LOCUS       NZ_CP013532.1          10387 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP013532.1 Rhizobium phaseoli strain R650 chromosome, complete
            genome.
ACCESSION   NZ_CP013532
VERSION     NZ_CP013532.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:25:25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1027265
            Orig. end    :: 1037652
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10387
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[1032265:1032652](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5387)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     cand_cluster    1..10387
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10387
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     CDS             718..1836
                     /locus_tag="ctg1_969"
                     /transl_table=11
                     /translation="MLKSIMIQSPDVSSLLTDMIYGSLFGECSWQDFLDRLAQTSPGGK
                     AALHYHDLTSSVAHVPFMSGFSQSEIDQFTSHFASVNPWIPRLDLVPVGQGLCGDEIVP
                     REELIRSEFYNDWLKRQTGCETSIGVSIIREQNRTFILSACTSSADPDLNSEAAKLYTQ
                     LAPHLKRAFDFIRKRDLFAPHEQTTQALFDSIGVGLIYVSEQRKARRWNRSAEALFAAG
                     VPVQIAADGTLGLQCEKSAAVLEFLTSRNGVQTQPHTAIVKGRNQDNYRITLVRLHSDT
                     FTQFLEGPTVAVIVEPIVATPLNERRDLLMQLYKLTATEIRIASSIASGHSPREVAMAD
                     DISYETVRTHLRNIYAKLGVNSRAGLVSLLMR"
     PFAM_domain     1663..1824
                     /aSDomain="GerE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00196.21"
                     /description="Bacterial regulatory proteins, luxR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_969_0066"
                     /evalue="1.20E-12"
                     /label="ctg1_969"
                     /locus_tag="ctg1_969"
                     /protein_end="369"
                     /protein_start="315"
                     /score="47.3"
                     /tool="antismash"
                     /translation="LTATEIRIASSIASGHSPREVAMADDISYETVRTHLRNIYAKLGV
                     NSRAGLVSL"
     CDS             complement(1868..3187)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 72.2; E-value: 7.6e-22)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_970"
                     /transl_table=11
                     /translation="LSQSRPTLGAILARRIAFFAILAMFLQLAIVFSDYYWNVGELSRL
                     FVEQETERLVAGITVDDDSIRYRLPDNVQQRYQRGDTGYVARIRAANGALVFQSCDAAC
                     EDRFLPADVNPPDFWLRSLKPGKPLSLVGGRAFVVGGQRFLVDIATISDPSDVMSDVLW
                     NEIIEHLVVPMSILLVLVLGGTLLSVRQALRPVRAAADAAEQIDPMDSRSHLDFDQMPR
                     EVAHLAAAVNRAFARVGELMKSQKVLTTGIAHEIRTPLAALKLELGHIDHPRARKAEGD
                     LDDLANFVAQLTALARLDSVDHGMFEEVDLVELSASVVSQLAPWVYENNHRLEFFSQVE
                     SSTVRGAPSLLRDALRNLIENAVKHTRDHTLVIVRAGNGIITVEDRSLETPLLHPKTFA
                     APSDSLGIGLKIIERIVEIHQASFSQTRLKSGHMFELDFR"
     CDS             complement(3184..3861)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 176.7; E-value: 8.5e-54)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_971"
                     /transl_table=11
                     /translation="MRILLIEDSARLRELLCEAIRDEGWRIDAFETAQEGRIALREGSY
                     DLLLLDLGLPDEDGIDFLKSLRDAGAQTPVLVLTARGAIDERIAGLDAGADDYLAKPFH
                     NGELTARIRALIRRSPVTSMPILEFAALKLDVASRQVTCAGYDVALAPSEKGLLELLMR
                     NGGKVVAKTKIEHAFSEFGDERSSNAVELAVSRLRKKLEGHKTRLSIETIRGVGYMMRE
                     VHD"
     PFAM_domain     complement(3202..3423)
