLFLSVGLAKTYTRTYSNEDIYYENFCNEYAGVVTEKTEQFLTEK
                     RAFYREIEAQIAELEQSESPNSYQIGQLTAQLNDKAAFEKFAQRVEQIPDSAEIFYDTG
                     YVRYFALDGNREGMVQVLLLTAALTLLLCPTTSMDCKTNLKQIYHATKIGRFGYLRQMF
                     RFAILNGILFSAVLILPYLLQILNHYGMQGWNTPLAGIEAYSTCPARISVGAAAIGVMG
                     IRTIGAALTGCSITWIASHCKSLVTAYCINGVLFVLPAGLCLLGLDMFRYVGLTPMLYG
                     II"
     CDS             9709..10521
                     /locus_tag="ctg132_12"
                     /transl_table=11
                     /translation="METGLNSVNDSDYMTTDYAYDAWGHLVNTTDSTGYNSGTTTYDLN
                     GNVLTVTDANGNVTTNTYDALNRVLAVNTVCDDSTKNVSKSYTYNNMGWMTNKSSNGTE
                     TSIEYDALGRVTKEWGPNFKGYFYEGVSNYVEKQLVGYAHLLLYSVTNYEYDAEMRIVK
                     VLESGSETASYTYDANGNKTSETQANGVVSTYTYNSANKITNHITKSGNSTISEYEYSY
                     YLDGSDAFKVRKEKWYNRDNILRVRWAEAADGRSSDDRKFDRHLFLRV"
     PFAM_domain     9832..9924
                     /aSDomain="RHS_repeat"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05593.16"
                     /description="RHS Repeat"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_12_0007"
                     /evalue="3.40E-07"
                     /label="ctg132_12"
                     /locus_tag="ctg132_12"
                     /protein_end="72"
                     /protein_start="41"
                     /score="30.7"
                     /tool="antismash"
                     /translation="YDLNGNVLTVTDANGNVTTNTYDALNRVLAV"
     aSDomain        9832..9927
                     /aSDomain="TIGR01643"
                     /aSTool="tigrfam"
                     /description="YD_repeat_2x: YD repeat (two copies)"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg132_12_0002"
                     /evalue="1.90E-05"
                     /identifier="TIGR01643"
                     /label="ctg132_12"
                     /locus_tag="ctg132_12"
                     /protein_end="73"
                     /protein_start="41"
                     /score="23.0"
                     /tool="antismash"
                     /translation="YDLNGNVLTVTDANGNVTTNTYDALNRVLAVN"
     aSDomain        10171..10284
                     /aSDomain="TIGR01643"
                     /aSTool="tigrfam"
                     /description="YD_repeat_2x: YD repeat (two copies)"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg132_12_0003"
                     /evalue="7.30E-05"
                     /identifier="TIGR01643"
                     /label="ctg132_12"
                     /locus_tag="ctg132_12"
                     /protein_end="192"
                     /protein_start="154"
                     /score="21.1"
                     /tool="antismash"
                     /translation="YDAEMRIVKVLESGSETASYTYDANGNKTSETQANGVV"
     PFAM_domain     10234..10335
                     /aSDomain="RHS_repeat"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05593.16"
                     /description="RHS Repeat"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg132_12_0008"
