LOCUS       NC_012780.1            18407 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_012780.1 [Eubacterium] eligens ATCC 27750 plasmid unnamed,
            complete sequence.
ACCESSION   NC_012780
VERSION     NC_012780.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:49:07
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 36947
            Orig. end    :: 55354
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..312)
                     /gene_functions="other (smcogs) SMCOG1241:lipoprotein dsbF
                     (Score: 49.3; E-value: 7.4e-15)"
                     /gene_kind="other"
                     /locus_tag="ctg3_48"
                     /transl_table=11
                     /translation="MEIKHVKASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVA
                     AKVDDVQIVKINVDEESSVAEKYNIMSIPTLLLFKSGECVAKSVGFISEGQVMEFIGK"
     protocluster    1..18407
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[45925:46653]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8979..9706
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..18407
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18407
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     aSDomain        complement(10..294)
                     /aSDomain="TIGR01068"
                     /aSTool="tigrfam"
                     /description="thioredoxin: thioredoxin"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_48_0001"
                     /evalue="1.50E-37"
                     /identifier="TIGR01068"
                     /label="ctg3_48"
                     /locus_tag="ctg3_48"
                     /protein_end="101"
                     /protein_start="6"
                     /score="125.8"
                     /tool="antismash"
                     /translation="KASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVAAKVDDV
                     QIVKINVDEESSVAEKYNIMSIPTLLLFKSGECVAKSVGFISEGQVMEFI"
     PFAM_domain     complement(10..306)
                     /aSDomain="Thioredoxin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00085.22"
                     /description="Thioredoxin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_48_0001"
                     /evalue="3.90E-31"
                     /label="ctg3_48"
                     /locus_tag="ctg3_48"
                     /protein_end="101"
                     /protein_start="2"
                     /score="107.2"
                     /tool="antismash"
                     /translation="IKHVKASEFNNEVLKADKPVLVDFWADWCGPCKMLGPVLEQVAAK
                     VDDVQIVKINVDEESSVAEKYNIMSIPTLLLFKSGECVAKSVGFISEGQVMEFI"
     CDS             complement(341..721)
                     /locus_tag="ctg3_49"
                     /transl_table=11
                     /translation="MLEKILLYNVKNPQHIIKAASNMRIISGFINESDTDRTLAEIADD
                     VRGISLSDAEGYQPQENKESLIVFCDVTDKHMDKLLFEMRQKSFDVSFKAVLTDTNRKW
                     NIKQMLVEMRREKFEYMRRNMK"
     PFAM_domain     complement(368..526)
                     /aSDomain="DUF3783"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12646.9"
                     /description="Domain of unknown function (DUF3783)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_49_0002"
                     /evalue="2.30E-15"
                     /label="ctg3_49"
                     /locus_tag="ctg3_49"
                     /protein_end="118"
                     /protein_start="65"
                     /score="56.4"
                     /tool="antismash"
                     /translation="LIVFCDVTDKHMDKLLFEMRQKSFDVSFKAVLTDTNRKWNIKQML
                     VEMRREKF"
     CDS             complement(721..1524)
                     /locus_tag="ctg3_50"
                     /transl_table=11
                     /translation="MRYYTVSQWLIFFFIYCFLGWIWECCYVSVRKHKWVNRGFLHGPF
                     LPIYGSGAIVILISTIAVKDIVPLVFLFGMVSSTILEFCTGCCMEKLFGVRYWDYSNLP
                     LNFKGHICFFISLAWGAFSILLVCVIHKPIEATVLMIPRTIADIIAVVLAIYMAADFAV
                     SINEAMDLKATLEKFTKENEQLQMYARRMEITATFAEEEFNKKKEQFMAAVAEERRQLS
                     ERADRRYSHITNIIKRNPNAVSRVHKESINEIKEIIANRKAKKDN"
     PFAM_domain     complement(1033..1494)
                     /aSDomain="ABC_trans_CmpB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06541.13"
                     /description="Putative ABC-transporter type IV"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_50_0003"
                     /evalue="8.70E-49"
                     /label="ctg3_50"
                     /locus_tag="ctg3_50"
                     /protein_end="164"
                     /protein_start="10"
                     /score="165.7"
                     /tool="antismash"
                     /translation="IFFFIYCFLGWIWECCYVSVRKHKWVNRGFLHGPFLPIYGSGAIV
                     ILISTIAVKDIVPLVFLFGMVSSTILEFCTGCCMEKLFGVRYWDYSNLPLNFKGHICFF
                     ISLAWGAFSILLVCVIHKPIEATVLMIPRTIADIIAVVLAIYMAADFAVS"
     CDS             complement(1574..1927)
                     /locus_tag="ctg3_51"
                     /transl_table=11
                     /translation="LEIKLCKRCGESYFVYHSSRHVCKEKVSDIIYFERTGRKIVMYSR
                     SSEAIAIYGSLAEIYNLLYDEGFEYINKSVVVNFYQVTNIKNNCVKFADGNYIEISRSR
                     RTFIMDKFFDVVK"
     PFAM_domain     complement(1610..1858)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_51_0004"
                     /evalue="1.70E-10"
                     /label="ctg3_51"
                     /locus_tag="ctg3_51"
                     /protein_end="106"
                     /protein_start="23"
                     /score="41.1"
                     /tool="antismash"
                     /translation="KEKVSDIIYFERTGRKIVMYSRSSEAIAIYGSLAEIYNLLYDEGF
                     EYINKSVVVNFYQVTNIKNNCVKFADGNYIEISRSRRT"
     CDS             complement(2051..4237)
                     /locus_tag="ctg3_52"
                     /transl_table=11
                     /translation="MGKVKVTSKNNQVKVQIRSSNGEQLNQNMAAYLSSVNVEGFLPFY
                     IVTNSEGFTAEYGAAGFETAKDFFKNRVIDQNTFYNFIDSSVKALSGMSAYNMEYGNVL
                     VSLDTVLVESRTGRAMYLYYPVYGYNNGNFFNTFLGDVVSNMTTPSATDVSYIERLNDM
                     LRHPDSMSWDTLKEYADSVKVIIPNVPQMHPASYSEPVITPVQPINSGNAGKTCPVCGT
                     YNALADAVFCSNCGNRLNLDDINVSIVETEYKTCPACGFVNSPDSVFCAGCGIKMDEYK
                     MPEDKQETDEKKEIQNTSILIKNGRVVDPVSGTDEVIDVFIKNNVIEEIGHDINAADFN
                     SEESDNIKIINADGMIVAPGLVDTHVHFRDPGFTYKEDIITGASAAARGGFTTVVCMAN
                     TKPVVDNVETLRYIQEKGETTGIHVMQTATVTKELNGTELVDMEALADAGAAGFTDDGI
