LOCUS       NZ_CP092643.1          12232 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP092643.1 Agathobacter rectalis strain VPI 0990 chromosome,
            complete genome.
ACCESSION   NZ_CP092643
VERSION     NZ_CP092643.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:46:22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2922909
            Orig. end    :: 2935141
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12232
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2927909:2930141](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7232)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12232
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12232
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(294..605)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2701"
                     /sec_met_domain="PF00881 (E-value: 8.7e-09, bitscore: 33.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILGEESGLEDTVEAALRQIDEKRIVEICDSLSIGAAIENMILTA
                     TGYGLGTLWIANTCFAYNELMDFIGTASQLTGIVAVGFAYEAPAKRPRKPLEEIVEYR"
     PFAM_domain     complement(360..524)
                     /aSDomain="Nitroreductase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00881.26"
                     /description="Nitroreductase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2701_0099"
                     /evalue="2.50E-07"
                     /label="ctg1_2701"
                     /locus_tag="ctg1_2701"
                     /protein_end="82"
                     /protein_start="27"
                     /score="31.0"
                     /tool="antismash"
                     /translation="ICDSLSIGAAIENMILTATGYGLGTLWIANTCFAYNELMDFIGTA
                     SQLTGIVAVG"
     CDS             complement(716..1177)
                     /locus_tag="ctg1_2702"
                     /transl_table=11
                     /translation="MKTIKIQHLFGRFSIFFLVLIVVVFAEEYSINRLFLNINGFPFIF
                     MNALMIVGIAYIYQKATRKLFIKEFEYEIYEDFFYINGNKYEYQDVIKCEIHYFDYFFI
                     NVLCLHIDMKNTSKSPLLLYSEDLDEGIDYKDIPLFKFYESVSEHLRIS"
     CDS             complement(1174..1737)
                     /locus_tag="ctg1_2703"
                     /transl_table=11
                     /translation="MNLNKEIVEGMYIALIFIAGYYLVKTKRINILWKILAAVNILSWA
                     CLLVILALDINVSADFISLNLAACMLLAIFTPIIWFSDRKNMDIYSLFGNIGFVLVLNK
                     EVNQIKNSARLKENLQKILGLDCYHKTWITISKSKDEEITLTMLFFSKKEFACFERKID
                     KKYIVEKENGFGTLVTMQIRGGII"
     CDS             complement(1823..2323)
                     /locus_tag="ctg1_2704"
                     /transl_table=11
                     /translation="MEYLNFEKSGLITILIPLNFLIGEYTLFFRLNGWSRKIIHLITGV
                     IDLFFVVATIASGEHPYYPFVIFGGMLIGIIQSEWRYREFSEETNYWDKIDILFKKGRI
                     LLGAILIIIEIVVRMLYPSMFMGLPLITRIFSYIILAVLPIEIIVFNSFLVKKHNGMAI
                     EYF"
     CDS             complement(2663..3070)
                     /locus_tag="ctg1_2705"
                     /transl_table=11
                     /translation="VKKYIVHFIIWGLGIISYYILDKTTAGDEFQNISVLLIGCLMFYA
                     VYYISMISEIKKIECELNESGIFGGRGMGILINMFSLQYIFELYKKPLVCIVLIVVSVI
                     VLILSRKYIKSFWTKIYGVNNFYLFLLHLMY"
     CDS             complement(3265..3408)
                     /locus_tag="ctg1_2706"
                     /transl_table=11
                     /translation="MDMCYDGALSTAFGLSSWLFTEGEKHGGMYIGFDSKKKKMVWGYG
                     RY"
     CDS             complement(3486..3656)
                     /locus_tag="ctg1_2707"
                     /transl_table=11
                     /translation="MALITGVILFQMNPKLFAVIVMMTIISIVLVFIFKHPYKKINEEQ
                     MQQGNLINFCM"
     CDS             complement(3825..4517)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2708"