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_971_0068"
                     /evalue="1.70E-16"
                     /label="ctg1_971"
                     /locus_tag="ctg1_971"
                     /protein_end="220"
                     /protein_start="146"
                     /score="60.2"
                     /tool="antismash"
                     /translation="DVALAPSEKGLLELLMRNGGKVVAKTKIEHAFSEFGDERSSNAVE
                     LAVSRLRKKLEGHKTRLSIETIRGVGYMM"
     PFAM_domain     complement(3523..3855)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_971_0067"
                     /evalue="8.30E-26"
                     /label="ctg1_971"
                     /locus_tag="ctg1_971"
                     /protein_end="113"
                     /protein_start="2"
                     /score="90.5"
                     /tool="antismash"
                     /translation="ILLIEDSARLRELLCEAIRDEGWRIDAFETAQEGRIALREGSYDL
                     LLLDLGLPDEDGIDFLKSLRDAGAQTPVLVLTARGAIDERIAGLDAGADDYLAKPFHNG
                     ELTARIR"
     CDS             complement(3858..4424)
                     /locus_tag="ctg1_972"
                     /transl_table=11
                     /translation="MTAISSRKEGVSPSDTTPKSVKVWDPIVRIFHWTIVTACTLNLFI
                     LEEGKYWHRLTGYVVGAAIAVRLIWGFIGTKHARFTDFWPTPRRVRDQIASIIDRNENR
                     YLGHNPLASMMMLLLVALLAATALTGWMTTWDAFWGEKWLERLHGTIANSIMVLVFIHA
                     GAAVLESWRHRENLIWAMVTGRKNA"
     PFAM_domain     complement(3873..4358)
                     /aSDomain="Ni_hydr_CYTB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01292.22"
                     /description="Prokaryotic cytochrome b561"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_972_0069"
                     /evalue="2.50E-25"
                     /label="ctg1_972"
                     /locus_tag="ctg1_972"
                     /protein_end="184"
                     /protein_start="22"
                     /score="89.2"
                     /tool="antismash"
                     /translation="VWDPIVRIFHWTIVTACTLNLFILEEGKYWHRLTGYVVGAAIAVR
                     LIWGFIGTKHARFTDFWPTPRRVRDQIASIIDRNENRYLGHNPLASMMMLLLVALLAAT
                     ALTGWMTTWDAFWGEKWLERLHGTIANSIMVLVFIHAGAAVLESWRHRENLIWAMVTG"
     CDS             complement(4428..4691)
                     /locus_tag="ctg1_973"
                     /transl_table=11
                     /translation="MLKAIIAVAIVALAPALAFASPSCTKEPKSKWMSEEAMKAKIDAL
                     GYKVKTFEITGNCYEIYGKDKDGKRAEVYFNPVSGDIVQKDD"
     PFAM_domain     complement(4437..4679)
                     /aSDomain="PepSY_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13670.8"
                     /description="Peptidase propeptide and YPEB domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_973_0070"
                     /evalue="3.80E-29"
                     /label="ctg1_973"
                     /locus_tag="ctg1_973"
                     /protein_end="85"
                     /protein_start="4"
                     /score="100.6"
                     /tool="antismash"
                     /translation="IIAVAIVALAPALAFASPSCTKEPKSKWMSEEAMKAKIDALGYKV
                     KTFEITGNCYEIYGKDKDGKRAEVYFNPVSGDIVQK"
     CDS             complement(5001..5387)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_974"
                     /sec_met_domain="ectoine_synt (E-value: 3.5e-31, bitscore:
                     106.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFVRSLKDVEQTERFVDWGNGTSHRLLTRDDGMGFTICHTVVRAN