                     PIMDEHVLVTAMKKAVELDLPISLHEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVM
                     VARDCMLALNTGASVCIQHISSGNSVELVRLAKKLGADIHAEATPHHFTLTEDAVLKYG
                     TNARMNPPLRTENDREKIIEGIKDGTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETS
                     LALGIKSLVEPGHISLMKLIELMSKNPAEFYRMVPGSITKGASADIVIFGEKDLWTVNR
                     EDFASKACNSPFIGWELPGKVHYTICSGKIIYQA"
     aSDomain        complement(2057..3280)
                     /aSDomain="TIGR00857"
                     /aSTool="tigrfam"
                     /description="pyrC_multi: dihydroorotase, multifunctional
                     complex type"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_52_0002"
                     /evalue="2.60E-117"
                     /identifier="TIGR00857"
                     /label="ctg3_52"
                     /locus_tag="ctg3_52"
                     /protein_end="727"
                     /protein_start="319"
                     /score="390.2"
                     /tool="antismash"
                     /translation="VFIKNNVIEEIGHDINAADFNSEESDNIKIINADGMIVAPGLVDT
                     HVHFRDPGFTYKEDIITGASAAARGGFTTVVCMANTKPVVDNVETLRYIQEKGETTGIH
                     VMQTATVTKELNGTELVDMEALADAGAAGFTDDGIPIMDEHVLVTAMKKAVELDLPISL
                     HEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVMVARDCMLALNTGASVCIQHISSGN
                     SVELVRLAKKLGADIHAEATPHHFTLTEDAVLKYGTNARMNPPLRTENDREKIIEGIKD
                     GTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETSLALGIKSLVEPGHISLMKLIELMS
                     KNPAEFYRMVPGSITKGASADIVIFGEKDLWTVNREDFASKACNSPFIGWELPGKVHYT
                     ICSGKIIYQ"
     PFAM_domain     complement(2066..3172)
                     /aSDomain="Amidohydro_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01979.22"
                     /description="Amidohydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_52_0007"
                     /evalue="8.70E-29"
                     /label="ctg3_52"
                     /locus_tag="ctg3_52"
                     /protein_end="724"
                     /protein_start="355"
                     /score="101.0"
                     /tool="antismash"
                     /translation="IVAPGLVDTHVHFRDPGFTYKEDIITGASAAARGGFTTVVCMANT
                     KPVVDNVETLRYIQEKGETTGIHVMQTATVTKELNGTELVDMEALADAGAAGFTDDGIP
                     IMDEHVLVTAMKKAVELDLPISLHEEDPEFIIRPGVNQGKVSDQLGYGGASATAEDVMV
                     ARDCMLALNTGASVCIQHISSGNSVELVRLAKKLGADIHAEATPHHFTLTEDAVLKYGT
                     NARMNPPLRTENDREKIIEGIKDGTIDMIVTDHAPHSEEEKAKPLENAPSGITGLETSL
                     ALGIKSLVEPGHISLMKLIELMSKNPAEFYRMVPGSITKGASADIVIFGEKDLWTVNRE
                     DFASKACNSPFIGWELPGKVHYTICSGKI"
     PFAM_domain     complement(3416..3589)
                     /aSDomain="DZR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12773.9"
                     /description="Double zinc ribbon"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_52_0006"
                     /evalue="6.20E-07"
                     /label="ctg3_52"
                     /locus_tag="ctg3_52"
                     /protein_end="274"
                     /protein_start="216"
                     /score="29.4"
                     /tool="antismash"
                     /translation="CPVCGTYNALADAVFCSNCGNRLNLDDINVSIVETEYKTCPACGF
                     VNSPDSVFCAGCG"
     PFAM_domain     complement(3743..4150)
                     /aSDomain="DUF6382"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19909.1"
                     /description="Domain of unknown function (DUF6382)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_52_0005"
                     /evalue="2.00E-07"
                     /label="ctg3_52"
                     /locus_tag="ctg3_52"
                     /protein_end="165"
                     /protein_start="29"
                     /score="30.9"
                     /tool="antismash"
                     /translation="AAYLSSVNVEGFLPFYIVTNSEGFTAEYGAAGFETAKDFFKNRVI
                     DQNTFYNFIDSSVKALSGMSAYNMEYGNVLVSLDTVLVESRTGRAMYLYYPVYGYNNGN
                     FFNTFLGDVVSNMTTPSATDVSYIERLNDMLR"
     CDS             complement(4290..5240)
                     /locus_tag="ctg3_53"
                     /transl_table=11
                     /translation="MFDEIYNSENDTFVKLEQIFELNVFCPVHIDGEKDIAVAYLMNDA
                     VESFLIFRDSAMTGNYCDIDVEQIASIDKLDDGYMLIVNQGGENIFTIRFRKLVLRTHL
                     FNYGCMGHFWVKGYEYLRQLEYQLADIRDKYRYLGDEYCSEKEMQLMKLADFPPIKRYK
                     SVPDRYYVPYPDCVYQETIDYLLSIAQQVNDSSMARAIRNYGKKTSRYNSFLIYMMLHT
                     KKHANFVDALIKELREAASIYDDRTFSEDERREHKRIHLVAENKLKEYEKRGFRGILYR
                     EEPFMYSKDSITYKEHLLIYRNGLVNRHTMILTFE"
     PFAM_domain     complement(4407..5210)
                     /aSDomain="DUF3878"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12994.9"
                     /description="Domain of unknown function, E. rectale Gene
                     description (DUF3878)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_53_0008"
                     /evalue="3.40E-57"
                     /label="ctg3_53"
                     /locus_tag="ctg3_53"
                     /protein_end="278"
                     /protein_start="10"
                     /score="194.3"
                     /tool="antismash"
                     /translation="DTFVKLEQIFELNVFCPVHIDGEKDIAVAYLMNDAVESFLIFRDS
                     AMTGNYCDIDVEQIASIDKLDDGYMLIVNQGGENIFTIRFRKLVLRTHLFNYGCMGHFW
                     VKGYEYLRQLEYQLADIRDKYRYLGDEYCSEKEMQLMKLADFPPIKRYKSVPDRYYVPY
                     PDCVYQETIDYLLSIAQQVNDSSMARAIRNYGKKTSRYNSFLIYMMLHTKKHANFVDAL
                     IKELREAASIYDDRTFSEDERREHKRIHLVAENKLKEYEKRGFRGI"
     CDS             complement(5277..6038)
                     /locus_tag="ctg3_54"
                     /transl_table=11
                     /translation="MYIFVCEDRFEDMMCCIYQAWEKALKVGHGCVRLERCGNEQPSLF
                     DEYIHVDFNEDEYNKVVRSIKQKISNEAYACVYYACLSSEQDALDAAYRFLVIGFKAGA
                     AITYMRTEPSVMRIKDIRRRVINEARYFREFARFNSVDGKVYVCHLEPKSDVIYEVAQH
                     FADRMPSENWLIIDDNRSKAVIHPIDGEMYIRYLTDYEIEALSGPEAVNDEYTDMWKAF
                     FEAIAIKQRNNEKCQRNLMPLWMRKHVTEFH"
     aSDomain        complement(5283..6029)
                     /aSDomain="TIGR03915"
                     /aSTool="tigrfam"
                     /description="SAM_7_link_chp: probable DNA metabolism