                     /sec_met_domain="Abi (E-value: 1.1e-14, bitscore: 52.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSSLNKLFYMRLLLYKTTMKKIYKVTIMVYAIIFIIGYLGGFKY
                     MNIVLNHYIEYSDYIMYALIFFLSIGIFYPFLREGFKTFDKEILNEISTVFLIIAFLSV
                     LIQVLLGEGEEKALSASVIIKIIIFSPVIEELFNRCAVITILKTILKADNVAYMLISAV
                     IFAMFHINSLKQSGFMPEISNLLIYFILGMGCAYVYLRTNNIVSAIVLHMFWNVSIVGG
                     IISGIAHR"
     PFAM_domain     complement(3867..4163)
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2708_0100"
                     /evalue="6.90E-15"
                     /label="ctg1_2708"
                     /locus_tag="ctg1_2708"
                     /protein_end="217"
                     /protein_start="118"
                     /score="55.3"
                     /tool="antismash"
                     /translation="SASVIIKIIIFSPVIEELFNRCAVITILKTILKADNVAYMLISAV
                     IFAMFHINSLKQSGFMPEISNLLIYFILGMGCAYVYLRTNNIVSAIVLHMFWNV"
     CDS             complement(4565..4897)
                     /locus_tag="ctg1_2709"
                     /transl_table=11
                     /translation="MDMCYDGALVLPSSYAVMDEEEMCYTEGGWSGRQVLKNVCGILAV
                     FSLGYAGAAFRHFVEKNKGLSYGRMLSKAGGTLLRFIKAVPWQVKVAIGVCTAATLYAL
                     GSYDLF"
     CDS             complement(5001..7232)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     247.2; E-value: 2e-75)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 305.2; E-value:
                     1.6e-92)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2710"
                     /sec_met_domain="TIGR01193 (E-value: 7.1e-183, bitscore:
                     607.3, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.9e-35, bitscore:
                     119.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYTFIKQHDATDCAAACMGMVCLHYRKETTITKLRDLMGTDLKG
                     TNLIGLSKCAEQLGFNCQAVKVDREGFLSRYTLPAIANVITKEGMSHFVVVFRITKKYV
                     IVGDPAKDIERISIDDFYKKFTGAMLLLKPNSEFEREKIKGTKLFDRYIKLLLPQKKLF
                     IYALVASLLVTLLGILSSLFNNIIYDEILPYRQKDVLKIMLAVFLGISLTSTFVSFVRQ
                     WILMHLSIKIDIPLMLGYFEHIYKLPMKFFASRKTGDITTRFSDAFTIKDIFTNIALSL
                     IMDISMALITGVILFQMNPKLFAIIVMMTIISIVLVFIFKQPYKKINEEQMQQSSILNS
                     EIIEGLRAVETIKGNANEDIELESIEREYIKSLRISYKEGMLSNVQGTISSVISGAGNL
                     VMLYVGIMQVINNSLTLGSYMAFMTLAGYFMDPIGNLVSLQLSIQEANISMKRLSEIMD
                     YEREQQSERQYQEITQIDGDIKLNHVTFGYGNRKPALDDVSFTIEKGQKVALVGASGSG
                     KSTIAKMLLKYYEPQSGDITIDGMDISEYRNDDIRRAVSYVPQNIELFSKSIYDNIRVT
                     RQSATLDEVREAAKAADAHEFIKRLPMQYYTYLEEAGNGLSGGEKQRIALARAFLKENQ
                     FYIMDESTSNLDFATENIIFDMIYNKFRKKTMLIIAHRLATVKNCDKIIVMDKGKIIEQ
                     GTHKELLEKKGQYYRLWEMQQGNFVIRQDESVDKENETEPDDGEVMSYT"
     aSDomain        complement(5100..7211)
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2710_0026"
                     /evalue="9.80E-183"
                     /identifier="TIGR01193"
                     /label="ctg1_2710"
                     /locus_tag="ctg1_2710"
                     /protein_end="711"
                     /protein_start="7"
                     /score="607.3"
                     /tool="antismash"
                     /translation="QHDATDCAAACMGMVCLHYRKETTITKLRDLMGTDLKGTNLIGLS
                     KCAEQLGFNCQAVKVDREGFLSRYTLPAIANVITKEGMSHFVVVFRITKKYVIVGDPAK
                     DIERISIDDFYKKFTGAMLLLKPNSEFEREKIKGTKLFDRYIKLLLPQKKLFIYALVAS
                     LLVTLLGILSSLFNNIIYDEILPYRQKDVLKIMLAVFLGISLTSTFVSFVRQWILMHLS
                     IKIDIPLMLGYFEHIYKLPMKFFASRKTGDITTRFSDAFTIKDIFTNIALSLIMDISMA
                     LITGVILFQMNPKLFAIIVMMTIISIVLVFIFKQPYKKINEEQMQQSSILNSEIIEGLR
                     AVETIKGNANEDIELESIEREYIKSLRISYKEGMLSNVQGTISSVISGAGNLVMLYVGI
                     MQVINNSLTLGSYMAFMTLAGYFMDPIGNLVSLQLSIQEANISMKRLSEIMDYEREQQS
                     ERQYQEITQIDGDIKLNHVTFGYGNRKPALDDVSFTIEKGQKVALVGASGSGKSTIAKM