                     /evalue="1.60E-05"
                     /label="ctg132_12"
                     /locus_tag="ctg132_12"
                     /protein_end="209"
                     /protein_start="175"
                     /score="25.4"
                     /tool="antismash"
                     /translation="YDANGNKTSETQANGVVSTYTYNSANKITNHITK"
     aSDomain        10234..10350
                     /aSDomain="TIGR01643"
                     /aSTool="tigrfam"
                     /description="YD_repeat_2x: YD repeat (two copies)"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg132_12_0004"
                     /evalue="1.30E-04"
                     /identifier="TIGR01643"
                     /label="ctg132_12"
                     /locus_tag="ctg132_12"
                     /protein_end="214"
                     /protein_start="175"
                     /score="20.3"
                     /tool="antismash"
                     /translation="YDANGNKTSETQANGVVSTYTYNSANKITNHITKSGNST"
     CDS             10478..11986
                     /locus_tag="ctg132_13"
                     /transl_table=11
                     /translation="VTTGSSTDTYSYEYDDYGNRSKMTATSSESYVTDYSYSDFNGNYT
                     ALLQKETKTVDGTSEEIVANGLATSPADLLTTDNSDVEQTVYTYDANGNQITKTADGKT
                     ETNTYDGLNQLIGFTDGETTASYTYDVDGLRLSKTVDGKTTKHVWDGNQQLVADVLDSE
                     LYSANCYLRGTNLVATYSYQNGEKSGYTYYTQNAHGDVVNLTDSTGEITKSYTYDAFGV
                     EKNIDNSDTNAFRYCGEYYDSETGTIYLRARYYDPSMGRFISRDSYAGKNSDPLSLNRY
                     TYCHNNPIFYADPKGHSAWTKFQEAAFAVEHPFIASKIGTAKPDDANSNTISSRAARFA
                     INSKVSYNYKKGQENEGGQRNALRHAIWSTTITRYYGKEIMKQVGYSHENLSEMLKITS
                     DPTKWYFSDMHTADTLCDIMNNETGMKIAASGDATNMRSITLEVLEYYHTNGLYVAVEY
                     ADNLYIVQNQKLSDQEYASATYNVFFLDQNGLRGNINTVADIVRQ"
     aSDomain        10802..10906
                     /aSDomain="TIGR01643"
                     /aSTool="tigrfam"
                     /description="YD_repeat_2x: YD repeat (two copies)"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg132_13_0006"
                     /evalue="8.00E-04"
                     /identifier="TIGR01643"
                     /label="ctg132_13"
                     /locus_tag="ctg132_13"
                     /protein_end="143"
                     /protein_start="108"
                     /score="17.8"
                     /tool="antismash"
                     /translation="YDGLNQLIGFTDGETTASYTYDVDGLRLSKTVDGK"
     aSDomain        11126..11368
                     /aSDomain="TIGR03696"
                     /aSTool="tigrfam"
                     /description="Rhs_assc_core: RHS repeat-associated core
                     domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg132_13_0005"
                     /evalue="1.20E-23"
                     /identifier="TIGR03696"
                     /label="ctg132_13"
                     /locus_tag="ctg132_13"
                     /protein_end="297"
                     /protein_start="216"
                     /score="81.4"
                     /tool="antismash"
