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Overview
1.1
1.2
1.3
3.1
3.2

### Identified secondary metabolite regions using strictness 'relaxed'

NC_012778.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | cyclic-lactone-autoinducer | 641,336 | 667,089 |
Region 1.2 | ranthipeptide | 1,425,526 | 1,447,122 |
Region 1.3 | betalactone | 1,963,186 | 1,989,064 |

NC_012780.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | cyclic-lactone-autoinducer | 36,948 | 55,354 |
Region 3.2 | cyclic-lactone-autoinducer | 58,689 | 84,141 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | cyclic-lactone-autoinducer | 641,336 | 667,089 |
Region 1.2 | ranthipeptide | 1,425,526 | 1,447,122 |
Region 1.3 | betalactone | 1,963,186 | 1,989,064 |
Region 3.1 | cyclic-lactone-autoinducer | 36,948 | 55,354 |
Region 3.2 | cyclic-lactone-autoinducer | 58,689 | 84,141 |

No secondary metabolite regions were found in these records:
  NC_012782.1

Compact view
NC_012778.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 641,336 - 667,089 nt. (total: 25,754 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.1 |  | 0.21 | RiPP | microcin C7 | Escherichia coli
BGC0001618.1 |  | 0.19 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0000925.1 |  | 0.18 | Other | quinolobactin | Pseudomonas fluorescens
BGC0000244.1 |  | 0.17 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000886.1 |  | 0.17 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000917.1 |  | 0.17 | Other | molybdenum cofactor | Rhodobacter capsulatus
BGC0000488.1 |  | 0.17 | RiPP | circularin A | Clostridium beijerinckii
BGC0000514.1 |  | 0.16 | RiPP | gallidermin | Staphylococcus gallinarum
BGC0000538.1 |  | 0.16 | RiPP | nisin Z | Lactococcus lactis
BGC0001289.1 |  | 0.16 | RiPP | penisin | Paenibacillus ehimensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.1 |  | 0.54 | RiPP | microcin C7 | Escherichia coli
BGC0001618.1 |  | 0.51 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0000925.1 |  | 0.49 | Other | quinolobactin | Pseudomonas fluorescens
BGC0000244.1 |  | 0.49 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000886.1 |  | 0.48 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000917.1 |  | 0.48 | Other | molybdenum cofactor | Rhodobacter capsulatus
BGC0000488.1 |  | 0.48 | RiPP | circularin A | Clostridium beijerinckii
BGC0000514.1 |  | 0.46 | RiPP | gallidermin | Staphylococcus gallinarum
BGC0000538.1 |  | 0.46 | RiPP | nisin Z | Lactococcus lactis
BGC0001289.1 |  | 0.46 | RiPP | penisin | Paenibacillus ehimensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_012778.1 - Region 2 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,425,526 - 1,447,122 nt. (total: 21,597 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000487.1 |  | 0.17 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000938.1 |  | 0.17 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000488.1 |  | 0.17 | RiPP | circularin A | Clostridium beijerinckii
BGC0000542.1 |  | 0.16 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000541.1 |  | 0.16 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000601.1 |  | 0.16 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000600.1 |  | 0.16 | RiPP | thurincin H | Bacillus thuringiensis
BGC0001407.1 |  | 0.16 | RiPP | bicereucin | Bacillus cereus SJ1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000487.1 |  | 0.48 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000938.1 |  | 0.48 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000488.1 |  | 0.48 | RiPP | circularin A | Clostridium beijerinckii
BGC0000542.1 |  | 0.47 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000541.1 |  | 0.47 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0000504.1 |  | 0.47 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000601.1 |  | 0.47 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000600.1 |  | 0.47 | RiPP | thurincin H | Bacillus thuringiensis
BGC0001407.1 |  | 0.47 | RiPP | bicereucin | Bacillus cereus SJ1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_012778.1 - Region 3 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,963,186 - 1,989,064 nt. (total: 25,879 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000649.1 |  | 0.18 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000701.1 |  | 0.16 | Saccharide | jinggangmycin | Streptomyces hygroscopicus subsp. yingchengensis
BGC0000805.1 |  | 0.13 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001411.1 |  | 0.13 | Saccharide | polysaccharide B | Bacteroides fragilis