                     LLKYYEPQSGDITIDGMDISEYRNDDIRRAVSYVPQNIELFSKSIYDNIRVTRQSATLD
                     EVREAAKAADAHEFIKRLPMQYYTYLEEAGNGLSGGEKQRIALARAFLKENQFYIMDES
                     TSNLDFATENIIFDMIYNKFRKKTMLIIAHRLATVKNCDKIIVMDKGKIIEQGTHKELL
                     EKKGQYYRLW"
     PFAM_domain     complement(5301..5750)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2710_0103"
                     /evalue="6.00E-34"
                     /label="ctg1_2710"
                     /locus_tag="ctg1_2710"
                     /protein_end="644"
                     /protein_start="494"
                     /score="117.6"
                     /tool="antismash"
                     /translation="LDDVSFTIEKGQKVALVGASGSGKSTIAKMLLKYYEPQSGDITID
                     GMDISEYRNDDIRRAVSYVPQNIELFSKSIYDNIRVTRQSATLDEVREAAKAADAHEFI
                     KRLPMQYYTYLEEAGNGLSGGEKQRIALARAFLKENQFYIMDESTS"
     PFAM_domain     complement(5937..6743)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2710_0102"
                     /evalue="1.20E-39"
                     /label="ctg1_2710"
                     /locus_tag="ctg1_2710"
                     /protein_end="432"
                     /protein_start="163"
                     /score="136.8"
                     /tool="antismash"
                     /translation="IYALVASLLVTLLGILSSLFNNIIYDEILPYRQKDVLKIMLAVFL
                     GISLTSTFVSFVRQWILMHLSIKIDIPLMLGYFEHIYKLPMKFFASRKTGDITTRFSDA
                     FTIKDIFTNIALSLIMDISMALITGVILFQMNPKLFAIIVMMTIISIVLVFIFKQPYKK
                     INEEQMQQSSILNSEIIEGLRAVETIKGNANEDIELESIEREYIKSLRISYKEGMLSNV
                     QGTISSVISGAGNLVMLYVGIMQVINNSLTLGSYMAFMTLAGYFMDP"
     PFAM_domain     complement(6825..7226)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2710_0101"
                     /evalue="1.10E-34"
                     /label="ctg1_2710"
                     /locus_tag="ctg1_2710"
                     /protein_end="136"
                     /protein_start="2"
                     /score="119.2"
                     /tool="antismash"
                     /translation="YTFIKQHDATDCAAACMGMVCLHYRKETTITKLRDLMGTDLKGTN
                     LIGLSKCAEQLGFNCQAVKVDREGFLSRYTLPAIANVITKEGMSHFVVVFRITKKYVIV
                     GDPAKDIERISIDDFYKKFTGAMLLLKPNS"
     CDS             complement(7344..8639)
                     /locus_tag="ctg1_2711"
                     /transl_table=11
                     /translation="MTWDKVMKLRNRIRIFAVIFILALGMEYLPMAVYAAEVTAEESDM
                     ANDAEPDMDETPETDNASETANASETDKEDKTDVHDMEQNIPVTDIEISDHEEEVEVGK
                     TINLTATALPANATESTITFRSSDINIATVTSGGEVKGISKGYVTIYVSAGSVIKEVSL
                     TVKVKTTGININKEYLVMKPGTAFKLSVSVFPAEAEQAVSYKSTNTSVAAVSGSGVVTA
                     KQTGSATIIVSNGDLSGAVSVIVNRDTESSVAEPAADSTEAENTSEQIFDENTDVSETP
                     VISEQMLYELYAAGRSMKVTGDGYSIIIDGKKIVNYKNELNTDIELERAGDCIKFNLND
                     GEYLCGEVTLHIDDVKGKYLYLYNNVKHKYELVSTEDMSGLNLSTPGKYMITAKPIREG
                     NAAVRYILIAGGIGIIAGIAVYVAVKRRYWFW"
     PFAM_domain     complement(7908..8135)
                     /aSDomain="Big_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02368.20"
                     /description="Bacterial Ig-like domain (group 2)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2711_0105"
                     /evalue="5.40E-10"
                     /label="ctg1_2711"
                     /locus_tag="ctg1_2711"
                     /protein_end="244"
                     /protein_start="168"
                     /score="39.1"
                     /tool="antismash"
                     /translation="TTGININKEYLVMKPGTAFKLSVSVFPAEAEQAVSYKSTNTSVAA
                     VSGSGVVTAKQTGSATIIVSNGDLSGAVSVI"
     PFAM_domain     complement(8145..8381)
                     /aSDomain="Big_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02368.20"