                     /translation="YDAFGVEKNIDNSDTNAFRYCGEYYDSETGTIYLRARYYDPSMGR
                     FISRDSYAGKNSDPLSLNRYTYCHNNPIFYADPKGH"
ORIGIN
        1 ttcacgaaaa cggtgttggg atgctcattt atagctactt gctttttgaa gaagggtgtg
       61 gtatgataaa aagaaaaagg ggtaaatgaa atgcttagga ttgctgtaat tgatgacgat
      121 aaaacactgt tatgtgatat gcacaagcta tttgatcgat ttatcattgc ttatgatttt
      181 gattttaccg tagaatattt ttcatcttgt gaagatatct atgcaaaatt caaagcagga
      241 gaaaaatatg atttactttt ccttgacatt gagtttccgg aaatgaaagg tacagaattt
      301 gggctgcagc tgcggagaca aatgaaaaat tatgatacgc aaattgtttt tatttctacg
      361 attcgggatt atgccatgga attattcaag attcgaccga ttgctttctt gatcaagcca
      421 attacttatg aggacttatg caaatgtttg caggattata tgttggatta cagtaattcg
      481 gatagttttt tggaatatat atcggaaaat acaaagcata aaatcaaatt gaaagaagtt
      541 tcgtatttgg aatctaacgg gaaaaaagtg atttttcaca caaaaacaga agagtttgcc
      601 gtgaatggga aaatcagcag tatcattgag ggaaacggta gtaaattcct ttgcatatca
      661 agaggcgttt atgtaaacat aaaacacatc attaaggcaa catcaaagga agtaacattg
      721 gaagacggca catcactttt tatcagccga gggcagcaaa gcattgtaag agatcgattg
      781 tctgaattat aaaattggga ggtatatatg gaaacttctt tatacttagt gtcaaatgta
      841 attcgcattt atgctattag tattttttta gattcgttct tcggtaattt gaaatgcaaa
      901 aggataataa aaataattgc atatatatcc tattatttta tcggaagtct ggtttggatt
      961 atatcacaaa atacgaatat caatcttgtt atcaatacag cagcaatcat cttaatttct
     1021 attctatacc gtgcaacttg gaagaaaaga gttttttctg caatatgggt ttgtgcggtt
     1081 ggaatgttta tagattggat tgcgttttct attttaggta attctcaatt tgtgcagagt
     1141 ggctttttac aatatgttct tctgttagat ctcgctttct tatttcgtca tttatatcat
     1201 cgtcatatag agtattcttc aaagtctcca tattttttgc tgattctttt agtttctctt
     1261 ggaacaattg cagtaggaat tctgacagta aatgatagtt ccaagcatga catcatcgtt
     1321 gcaattatcc tgcttcttat taatcttatc aatttttaca cgtatcatct ggaacaagac
     1381 cgactgaaaa acaaacacat ggtggaattg attcaggcat caaatgatgc ttatcaaaat
     1441 cagcttaaaa tcatggagac ttcccaaaga gaaatgcggt atttgcggca cgatatgcaa
     1501 aagcacttga acaccatgcg taggatgctg caagagaagg agtatgcgga ggtgcaggag
     1561 tatctcacga caatcgagaa cgcaattatt gtgaaggaag aatactcgaa aacaggcaat
     1621 cgtgatgtgg atagcctgat taattatgag ttggctttag cgtctgattt aggtacagca
     1681 attatgtgca gaattgactt accggcagaa ttgaatattt catcctttga tatgaccgtg
     1741 atacttggaa acttgttgga taatgcgata gaagctttgc gtcagtcaga aaacaaacgg
     1801 cttctgctct ccatgaaatt gactcgtgga attgtacgaa ttgatattga aaacagctac
     1861 aacccaaaac agaaaaagaa agcggatcaa aaacaacatg gaattggtct cctaagtgtt
     1921 tcacatacgc ttgaaaaata ccatggtgat ctgaagcact atgtagaaga taacaacaaa
     1981 tatcatacaa cagtgaccat gttcaatgga acagaatgaa gaaatcggac gttctaaagc
     2041 gtccgatttt tgcatttcat acccaaaagt catacagttc atgccataag tcggttttaa
     2101 aagtcctatt tgtgctatca taaattagcg aagaaagaag gtgcatggga tgtttgaaga
     2161 agcatcaaat cggattacag tatggctgtc caaaaccaaa atcataagtt cagaccaaga
     2221 agttgtatgc aaatggggaa tgacacacat attggatacc cttttcaaca ttgcaacttt