                     protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_54_0003"
                     /evalue="3.30E-69"
                     /identifier="TIGR03915"
                     /label="ctg3_54"
                     /locus_tag="ctg3_54"
                     /protein_end="252"
                     /protein_start="3"
                     /score="231.3"
                     /tool="antismash"
                     /translation="FVCEDRFEDMMCCIYQAWEKALKVGHGCVRLERCGNEQPSLFDEY
                     IHVDFNEDEYNKVVRSIKQKISNEAYACVYYACLSSEQDALDAAYRFLVIGFKAGAAIT
                     YMRTEPSVMRIKDIRRRVINEARYFREFARFNSVDGKVYVCHLEPKSDVIYEVAQHFAD
                     RMPSENWLIIDDNRSKAVIHPIDGEMYIRYLTDYEIEALSGPEAVNDEYTDMWKAFFEA
                     IAIKQRNNEKCQRNLMPLWMRKHVTEF"
     PFAM_domain     complement(5286..5774)
                     /aSDomain="DUF4130"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13566.8"
                     /description="Domain of unknown function (DUF4130"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_54_0009"
                     /evalue="2.00E-43"
                     /label="ctg3_54"
                     /locus_tag="ctg3_54"
                     /protein_end="251"
                     /protein_start="88"
                     /score="148.0"
                     /tool="antismash"
                     /translation="LDAAYRFLVIGFKAGAAITYMRTEPSVMRIKDIRRRVINEARYFR
                     EFARFNSVDGKVYVCHLEPKSDVIYEVAQHFADRMPSENWLIIDDNRSKAVIHPIDGEM
                     YIRYLTDYEIEALSGPEAVNDEYTDMWKAFFEAIAIKQRNNEKCQRNLMPLWMRKHVTE
                     "
     CDS             complement(6080..7537)
                     /locus_tag="ctg3_55"
                     /transl_table=11
                     /translation="MFYNEHMFEIKCNLTTKEKLEILADAAKYDVACTSSGVDRKGRKG
                     FLGNSEACGVCHSFGADGRCISLLKVLFTNHCVYDCKYCVNRCSNDVPRASFEPDELCQ
                     LVIEFYKRNYIEGLFLSSGVLKNPSYTMEKICETLLLLRTKYRFNGYIHVKAIPGAPDE
                     LLSKAGYLADRVSVNLELPTSDSLSKLAPNKNFKNILEPMEKITGTIAANRLSVGKDAR
                     MERSSINKYLTGSIFNSANNSRYGSLSGKNRTALESGTGLSLPAVSGNTGMNRAFAPAG
                     QSTQMIIGATPETDLTLIRTTQHLYQNYDLKRVFYSAYIPLNEDSALPELDAEIPLLRE
                     HRLYQADWLLRYYGFQADELLSENRPNFNEYLDPKCDWAVRHLGQFPVEIQTASYDMLL
                     RIPGVGPKSAKRIVQTRKYARLDFDTLKKMGVVLKRAHYFITCNGKMMYKIPINENYIT
                     ACLMGDNQKENWEIKHQNQQYQQLSLF"
     aSDomain        complement(6083..7489)
                     /aSDomain="TIGR03916"
                     /aSTool="tigrfam"
                     /description="rSAM_link_UDG: putative DNA
                     modification/repair radical SAM protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_55_0004"
                     /evalue="6.20E-206"
                     /identifier="TIGR03916"
                     /label="ctg3_55"
                     /locus_tag="ctg3_55"
                     /protein_end="485"
                     /protein_start="16"
                     /score="682.3"
                     /tool="antismash"
                     /translation="KEKLEILADAAKYDVACTSSGVDRKGRKGFLGNSEACGVCHSFGA
                     DGRCISLLKVLFTNHCVYDCKYCVNRCSNDVPRASFEPDELCQLVIEFYKRNYIEGLFL
                     SSGVLKNPSYTMEKICETLLLLRTKYRFNGYIHVKAIPGAPDELLSKAGYLADRVSVNL
                     ELPTSDSLSKLAPNKNFKNILEPMEKITGTIAANRLSVGKDARMERSSINKYLTGSIFN
                     SANNSRYGSLSGKNRTALESGTGLSLPAVSGNTGMNRAFAPAGQSTQMIIGATPETDLT
                     LIRTTQHLYQNYDLKRVFYSAYIPLNEDSALPELDAEIPLLREHRLYQADWLLRYYGFQ
                     ADELLSENRPNFNEYLDPKCDWAVRHLGQFPVEIQTASYDMLLRIPGVGPKSAKRIVQT
                     RKYARLDFDTLKKMGVVLKRAHYFITCNGKMMYKIPINENYITACLMGDNQKENWEIKH
                     QNQQYQQLSLF"
     CDS             complement(7622..7957)
                     /locus_tag="ctg3_56"
                     /transl_table=11
                     /translation="MEKQIVNIGPRLKQRRKEMHIKQIDMAKQLGVSQAFLSNVEAGRI
                     NCSLPLLTDICCILNVTPDYLILGHMRGNKASSDLIDELKMCNTEELEAIKRIVDAFVI
                     KKTGMYA"
     PFAM_domain     complement(7760..7924)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_56_0010"
                     /evalue="5.70E-11"
                     /label="ctg3_56"
                     /locus_tag="ctg3_56"
                     /protein_end="66"
                     /protein_start="11"
                     /score="42.4"
                     /tool="antismash"
                     /translation="LKQRRKEMHIKQIDMAKQLGVSQAFLSNVEAGRINCSLPLLTDIC
                     CILNVTPDYL"
     CDS             complement(7965..8666)
                     /locus_tag="ctg3_57"
                     /transl_table=11
                     /translation="MEYTDSYRAFCERLKISRKLLDYDQVRMASELDMTRDEYANKETG
                     RTMITGTDLKKINNIGMDIDKLLVNVERDVNCQILKGKVATFNNTSEIEYVKGVVTEYM
                     LYLCEQHLDDFTENVLKNIRILKAFDNISSKNTGSMLKCVRDINGITDQLMISEDLGIS
                     RYKYSKIENNKEYPDAMVLIRLYELYGYLPTMYLDLYDVRIEMLDNIYDSMEIREQDLI
                     IKFIDNLKQFV"
     PFAM_domain     complement(8061..8255)
                     /aSDomain="HTH_19"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12844.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_57_0011"
                     /evalue="2.20E-14"
                     /label="ctg3_57"
                     /locus_tag="ctg3_57"
                     /protein_end="202"
                     /protein_start="137"
                     /score="53.3"
                     /tool="antismash"
                     /translation="GSMLKCVRDINGITDQLMISEDLGISRYKYSKIENNKEYPDAMVL
                     IRLYELYGYLPTMYLDLYDV"
     CDS             8979..9128
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_58"
                     /sec_met_domain="TIGR04223 (E-value: 1.5e-07, bitscore:
                     26.6, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVIKSTLSKGVTAVLNRTLTSSANESSSLVFSQPVEPAELKKF
                     KKVR"
     aSDomain        9003..9110
                     /aSDomain="TIGR04223"
                     /aSTool="tigrfam"
                     /description="quorum_AgrD: cyclic lactone autoinducer
                     peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_58_0005"
                     /evalue="1.10E-06"
                     /identifier="TIGR04223"
                     /label="ctg3_58"
                     /locus_tag="ctg3_58"
                     /protein_end="44"
                     /protein_start="8"
                     /score="26.6"
                     /tool="antismash"
