LOCUS       NZ_CP011025.1          10858 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP011025.1 Pseudoalteromonas arctica A 37-1-2 chromosome I,
            complete sequence.
ACCESSION   NZ_CP011025
VERSION     NZ_CP011025.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:34:44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1399265
            Orig. end    :: 1410123
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10858
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1404265:1405123](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5858
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10858
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10858
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             365..1624
                     /gene_functions="other (smcogs) SMCOG1272:TPR
                     repeat-containing protein (Score: 48.1; E-value: 1.5e-14)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1222"
                     /transl_table=11
                     /translation="MRNFSKVTALAILMSVSGATLSASVLAAPDYAKIEERKKAKTKIM
                     GERTGKKVIKAFDLYNEEKVDEAIVLLREIEPSNDFDKATVNRYLGSMYAQKEKYDEAI
                     KYSKQAVAPDVLNFADQEQTLKLLGDLYAGTEKYQEAKKAYVTWMDFTGEEDPTVYTRI
                     AQANYQLEQFRDVFEPADKAIKLQKEPNKGPYQLKLGAYFELKDYANMVKIGEEIVRVW
                     PDDKKAWVSLGKYYLQTEDYQKGLATMEVAYKNGYFENEVEYKVLSNFYSLNEIPFRAA
                     VTLEKAVKSEKVKRTKQNVSAIASNYHRSKDLEKAAKYYEEAAKFDDDAELYRKAGSLL
                     LQSEKFSAAVVRLNKALELGSDKKGTIYSDLAEAYYYQGKYKQAYAAITKAMDDPRTRK
                     FAKGWSTYIKDKAARNGVKI"
     PFAM_domain     962..1129
                     /aSDomain="TPR_16"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13432.8"
                     /description="Tetratricopeptide repeat"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1222_0001"
                     /evalue="3.40E-03"
                     /label="ctg1_1222"
                     /locus_tag="ctg1_1222"
                     /protein_end="255"
                     /protein_start="199"
                     /score="18.0"
                     /tool="antismash"
                     /translation="GAYFELKDYANMVKIGEEIVRVWPDDKKAWVSLGKYYLQTEDYQK
                     GLATMEVAYKN"
     CDS             1686..2729
                     /locus_tag="ctg1_1223"
                     /transl_table=11
                     /translation="MYKKLSFSLLLCLFLAACSKQPQPYESFEDAQVALKTLNMALVQP
                     DAKKIDRITKEQLVFSDAYLVKRHTIYQNLMGMELNLNQIAQVNYLVIAERFPERYFNW
                     PAQVDVLKNMLAFEGSKSTPDNIITWLKLTQDTLDSAKQSNLKLNKIELTLLQSYVLSA
                     IGSNDVQPALKSHIRAFSDYLTSYKPRGSVGLRGLPNGSQWYQSKLNYFSGEVHSPLEW
                     VTILNENIKVLDRVAFDSKLSISHKKSFLVQYLSDEKLIEGLDWQADYQDLPAMASNMN
                     MSDKDKTLMLAMMESDIGIHYHAWTLPQAKVNLMKRLEITQEEAQYLVEDIILYPGQSF
                     SFIQQII"
     CDS             complement(2746..3072)
                     /locus_tag="ctg1_1224"
                     /transl_table=11
                     /translation="MHHQKRLNDEIAQIKLKILTMLSKSAYPTHQHLIQILDNTANNEW
                     LDCAAEKLGPEYAFLISRMTKLEAAVSQIEIGQYGYCCDCEEKIPAKSLELDPATQRCT
                     KCAQ"
     CDS             complement(3134..4114)
                     /locus_tag="ctg1_1225"
                     /transl_table=11
                     /translation="MKLVLAPMEGVVDFKMRQLLTDIGGFDLCVTEFVRVVETCLPDKV
                     FHRFCPELHNNGFTRAGTPVRVQLLGQEANPLAENAVRAIALGSHGVDLNFGCPAKTVN