                     TQALLQYRNHLEACYCIQGEGEVEDMDGNVFPIRVGDIYVLDQHDRHYLRGGKDEDLIL
                     VSVFNPPLKGTERHDLNNRSGSEY"
     PFAM_domain     complement(5025..5387)
                     /aSDomain="Ectoine_synth"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06339.14"
                     /description="Ectoine synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_974_0071"
                     /evalue="2.60E-40"
                     /label="ctg1_974"
                     /locus_tag="ctg1_974"
                     /protein_end="121"
                     /protein_start="0"
                     /score="137.7"
                     /tool="antismash"
                     /translation="MFVRSLKDVEQTERFVDWGNGTSHRLLTRDDGMGFTICHTVVRAN
                     TQALLQYRNHLEACYCIQGEGEVEDMDGNVFPIRVGDIYVLDQHDRHYLRGGKDEDLIL
                     VSVFNPPLKGTERHDLN"
     CDS             5577..6461
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 192.7; E-value: 1.5e-58)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_975"
                     /transl_table=11
                     /translation="MQLPPLNALRAFEATARLMSLSKAGDELHVTHAAISHQIKHLETW
                     LGRKLLQKSGRGVALTPAGAEYYLAVSGALAAIAHATGNMRRDHNMRSITVGCIPSIAS
                     RWLVPALPSFRESDPDLDVRIVYARAEERFDDESLDVLITMGEDLSAGRESRLLFSRRN
                     QPVASVHYLAKRNWTIENVPFARADLLHDESVDGWKEWFRKAELKPTEPIRGPIFQDFN
                     ILATAVIAGHGVALCPVEVFRREIERGDLVVLSDISTAETQGYYLITSAWAKKPVRRFA
                     EWFIQECNSSSLR"
     PFAM_domain     5592..5768
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_975_0072"
                     /evalue="2.40E-18"
                     /label="ctg1_975"
                     /locus_tag="ctg1_975"
                     /protein_end="64"
                     /protein_start="5"
                     /score="65.9"
                     /tool="antismash"
                     /translation="LNALRAFEATARLMSLSKAGDELHVTHAAISHQIKHLETWLGRKL
                     LQKSGRGVALTPAG"
     PFAM_domain     5850..6440
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_975_0073"
                     /evalue="2.40E-24"
                     /label="ctg1_975"
                     /locus_tag="ctg1_975"
                     /protein_end="288"
                     /protein_start="91"
                     /score="86.0"
                     /tool="antismash"
                     /translation="RSITVGCIPSIASRWLVPALPSFRESDPDLDVRIVYARAEERFDD
                     ESLDVLITMGEDLSAGRESRLLFSRRNQPVASVHYLAKRNWTIENVPFARADLLHDESV
                     DGWKEWFRKAELKPTEPIRGPIFQDFNILATAVIAGHGVALCPVEVFRREIERGDLVVL
                     SDISTAETQGYYLITSAWAKKPVRRFAEWFIQEC"
     CDS             complement(7006..7569)
                     /locus_tag="ctg1_976"
                     /transl_table=11
                     /translation="MSTRDLVLTALFAAIIVALGLLPPISLGFIPVPITAQSLGVMMAG
                     VVLGARRGAIAVLIVLLLVAIGLPVLSGGRGGLAIFASPSAGFLVGWIFGAFVTGYLSE
                     RLVNHGQFGLVQTVSFFLAAMVGGVVVLYAFGIAYLATVAGLGFTKAFVGSMAFIPGDV
                     IKAFVAALLGRAVMAGYPLLPARA"
     PFAM_domain     complement(7042..7485)
                     /aSDomain="BioY"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02632.16"
                     /description="BioY family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_976_0074"
                     /evalue="5.10E-36"
                     /label="ctg1_976"
                     /locus_tag="ctg1_976"
                     /protein_end="176"
                     /protein_start="28"