                     /translation="LSKGVTAVLNRTLTSSANESSSLVFSQPVEPAELKK"
     CDS             9128..9706
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_59"
                     /sec_met_domain="AgrB (E-value: 1.2e-29, bitscore: 98.3,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEKFSRKIAVWLIKSGILENDNSELYGYAIQYLLLIIIPTINFL
                     AYCIATHNNIIGLIILFSFLLIRKYSGGYHCKSSTVCLIFSTIVLIAMVFYANLMNFSP
                     VIIITIILCELELIIKGPIISINHDISDKERIIYRKYLYVILAVYDIIMALFIYFNKIH
                     LACSIAIVIITCSLAHMICMIGKNKEVYY"
     PFAM_domain     9143..9667
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_59_0012"
                     /evalue="4.50E-28"
                     /label="ctg3_59"
                     /locus_tag="ctg3_59"
                     /protein_end="180"
                     /protein_start="5"
                     /score="97.9"
                     /tool="antismash"
                     /translation="SRKIAVWLIKSGILENDNSELYGYAIQYLLLIIIPTINFLAYCIA
                     THNNIIGLIILFSFLLIRKYSGGYHCKSSTVCLIFSTIVLIAMVFYANLMNFSPVIIIT
                     IILCELELIIKGPIISINHDISDKERIIYRKYLYVILAVYDIIMALFIYFNKIHLACSI
                     AIVIITCSLAHM"
     CDS             complement(9729..11042)
                     /locus_tag="ctg3_60"
                     /transl_table=11
                     /translation="MGIVLSYAFAHIIEAVILWMSMSQMYEHRYKKWVTGLIIMIGHAI
                     MFMVFLSNNMAISMTVNNIVYILLIAVLYKVNKKAAVFWAVLFNSLISLAEVMVLFMTQ
                     YIVGIENVKSQNTLIILTVLCLCKILYFLFAQIIIIIKKKSFVKMSESIDISMALLLLI
                     LVSSLIVCMTFYSIGMKWNLEKRETIWMIISMIVLVISDILILLVNIKINERNAENQRI
                     KLELAKERADAEYYKLEHEKNEKFEILRHDIKAHLNAMLDMGTDENIKQYILEIIEDYS
                     IGIKTKFSKSNVLNGLLSQYMNKCSDNGINMLVDIRPDTVEYLSQTDIVALFGNMLSNA
                     YEASCKCIATEKPYIELITKRNGSLLIIKTTNSCDIKPEKINNNYVTSKLDDKNSHGYG
                     MKSIYNVVDKYNGSHVENYDENSREFSISIILLIEKEE"
     PFAM_domain     complement(9750..10070)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_60_0013"
                     /evalue="1.90E-18"
                     /label="ctg3_60"
                     /locus_tag="ctg3_60"
                     /protein_end="431"
                     /protein_start="324"
                     /score="66.3"
                     /tool="antismash"
                     /translation="SQTDIVALFGNMLSNAYEASCKCIATEKPYIELITKRNGSLLIIK
                     TTNSCDIKPEKINNNYVTSKLDDKNSHGYGMKSIYNVVDKYNGSHVENYDENSREFSIS
                     IIL"
     CDS             complement(11046..11756)
                     /locus_tag="ctg3_61"
                     /transl_table=11
                     /translation="MNILICDDDKICVERMKEYVQDFFRDRKIADYKIYEYFSGEAAAR
                     ESDIIDIAFLDVEMEGINGIEASKILRKNNKGIVVFIITSYMGYLDDAMDEGVFRYINK
                     PLDKNVISRGLRKAVELCYKKQSKKIVIKESKNNVIIEQDDIIYIESIARKRCVYTEKQ
                     EYLTLESLAYWKKLLDDDMFFLVNKSIIVNIKKVEQFSNNNIRLKGIEQEIPLSRDRKS
                     EFKQKLLLYLAGQE"
     PFAM_domain     complement(11073..11342)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_61_0015"
                     /evalue="5.80E-18"
                     /label="ctg3_61"
                     /locus_tag="ctg3_61"
                     /protein_end="228"
                     /protein_start="138"
                     /score="65.0"
                     /tool="antismash"
                     /translation="VIIEQDDIIYIESIARKRCVYTEKQEYLTLESLAYWKKLLDDDMF
                     FLVNKSIIVNIKKVEQFSNNNIRLKGIEQEIPLSRDRKSEFKQKL"
     PFAM_domain     complement(11424..11750)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_61_0014"
                     /evalue="1.00E-13"
                     /label="ctg3_61"
                     /locus_tag="ctg3_61"
                     /protein_end="111"
                     /protein_start="2"
                     /score="51.5"
                     /tool="antismash"
                     /translation="ILICDDDKICVERMKEYVQDFFRDRKIADYKIYEYFSGEAAARES
                     DIIDIAFLDVEMEGINGIEASKILRKNNKGIVVFIITSYMGYLDDAMDEGVFRYINKPL
                     DKNVI"
     CDS             complement(11797..13764)
                     /locus_tag="ctg3_62"
                     /transl_table=11
                     /translation="MAELKRVFSYKRWLLLILCILVNLCLFAYKNIPLSKNDISERTLK
                     SQEEYISGYNGYVTAIINKAEELQKFSIFAEEGTFAYSNIIKTSEDFERISNVNVSVDE
                     SRAVSAFTEYHYSFYIAFVFMLGIIYELFRYRDNGMWAINCSTAKGREYIAVSSIFAII
                     IGGFISVVSMAVTTFILALLIYGGAGDIGNAIQNIKQFSKFTYPVSKIEYVIILIIISS
                     IVIIMLGLIIWSVFVAFRQRNNALLCLGLFIGVEIILYRNISIQSRYNVFHFINIINLL
                     QINDMIRTYINWGFRYYVFSAASVTLFVTTITTVLLMCMAYYRCIIMKPYGKRTIIDKI
                     TGKINEAYQHVLKKMPQICKELHKLIFSGYGLWLIVTVIFVTCYFSRNNVMHYNDAQIV
                     MDKMYIEHGGYDSSYIRSYVEEKQEAVREMKNKLDELKAQESMKETYPEWESEYMHAYG
                     EYQYVLKEAAACLEYSQKLANADNIYSVYGRKAWIISDRNYEQLIGESARLREFIIFIV
                     SIIVVVIITVENIMLEQKTGMEYILNSSAYGRKKRWLRKYLAMVIFTGCFTLITCIIQF
                     MIIKSLYGMPYINAPVLSLSFIYEKIGKGIYKINIFKNLLINLNIRQYIFIHYAKWIVI
                     SYVVMNVSILVSALWMHKRK"
     CDS             complement(13785..15038)
                     /locus_tag="ctg3_63"
                     /transl_table=11
                     /translation="MNRVAKKLIIPAGILLAILAVIAVYFGTHKVSKHSAQPDYGSLGS
                     GYELDDSQSYWKANFLHDFTAAEDGYYFITPDMTYLMYFDYATKEVVPVCGKPDCAHDN
                     STCNANMMKQSYVVSNIYYHEGYLYYMQIQNGMSVLTRMDKSGNNVENIGEIFPSDQDS
                     STHLVFHGDYVYAYYLCAHYGMEGEFTEAIKKMSLKDGSSENIYEVTGNNISIGLVKSY
                     GDKLYFAVQEQLEKRSMRSKTKALYSYDYNTKEIKLVAEDDISDYCFIPEKNIFAYYVV
                     GEGLYYADAKEQVMKLVMKSDSLYDRCSMSYDGKHIYMDNITFQNMTRTVEKREYRIII
                     IDSDGNKINEIECDDTINNIYYGDERCMFAWGSVPKKDERAEYFSGYLYIDKKDIEHAA
                     QWESVYDDTIFLFNPFKK"
     CDS             complement(15047..15745)
                     /locus_tag="ctg3_64"
                     /transl_table=11
                     /translation="MKKKKIFILAVAIFICIATAIITLICVFSKKEYPVIKKTKVDGEN
                     YIREIYPEIEVRYPKVEIDEESKEVYMTDVFSHWSYDKENDADRMRRTIAYIFSLTDIY
                     NEENAEKIYLRAANAAVTIADTRSYTFLESEKRNKLRYTSRWVEINPEKQRNVKMYIYC
                     NVPLKFKFGSEYYTEPNAQITALLEELESVVIEEKVIYKDGSEKTDYFIFKSGSSTCLN
                     DETMFRVKLK"
     CDS             complement(15816..16217)
                     /locus_tag="ctg3_65"
                     /transl_table=11