     2281 tactgcaatc ggattgcttt ttcgaatgct tccggaaaca gctgtattta cagtcgcata
     2341 tattccgttg cggtcattcg caggtggcta tcatgcaaaa acaccatttc gatgctgggt
     2401 tatttccaat tttcttttaa tcgcggcatt gctaatagtt cggtatgttt ctcattttac
     2461 tgccttcttt ttattgctga cagctttgag tttgctctgt ctcgttgttt tgatgcctgt
     2521 atctgatatc cataaaaagt tatcggaaaa ggacagaaaa aagtatcgaa gaaaaggact
     2581 catgatattg atggtagaat tatgtgcatc tgctatgctc tattattttg ccttaataaa
     2641 tttctcttac agcattttta gtgcatggat actgttgtcc atcatgctca ttggcggaat
     2701 gattaagaat ggcgtacaag cgaaaaaatg agaaaaagtg catttcatac ccaaaaatca
     2761 tacagttcgt gccataagtc agtttttttc ttgactttgt gttacaatgt aggcagacca
     2821 aatgaaggcc taaatatcaa attggaaagg tggtgcattc acatgaaaaa gaagatttgc
     2881 tctttcatta cacgttttgg cggtacaatg gcagcattgg cacttgttgt tgctaccatg
     2941 acagcaaatt caacttgtgc atggttggct tatcagccgg aagagccgga agaagtgaag
     3001 atgctgaaaa aggattgatg aggcactgta tttttagata tgccgataaa ttaatccact
     3061 tttatattga ttttaaaaga aataattttt caagatgata accactgtac aggacaacaa
     3121 aagcttttgg atttctatct tactaaaatt tttctttgaa gaataaattc gaatatctgt
     3181 tgctgatttc aataagaatt cgcctgactg aatgaaagga ggtgaaatca aaatgaccaa
     3241 acttaaaaaa gtggtagccg gcattcttgc agcggcagct atggcaacga gcgttgttgg
     3301 tatgagtgca agtgcatata gtcctactgt ttccagaact gttggtagcg ttacaggaac
     3361 actttattct gatacaacgt atggatacgg tacaacagct tgcagtaatc aaacgtgtta
     3421 tgtcaaagta aaacacggtg gaacaacctc aggttgggca aactcatatg gctatgcaag
     3481 ttgcaaaaac tctgccacta atggaacaac gaatgcacaa tcatggcaca gaacagcgtc
     3541 aacatcatca ttcagtcttt atttctaaaa agcctgttta ttgacttaat ccatttttaa
     3601 tcaaatgagg ggattgtatt tcacttgatg tacactcccc tttttgagta taatagacat
     3661 tttgtttaag aaaatcgtaa ctattcagaa ccccgccata gccgtgactg aatttcgtat
     3721 acatgcataa tagaaattta cctttcagac cgatagaaac cgttcaagtg aagtgaaaac
     3781 aaaatctcga tctattattg gctgtaagcc cctaaaaatc agcacttgaa aatctgcgtt
     3841 gatcgcaatt cgtcaatatg ccgacaccga ttattctgtg catttgcgat atgtctttaa
     3901 tcgtgatata atgtagatag acattatcat ggaggtgagc atatgccgga ttataaggat
     3961 cagattattg agaatcttca aaaagaggta gaggaattaa agcgcattgt cgagatgcag
     4021 aacgatatta tccgtgacct gagagaacaa ctccgcaaga attccagcaa cagctaaaaa
     4081 cctccgtcat ctgatgggct taagaaaaag cctgtcaaca agaatagaag tttgcgtgag
     4141 aaaagcggga agaaacaagg cggtcagaaa ggtcattctg gcacacatct tgctgtgctt
     4201 tcagagcctg accatgtcat taatcatctg cacgctgact gccagcactg cccgaagcgt
     4261 gagatttgca tgatgaattc tgaggtgaaa gaaattcgcc acgaaattga tatgattgct
     4321 caggttgatg tgaccgaaca tgagcttatt acaatacccg tatgcccgat ttgcggtgaa
     4381 gcaaaaacgg gttctttccc tgcggaaatt aaggcggtcg ttcagtacgg acaaaacctt
     4441 gaagcactcg ctgttgcttt gaacaccatt ggcgcagtca gctttaatcg tactcacgat
     4501 atattaagcg gcgtgtttaa cgttccgatt tctgtcggga cgataaagaa catggtttct
     4561 cgttgtgctg ctaaagtcga ggaggctaat actgtctcgg ctgagaagct gaaatcagca
     4621 caccacaagc acggtgacga aactggttgc cgcgctgacg gcaaaacgcg atggacgcat
     4681 tgtctttcaa acgaactcta cacagttctg tttcttcacg acaaaagagg gcatattgct