                     RSRGGAVLLKDPDHMYTIIKAVRDAVDDKHEVSAKIRLGFDDDSNSQEIVDAVVSAGAN
                     SVAIHARTKRDGYNPPAYWEKIPPIIKDKNIAVVANGEIWQVEDAMLCQKRSGCTDLML
                     GRGALSHPDLAKKIKAHVNNEQYDGLQWEHIIYHLIHSAIHQDPAKDEKYFASRTKQWL
                     GYLKRQYPQAIDLFDEIRRLKSKEDVASVLNKYAKAPQLDSNHNG"
     PFAM_domain     complement(3182..4102)
                     /aSDomain="Dus"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01207.19"
                     /description="Dihydrouridine synthase (Dus)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1225_0002"
                     /evalue="1.30E-70"
                     /label="ctg1_1225"
                     /locus_tag="ctg1_1225"
                     /protein_end="311"
                     /protein_start="4"
                     /score="238.1"
                     /tool="antismash"
                     /translation="LAPMEGVVDFKMRQLLTDIGGFDLCVTEFVRVVETCLPDKVFHRF
                     CPELHNNGFTRAGTPVRVQLLGQEANPLAENAVRAIALGSHGVDLNFGCPAKTVNRSRG
                     GAVLLKDPDHMYTIIKAVRDAVDDKHEVSAKIRLGFDDDSNSQEIVDAVVSAGANSVAI
                     HARTKRDGYNPPAYWEKIPPIIKDKNIAVVANGEIWQVEDAMLCQKRSGCTDLMLGRGA
                     LSHPDLAKKIKAHVNNEQYDGLQWEHIIYHLIHSAIHQDPAKDEKYFASRTKQWLGYLK
                     RQYPQAIDLFDEIRRLKSKEDVASVL"
     CDS             4340..4933
                     /locus_tag="ctg1_1226"
                     /transl_table=11
                     /translation="MNTVKKNTIALTLGAVVVGSASFVSADVQANPFEFQQLVTGYQLD
                     AKEGKCGEGKCGGDAKDAKAKTEGKCGEGKCGGDAKDAKAKTEGKCGEGKCGGDAKDAK
                     AKTEGKCGEGKCGGDAKDAKAKTEGKCGEGKCGGDAKDAKAKTEGKCGEGKCGGDAKDA
                     KAKTEGKCGEGKCGGDAKKTKKEGKCGEGKCGGR"
     CDS             5001..5858
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1227"
                     /sec_met_domain="DUF692 (E-value: 3.6e-103, bitscore:
                     342.1, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIQSTDFGMVGLGLRREMLDELLEHVPNQVDFLEVAPENWLKL
                     GGRFKKQFRTLTDANNFVCHGLSLSIGSPEPLDVEFVESLKVFFEEHNIKIFSEHLSYC
                     SGTGHMYDLMPIPFTQDAIAHVVPRIKQVQDILEQQIAIENVSYYGAPGQQLSELEFTN
                     TILEQADCKLLLDVNNIYVNSINHGYNAQAFLTGLPSNRIAYGHVAGHYNEADDLIVDT
                     HGADVIDPVWELLDKAYEVHGVFPTLLERDFNIPTMNILTKELDIIHELQAKHITSTVS
                     KQRA"
     PFAM_domain     5034..5816
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1227_0003"
                     /evalue="3.60E-100"
                     /label="ctg1_1227"
                     /locus_tag="ctg1_1227"
                     /protein_end="272"
                     /protein_start="11"
                     /score="334.6"
                     /tool="antismash"
                     /translation="VGLGLRREMLDELLEHVPNQVDFLEVAPENWLKLGGRFKKQFRTL
                     TDANNFVCHGLSLSIGSPEPLDVEFVESLKVFFEEHNIKIFSEHLSYCSGTGHMYDLMP
                     IPFTQDAIAHVVPRIKQVQDILEQQIAIENVSYYGAPGQQLSELEFTNTILEQADCKLL
                     LDVNNIYVNSINHGYNAQAFLTGLPSNRIAYGHVAGHYNEADDLIVDTHGADVIDPVWE
                     LLDKAYEVHGVFPTLLERDFNIPTMNILTKELDIIHELQ"
     CDS             5895..6647
                     /locus_tag="ctg1_1228"
                     /transl_table=11
                     /translation="MSFIEIQNEFMAHIREPKKNKKPSGIEDRRMAIYRDLFFNNIEGF
                     ISSGFPVLKTLYTDKQWLVLVRQFFSEYDCHSPYFLDIAGEFINYLSSDYKMKRYDPVF