                     /translation="MVKKSIKRLVVAGIVSVLVVANSIIAFASSHDFDGYAGSCHYSGG
                     AYIDPNRDNGIYDAFGAYVSTSETADLTVLGYGTYDDDMTKLWYSGGEAQTTYASGYRY
                     SNVSIGKNAGYVLIDAMDDAVREDYVVYR"
     CDS             complement(16557..18407)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     320.1; E-value: 1.7e-97)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 345.9; E-value:
                     7.1e-105)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_66"
                     /transl_table=11
                     /translation="MEDNKNIKMPPKRRMGPPGRGMAPVEKAKDFKGSIGKLIRYIGSY
                     KIAIIFVAVMAVCSTVFSVVGPKVLGKATTALSEGLVKKIGGTGGIDFGKIGTILIFVL
                     CLYAASAVFNFVQGWIMTGITQKVCYRLRKEISEKINRMPMKYFESRTYGEVLSRITND
                     VDTLGMGLNQSITTIITSLTTMIGVLVMMLSISPLMTLIAVIILPISVGLVSFVVKKSQ
                     GYFKTQQEYLGHINGQIEETYGGHMIVKSFNKEKDMVDSFNKTNDVLYGSAWKSQFLSG
                     MMHPIMMFVGNLGYACVALTGGLLAIKNVITIGDIQAFIQYVKNFTQPIQQIAQVINQV
                     QSMVAASERVFEFLDEEEEDQTVKNPVSTEGIKGEVDFEHVRFGYNENQTIIKNFSVNV
                     KPGQKVAIVGPTGAGKTTIVKLLMRFYDVNDGAILVDGHNVKDFNRRELRDAFGMVLQD
                     TWLYKGTIMENIRYGKLDATDEEVIAAAKAANAHHFIETLPGGYDCELNEDASNVSQGQ
                     KQLLTIARAILADNPILILDEATSSVDTRTEERIQKAMDNLMKGRTSFIIAHRLSTIKD
                     ADVILVMKDGDIVEQGTHDELLAKNGFYADLYNSQFEQAS"
     PFAM_domain     complement(16785..17231)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_66_0017"
                     /evalue="2.20E-30"
                     /label="ctg3_66"
                     /locus_tag="ctg3_66"
                     /protein_end="541"
                     /protein_start="392"
                     /score="106.1"
                     /tool="antismash"
                     /translation="KNFSVNVKPGQKVAIVGPTGAGKTTIVKLLMRFYDVNDGAILVDG
                     HNVKDFNRRELRDAFGMVLQDTWLYKGTIMENIRYGKLDATDEEVIAAAKAANAHHFIE
                     TLPGGYDCELNEDASNVSQGQKQLLTIARAILADNPILILDEATS"
     PFAM_domain     complement(17421..18263)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_66_0016"
                     /evalue="2.40E-53"
                     /label="ctg3_66"
                     /locus_tag="ctg3_66"
                     /protein_end="329"
                     /protein_start="48"
                     /score="181.7"
                     /tool="antismash"
                     /translation="IIFVAVMAVCSTVFSVVGPKVLGKATTALSEGLVKKIGGTGGIDF
                     GKIGTILIFVLCLYAASAVFNFVQGWIMTGITQKVCYRLRKEISEKINRMPMKYFESRT
                     YGEVLSRITNDVDTLGMGLNQSITTIITSLTTMIGVLVMMLSISPLMTLIAVIILPISV
                     GLVSFVVKKSQGYFKTQQEYLGHINGQIEETYGGHMIVKSFNKEKDMVDSFNKTNDVLY
                     GSAWKSQFLSGMMHPIMMFVGNLGYACVALTGGLLAIKNVITIGDIQAFIQYVKNFTQP
                     "
ORIGIN
        1 ttatttacca ataaattcca ttacctgtcc ttcacttata aaaccaacac tctttgccac
       61 acactcacca ctcttaaata aaagtaatgt agggattgac ataatattat atttctctgc
      121 aactgatgat tcctcatcca cattaatctt tacaatctga acatcatcca ccttagctgc
      181 aacctgttca agaactggtc ctaacatctt gcatggtccg caccagtctg cccagaaatc
      241 cacaagaacc ggcttatccg ctttaagtac ctcattattg aattcacttg cttttacatg
      301 tttgatttcc atatcttatc tcctttatct ttaataatta ttatttcata tttctccgca
      361 tatattcaaa tttttctctt ctcatctcca caagcatctg cttaatattc cactttctat
      421 tagtatctgt caatactgcc ttaaatgata catcaaaact cttctgtctc atttcaaaaa
      481 gaagcttatc catatgctta tctgtcacat cacaaaatac aataagactc tctttatttt
      541 cttgtggctg atatccctct gcatctgata atgatatgcc tcttacatca tctgcaattt
      601 ctgccagagt ccggtctgta tccgactcat taatgaatcc acttataatt ctcatattag
      661 atgctgcttt aatgatatgc tgagggttct taacattata taacaatatc ttttccaaca
      721 ttaattatcc ttctttgcct ttctgttagc aataatttct ttgatttcat taatagattc
      781 tttatgtact ctcgaaacag cattaggatt tctcttaata atatttgtaa tatgactgta
      841 tcttctatca gctctctcag ataactgtct tctttcttca gccactgctg ccatgaattg
      901 ttcctttttc ttattaaatt cttcttctgc aaatgtggcc gtaatctcca ttcttctggc
      961 atacatctga agctgttcat tctctttcgt aaatttttca agtgtcgcct taaggtccat
     1021 agcctcatta attgaaacag caaaatctgc tgccatgtat attgccagaa ctactgcaat
     1081 aatatctgct attgttcttg gaatcataag tactgttgct tcgatgggct tgtgtattac
     1141 acacacaagc aaaatagaga atgctcccca tgcaagtgat ataaagaaac atatatgccc
     1201 tttaaaatta agtggaagat tgctgtaatc ccagtatctt acaccaaaaa gcttctccat
     1261 gcagcagcct gtgcagaatt caagtattgt agatgatacc attccaaaca gaaaaactaa
     1321 tggaacaata tctttcactg caatcgtact aatcaatatt acaattgccc ccgaaccata
     1381 tattggcagg aatggaccat gcaggaagcc tctgtttacc cacttatgtt tcctcactga
     1441 aacataacag cattcccata tccaacctaa aaaacaatat ataaagaaaa aaataagcca
     1501 ctgtgataca gtataatatc tcataaacaa tcctcacttt ccattttgta agaactatta
     1561 atatttcctg tcattattta acaacatcaa aaaacttatc cataataaaa gttctcctac
     1621 ttctgctaat ttcgatataa ttaccatctg caaatttcac gcaattattc ttaatgtttg
     1681 taacttgata aaaattaaca actacagatt tattaatata ttcaaaacct tcatcgtaaa
     1741 gcagattata tatttcagcc agacttccat atatagctat ggcttcagaa ctccgggaat
     1801 acatcactat tttccttcca gttctttcaa aataaataat atcagacacc ttttccttac
     1861 acacatgtct cgatgaatga tacacaaaat aactctcccc acatcgcttg cataatttta
     1921 tctccaagta aatattctcc tctcacatat tatcaaagct ttttatcagc tccatcttaa
     1981 ttatatatga tataaaaaat atttcaatgg aataattctg tatgttcata cgcaattagg
     2041 tcgaaaatta ttacgcctga taaataatct ttcctgagca tatagtatag tgtactttcc
     2101 caggaagctc ccatcctata aacggactgt tacatgcctt agatgcaaaa tcctctctat
     2161 tgactgtcca caaatctttc tctccaaaaa taacaatatc cgctgatgca ccttttgtta
     2221 tacttccagg aaccattcta taaaactcag caggattctt actcataagc tcaataagtt
     2281 tcattaatga tatatgtccc ggttcaacaa gcgattttat accaagtgca agtgatgtct
     2341 ctaatcctgt tattccactt ggtgcatttt ctaatggctt tgctttttct tcttcactat
     2401 gcggagcatg atctgttact atcatatcaa tcgttccatc ttttatgcct tctataatct
     2461 tttctctgtc attctctgtt cttagtggag gattcatcct tgcattagtt ccatacttaa
     2521 gtacagcatc ctcagtaagt gtaaagtgat gaggagtggc ttctgcatgt atatcagcgc
     2581 ccagtttctt tgcaagtctt accagttcta cagaattacc tgaactgata tgctgaatgc
     2641 atactgatgc tcctgtattt aatgccagca tacaatctct ggcaaccata acatcctctg
     2701 ccgttgcaga agctccacca tagccaagct gatcagatac ctttccctga ttaactcccg
     2761 gccttattat aaattcaggg tcttcttcat gcagacttat tggcagatcc agttctacag
     2821 ctttcttcat ggctgtaaca agaacatgtt catccataat aggaatacca tcatctgtaa
     2881 atcctgctgc tcctgcatct gcaagtgctt ccatatctac aagctctgtt ccattaagtt