                     /description="Bacterial Ig-like domain (group 2)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2711_0104"
                     /evalue="1.10E-12"
                     /label="ctg1_2711"
                     /locus_tag="ctg1_2711"
                     /protein_end="165"
                     /protein_start="86"
                     /score="47.7"
                     /tool="antismash"
                     /translation="PVTDIEISDHEEEVEVGKTINLTATALPANATESTITFRSSDINI
                     ATVTSGGEVKGISKGYVTIYVSAGSVIKEVSLTV"
     CDS             complement(8636..9766)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 74.4; E-value:
                     1.3e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2712"
                     /transl_table=11
                     /translation="MSRSVKSLDEIRESRILFDKNPPAFGYILITVVAVFLIVAVVWSI
                     KTPKVYTIQAQGTVTNDESNYVMCSYTGELLDSNMEEGALVEAGDVLFTIKSTDYDLQQ
                     TQLEDNRKSYEEQISQYSLLIKSIKDDTNYFDETKADDGLYWSLFETYKSQVEQNKVDV
                     STYQAYGYTDEQIQAQLETNQGKIDEVYYSAIQSAETKIEEANLQIASIDAQLAAVTSG
                     QDAYEVKATTSGVLHMLGNYKSGMVVQTTTTVATITPENSQRYLEAYVSTSDMARMHEG
                     DRVQVVMDGLSQNVYGTISGSVSRIDSNVTTQEGQDGATSRAFKVMIVLDQDYVLSREG
                     DKVDVTNGMTAAARIQYDKVTYFNYVLEKLGIKTGK"
     PFAM_domain     complement(8747..9085)
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2712_0107"
                     /evalue="9.80E-12"
                     /label="ctg1_2712"
                     /locus_tag="ctg1_2712"
                     /protein_end="340"
                     /protein_start="227"
                     /score="45.6"
                     /tool="antismash"
                     /translation="VKATTSGVLHMLGNYKSGMVVQTTTTVATITPENSQRYLEAYVST
                     SDMARMHEGDRVQVVMDGLSQNVYGTISGSVSRIDSNVTTQEGQDGATSRAFKVMIVLD
                     QDYVLSREG"
     PFAM_domain     complement(9440..9532)
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2712_0106"
                     /evalue="3.20E-06"
                     /label="ctg1_2712"
                     /locus_tag="ctg1_2712"
                     /protein_end="109"
                     /protein_start="78"
                     /score="26.9"
                     /tool="antismash"
                     /translation="NMEEGALVEAGDVLFTIKSTDYDLQQTQLED"
     CDS             complement(9833..9946)
                     /locus_tag="ctg1_2713"
                     /transl_table=11
                     /translation="MVIFISCILVYVRCADTNIYTSNIGEESWMAAIIRST"
     CDS             complement(9948..10637)
                     /locus_tag="ctg1_2714"
                     /transl_table=11
                     /translation="VLGMILIISDVVYYAGIFILYKLICEDDFNYLVLISFIFLLVGLL
                     GASVSNFLKDKEYISLHSKCVEVNVIIKQLLIGISFIGAQIDSVVFKYALIGFSMIGII
                     VTILICKELYGKHIKLIDFIDTYEKADDCRIKEMNKWLLANGIITCMFMNTTNTKTEYA
                     LMCIIILIYMILFIRYNNDRIGGVNCAIAVIFEFIIVLSVLYEWNLITCAIFGYYYLWM
                     IKIRKNM"
     CDS             complement(10693..11085)
                     /locus_tag="ctg1_2715"
                     /transl_table=11
                     /translation="MELCYDGALVLPSSYAVMDEEEMTYLEGGKEIANLSKKQCINGLC
                     AIGLSPQVAIAGALTYTLAKCLINKVSKFGGLATAVVAGILTWAAGQVIAFGKGLARGA
                     LNNGVRVSWNWNPFKEAVGIGITVKY"
     CDS             complement(11034..11168)
                     /locus_tag="ctg1_2716"
                     /transl_table=11
                     /translation="MIYIKLCLIANRHGRKILFRRKKQEDTKWNYVTMEHWCSQAVML"
     CDS             complement(11198..11674)
                     /locus_tag="ctg1_2717"
                     /transl_table=11
                     /translation="MNSINIYENKTLKLQNVIVRRLDLESDDQNLFDSEINKISTYIQT
                     HGANQIGPLIQYSKVELDENNEPDINMQFMLQANNFIHNVEQPYRMESLLRVKNCLYAR