                     MLELAHYEWVELDVSIAHEDEQEQKLQTTALTSSALYLSKTARNLSYQFPVQNISNRFK
                     PKEPSPQPNYFVVYRDEDDDVQFLATNAMTALLLSIIEASDGATFDDVCQQVFAHAPQF
                     NAEQIAQGALVTLNAMVERGVIVTKNQD"
     PFAM_domain     5907..6167
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1228_0004"
                     /evalue="1.60E-24"
                     /label="ctg1_1228"
                     /locus_tag="ctg1_1228"
                     /protein_end="91"
                     /protein_start="4"
                     /score="86.0"
                     /tool="antismash"
                     /translation="EIQNEFMAHIREPKKNKKPSGIEDRRMAIYRDLFFNNIEGFISSG
                     FPVLKTLYTDKQWLVLVRQFFSEYDCHSPYFLDIAGEFINYL"
     CDS             6720..6842
                     /locus_tag="ctg1_1229"
                     /transl_table=11
                     /translation="MSDDKDFKDPFNATYFLAFLAVFAGIGCLNAILGWITSLT"
     CDS             7012..7557
                     /locus_tag="ctg1_1230"
                     /transl_table=11
                     /translation="MTQVTPAIIKNSITTIADYPKPGIMFRDVTTLMANPEAFKATIDA
                     FIAEYKDQGFTKIIGTESRGFIFGAPLSYALGIPFIPVRKPGKLPREVIRQDYLLEYGE
                     DTLELHVDAIVPGDKVLLVDDLLATGGTIEATAKLVHKLGGKATDAAFVVSLPELGGEQ
                     RIKKMGIKILKLVEFEGE"
     aSDomain        7036..7542
                     /aSDomain="TIGR01090"
                     /aSTool="tigrfam"
                     /description="apt: adenine phosphoribosyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1230_0001"
                     /evalue="1.60E-67"
                     /identifier="TIGR01090"
                     /label="ctg1_1230"
                     /locus_tag="ctg1_1230"
                     /protein_end="177"
                     /protein_start="8"
                     /score="224.8"
                     /tool="antismash"
                     /translation="IKNSITTIADYPKPGIMFRDVTTLMANPEAFKATIDAFIAEYKDQ
                     GFTKIIGTESRGFIFGAPLSYALGIPFIPVRKPGKLPREVIRQDYLLEYGEDTLELHVD
                     AIVPGDKVLLVDDLLATGGTIEATAKLVHKLGGKATDAAFVVSLPELGGEQRIKKMGIK
                     ILKLVE"
     PFAM_domain     7111..7488
                     /aSDomain="Pribosyltran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00156.29"
                     /description="Phosphoribosyl transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1230_0005"
                     /evalue="5.40E-12"
                     /label="ctg1_1230"
                     /locus_tag="ctg1_1230"
                     /protein_end="159"
                     /protein_start="33"
                     /score="45.4"
                     /tool="antismash"
                     /translation="ANPEAFKATIDAFIAEYKDQGFTKIIGTESRGFIFGAPLSYALGI
                     PFIPVRKPGKLPREVIRQDYLLEYGEDTLELHVDAIVPGDKVLLVDDLLATGGTIEATA
                     KLVHKLGGKATDAAFVVSLPEL"
     CDS             7561..10086
                     /locus_tag="ctg1_1231"
                     /transl_table=11
                     /translation="MSYQVLARKWRPQTFHELVGQSHVKQALVNALTQNRLHHAYLFTG
                     TRGVGKTTIARIFAKSLNCDEGISANPCGQCSSCLDIEAGRYIDLLEIDAASRTKVEDT
                     REILDNVQYAPTRGRYKVYLIDEVHMLSKHSFNALLKTLEEPPEHVKFLLATTDPQKLP
                     VTILSRCLQFNLNALSQSEIKTQLEHVLTQEQLSFDTDALSIISKAADGSMRDALSLTD
                     QAIAQTNGDINNQAVQTMLGLMDTHYSQSLLAALLAQDGAALMDEIAQVASRNPNYVAL
                     LDDLIALTHLTQLTQLVPEAAGLDEKNVDYIAHVAQHTSPQQIQIYYQLLLNGKKDLQW