     2941 ccttcgtaac agtagctgtc tgcataacat gaattcctgt tgtttcacct ttttcctgaa
     3001 tatacctaag agtctctaca ttatctacaa ctggctttgt attagccata catacaacag
     3061 ttgtaaaacc tcctctggct gctgcagatg cacctgtgat aatatcttcc ttataggtaa
     3121 aacccggatc cctgaaatgc acatgagtat ccacaagacc tggagctaca atcatgccat
     3181 ctgcattaat aatcttaata ttatcagatt cttcagaatt gaaatcagct gcattaatgt
     3241 catgaccgat ttcttcaata acattattct taataaaaac atcaataacc tcatctgttc
     3301 cagacacagg atcaacaaca cggccattct taatgagaat acttgtattc tgtatctctt
     3361 tcttctcatc tgtttcctgt ttatcttctg gcattttata ttcatccatc ttaattccac
     3421 atcctgcaca aaatacagaa tcaggactat taacaaaacc acatgctgga catgttttat
     3481 attcagtttc aacaattgat acattaatat catctaagtt gagtctgttt ccgcaattac
     3541 tacagaacac tgcatctgcc aaagcattat atgttccaca caccggacat gttttccctg
     3601 cattaccact atttattggc tgtactggtg ttattaccgg ctcagaatat gaagcaggat
     3661 gcatctgtgg cacatttgga ataataacct ttactgaatc ggcatattcc ttaagagtat
     3721 cccacgacat gctgtccgga tgccttaaca tatcattaag tcgttcaata tatgacacgt
     3781 ctgtagcaga tggtgtcgtc atgttgctga caacatcgcc caaaaaagta ttaaaaaagt
     3841 tgccattatt atatccatat accggataat acaagtacat tgcccttcct gttcttgatt
     3901 caacaagtac agtatcaagt gaaactaaaa cattgccata ctccatatta tatgccgaca
     3961 ttcctgataa tgctttaaca ctgctatcga taaaattata aaatgtattc tgatctatca
     4021 ctctgttttt aaaaaaatcc ttcgcagtct caaatccagc agcaccatac tctgctgtaa
     4081 atccttctga attagtaact atataaaaag gcagaaatcc ctcaacatta acactagaaa
     4141 ggtaggcagc catattctga ttgagttgct caccattaga acttctgatt tgaactttaa
     4201 cctgattatt ctttgatgta acctttactt tccccataat aaactcctct cttttcttta
     4261 attcagatat aataaaagat atatataaat cattcgaaag tcaatatcat tgtatgcctg
     4321 tttacaagac catttctata tataagtaaa tgttctttat atgtaattga atcctttgag
     4381 tacataaatg gttcttctct gtataatatt cccctgaatc ctcttttttc atactctttc
     4441 agtttgtttt ccgcaacaag gtgaatccgt ttatgttccc ttctttcatc ctctgaaaat
     4501 gttctgtcat catatatgga tgctgcctct ctcagctcct taattaaggc atctacaaaa
     4561 tttgcatgtt tcttggtatg aagcatcata tatattaaaa aactgttata tctcgatgtt
     4621 ttctttccgt agtttcttat tgcccttgcc atagagctgt cattaacctg ctgtgcaata
     4681 cttaaaagat aatcaatggt ctcctgatac acacaatccg gataaggtac ataatacctg
     4741 tctggaacag acttatatct cttaattggc ggaaaatctg ccagcttcat aagctgcatt
     4801 tctttctcac tacaatattc atcgccaaga tatctgtact tatctcttat gtctgcaagc
     4861 tgatattcaa gctgtcttag atactcataa cctttaaccc agaaatgtcc catacatcca
     4921 taattaaata aatgagttct taacaccagt ttcctaaatc tgattgtaaa tatattctct
     4981 ccaccttgat taacaatcag catatatcca tcatcaagct tatcaatact tgcaatctgt
     5041 tccacatcaa tatcgcaata attcccggtc attgcagaat ctctgaatat aagaaaactc
     5101 tcaacagcat cattcataag atacgcaact gctatatcct tttcaccatc tatatgaaca
     5161 ggacaaaaca cattgagttc aaatatctgc tccagcttca caaatgtatc attttcacta
     5221 ttgtatattt catcaaacat attcctataa aaactaatcc tttaatatac tgtgtattaa
     5281 tgaaactccg tcacatgctt ccgcatccat aacggcataa gatttctctg acacttctca
     5341 ttatttctct gtttaatggc aatagcttca aaaaaagctt tccacatatc cgtatactca
     5401 tcattaacag cttctggacc agacaaagcc tctatctcat aatccgttaa atacctgata
     5461 tacatctcac catctatagg atgtataacc gctttactac ggttatcatc aattataagc
     5521 cagttctctg acggcatcct gtctgcaaaa tgctgtgcca cttcgtatat cacatcactc
     5581 ttcggttcaa gatgacacac atataccttt ccatcaacag aattaaacct tgcaaactcc
     5641 ctgaaatatc ttgcttcatt aataactctt ctgcggatat ccttaattct cataacagac
     5701 ggttccgtcc gcatataagt aattgctgca cctgccttga atccaattac tagaaatctg
     5761 tatgcagcat ccagtgcatc ctgttctgac gaaaggcatg cataatatac gcatgcataa
     5821 gcttcattag aaatcttctg ctttatagaa cggacaacct tattatattc atcctcattg
     5881 aaatctacat gaatatattc atcaaataaa gacggctgtt catttccaca cctctcaagt
     5941 ctaacacatc cgtgtcctac tttcaaagcc ttctcccatg cctggtatat gcagcacatc
     6001 atatcttcga atctgtcttc acaaacaaat atatacatac cacagcctcc actcataata
     6061 attatgtgca ttaattcttc taaaacaatg ataattgctg atattgctgg ttctgatgct
     6121 ttatctccca attctccttt tggttgtcac ccataagaca tgctgttata taattctcgt
     6181 ttattggaat tttatacatc atctttccat tacatgtaat aaaataatgt gctctcttaa
     6241 gtactactcc catcttcttt aatgtatcaa agtccagcct tgcatacttt cttgtctgca
     6301 caattctctt ggcagactta ggaccaactc ccggaatccg caacaacata tcatatgatg
     6361 cggtctgtat ctcaaccgga aattgtccca gatgccttac tgcccagtca cacttcggat
     6421 ccagatattc gttaaaattc ggtctgtttt cagataaaag ctcatcagcc tggaatccat
     6481 aataccttaa aagccagtct gcctgataaa gtctgtgttc cctaagaaga ggaatctctg
     6541 catccaattc tggtaatgct gaatcctcat taagtggtat atatgccgaa taaaaaactc
     6601 tctttaaatc ataattctga taaagatgct gggtagtcct tataagtgta agatctgtct
     6661 ctggcgtagc tcctattatc atctgagtgc tctggcctgc aggcgcaaaa gccctgttca
     6721 tccctgtatt tccagaaaca gctggcaaag ataacccggt tcccgattca agtgctgtcc
     6781 tgttctttcc tgataatgaa ccatatctgc tattgttcgc cgaattaaat atacttcctg
     6841 taagatattt attaatactg cttctttcca ttctggcatc cttgcccaca gacagcctgt
     6901 tagccgctat agtgcctgtt atcttttcca tcggttcaag gatattctta aaattcttgt
     6961 tcggtgcaag cttagaaaga ctatctgatg tcggcagttc aagattcacg cttaccctgt
     7021 cagcaagata acccgccttt gataataatt catctggcgc cccaggaatt gctttcacat
     7081 gaatatatcc attaaatcta tacttggttc ttaaaagcag caaagtctca catatcttct
     7141 ccatcgtata ggacggattc ttaagtaccc cagaacttaa aaataatcct tcaatatagt
     7201 ttcttttata aaattcaata acaagctgac ataattcatc cggttcaaaa gatgctcttg
     7261 gaacatcatt ggagcacctg ttcacacagt acttacaatc atatacgcaa tgattagtaa
     7321 acaaaacctt aagaagagaa atacatctgc catcagcacc aaaactatga cacacgccgc
     7381 atgcctcact gtttccaagg aatcctttcc tgcctttcct gtctactcca cttgatgtac
     7441 atgcaacatc atatttagct gcatcagcca gaatctccag cttctccttt gttgttaaat
     7501 tacattttat ttcgaacatg tgttcattat aaaacatttg ttcgaaaagt caatatctaa
     7561 tcgtaaaata tacaaaaaac cctttaccag aattctccag taaagggctt atttctatac
     7621 attatgcata cattcctgtc ttttttatta caaatgcgtc aactattctt tttatcgctt
     7681 ccaactcttc cgtattgcac attttaagtt catctatcaa atcactgctt gctttgttgc
     7741 ctctcatatg acctaaaatc agataatcag gcgtaacatt tagaatacag catatatcag
     7801 taagcaaagg tagactgcaa ttaattcttc ctgcttcaac attagataaa aatgcctgtg
     7861 aaacacctaa ctgctttgcc atatcaatct gcttaatatg catttctttt cttctctgtt
     7921 taagtctcgg tccaatatta actatctgtt tctccataac ttcctcacac gaactgttta
     7981 agattatcta taaactttat aatcaaatcc tgttccctga tttccatact gtcatatatg
     8041 ttatcaagca tttctattct tacatcatat aaatcaagat acattgttgg cagatatcca