                     YNGPDDKLKFAYDKLGVYAFENDIELDGCNYTIYVDRNEEEETMVADVFMPVKE"
ORIGIN
        1 agggataaat attaggatta ttcacttttc ttttacttaa tctaaaacta cttaaatata
       61 tcatatcttt tcattatccc tttcctgata aaagagctcc aacaccatta tttctcgaat
      121 atgtgaaaat gaaggattat tcactaatac atctggttta gttatgaatt ggtgagacac
      181 tgtcacactt tttccaaaat cttgtgcagt atttatataa ctaattttta agtatttcct
      241 tattttcaaa tgacaaacac attatattaa agattttgat caatccgatt ttcctatcta
      301 tactcaacga tttcttccaa tggtttcctt ggtcttttag ccggagcttc ataggcaaag
      361 ccaacagcaa caattcctgt caactggctg gctgttccga taaaatccat caactcattg
      421 taggcaaagc aagtattggc aatccataag gtacctaatc catatcccgt tgccgtgaga
      481 atcatatttt caattgccgc acctatggac agtgaatcac aaatttcaac gattcgtttc
      541 tcatcaattt gtctgagcgc tgcctcaacc gtatcttcta gtccactttc ttctcctaaa
      601 atcatatatg cctattatat aattcttttg aaacgattac aagcaaagaa agataccgct
      661 tacgattgcc gaaaaaagaa aggctatatt ttctttcacc cctatctgtc aatagttagc
      721 tgattctcaa atgttcgcta actgattcat aaaacttaaa caatggaatg tctttatagt
      781 ctattccttc atccaagtct tctgaatata acaaaagggg gcttttagaa gtgtttttca
      841 tgtctatatg taaacacaat acatttataa aaaaataatc gaaataatga atttcacact
      901 ttattacatc ttgatattca tatttattcc cattaatata gaagaaatct tcatatatct
      961 catactcaaa ttcctttatg aataatttcc ttgttgcttt ttgataaata tatgctattc
     1021 ctacaatcat aagtgcattc ataaaaataa atggaaatcc atttatattc aagaacaacc
     1081 tattaattga atattcctca gcaaatacta ccacaattaa caccaagaaa aatatagaaa
     1141 atctaccaaa taagtgctgt atttttatcg ttttcatata atacctcctc gtatttgcat
     1201 agtaaccaat gttccaaatc cattttcctt ttctactata tacttcttat caatttttcg
     1261 ttcaaagcag gcaaattcct ttttactgaa aaataacata gtcaatgtaa tttcttcatc
     1321 ttttgatttc gatattgtga tccatgtctt atgataacaa tcaagaccta gaattttctg
     1381 aaggttttct tttagtctgg cactattttt tatttgattt acttccttgt taagcactaa
     1441 tacaaatcct atatttccaa ataaactgta gatatccata ttttttctat cagaaaacca
     1501 tattattggt gtaaaaatag ccaacaacat acatgctgct aaatttaagg atataaaatc
     1561 agcacttaca tttatatcta gtgctaatat tactaataaa cacgcccatg aaagtatatt
     1621 cacagctgcc aatatcttcc acaaaatatt aattcttttc gtctttacta aatagtatcc
     1681 cgcaataaaa ataagagcta tgtacattcc ttcaacaatc tctttattca aattcattac
     1741 tcccttcatg cactttaaaa ttaataaagt aggtcacgaa cgacactttc ttgtcatgaa
     1801 cggcatgttt ttaccttgct ttttaaaaat attcaattgc cataccatta tgttttttta
     1861 caagaaaact gttaaaaact attatttcaa taggtaacac cgctaaaatg atatacgaaa
     1921 agatacgtgt tattaatggc aatcccataa acattgacgg atacaacatt ctaaccacta
     1981 tttcaataat aattaatatc gctcccaaca aaattctccc ctttttaaac aatatatcta
     2041 ttttgtccca ataatttgtt tcttcactga attctctata acgccattca ctttgaatga
     2101 ttccaattaa cattccaccg aaaatcacaa atggataata tggatgctct ccactagcaa
     2161 ttgttgccac cacaaaaaat agatcaatca cacctgtgat taagtgaatt attttccggc
     2221 tccatccatt caagcgaaaa aacaatgtat attctccaat taaaaaatta aggggaatca
     2281 ggatcgtaat aagtcctgac ttttcgaaat tcaagtattc catatcactt acctcttata
     2341 taagatgatt aaatggtcaa aaggtatcat cgatgcatgg ccgctgcaca gtctgttgca
     2401 tcatgctgct ttataaatgt gtatcgcatt gtttcccttt cgtatgctat atattaaaag
     2461 cttattttct aatttcttct gtctaacaaa gcctcatttt tagaagcaag tcttataaaa
     2521 aaactgtttg gcaactctgt atttttaaaa atgacaatat aaaatattat aagaattaat
     2581 tttgttacgt ttgatacatt ttttacatta accaacaaaa tatcatccca cttataacca
     2641 agaacactgc ctatagaact cgtcaataca ttaaatgcaa taaaaataag taaaaattgt
     2701 ttactccata tatttttgtc caaaaagatt ttatatattt acgtgatagt atcagcacaa
     2761 taacagaaac tactataaga acaatgcaaa ctaatggttt cttataaagt tcaaatatat
     2821 actgcaagct aaacatgttt attaaaatcc ccatgccacg tccgccaaat attcccgatt
     2881 cattcaattc acattcaatt ttcttgattt ctgatatcat agaaatataa tacactgcat
     2941 aaaacatcaa acatccgatt aataatacgc taatattctg aaactcatct ccggccgttg