     4741 atggaggaaa tgggtatcat tcagtatagc ggcggcactc ttgtccatga ttgctgggct
     4801 ccttattggt gctttacgaa tgttaagcac cagctttgcg gtgcccattt gctccgagag
     4861 ctgaagggaa tagtggagaa tcatccaaaa caaacatggg ctaaaaaatt cacaactcta
     4921 ctgctgaatc ttaagcgcgc aaaggaaaag gcgattgcaa aaggtaaaac cgctctacat
     4981 cgaaatacct tgaagcggta ttccaacctc tatgatgaga tcatgagagc agcttatgag
     5041 gagaatccgc ttccggaacg aaagccggga cagagaggaa gaaccaagcg cggaaaggtg
     5101 ctgtgcctta tagatcggct ttctgcacac aagggagagg tctgcctttt tgcacatgac
     5161 ttcgatgtgc cttttgacaa caatcaagct gaaagagaca ttcgtaacat taaggtgaaa
     5221 accaaagtgt ccggctgttt cagatcagtt gacggggcaa aagaatacct gaaaatcatg
     5281 tcatatgttt ccacagcaat caaacacggc tttaccagtt ttgatgcgat tcgtcgtgct
     5341 gttatgggca attctatgtc tatctttgct caggactctg aatagttaca gaaaatcata
     5401 atttagaggt gcaaaatatg agtagaattc ataagctaat tgttcctatc atgctgacaa
     5461 tgaatctatg tgcctgtgga agcgaaagca tacaaaaggg gagcaacatt caaaacttcg
     5521 agcaaaatca ctatatcaca catgcgaata cttatcagaa tggcgtaatc tataccggtt
     5581 ctgagggcag ttccacagca gcttactttt tagactatga gagtatgcaa gctgttccac
     5641 tttgtaataa gccaaattgt gctcacaagg acacctcgtg cttggcattt cagtgtgttc
     5701 aggatagcat catgccattt gtttatcaag gtatggtgta ttggtttcat acggattcta
     5761 aaatcacgga ttccgatgat ggaagaagta cagcatatca atttcaaact acatgctact
     5821 gtgggaatat gactacgggc gaagtagaaa gcttcgtgga aattccggat gtcagcatga
     5881 aggatgccat tgaatttgtc atatccaatc acacactcta catcatcggc tgtgattgtg
     5941 catatcagga agaggatgga tcgtggacgg aaatgtctcg aatcggagac cagtatcttt
     6001 atgcgatcaa tctggataca gcggatgtca agaattacgg tctcatcaat gatgcaccaa
     6061 ctgcatccta caattggaca ctgaatggtg caatgtttgc agatgtagaa ttgacaggta
     6121 tctatcaaaa taaactttat ctgtcttatc gctatgtaga tgatcccaat gatattattg
     6181 attatgtcaa caccggagac ccggatagtc cggattggtc ggatgccgga acagcaatcc
     6241 cctggcatcg ggtgaacaaa tgcctcaatt tagaaacgga taccatagaa ccaagcgaat
     6301 atcccgcagc agacttgatt caagacgaca catatattta ttatatggat gggcaatacc
     6361 acgtaatgga tgcagatgga acagagacag tgagtgcaga tattcctgca aataattctc
     6421 gtaatctaac ttttgtcaat ggaatctttt gggatggtcc gcaaagcacc tgttttcaac
     6481 cgaaaaccgg agaaacacat gtcttatccg aaacatattc cgatacaaat cttaccgtaa
     6541 ttgcctatta caaagaaaga tacattatta actatacaga tgaaaacaac ctcattcatt
     6601 ttgaagctgt tccggaatcg gatttgattg gaggcatagt agaatgacac tggttcttcg
     6661 tcattgcaac aaacactatg gcaagaagca cgcccttaaa gatttcacat tttcctttga
     6721 aacgggtgtt tatggattgc ttggtcccaa cggtgcggga aaatccacgc taatgaactt
     6781 aatcacggac aacttaaagc cagacaaaga cggcggcgaa atactctggg atggacagcc
     6841 gattcggaaa cttggaaaaa gctatcgtgc ttgcttgggt tttatgccgc agcagcagga
     6901 attatacgcc aatatgacag cacgagattt tctggggtat ctgtcggcac tcaagggcat
     6961 tcctcggaaa gaggcgaaag accagattgc agatgttttg gaacaggtag aactttctga
     7021 gcaggcagca caaaaaatcg gcggcttttc cggcggcatg aagcagcggc ttctgattgc
     7081 acaggcattg cttggaaatc cgtctctgtt aattttagat gaaccaactg ccggattaga