BGC0001544.1 |  | 0.13 | NRP, Polyketide | chlorflavonin | Aspergillus campestris IBT 28561
BGC0001627.1 |  | 0.12 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0000353.1 |  | 0.12 | NRP | tacrolimus | Streptomyces sp. MA6548
BGC0001298.1 |  | 0.10 | Polyketide | 4-Z-annimycin | Streptomyces calvus
BGC0001515.1 |  | 0.10 | NRP | aspercryptins | Aspergillus nidulans FGSC A4
BGC0001007.1 |  | 0.09 | Polyketide, NRP | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000649.1 |  | 0.49 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000701.1 |  | 0.46 | Saccharide | jinggangmycin | Streptomyces hygroscopicus subsp. yingchengensis
BGC0000805.1 |  | 0.42 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001411.1 |  | 0.41 | Saccharide | polysaccharide B | Bacteroides fragilis
BGC0001544.1 |  | 0.41 | NRP, Polyketide | chlorflavonin | Aspergillus campestris IBT 28561
BGC0001627.1 |  | 0.40 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0000353.1 |  | 0.40 | NRP | tacrolimus | Streptomyces sp. MA6548
BGC0001298.1 |  | 0.36 | Polyketide | 4-Z-annimycin | Streptomyces calvus
BGC0001515.1 |  | 0.35 | NRP | aspercryptins | Aspergillus nidulans FGSC A4
BGC0001007.1 |  | 0.34 | Polyketide, NRP | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_012780.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 36,948 - 55,354 nt. (total: 18,407 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002009.1 |  | 0.16 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000518.1 |  | 0.16 | RiPP | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001494.1 |  | 0.16 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0000571.1 |  | 0.15 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000486.1 |  | 0.15 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000617.1 |  | 0.15 | RiPP | coagulin | Bacillus coagulans
BGC0001639.1 |  | 0.15 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0000620.1 |  | 0.15 | RiPP | lacticin Q | Lactococcus lactis
BGC0000584.1 |  | 0.14 | RiPP | colicin V | Escherichia coli
BGC0001484.1 |  | 0.13 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002009.1 |  | 0.47 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000518.1 |  | 0.47 | RiPP | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001494.1 |  | 0.46 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0000571.1 |  | 0.46 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000486.1 |  | 0.46 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000617.1 |  | 0.46 | RiPP | coagulin | Bacillus coagulans
BGC0001639.1 |  | 0.45 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0000620.1 |  | 0.45 | RiPP | lacticin Q | Lactococcus lactis
BGC0000584.1 |  | 0.43 | RiPP | colicin V | Escherichia coli
BGC0001484.1 |  | 0.42 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_012780.1 - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 58,689 - 84,141 nt. (total: 25,453 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001618.1 |  | 0.17 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0001973.1 |  | 0.17 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.17 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000488.1 |  | 0.17 | RiPP | circularin A | Clostridium beijerinckii
BGC0000528.1 |  | 0.16 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000538.1 |  | 0.16 | RiPP | nisin Z | Lactococcus lactis
BGC0001289.1 |  | 0.16 | RiPP | penisin | Paenibacillus ehimensis
BGC0000486.1 |  | 0.15 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000535.1 |  | 0.15 | RiPP | nisin A | Lactococcus lactis subsp. lactis
BGC0000536.1 |  | 0.15 | RiPP | nisin Q | Lactococcus lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001618.1 |  | 0.48 | RiPP | hyicin 3682 | Staphylococcus hyicus
BGC0001973.1 |  | 0.48 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.48 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000488.1 |  | 0.47 | RiPP | circularin A | Clostridium beijerinckii
BGC0000528.1 |  | 0.47 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000538.1 |  | 0.46 | RiPP | nisin Z | Lactococcus lactis
BGC0001289.1 |  | 0.46 | RiPP | penisin | Paenibacillus ehimensis
BGC0000486.1 |  | 0.45 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000535.1 |  | 0.45 | RiPP | nisin A | Lactococcus lactis subsp. lactis
BGC0000536.1 |  | 0.45 | RiPP | nisin Q | Lactococcus lactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names