     3001 tcttgtctaa tatataataa ctaattatac ctagtcccca tataataaaa tgtacgatat
     3061 attttttcac tcttcacccc tgcattttta gaatgatcat aataaatatt acagctatga
     3121 tctgacatac tattcctata atattaaatt tcctgctatt atgagcttcc aatatgtctt
     3181 tttttgaact tttcaaatta caaaaaacag atattaactg aaaagtcaga aatcctatat
     3241 ataatacttt atacattttt acccctaata tctaccatat ccccaaacca tttttttctt
     3301 ttttgaatca aatccaatat acattccacc gtgtttttca ccttcagtaa aaagccagct
     3361 agataaccca aaagcagttg acagtgctcc atcataacac atatccatat atgtgtacct
     3421 cctcttctct ttgttttatt tttgccattc ccgtctgcag acagtcctga ctctatgtaa
     3481 agcttttaca tacaaaaatt aatcaaattt ccctgctgca tctgctcctc atttatcttc
     3541 ttataaggat gtttaaatat aaataccagc actatactta tgattgtcat cattacaatt
     3601 accgcaaaaa gctttgggtt catctgaaac agtatcacac ctgtgataag agccattgat
     3661 atatccatga taagcaataa tgctatattt gtaaacattt aaaatcgccg gaagtgtata
     3721 tctgctaagg aagccttccc tgtcaacctt aaccgcctgg cagttaaatc caagctgctc
     3781 tgcacatttt gacagaccta tgagatttgt tcctttcttt tacatcatct atgtgcaatg
     3841 ccacttatta tcccaccaac tatagacaca ttccaaaaca tatgcagtac gattgctgat
     3901 acgatattat tagtgcgtaa atatacatat gcacatccca ttccaagtat gaaatatatt
     3961 aataaattgc ttatttccgg cataaatcca ctctgtttta agctatttat gtgaaacatt
     4021 gcaaatataa ctgcacttat taacatataa gcaacattat ctgcctttaa tatagttttt
     4081 agaatagtaa taactgcaca tctattaaat aattcttcta ttactggtga aaatattata
     4141 attttaatta taacactagc cgataacgcc ttctcttctc cttctcccag caaaacttga
     4201 attaatactg acaaaaatgc tattattaaa aatactgtac taatttcatt taaaatctct
     4261 ttatcaaagg ttttaaatcc ttccctcaaa aatgggtaaa atatacctat tgataaaaaa
     4321 aagattaaag catacattat atagtcgcta tattctatat aatggtttaa tacaatattc
     4381 atgtatttaa acccaccaag atatcctatt ataaatatta tggcatatac cattatcgta
     4441 actttatata tttttttcat tgttgttttg tacaaaagta gtctcatata aaataattta
     4501 ttgagactac ttttcatttt ctgtctatcc ttaaatattt attgccttat aaacatacaa
     4561 tattttaaaa taaatcgtat gatcctaatg catacagagt tgctgctgtg catactccta
     4621 tagccacctt tacctgccat ggaaccgctt tgataaatct caataaagtt ccacctgctt
     4681 tactcaacat tcttccatat gataatccct tatttttttc aacaaaatgt ctaaatgcag
     4741 cccctgcata acctaatgaa aatactgcaa gaattccaca tacattctta agcacttgac
     4801 gtccactcca ccctccttcc gtatagcaca tttcctcttc atccattaca gcataactgc
     4861 ttgggagcac cagtgctcca tcataacaca tatccatata tgtgtacctc cttttctatt
     4921 tgttttaatg tttctgtcat tcctgtttgc aaccaggcac gactttatgt aaatgatcat
     4981 tacatacaaa attataatcg ctaagtgtag ctcatcactt cgccatcatc cggctctgtt
     5041 tcattctcct tatccacgct ttcgtcctgc ctgataacaa aatttccctg ctgcatctcc
     5101 catagtctgt aatactgccc tttcttttcc agcagttcct tatgtgttcc ctgttctatt
     5161 atctttcctt tgtccatgac tattattttg tcacagtttt ttactgttgc cagcctgtgt
     5221 gctattataa gcatggtctt ttttctgaat ttattgtata tcatatcaaa aatgatattt
     5281 tctgttgcaa aatccagatt gctggtggat tcatccatga tataaaactg gttttccttt
     5341 agaaatgccc ttgcaagcgc aattcgctgt ttttcaccac cgcttagtcc atttccggct
     5401 tcttcgagat atgtgtaata ctgcatcgga agtctcttga taaattcatg tgcatcggcc
     5461 gcttttgctg cctccctgac ctcatcaaga gtcgcactct gtcttgtaac ccttatatta
     5521 tcatatatgc tttttgaaaa aagctctatg ttctgcggta cataggatac agcacgccgg
     5581 atatcgtcat ttctgtattc cgagatatcc atgccatcta ttgttatgtc accagactgt
     5641 ggctcataat atttaagcag catcttagct atcgtagact ttccgcttcc gcttgcgcct
     5701 acaagtgcaa ctttctgccc tttttctatc gtaaaactca catcatccag cgcaggtttt
     5761 cggtttccat agccgaatgt gacatgatta agctttatat caccatcaat ctgtgttatt
     5821 tcctgatact gtctttcact ctgctgctct ctttcataat ccatgatctc agacagtctc
     5881 ttcatggaaa tgtttgcctc ctgtattgaa agctgcagac ttacaagatt gccgattgga
     5941 tccatgaaat atcccgccag agtcataaac gccatataac ttccaagtgt caggctattg
     6001 tttatcacct gcataatgcc gacatacagc attacgagat tccctgctcc tgatatgaca