                     /score="123.8"
                     /tool="antismash"
                     /translation="FIPVPITAQSLGVMMAGVVLGARRGAIAVLIVLLLVAIGLPVLSG
                     GRGGLAIFASPSAGFLVGWIFGAFVTGYLSERLVNHGQFGLVQTVSFFLAAMVGGVVVL
                     YAFGIAYLATVAGLGFTKAFVGSMAFIPGDVIKAFVAALLGRAV"
     CDS             complement(7594..8202)
                     /locus_tag="ctg1_977"
                     /transl_table=11
                     /translation="MQSLYVEGNSPMHRLSPRVKLVSLAVFGVVLFISQNITLLSGLVV
                     LTAVVYRTTGLPLGEGLRRLRPVFLTIAVVALFNLLFNPWQAALVPVLRLTALMLLAAA
                     VTATTSITAFIDEVTALARPLERTGFVQADDIGLALGLVLRFVPDIVGRYQAIREAHKA
                     RGLKARPTTLLAPLIILTLRDADNVAAAIDARRIRRHGS"
     PFAM_domain     complement(7618..8178)
                     /aSDomain="CbiQ"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02361.18"
                     /description="Cobalt transport protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_977_0075"
                     /evalue="5.10E-14"
                     /label="ctg1_977"
                     /locus_tag="ctg1_977"
                     /protein_end="195"
                     /protein_start="8"
                     /score="52.5"
                     /tool="antismash"
                     /translation="NSPMHRLSPRVKLVSLAVFGVVLFISQNITLLSGLVVLTAVVYRT
                     TGLPLGEGLRRLRPVFLTIAVVALFNLLFNPWQAALVPVLRLTALMLLAAAVTATTSIT
                     AFIDEVTALARPLERTGFVQADDIGLALGLVLRFVPDIVGRYQAIREAHKARGLKARPT
                     TLLAPLIILTLRDADNVAAAIDAR"
     CDS             complement(8202..8876)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 151; E-value:
                     7.4e-46)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_978"
                     /transl_table=11
                     /translation="LDIQFEGAGVSFGTRVALAPLTLGISGKRIGVIGLNGSGKTTFAR
                     LINGLTKPTIGRVTVNGRDTADDKAGAVDVGFIFQSPQNQIILPIVRDDIAFGLKRHGF
                     SKAEIEAKVERVLARFGAEALADRRAHELSGGELQVAALCSVLVTGPGILILDEPTNQL
                     DLKNRALVERIIAGLPESAIVITHDLELIADFERVLLFHEGRLAADAPATEAIARYREI
                     AA"
     PFAM_domain     complement(8394..8801)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_978_0076"
                     /evalue="1.00E-24"
                     /label="ctg1_978"
                     /locus_tag="ctg1_978"
                     /protein_end="161"
                     /protein_start="25"
                     /score="87.7"
                     /tool="antismash"
                     /translation="SGKRIGVIGLNGSGKTTFARLINGLTKPTIGRVTVNGRDTADDKA
                     GAVDVGFIFQSPQNQIILPIVRDDIAFGLKRHGFSKAEIEAKVERVLARFGAEALADRR
                     AHELSGGELQVAALCSVLVTGPGILILDEPTN"
     CDS             9165..10355
                     /locus_tag="ctg1_979"
                     /transl_table=11
                     /translation="MTNLLSNSDARRVFLAKQGLSAPPNRALSKEGLLQLIHDLGFVQV
                     DSIQTVERAHHQILFSRNQTYRREHLTALLEKDGTLFEHWTHDASILPSAFFVYWKHKF
                     RHQEKVIIERWRKWRGEGFEAAFEETYERVARDGAILARDIKADGHVSGGWWNWHPNKT
                     ALEYFWHTGKFAIAGRSNFQKIYDLTERVVPAHFREPEVSRAEFVDWACRSALTRLGFA
                     THGEIAAFWNLVSPDEAKTWVSAHRDELAEMLIEPALGAKPRPSWAFADFLTTLGSYPA
                     APPRIRVLSPFDPMIRDRNRTERLFGFFYRIEIFVPEAKREYGYYVFPLLEGDRLIGRI
                     DMKADRKKSTLDVRRLWLEPGVKASAGRLERLEAELERVARFAGVEKVVLLEGWRG"
     PFAM_domain     9276..10310
                     /aSDomain="HTH_42"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06224.14"