     8101 tataactcat acaatcttat aagaaccatt gcatcaggat attctttgtt attctcaatc
     8161 ttgctgtatt tatatcttga aattcctaaa tcttcagaaa tcatcagttg gtcagttatg
     8221 ccgttaatat ccctgacaca tttaagcata gagcctgtat tttttgatga tatattatca
     8281 aatgctttaa gaattctgat atttttcaga acattttctg taaaatcatc caaatgctgt
     8341 tcacacagat ataacatata ttcagttaca acacctttaa catattctat ttctgaagta
     8401 ttattaaatg tagcaacttt cccctttaaa atctgacaat ttacatctct ttcaacatta
     8461 accaataatt tgtcgatatc cattcctata ttgtttattt tctttaaatc agttccagta
     8521 atcattgtac ggcctgtttc tttatttgca tattcatctc tggtcatatc caattcagac
     8581 gccatcctca cctgatcata atccaataac tttctagata tcttcaatct ttcacaaaat
     8641 gctctataac tatctgtata ctccatagca acccctatac attagtatga ttactattaa
     8701 attttagtat acgcgcgggt tgcacatgta taatgtatat tgcgaattta attattaata
     8761 atgtgtatat ataatctttg atatttattg tatatcagtt attgttctta attagtattt
     8821 ttatatataa taatattcct atatattata aaatattaca taattttatc gtaaaataca
     8881 tttaagacat caaaatatac agatgcgaca aataccattt aatatttgaa aatatagaat
     8941 ataattaagt atatcaatta tcaaggaggt ttttgcatat gaaaaaggtt attaaatcta
     9001 cattaagcaa gggtgtaaca gcagttctta accgcacact tacatcaagt gctaatgaat
     9061 cttcaagctt ggttttcagc cagcctgtag agccagcaga attaaagaaa ttcaagaagg
     9121 ttagataatg cttgagaaat tttctagaaa aattgctgta tggttaatta aatcaggcat
     9181 actggagaat gataactctg agttatacgg atatgcaatt caatatttat tattgattat
     9241 tattccgact attaactttt tagcatactg tatagccacc cacaataata taatcggact
     9301 tattatatta ttttcatttc tgctcatccg gaaatatagt ggtggatatc attgtaaatc
     9361 atctacagta tgtctgattt tttcaaccat agttttaata gctatggttt tttacgctaa
     9421 tttaatgaat ttttctccag taattattat aacaattata ttatgtgaac tggaattaat
     9481 aataaaaggg cctataatat ctattaatca tgatatttct gataaagagc gtattattta
     9541 tcgaaaatat ttatatgtaa tcttagccgt atatgacatt ataatggcat tattcatata
     9601 ttttaataag attcatctag cttgcagtat agcaattgtt attataacct gttcgcttgc
     9661 acatatgata tgcatgattg gaaaaaacaa ggaggtgtat tattaattta atatacctcc
     9721 gcttttattc attcttcttt ttctatcaaa agtattattg atatactaaa ttctcggcta
     9781 ttctcatcgt aattttcaac atgacttcca ttgtacttat caacaacatt ataaatactt
     9841 ttcattccgt atccatgaga atttttatca tccaattttg atgtcacata attattattt
     9901 atcttttcag gttttatatc acaggaattt gttgttttta taatcaacaa actgccattc
     9961 cttttagtta taagctctat atagggtttt tctgtagcaa tgcatttaca tgacgcttca
    10021 tatgcattcg ataacatgtt accaaataat gcaacaatat ctgtttgcga taaatattcc
    10081 acagtatcag gtctaatatc tacaagcata ttaataccat tatcactaca tttattcatg
    10141 tattgactga gaagcccatt taatacatta cttttagaaa atttcgtctt tattcctata
    10201 ctataatctt ctattatctc taaaatatat tgttttatat tttcatccgt tcccatatca
    10261 agcatagcat taaggtgtgc ctttatatca tgtcttaaaa tttcaaattt ttcgtttttt
    10321 tcatgctcca atttataata ttcagcatct gccctttcct ttgccagctc taacttaatt
    10381 ctttgatttt ctgcatttct ctcattaatc ttaatattaa ccaacaatat aagtatgtct
    10441 gatataacca atacaatcat gcttataatc atccatattg tttcccgctt ctctaaattc
    10501 cacttcatgc caatagaata aaatgtcata cagacaataa gtgatgaaac taatattaat
    10561 aacagcaatg ccatagatat atctatactt tcagacattt taacaaaact tttctttttt
    10621 attattataa ttatctgcgc aaataaaaaa tatagtattt tgcataaaca taaaacagtt
    10681 aaaataatca gtgtgttctg gcttttaaca ttctcaattc caacaatata ttgtgtcata
    10741 aataagacca ttacttctgc cagtgaaatt aatgaattaa ataaaacagc ccagaaaacc
    10801 gcagcctttt tattcacctt atacaatact gcaattaata atatatacac tatattatta
    10861 accgtcattg atattgccat attgttagaa agaaacacca taaacattat ggcatgacca
    10921 atcattataa ttaatcctgt tacccatttt ttataacgat gctcgtacat ctgagacatg
    10981 ctcatccata aaattacagc ttctataata tgagcaaacg catagcttaa aacaatcccc
    11041 atcccctact cctgtcctgc aaggtataga agcaattttt gtttaaactc acttttcctg
    11101 tcgcgtgata acggaatctc ctgctctatt cctttaagcc ttatgttatt atttgaaaat
    11161 tgttcaactt tcttaatatt tactataata gatttattta ccagaaaaaa catatcatca
    11221 tccagaagct ttttccaata agctaaactc tctaaagtta aatactcctg tttttcagta
    11281 tacacacatc ttttccttgc aattgattca atatatatta tatcgtcctg ttctataatc
    11341 acattgtttt tggattcctt aatcacaatc ttcttacttt gtttcttata gcacagctca
    11401 actgctttcc gcaaccctct gcttattaca ttcttatcaa gcggtttatt aatataccga
    11461 aacacacctt catccatagc atcatctaga taacccatat aagatgtaat aatgaaaaca
    11521 acaataccct tattattttt tcttaaaatt ttgctggctt ctataccatt aatgccctcc
    11581 atctcaacat caagaaaagc tatatctata atgtcagatt ctctggcggc tgcttctcca
    11641 ctaaaatatt catatatctt ataatcagca atttttctgt ctctgaaaaa atcctgcaca
    11701 tattccttca tccgctcaac acagatttta tcatcatcac atattaatat attcataagc
    11761 ttctcctcgt aatttacgac ttaggaatat tatacattat tttcttttgt gcatccatag
    11821 tgcagatacc aatatactga cattcattac aacataagaa ataacaatcc atttcgcata
    11881 atgaataaaa atatactggc ggatattcag attaatgagt aaatttttaa atatattaat
    11941 tttatagatt ccttttccaa ttttctcata tataaaagaa agacttaaaa ctggtgcatt
    12001 aatatatggc attccatata aactcttaat tatcataaat tgtataatgc atgtgataag
    12061 cgtaaaacat cctgtaaata taaccattgc cagatatttt ctcaaccacc ttttctttct
    12121 tccatatgca gatgaattca aaatatactc cataccagtt ttttgttcca gcataatatt
    12181 ttcaactgta attatcacta caacaataat agatactata aatattatga attcccttaa
    12241 ccttgcactc tcacctataa gctgctcata atttctgtca gatataatcc atgctttcct
    12301 gccgtacaca ctatatatat tatcagcatt tgccaatttc tgactatact ccaagcatgc
    12361 cgctgcctct ttcaatacat attgatattc cccatacgca tgcatatatt cagattccca
    12421 ctcaggatat gtttccttca tactctcctg tgctttcaac tcatcaagct tatttttcat
    12481 ttccctgaca gcttcctgct tttcttcaac atagctgcgt atataactgc tatcatatcc
    12541 tccatgttca atatacattt tgtccattac tatctgtgcg tcattataat gcatgacatt
    12601 atttcttgaa aaataacatg taacaaatat aaccgtaaca ataagccaca atccatatcc
    12661 tgaaaatatc agtttatgca attctttaca gatctgtggc attttcttaa gaacatgctg
    12721 atacgcttca ttaatttttc ctgttatctt atcaataatt gttcgttttc catacggctt
    12781 catgattatg catctgtaat atgccataca cattaataaa accgtcgtaa tagtagttac
    12841 aaacaatgtt accgaagctg ctgaaaacac ataatatctg aacccccaat ttatataagt
    12901 tcttatcatg tcattaatct gcagcagatt aataatattt ataaaatgaa acacattata
    12961 tctgctttga atcgaaatat ttctatatag aataatctct actcctataa acaatcccag
    13021 acataataac gcattatttc tctgtctgaa tgccacaaat acagaccaga ttataagtcc
    13081 aagcatgata atcacaatac tcgatataat tatcaaaata ataacatact caatcttact
    13141 taccggatat gtaaatttac tgaattgttt aatattctga atagcatttc caatatctcc
    13201 tgccccacca tatattaaca atgcaagtat aaatgttgta actgccatag atactaccga