     6061 cttgatatgg ttccctgcac atttgaaagc attccctctt tataacttat cctaagtgac
     6121 tttatgtatt cgcgttctat actttccagt tcgatgtcct cgttcgcatt tccttttatt
     6181 gtctcaaccg cgcgcaatcc ttctattatc tctgaattga gtattgatga ctgctgcatc
     6241 tgctcctcat ttatcttctt ataaggctgt ttaaatataa ataccagcac tatacttatg
     6301 attgtcatca ttacaattat cgcaaaaagc tttgggttca tctgaaacag tatcacacct
     6361 gtgataagag ccattgatat atccatgata agcgataatg ctatatttgt aaaaatatcc
     6421 tttatggtaa atgcatctga gaaacgtgtc gtaatgtcac ctgttttacg gcttgcaaag
     6481 aatttcatcg gcagcttgta tatgtgttca aaatatccca gcataagcgg aatatctatc
     6541 tttattgaca ggtgcataag tatccactgt cttacaaagc tgacaaatgt cgaggtcagt
     6601 gaaattccta ggaatactgc aagcatgatc tttaaaacat ccttctgccg gtaaggcagt
     6661 atctcatcat atattatgtt gttgaaaagt gatgataaaa tcccaagaag agttacaaga
     6721 agtgatgcca caagtgcata tataaaaagc tttttctgtg gaagaagcag ctttatgtac
     6781 ctgtcaaata gctttgttcc cttaatcttc tcacgttcaa attcgctgtt tggttttaac
     6841 agcagcatcg cacctgtaaa tttcttatag aaatcatcta ttgaaattct ctctatatcc
     6901 ttcgccggat ctcccactat cacatacttt ttcgttatcc tgaaaacaac aacaaaatgc
     6961 gacattccct ctttagtaat aacatttgca atcgccggaa gtgtatatct gctaaggaag
     7021 ccttccctgt caaccttaac cgcctggcag ttaaatccaa gctgctctgc acattttgac
     7081 agacctatga gatttgtccc tttcaggtca gttcccataa gatcccttaa tttcgttatt
     7141 gtggtttctt ttctgtaatg cagacagacc atacccatgc atgccgctgc acagtctgtt
     7201 gcatcatgct gctttataaa tgtgtatcgc attgtgtccc ttcctgttcg ctatatatta
     7261 attttctctt ctaaacatta tttttctgcc atgtctgttt gcaactgggc atgactttat
     7321 gtaaatcatg attacataca cctttaccag aaccagtatc ttctctttac cgccacatac
     7381 acagcaattc ctgcaattat gccgattcca cctgcaatca gtatatatct gaccgctgcg
     7441 ttgccctctc tgatgggctt tgccgtgatc atatactttc ctggtgtgct taaattaagc
     7501 ccgctcatgt cttctgtact cacaagttcg tatttatgct ttacgttatt atatagatac
     7561 agatattttc cttttacatc atctatgtgc agtgtcactt ctccgcacag atactctcca
     7621 tcgttgagat tgaattttat gcagtcccct gccctttcga gttctatatc cgtattaagt
     7681 tcatttttat aatttactat cttctttccg tctattatga tgctgtagcc gtctccggtc
     7741 actttcattg atctgcctgc tgcgtacagt tcatatagca tctgctcact tattacaggc
     7801 gtttcggata catccgtatt ttcatcaaat atctgttcac ttgtgttttc tgcttctgta
     7861 ctatctgctg ccggttcagc cacagaactt tccgtatctc tgtttacgat taccgacact
     7921 gcgcccgaca aatccccatt tgaaactatt attgtagctg aacctgtctg ttttgccgtt
     7981 accacaccac tgcctgatac tgctgcaact gatgtgttgg ttgatttgta tgaaaccgcc
     8041 tgctctgcct ctgccggaaa cacagatacg ctcagtttaa atgccgttcc cggcttcatt
     8101 acgagatatt ctttatttat atttattcca gtggttttta cttttactgt cagacttacc
     8161 tcttttatta cacttccggc agatacatat atggtaacat atccttttga gatacccttt
     8221 acttcacctc cagaagtcac agttgctata tttatatcag atgaacggaa ggttatcgtg
     8281 ctttccgtgg cattcgccgg aagtgctgtg gctgtaaggt ttattgtctt tcctacttcc
     8341 acttcctcct catgatctga tatctcgata tctgttaccg gtatattctg ttccatatca
     8401 tgtacgtctg ttttgtcttc cttgtccgtt tccgatgcat tggccgtttc tgatgcattg
     8461 tccgtttccg gggtttcatc catatccggt tctgcatcat ttgccatatc gctttcttcc
     8521 gctgtcactt ctgcagcata tacagccatc ggtaagtact ccatacccaa agccagtata
     8581 aatataacag caaatattct gattctgttt cttaacttca taaccttatc ccatgtcatt
     8641 ttccggtttt tattccgagt ttctcaagca catagttaaa atatgtgact ttatcatact
     8701 gtatccttgc agccgccgtc ataccgttag tcacgtctac cttgtctccc tcacggctca
     8761 gcacataatc ctggtctagc actatcatca ctttaaacgc ccggcttgtc gctccatcct
     8821 gcccttcctg tgtagtgaca ttgctgtcta tccgtgatac gcttccgctt atcgtcccat
     8881 agacattctg tgacagaccg tccataacca cctgcactct gtctccctca tgcattctgg
     8941 ccatatcaga tgtggaaaca tatgcttcga gatatctctg cgaattttcc ggtgtgattg
     9001 ttgccacagt tgtcgttgtc tgtacaacca ttccactctt ataatttccc agcatatgca
     9061 gaactcctga tgtggtagct tttacctcat aagcatcctg cccacttgtc accgctgcaa
     9121 gctgtgcatc tattgatgca atttgcagat tcgcctcttc aatctttgtc tcggcagatt