                     /description="Winged helix DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_979_0077"
                     /evalue="1.20E-66"
                     /label="ctg1_979"
                     /locus_tag="ctg1_979"
                     /protein_end="382"
                     /protein_start="37"
                     /score="225.6"
                     /tool="antismash"
                     /translation="HDLGFVQVDSIQTVERAHHQILFSRNQTYRREHLTALLEKDGTLF
                     EHWTHDASILPSAFFVYWKHKFRHQEKVIIERWRKWRGEGFEAAFEETYERVARDGAIL
                     ARDIKADGHVSGGWWNWHPNKTALEYFWHTGKFAIAGRSNFQKIYDLTERVVPAHFREP
                     EVSRAEFVDWACRSALTRLGFATHGEIAAFWNLVSPDEAKTWVSAHRDELAEMLIEPAL
                     GAKPRPSWAFADFLTTLGSYPAAPPRIRVLSPFDPMIRDRNRTERLFGFFYRIEIFVPE
                     AKREYGYYVFPLLEGDRLIGRIDMKADRKKSTLDVRRLWLEPGVKASAGRLERLEAELE
                     RVARF"
ORIGIN
        1 ccgaagacgc agaaggcggc aatcgacaag gtcagctggt cgaccgtgct gctcattgcc
       61 ggcatcatca cctatgtcgg ggtcatggag aaggccggta ccgtcgacta cgtggcgaac
      121 ggcatatcca gcctcggcat gccgctgctg gtggcgctgc tgctttgctt taccggtgcc
      181 atcgtttcgg cctttgcatc ctcgaccgcc ctgctcggcg ccatcattcc gctggccgtt
      241 ccgttcctca tgcagggaca tgtcagcgcc atcggcgtcg tcgccgccat cgcgatctcg
      301 acgacgatcg tcgataccag cccgttctcc accaatggtg cgcttgtcgt cgccaatgcg
      361 ccggatgaga ggcgagacca ggtcctcaag cagttgctgg tctacagtgc gttgattgcc
      421 atcatcggcc cgatcgtcgc ttggctggtg ttcgtcgtgc cgggcctggt ttgacgatgg
      481 gccgccgcgg gccttcgctc gcggcggtca aggcattcac gccgtgggca aggtattccg
      541 agttccatgc tccggcgggg agacgcgccg accggaaata tagtaccgga gaagctataa
      601 catgctgtgg ttgtagtatt tctcgctcac tccggagcct ccgatattgc acatgcgaat
      661 ttcgttgcaa ttgcgaagac aacactgttc tatcttcgaa gatgctttca ttcgcagatg
      721 ttgaaatcga tcatgattca atcgcctgac gtctcatctc ttctgacgga tatgatttat
      781 ggaagcctct tcggagagtg cagctggcag gatttcctgg atcgccttgc acagacgtcg
      841 ccgggcggca aggcggcgct tcactaccat gatctgacct cttcggttgc ccatgttccc
      901 ttcatgtcgg gattttcgca atccgagatc gatcagttca ccagccactt tgcctcggtc
      961 aatccctgga ttccgagact ggatctcgtg cccgtcggcc agggcctctg cggcgacgag
     1021 atcgttccac gcgaagagct gatcagatcg gaattctaca atgactggct gaagcgtcag
     1081 accggatgcg agacgagcat cggcgtctcg atcatccgcg agcaaaaccg caccttcatc
     1141 ctttcggcct gcacatcgtc cgccgaccca gatctcaaca gcgaggcggc caagctctac
     1201 acacagctcg caccgcattt gaagagggcc ttcgacttca tccgcaagcg cgatctcttt
     1261 gcgccgcacg aacagacaac tcaggccctt ttcgacagca tcggcgtcgg attgatctat
     1321 gtctcggagc aacgaaaagc ccgtcgctgg aacaggagcg cagaggcgct gttcgccgcc
     1381 ggcgtgcccg tgcagatcgc cgccgacgga accctaggac ttcaatgcga gaagtcggcg
     1441 gcggttctcg aattcctgac ctccagaaac ggtgtacaga cccaaccgca cacggcgatc
     1501 gtcaagggcc ggaaccagga taactaccgc atcaccctcg tccggctgca ctccgatacg
     1561 ttcacccagt ttctggaagg gccgaccgtg gcggtgatcg tcgaaccgat cgtggcgacg
     1621 cccctcaatg agcggcgcga tttgctgatg cagctttata aactgacggc aacggaaatc
     1681 aggatcgcct cgagcatcgc atccggccat tccccaaggg aagtggcgat ggccgacgac
     1741 atcagctacg agaccgtcag aacgcatctt agaaacattt atgcgaagct cggggtcaat
     1801 tcccgagccg gtctggtgtc gttgctgatg cggtgaatgg gatcagccgc ctcagaagcg
     1861 cacggtttca tctgaagtcc agttcaaaca tatgcccgga cttcaacctt gtttgcgaga
     1921 acgacgcctg atgtatttcc acgatccgtt cgatgatctt cagcccgatg ccgagactgt
     1981 cagagggggc agcgaaagtt ttgggatgaa gcaacggtgt ttcaagggac cgatcctcga