    13261 tatgaatccg ccaattataa ttgcaaatat actggaaact gctatatatt ccctgccttt
    13321 tgcagtactg cagttaatag cccacattcc gttatctctg tatctgaaca attcatatat
    13381 tatgccaagc atgaatacaa atgctatata aaatgagtaa tgatattctg taaatgcact
    13441 aacagcccgg ctctcatcaa ccgaaacatt tacattactt attctttcaa aatcctctga
    13501 tgtttttatt atgttactgt atgcaaatgt accctcctcc gcaaaaatag aaaatttctg
    13561 taactcctct gctttattta ttatagcagt gacatatcca ttataacctg atatatattc
    13621 ctcctgactt tttaatgtcc tttcagatat atcattttta ctcaacggaa tatttttata
    13681 ggcaaataaa cataaattaa ccaatataca taatattaat aacaaccatc ttttataaga
    13741 aaataccctc tttaattctg ccatatagct tcctcattta catcctattt tttgaaagga
    13801 ttaaataaaa atatagtatc atcatataca ctttcccatt gagcggcatg ctctatatcc
    13861 tttttatcta tgtaaagata tccgctaaag tattcagcgc gttcatcttt tttcggtaca
    13921 cttccccatg caaacatgca tctttcatca ccataatata tattatttat tgtatcatca
    13981 cattctatct cattgatttt atttccatcc gaatcaataa taataattct gtattctctt
    14041 ttttctactg ttcttgtcat attttgaaat gttatattat ccatgtatat atgcttccca
    14101 tcatatgaca tactgcaacg atcatataaa gaatccgatt tcatcacaag cttcataacc
    14161 tgttctttag catcagcata ataaagccct tcacctacaa cataataagc aaatatattc
    14221 ttttccggta taaaacaata atctgatatg tcatcctcgg ctactagttt tatctcttta
    14281 gtgttataat catatgaata taatgctttt gttttagatc tcatagatct cttttcaagc
    14341 tgttcctgta ccgcaaagta taatttatcc ccatagcttt tcactaaccc aattgatata
    14401 ttattgcctg taacctcata tatgttttct gaacttccat cctttaatga cattttctta
    14461 attgcttcag tgaattctcc ttccatgcca taatgagcac atagataata agcatataca
    14521 taatccccat gaaatactaa atgtgttgaa gaatcctgat cactaggaaa tatttctcca
    14581 atattttcta cattatttcc tgacttatcc atccttgtaa gcacagacat accattctgt
    14641 atctgcatat aatataaata tccttcatga taatatatat tagatactac atagctctgt
    14701 ttcatcatat tggcattaca tgtgctgtta tcatgtgcac agtccggctt accacacact
    14761 ggtactacct cttttgtcgc ataatcaaaa tacataagat aagtcatgtc aggtgttata
    14821 aaataataac catcctccgc agctgtaaaa tcatgtaaaa aattcgcttt ccagtagctc
    14881 tgggaatcgt ccaactcata tccgcttcct aaagaaccat aatcaggctg tgctgaatgc
    14941 tttgatacct tatgtgttcc gaaatacaca gcaattactg ccaatatagc taatagtatt
    15001 cctgccggta ttattaattt ctttgcaact ctattcataa aacctcctat tttaatttca
    15061 ctctgaacat tgtttcatca tttaagcatg tgctggatcc agacttgaat ataaaataat
    15121 ctgttttttc gctcccatcc ttatatataa ccttttcctc tataaccacg gattctagtt
    15181 cttctaataa tgcagttatt tgtgcattgg gttctgtata atattcactt ccaaacttaa
    15241 atttaagcgg tacattacaa tatatataca ttttcacatt tctctgtttt tcaggattaa
    15301 tttcaaccca tctgcttgta taccgcagct tatttctttt ttcactttcc aaaaaggtgt
    15361 aacttcttgt atcggcaatt gtaacagcag cattcgctgc tcttaaatat atcttttctg
    15421 cattctcttc attatatata tccgtcagac tgaaaatata cgctattgtt cttctcatac
    15481 gatctgcgtc attctcttta tcatacgacc aatgtgaaaa cacatccgtc atatatactt
    15541 cttttgattc ttcgtctatc tcaactttag gatatcttac ttctatttct ggatatattt
    15601 ctcttatata gttttcccca tcaaccttag ttttctttat tactggatat tcttttttac
    15661 taaacacaca tatcaatgta attattgcgg tcgctataca tataaatata gctacagcaa
    15721 gtataaaaat ctttttcttt ttcataatat cccctttaca ttactcaaat agcaaagctt
    15781 tattataaat aataaagctt tgctatctta aaaaattatc tataaactac ataatcttct
    15841 cttacagcat catccatagc atcaattaat acatatcctg cattttttcc tatactaaca
    15901 ttagaatatc tatatcctga tgcatatgtt gtctgtgctt ctcctccact gtaccataat
    15961 ttggtcatat catcatcata agttccatat cccaaaacag ttaaatccgc cgtttcacta
    16021 gttgaaacat atgctccaaa tgcatcatag attccattat ctctattagg atctatatat
    16081 gcaccaccac tataatgaca cgaacctgca tagccatcga aatcatgtga actagcgaat
    16141 gcaattatac tattagccac taccaataca cttacaattc ctgcaacaac caatctttta
    16201 atgcttttct taaccataat ttaacctcca ttgtacattt accttttgtt acattattaa
    16261 attattcatt ctcctttctt ataattcgtc aggcaacctt ctcagcatta ttcctatgta
    16321 tcacattcag tttccttgta ataaactata tcattagact aaaaaaattc aatgcactat
    16381 gtctcaaatg tcgtttttta tgtctcaact gtatatttta tgacatttaa tatcaaatta
    16441 ttttactaaa ttgattacat tctaatcact ttatagcatt cccataaaca aaaaagaact
    16501 ccttcacacc agctcaatca aggtgtaacg gagttcccat tctgtatata ttaattctaa
    16561 gaagcctgct caaactgcga attataaagg tcagcataga aaccgttctt ggcgagaagc
    16621 tcatcatgag ttccctgctc aacgatatca ccatccttca taacaagtat cacgtcagca
    16681 tctttgatgg ttgaaagtct gtgtgcaata ataaagcttg ttctaccctt catcagatta
    16741 tccatagcct tctggattcg ctcctctgtt cttgtatcaa cagaagatgt tgcttcatca
    16801 agaataagga ttggattatc tgcaaggatt gctcttgcaa ttgtaagaag ctgcttctgt
    16861 ccctgtgaga cattgcttgc gtcctcgtta agctcacaat cataaccgcc cggaagagtc
    16921 tcaataaagt gatgggcgtt agcagccttg gctgctgcaa taacttcctc atcagttgca
    16981 tcaagctttc cgtatctgat attctccata attgtaccct tatagagcca tgtatcctga
    17041 agaaccattc caaatgcgtc tcttaattct cttctgttga aatccttaac attatgtcca
    17101 tcaacaagaa tagctccatc attaacatca tagaatctca taagcagttt aacaatagtg
    17161 gtcttacctg cacctgtcgg tccaacgata gcaaccttct gtccaggctt aacatttaca
    17221 ctgaaattct tgatgatagt ctggttctca ttgtatccga atcttacatg ctcgaaatca
    17281 acctcgccct taattccttc tgtagaaaca ggattcttaa cagtctggtc ttcctcttct
    17341 tcatcaagaa attcaaatac tctctcagaa gctgctacca tagactgtac ctgattgata
    17401 acctgagcaa tctgctggat tggctgtgtg aaattcttta catactggat aaatgcctga
    17461 atatcaccga ttgttataac atttttaata gcaagaagac cgccggttaa tgcaacacat
    17521 gcgtaaccta agttacctac aaacatcatg attggatgca tcattcctga aaggaactgt
    17581 gacttccatg ctgaaccata aaggacatca ttagtcttgt taaatgaatc aaccatatcc
    17641 ttttctttgt taaatgattt aacaatcata tgtccgccat aagtttcctc aatctgtccg
    17701 ttaatatgtc caagatactc ctgctgtgtt ttgaaatatc cctgtgactt cttaacaacg
    17761 aaagaaacaa gtccgactga tattggcagg attataaccg ctataagtgt cataagcggt
    17821 gaaatgctta acatcataac aagaacacca atcatagtag ttaaagatgt aatgattgtt
    17881 gtaatactct ggttaagtcc cattccaagt gtatcaacat cgttagtaat tcttgataac
    17941 acctcaccat atgtcctgct ctcgaaatac ttcataggca tacggttaat cttctcgctg
    18001 atttcttttc ttaatctata gcagaccttc tgtgtaatgc ctgtcattat ccagccctgt
    18061 acaaagttaa atactgcact tgcggcatac agacaaagca cgaatataag aattgttcca
    18121 atctttccaa agtcaattcc gccagttcca ccgattttct ttacaagacc ttctgacaga
    18181 gctgtagttg ccttaccaag aacctttgga cctacaacag aaaatactgt tgagcataca
    18241 gccataactg caacaaatat tatcgcaatc ttatagcttc caatatatct tataagcttt
    18301 cctattgatc ctttgaaatc cttggctttc tcaacaggtg ccattcctct tcccggaggt
    18361 cccattcttc ttttcggtgg cattttgata tttttattat cttccat
//