     9181 gtatggcaga ataatatact tcatcaatct taccctgatt agtttcaagc tgtgcctgta
     9241 tctgctcatc agtatatcca tatgcctgat acgttgacac atcaacctta ttctgttcca
     9301 cctgtgattt gtaggtttca aaaaggctcc agtacagacc gtcatccgct tttgtctcgt
     9361 caaaataatt ggtatcgtct tttattgatt ttataagaag actatactgt gatatctgtt
     9421 cttcatatga ttttctgttg tcttcaagct gtgtctgctg cagatcataa tcagtgcttt
     9481 taattgtaaa aagcacatcc ccggcttcca caagtgcgcc ctcttccatg ttgctgtcaa
     9541 gaagctctcc cgtatagctg cacatgacat aatttgactc atcattcgtc acagtaccct
     9601 gtgcctgtat ggtatacacc tttggtgttt ttatactcca tactactgcc acaataagaa
     9661 aaacggctac aactgttata agtatatagc cgaatgccgg tggattctta tcaaacagta
     9721 ttcttgattc ccttatttca tctaaactct taacgcttct gctcataacg cttttattcc
     9781 tttacaggca tgaatacatc tgcaaccatt gtctcttctt cttcgtttct gtctacgtag
     9841 atcgtataat tgcagccatc cagctctcct ctcctatatt cgatgtgtag atattagtat
     9901 ctgcacaccg aacatatact aaaatacatg atataaaaat caccatatca catatttttc
     9961 cttattttta tcatccaaag ataataatat ccaaaaatag cacatgttat tagattccat
    10021 tcatacaaca ctgataatac tataataaat tcaaatatta cagcaattgc acaattaacg
    10081 cctcctattc tatcattatt gtaccttata aacaaaatca tatatatcaa aatgattata
    10141 cacattaacg cgtattctgt ttttgtatta gttgtgttca taaacataca cgtaataatt
    10201 ccatttgcca atagccattt attcatttcc tttatacggc aatcatctgc tttttcgtac
    10261 gtatcaatga aatctatcaa ctttatatgc tttccatata actctttaca aatcagaatt
    10321 gttactatta tcccaatcat actaaaacca ataagagcat acttaaacac aacactatca
    10381 atttgtgcac caataaatga tattcctatc aagagctgtt taattattac atttacctct
    10441 acgcacttac tgtgtaatga aatatattct ttgtctttaa ggaaatttga tactgatgct
    10501 cctaaaagtc ctaccagtag aaaaataaac gatataagca ctaaatagtt aaaatcatct
    10561 tcacaaataa gtttatataa tataaatatt cctgcataat agactacgtc tgatattatt
    10621 aatatcattc ccaacacttc tatccatctc caatttcatt tataaaacac agtacaagtg
    10681 ctctcacgac aattagtatt ttaccgtaat tcctattcca acagcctcct taaaaggatt
    10741 ccagttccat gacactctca ccccattatt tagtgctcct ctagccaagc cctttccaaa
    10801 cgctataacc tgtcctgctg cccatgtaag tatacctgca acaacagcag ttgctaaccc
    10861 gccaaattta cttaccttat taatcagaca tttagctaac gtatacgtca aagctcctgc
    10921 aattgccact tgtggagata atccaattgc acaaagtcca tttatgcatt gctttttgct
    10981 aagatttgca atttccttac caccttctaa atatgtcatt tcctcttcat ccattacagc
    11041 ataactgctt gggagcacca gtgctccatc gtaacataat tccattttgt gtcctcctgt
    11101 ttctttcttc taaacaatat ttttctgcca tgtctgtttg caatcagaca taactttatg
    11161 taaatcatga ttacatcctc ttctgctcat aacactttta ttcctttaca ggcatgaata
    11221 catctgcaac cattgtctct tcttcttcgt ttctgtccac gtagatcgta taattgcagc
    11281 catccaactc aatatcattc tcaaatgcat acaccccaag cttatcataa gcgaacttca
    11341 gcttatcatc cggtccgtta tatctggcat acagacagtt ttttacacgc agcagagact
    11401 ccatcctata tggctgctct acgttgtgga taaagttgtt cgcctggagc ataaactgca
    11461 tgttgatatc aggctcatta ttttcatcca gctcaacctt tgaatattga attaacggtc
    11521 cgatctggtt tgctccatgc gtctgtatgt atgtacttat tttgttaatt tcagaatcaa
    11581 aaagattttg atcatctgat tcaagatcaa gcctacggac tatgacgttt tggagtttca
    11641 gtgttttgtt ttcataaata tttatgctat tcataattca cttcctttct gattttttat
    11701 agtattgttg tcagaagtgt ttgcaaccac ttctgactct atgtaaaagc tgttacatac
    11761 aaaatcacta cctactaaac taaatattct ttcccattta aatattataa ttacccattt
    11821 cttatctctt attaaaaaat gtccatatcc actgtgccag attttccaat ccatacgtaa
    11881 ccattatgtt tcgcctcctt tgtgacaatc ttattattca ccaagggatt gtctacaagc
    11941 aacatatatg ttattatcgg tttgaaattg ttattatcgg tttgaaattg ttattaacgg
    12001 tcataattat aaaagaggaa cactatgagc cctacaaaat atgctattgc catttgtgat
    12061 gatgaaaaat actggcagaa tcaaattctt aattgttgta aacttttgga gaacgatata
    12121 aattttaatt ttgaatacca tatattttca tctggcgaag atgtacttaa ataccagagc
    12181 aatattgata ttttgttact agacgaagaa ttgccaggca cttccggaca gt
//