     2041 ccgtgatgat gccgttgccg gcacgaacga tgacgagggt gtgatcccgt gtgtgcttga
     2101 cggcgttctc gatcaaattc cggagtgcgt cgcgtaaaag ggagggagca cccctcaccg
     2161 tggaactttc gacctggctg aagaactcca gcctatgatt gttttcgtaa acccaggggg
     2221 cgagttgcga tacgacggat gcggatagct ccacgagatc cacctcctcg aacatgccgt
     2281 ggtcgacgct gtcgagccga gcgagagcag tgagctgcgc gacgaagttt gcgaggtcat
     2341 ccaggtcccc ttccgccttc ctggcgcgtg ggtgatcgat atggccgagt tccagcttca
     2401 atgctgcaag cggtgtccgg atttcgtggg cgatccctgt tgtcaggacc ttctgcgact
     2461 tcatcaactc gccgacccgc gcgaaggcgc gattgacggc ggctgcgaga tgagcgactt
     2521 cgcgcggcat ttgatcgaag tccaggtgcg aacgggaatc catagggtcg atctgctcgg
     2581 ccgcatctgc ggcggctcgg actggccgca atgcctggcg gacagacagc aaggtgccac
     2641 cgagcacgag aaccagaaga atgctcatcg gcacgaccag gtgttcaatg atctcgttcc
     2701 agagaacgtc ggacatcacg tcagagggat cactgatcgt cgcgatatcg acgaggaaac
     2761 gctggccgcc aacgacgaat gcccgaccgc cgaccagcga caacggcttt cccggtttca
     2821 aactccgcaa ccagaaatcc ggcgggttca catcggcggg aaggaagcga tcctcacagg
     2881 cggcatcaca tgattggaac accagcgcac catttgctgc ccgaattcgg gcaacataac
     2941 ctgtgtcgcc tctttggtaa cgctgctgca cattgtccgg aaggcggtag cgaatgctgt
     3001 catcgtccac ggtgatcccg gccacgagcc gctctgtttc ctgctcgacg aacaatcggg
     3061 atagctcacc aacgttccag taatagtccg agaagacgat ggcgagttgc aggaacattg
     3121 ccaagatcgc gaagaaggcg atccggcggg cgagaatggc tcctaatgtg gggcgcgact
     3181 ggctcaatca tgcacctcgc gcatcatata gccgacacct ctgatcgtct cgatcgacaa
     3241 gcgcgtcttg tgaccctcca gcttcttgcg aagacgcgat actgccagct cgacggcatt
     3301 gctgcttctc tcgtcgccaa attccgagaa cgcatgctcg atctttgttt tggcaacgac
     3361 ctttccaccg ttgcgcatca gcagttcgag caatcccttt tcggaggggg caagagcgac
     3421 gtcataaccg gcgcaggtca cttgccgcga cgcgacatcg agtttcagtg cggcgaattc
     3481 gaggatcggc atggatgtaa cgggcgaccg gcggatcagt gcgcgtatcc gggctgtgag
     3541 ttcgccattg tgaaacggct tggccaggta gtcgtctgcg cctgcatcaa gtccggctat
     3601 tcgctcgtcg atcgcgcctc ttgcagtcaa gacaagcacc ggcgtctgag cgccggcatc
     3661 ccggagcgac ttcaggaagt cgatcccatc ctcgtcaggg agaccgagat cgagcagcag
     3721 caggtcgtaa cttccctctc gaagggcgat ccgcccttcc tgtgccgtct cgaacgcgtc
     3781 gatccgccag ccctcatccc ggattgcctc gcaaagaagc tcacgaagcc gggcgctgtc
     3841 ctcgatgagc agaattctca tgcgtttttt cgacctgtaa ccatggccca gatgagattt
     3901 tctcgatgcc tccagctttc caggactgca gcgccggcat ggatgaagac gaggaccata
     3961 atgctgttgg cgattgtccc gtgcaatcgc tcaagccact tttcgcccca gaaagcgtcc
     4021 cacgtcgtca tccagcccgt taaggccgtt gcagcaagaa gagcgacaag caagagcatc
     4081 atcattgatg ccagcggatt atggccgaga tatcggttct cgttcctgtc gataatgctg
     4141 gcgatttggt ctcttactct tcgcggcgtt ggccagaagt cggtgaagcg cgcgtgcttg
     4201 gtgccgatga aaccccagat gaggcggact gcgatggccg ccccgacgac gtagcccgtc
     4261 aggcgatgcc agtatttgcc ttcttccaga atgaagaggt tcagcgtgca cgccgtgacg
     4321 atggtccaat ggaaaatccg gacgatcgga tcccagacct tgacgctctt cggtgtggtg
     4381 tcggagggcg atacgccctc cttcctcgat gaaatcgccg tcatcgctca atcgtccttc
     4441 tgaacgatgt caccggatac cggattgaaa tagacctcgg ctcgcttgcc atccttgtcc
     4501 ttgccgtaga tttcatagca gttgccggtg atctcgaagg tcttgacctt gtagccaagt
     4561 gcatcgatct tcgccttcat ggcctcttcg gacatccatt tggatttcgg ctccttggtg
     4621 cagctcgggc tagcgaacgc cagtgccggg gcgagggcga caattgcgac tgcgataatt
     4681 gctttcaaca tgatcattcg gtcctttgat tacgcccggg ctgggcgacg gaccgatcaa
     4741 taggattcac tcgctgtcgg tttgctgtcc gaggaagcga aacgtgcctt gccgctcaat