     7141 tccaaaacag cgtgtgatta ttcgcaatct gactgatcgt ttgggacaag agaaaatcat
     7201 tctcatttct acgcacatca tttccgacat tgaaaccatt gcagaccaaa ttctgcttct
     7261 gcggaaggga acgcttttga cgcacggaac agtttctgaa ctgatagagc aggtacagac
     7321 cggcgaaaag acgctggaga atctctatct gcaatactat ggaggtgagg caaatgctgc
     7381 gggcggagct taaaaaatgc ctatcctttc gagtcctttg gattctgctc ttttgtctgc
     7441 tctgcatcaa tggctattcc caaatcacaa atgcttacga ccggtattac acgccttcgg
     7501 aatataacgc tttatacgag cagttaaaca gaatgtcttt acaggaagca aacgcatttg
     7561 tcagtgccaa aatcgagtct gcttctccgg actcggatgc agactacaac ggctatctat
     7621 actatgacac attggaaatt atcgaggggc tgcaaaatta tccggcatat ttggagagca
     7681 ttcagaccaa tgcagagaat atgacagcag tttccatttg gggcgggaca gacacgtttt
     7741 cctatcggaa cattcaaaaa acgccgtccg cctatactgc ccttgctgga accacactgg
     7801 ttttggatac ctctcttggc atagaggatt tgctgtccag tcccttgacg gatttcttgg
     7861 cggtgctgtt gctattcttt tgcgtctgcc gtattttttt acgggatcgg gaacaaggca
     7921 ttttgccgct gctctatgcg acgcccaacg gaagacttcg actgatgagc tgtaaactgg
     7981 gaatagcagt gctctgtgcc atcggattgg tactgctttt ttatggcgaa attgcactga
     8041 tttcctgtaa cttgtacgga cttggtgacc tttcccgtcc aattcagtgc atctatggct
     8101 atgaaacctg caaccttccg gtttctgtcg gaacttacat tagcatctat ctgctgttca
     8161 aaatggctgc ctatgcggta tttgccgtgc tattcggctt tttctgtacg attgccaaaa
     8221 ataatctgat ggtatacggt gcatccattg gcgttgttgg aatatcctac ttactctatg
     8281 cgaaaatttc tgttttgtca ccgattagcc tattgcattt ctggaatccc atccagtttt
     8341 tacaaggcaa agaaattctc ggaacctata ccaatgtcaa ctgtttcggc tatccgattt
     8401 ctctgaagat ttccgcttgc gtagtcatag gactatggct ctttcttttt ataggcagta
     8461 gcttcatcgt gtttacacac gccgggaatt tgcaatatcg cagtttttcc gtccgacata
     8521 aactgcatat tcggtttcgt gtccatcaaa aattttggta cacttgctat cggattttga
     8581 ttttgcaaaa gggcttgctt gtagtatttc tgttgctttt cctatcggtt ggtttggcaa
     8641 aaacatatac tcgaacttac agcaatgagg atatttacta cgaaaatttt tgtaacgaat
     8701 atgccggagt tgtaacagaa aaaaccgaac aatttctcac ggaaaagcga gctttctatc
     8761 gtgaaatcga agcacagatc gcagagctgg aacagtcgga atcgccgaat tcctatcaga
     8821 ttggacaatt gaccgcacaa ctgaatgaca aggcagcttt tgaaaaattt gcacagcgag
     8881 tagaacagat tcccgattct gcggagattt tctacgacac cggatatgtt cgctatttcg
     8941 cactggatgg caaccgggag ggcatggtac aagtgctgct tttaacggct gcactgacac
     9001 ttttattgtg ccccactaca tctatggatt gtaaaaccaa tctaaagcag atttatcacg
     9061 ccacgaaaat agggagattt ggataccttc ggcagatgtt tcgttttgcg attctgaacg
     9121 gcatactatt ttccgctgtg ctgatattgc cctacttgct gcaaattttg aatcattacg
     9181 gaatgcaggg ctggaacaca ccgcttgccg gaatcgaagc atacagtact tgtcctgctc
     9241 gcatttccgt tggtgcagcg gcaattggtg tcatgggaat ccgcacaatt ggagcagctc
     9301 ttaccggatg cagcatcaca tggattgcct ctcattgcaa gagccttgtc acggcgtatt
     9361 gcatcaatgg tgtccttttc gttcttccgg cgggattgtg cctgttgggg ctggatatgt
     9421 ttcgctacgt tgggctaacg ccgatgttgt atgggataat ttagagtttt gaaatggatt
     9481 tctttccatt gcggagcaac ttcggctgct ccgcaatttt atgtgtgttc aatggaacat