     4801 tttgaggcgt tatcgcgtcg ttgtgcatag gccgttgtgg ttggtgccgg gcgagagatc
     4861 gatggcggcg gcttgaacca gggtatcgat cttcggccgg atcacagcag cacgcccacg
     4921 ggcggccgtt gatgaaagcc atgaccaagc acgaccgcaa aatcaaggag atcgagcgaa
     4981 cggggccgct cgagctcggc tcaatattcc gaaccgcttc tgttgttgag gtcgtgacgc
     5041 tccgtcccct tgagcggcgg attgaagacg ctgacgagaa tgaggtcctc gtccttgccg
     5101 cccctgagat agtggcggtc gtgctggtcg agaacataga tgtcgccgac gcggatggga
     5161 aagacattgc cgtccatatc ctcgacctcg ccttctccct gaatgcagta gcaggcctcc
     5221 aggtggttgc ggtactgcag cagggcttgc gtgttggcgc gcacgacggt gtggcagatc
     5281 gtaaagccca tcccgtcatc cctggtcagt agtcgatggc tcgtgccatt gccccaatcg
     5341 acgaaacgct cggtctgttc cacgtccttc aggcttctca caaacatgtt cttctcctcg
     5401 caaatggcgg agatgactcg atctccgtga tcgattaggc actgaaatcg acgtggcttc
     5461 aaatgatcta aattgagaaa gccgttagaa taacttacat gtagcctcct ggttcgatcc
     5521 gtgtgatgcg gatgcagggc gaaacattcc ggctatcatg taaggaattc gaacatatgc
     5581 agctgccgcc gctgaatgcg ttgagggcct tcgaagcgac cgcccggctg atgagcctgt
     5641 caaaggccgg agacgagctg catgtgaccc acgccgcgat cagtcaccag atcaaacatc
     5701 tggagacgtg gctgggtcgc aagctgctgc agaaatccgg acgcggcgtg gcgctgacgc
     5761 cggcgggcgc cgaatattat ctggccgtct ccggcgcatt ggcagccatc gcccatgcaa
     5821 ccggcaacat gcgccgagac cacaatatgc gttcgatcac cgtcggctgc atcccgtcga
     5881 tcgcatcgcg ctggctggtt ccggcacttc cgtctttccg ggagagcgat cccgatctcg
     5941 atgtcaggat cgtctatgcc agagcggaag agcgcttcga tgacgaaagc ctggatgttc
     6001 tgatcaccat gggggaagac ctgtcggcag ggcgcgagag caggctgctc ttctcccggc
     6061 gcaaccagcc ggtggcgagc gtccattatc tggcaaagcg gaattggact atcgagaacg
     6121 ttccctttgc gagggccgac ctgctgcatg acgaatcggt ggacggctgg aaagaatggt
     6181 tccgcaaggc tgagctaaag ccaaccgagc cgatccgagg gccgatcttt caggacttca
     6241 acattcttgc gacggcagtg atcgccggac atggggtcgc cttgtgccct gtcgaagtgt
     6301 tccggcgaga gatcgagcgc ggcgacctcg tcgtgctgtc ggacatctcg acggccgaga
     6361 cccagggata ttatctgatc accagcgcct gggcgaaaaa gccggtgcgc cgttttgccg
     6421 aatggttcat tcaggagtgc aactccagca gtcttcggta agtgaacggc gacatggcat
     6481 tcgcttgcgc tgaccaagca tggattgtca tgaaagtttc atattgaagc tattgcggaa
     6541 aacgaaattt aatctacaat ttctatcaag aaacatgatt tgatgaagca ccgaaaggag
     6601 actgattgag cgcatttttc tcgaatgcct tcgtgattgc atatttcgcc ttggttattg
     6661 ccctgcttgt cgcgagtggt aagtgccgtt caataagctt cggcgatggc gatggcgatg
     6721 gcgatggcgg gggaggctgg tgcgatgccg cgggtgacgg cggcggtgac ggaggtggag
     6781 gagactagat caaactgaaa tcgatagaat gcccgaccgc ctcaaggcgg ttttttgttg
     6841 cctaggttcc aggccgtacc tgctcgaagc gagctttcct tcctcaatcc atcagcatcg
     6901 agacgcagag cctgcgccac aggcaagtgg tcttggcgtg ccgcaaatac aaatggccgc
     6961 cttcgggtga agacggccaa tgcatgtatt tgcggtcgag gcgccttatg cgcgcgccgg
     7021 cagcagggga tagccggcca tgacggcgcg gccgagcagg gcggcgacaa aagccttgat
     7081 cacgtcgccc ggaatgaagg ccatcgagcc gacgaaggct ttggtgaagc cgaggccggc
     7141 gacggtggcg agataggcga taccgaaggc atacagcacg acgaccccgc cgaccatggc
     7201 ggcgaggaag aagctcaccg tctgcaccag gccgaattgg ccgtggttga ccaggcgctc
     7261 gctgagatag ccggtgacga aggcgccgaa gatccagccg acgaggaagc cggccgacgg
     7321 cgaggcgaag atggcgaggc cgccgcggcc gccggaaagc accggcaggc cgatggcgac
     7381 gagcagcagc acgatcagca cggcaatcgc gccgcggcga gcgccgagca cgacaccggc
     7441 catcatgacg ccgagcgact gggcggtgat cggcaccgga atgaagccga gcgagatcgg
     7501 cggcagcagg ccaagggcca cgatgatcgc agcgaagagg gcagtaagga cgaggtcgcg
     7561 ggtgctcatc atgaactccg tggttaaaat tggttaactt ccatgccgtc gaatgcggcg
     7621 cgcgtcaatc gccgcggcga cattatccgc atccctgagc gtcaggatga tcagcggcgc
     7681 aagcagcgtc gtcggccggg ccttcagccc gcgcgccttg tgggcctcgc ggatcgcctg
     7741 ataacggccg acaatatcgg gcacgaaacg caggacgagc ccgagcgcca ggccgatatc
     7801 atcggcctgc acgaagccgg tgcgctcgag cgggcgggcg agcgccgtca cctcgtcgat
     7861 gaaggcggtg attgacgtcg tcgccgtcac ggcggcggca agaagcatca gcgccgtcag
     7921 ccgcagcacc ggcacgagtg ccgcctgcca gggattgaag aggagattga agagcgccac
     7981 gaccgcaatc gtcaggaaga ccggccgcaa ccgccgaagg ccctcgccga gcggcaggcc
     8041 ggtggtgcgg tagacgaccg ccgtcagcac aaccaagccg gaaagcaggg tgatgttctg
     8101 gctgatgaac agcacgacgc cgaagaccgc aagcgacacc agcttgaccc gcggcgaaag
     8161 ccggtgcatc gggctgttgc cttctacata gagcgactgc atcaggcggc gatctccctg
     8221 tagcgggcga tcgcctcggt cgccggcgca tcggcggcga gccgcccttc atgaaacaac
     8281 agcacccgtt cgaaatcggc gatcagctcc agatcgtggg taatgacgat ggcgctttcc
     8341 ggcagcccgg cgataatccg ctcgaccagt gcccggttct tcaggtcgag ctggttggtc
     8401 ggttcgtcga gaatgagaat gccgggcccc gtcaccagca ccgagcagag ggccgccacc
     8461 tgcagctcgc cgccggaaag ctcgtgcgcc cggcggtcgg cgagcgcttc ggccccgaag
     8521 cgggcgagaa cacgctcgac cttcgcctcg atctccgcct tgctgaagcc gtggcgcttc
     8581 agcccgaagg cgatgtcgtc ccggacgatc ggcaggatga tctggttctg cggcgactgg
     8641 aagatgaaac cgacatcgac tgcgccggcc ttgtcatcgg ctgtatcgcg gccgttgacg
     8701 gtgacgcgcc cgatcgtcgg cttggtcagc ccgttgatca gccgcgcaaa cgtggtcttg
     8761 cccgagccgt tgagcccgat gacgccgatg cgtttgccgc tgatgccgag cgtcagcggc
     8821 gcgagcgcca cccgcgttcc gaaactgacc ccggcgcctt cgaattgtat gtccaaacca
     8881 gttcctcgca tccatgcgat cgtgctgccg caccagcccc tcatccgcct gccggcacct
     8941 tctcctgctc gcggggagaa ggggatattc cgcaccgtct ccctttatat cgacgctgcg
     9001 tttggcacgt cccctctccc cggttttacg gggagagggt tagggtgagg ggcagctatt
     9061 agcgcaaacc tgacagcagc gcttctacaa agagcaaatc tcgctgtcga tatctgatct
     9121 cgatatcggg tggctaggaa gattttccgc gatatgatgc cctcatgacg aatctgcttt
     9181 caaattccga cgcccgccgg gtcttcctgg ccaagcaggg cctcagcgct ccgccgaacc
     9241 gcgccttgag caaggagggc ctgctgcagc tcatccatga tctcggcttc gtccaggtcg
     9301 acagtatcca gacggtcgag cgggcgcatc accagattct gttttcgcgc aaccagacct
     9361 acaggcgcga gcatctgacc gcgctgctcg aaaaggacgg cacgctgttc gagcactgga
     9421 cgcatgacgc ctcgatcctg ccgagcgcct tcttcgtcta ttggaagcac aagttccgcc
     9481 atcaggagaa ggtcatcatc gagcgctggc gcaaatggcg cggcgagggt ttcgaggcgg
     9541 ccttcgagga gacctatgag cgcgtggcgc gcgacggcgc catcctggca cgcgacatca
     9601 aggccgacgg ccatgtttcc ggcggctggt ggaactggca tccgaacaag acggcgctcg
     9661 aatatttctg gcacaccggc aagttcgcca tcgccggccg ctcgaatttc cagaagatct
     9721 acgatctgac cgagcgcgtc gtcccggccc atttccgcga gccggaggtg agccgcgccg
     9781 aattcgtcga ctgggcctgc cgcagcgcgc tcacccgcct cggctttgcc acccatggag
     9841 agatcgccgc cttctggaac ctcgtctcgc ctgacgaagc caagacctgg gtgtcggccc
     9901 atcgcgatga actcgccgaa atgctgatcg agcccgcact cggggccaag ccgcggccct
     9961 cctgggcctt tgccgatttc ctgacgacgc tcggcagcta ccccgccgcg ccgccgcgca
    10021 tccgcgtgct cagccccttc gacccgatga tccgcgaccg caaccgcacc gaacgcctgt
    10081 tcggcttctt ctaccgcatc gagatcttcg tgccggaagc caagcgcgaa tatggctatt
    10141 acgtcttccc gctgctcgaa ggcgaccggc tgatcggccg catcgacatg aaggcggacc
    10201 ggaagaaatc gacgctcgat gtcaggcggc tctggcttga gccgggcgtg aaagcgtccg
    10261 cagggcggct ggagcggctg gaagcggagc tcgagcgggt ggcgcggttt gcgggcgtgg
    10321 agaaagtggt gttgttggag gggtggaggg ggtagtctct tccacgttga gagagctgca
    10381 tttgccc
//