     9541 atttctaaaa agtgaaaatt tcaaatccac ctgacgaaaa aaatcgaatc agaccatgta
     9601 caaagttaaa agggtttact gacgcaggta acgctgagcg atggtaccgc aaatggcgaa
     9661 aagaatatca ccaagtattt ctacaacaac ggcggtattc aaaccaagat ggaaaccggt
     9721 ctgaacagtg taaatgattc ggactacatg actaccgatt acgcatatga tgcgtgggga
     9781 catctggtaa ataccactga cagcacgggc tacaattccg gtacgactac ctatgactta
     9841 aacggaaatg ttttgactgt tacggatgca aacggcaatg taacaaccaa tacctatgac
     9901 gcactgaatc gtgttttagc agtcaatacc gtttgtgatg acagcacaaa gaacgtttct
     9961 aaatcctata cttacaacaa tatgggatgg atgaccaaca agtccagcaa cggtacagaa
    10021 acttccattg agtacgatgc tctgggcaga gtaactaaag agtggggtcc gaatttcaag
    10081 ggctacttct atgaaggcgt ttcgaattat gtagaaaagc aactggtcgg ttatgcacat
    10141 ctgttgctgt attctgttac aaactatgaa tacgatgcag aaatgcgaat cgtaaaagtt
    10201 ctggagagtg gcagcgaaac tgcttcctac acctacgatg ccaacggaaa caagacaagc
    10261 gaaacgcagg cgaacggcgt agtttccact tacacttata acagtgcaaa caaaatcacg
    10321 aaccacatca cgaaatccgg caattctacc atatctgagt acgaatattc ctattatctt
    10381 gatggttctg acgctttcaa agtccgcaag gaaaagtggt ataatagaga caacatccta
    10441 cgagtacgat gggctgaagc ggctgacgga agaagcagtg acgaccggaa gttcgacaga
    10501 cacctattct tacgagtatg acgattacgg caaccgttct aagatgacgg caactagctc
    10561 ggaaagttat gtaactgatt acagctacag cgatttcaac ggaaattata ctgctttact
    10621 tcagaaagaa accaaaaccg tagatggcac ttccgaagaa attgttgcaa atggcttggc
    10681 aacgagtccg gcagacttgc tgacaacgga taattctgac gtagaacaga cagtttacac
    10741 ctacgatgcc aacggtaatc agattacaaa gactgccgat ggcaagacgg aaaccaacac
    10801 ttacgatggc ttgaatcagt tgattggctt cacagatggt gaaacgactg caagctatac
    10861 ctatgatgtg gatggcttgc gactgagcaa aactgtcgat ggtaaaacga caaaacacgt
    10921 ctgggacggc aatcaacagc ttgttgcaga tgtgttggat agcgagcttt atagtgcaaa
    10981 ttgctatctg cgaggcacaa atctggtagc gacttatagc tatcagaacg gcgaaaagtc
    11041 cgggtatacc tactatacgc agaacgcaca tggcgatgtg gtgaatctaa cggattcgac
    11101 aggtgaaatt accaagtcct atacctatga tgcgtttggt gtggagaaga atatcgataa
    11161 ctccgatacg aatgcgttcc ggtattgcgg tgaatattac gactctgaaa cgggtacgat
    11221 ttatttaaga gctaggtatt atgatccgag tatgggtagg tttatctcaa gagattctta
    11281 tgcaggtaag aattctgatc cactgagctt gaatcggtat acgtattgcc ataataatcc
    11341 aatattttat gccgatccca aaggacattc tgcttggaca aaatttcaag aggcggcatt
    11401 tgcggttgag catccgttta tagcatcaaa aattggaacg gcaaaaccgg atgatgcaaa
    11461 cagcaatact atatcttcaa gagcagctcg ctttgcaatc aattctaaag tatcatataa
    11521 ttacaaaaaa ggtcaagaaa atgaaggcgg tcaaaggaac gctcttagac atgcaatctg
    11581 gtctacaaca ataactagat attacggtaa agaaataatg aagcaagttg gttattctca
    11641 cgaaaacctt tctgaaatgc tgaaaataac atccgatcct acgaaatggt atttttcaga
    11701 tatgcacact gccgacacac tttgtgacat tatgaataat gaaacaggta tgaaaattgc
    11761 agcttcgggg gatgccacca atatgagaag catcacttta gaggtactag agtactatca
    11821 tactaatggt ttgtacgttg ctgttgaata tgctgataac ctctatattg tacaaaatca
    11881 aaaattatca gatcaggaat atgcgtcagc aacatataat gtatttttct tggatcaaaa
    11941 tggactaaga ggcaacatta atactgttgc agatatcgta agacaaag
//