                     APEPRLGFEMIMLRLLAFKPTDAQQTVHTVNEEPAPNKQGRANALRDILNKNKTSQNTV
                     ASQSSVPVNNTKPVSNTEQPKSLEIEPLPNVAAQTSNNDVVQSNNEPAQVAVEQPVQQS
                     ENAFEQQASANDQPQTNVVSDAQAQRQSEDEAYMQHSDAEQTLASQFDDIMSSAVDQGF
                     KPAPTANSESSPEPLTNHNASTPIAEQEAQAQSAIARILRDRNISGAGRLSGKSTSTSA
                     NNVAVQPSQVPAKKPEQHPRMPKAQSVHQGSADTSASELNSPSSTASGDIPPWATDSEG
                     ESEKKHELPVTGGQTQAHNHSNIKPASKIDFKAKHQTITENLAPELLEQINPQKAPEIV
                     PEEVSIPAPDDFQSPISEIRFAHQQDEWAYLIKRMGLGGRMRQFALHSIFTKQGNSLHI
                     DVDESQKHLDTPMLRQRLDAALSSIYEHNVSLSINFAKGVIDSPYLIQQKIDAGRHQQA
                     IDVITSDENIVQFQQVFSAEIDENSIQAL"
     aSDomain        7567..8625
                     /aSDomain="TIGR02397"
                     /aSTool="tigrfam"
                     /description="dnaX_nterm: DNA polymerase III, subunit gamma
                     and tau"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1231_0002"
                     /evalue="1.40E-135"
                     /identifier="TIGR02397"
                     /label="ctg1_1231"
                     /locus_tag="ctg1_1231"
                     /protein_end="355"
                     /protein_start="2"
                     /score="450.1"
                     /tool="antismash"
                     /translation="YQVLARKWRPQTFHELVGQSHVKQALVNALTQNRLHHAYLFTGTR
                     GVGKTTIARIFAKSLNCDEGISANPCGQCSSCLDIEAGRYIDLLEIDAASRTKVEDTRE
                     ILDNVQYAPTRGRYKVYLIDEVHMLSKHSFNALLKTLEEPPEHVKFLLATTDPQKLPVT
                     ILSRCLQFNLNALSQSEIKTQLEHVLTQEQLSFDTDALSIISKAADGSMRDALSLTDQA
                     IAQTNGDINNQAVQTMLGLMDTHYSQSLLAALLAQDGAALMDEIAQVASRNPNYVALLD
                     DLIALTHLTQLTQLVPEAAGLDEKNVDYIAHVAQHTSPQQIQIYYQLLLNGKKDLQWAP
                     EPRLGFEMIMLRL"
     PFAM_domain     7618..8094
                     /aSDomain="DNA_pol3_delta2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13177.8"
                     /description="DNA polymerase III, delta subunit"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1231_0006"
                     /evalue="2.10E-45"
                     /label="ctg1_1231"
                     /locus_tag="ctg1_1231"
                     /protein_end="178"
                     /protein_start="19"
                     /score="154.8"
                     /tool="antismash"
                     /translation="GQSHVKQALVNALTQNRLHHAYLFTGTRGVGKTTIARIFAKSLNC
                     DEGISANPCGQCSSCLDIEAGRYIDLLEIDAASRTKVEDTREILDNVQYAPTRGRYKVY
                     LIDEVHMLSKHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFNLNAL"
     PFAM_domain     8257..8649
                     /aSDomain="DNA_pol3_gamma3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12169.10"
                     /description="DNA polymerase III subunits gamma and tau
                     domain III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1231_0007"
                     /evalue="3.10E-25"
                     /label="ctg1_1231"
                     /locus_tag="ctg1_1231"
                     /protein_end="363"
                     /protein_start="232"
                     /score="88.7"
                     /tool="antismash"
                     /translation="NNQAVQTMLGLMDTHYSQSLLAALLAQDGAALMDEIAQVASRNPN
                     YVALLDDLIALTHLTQLTQLVPEAAGLDEKNVDYIAHVAQHTSPQQIQIYYQLLLNGKK
                     DLQWAPEPRLGFEMIMLRLLAFKPTDA"
     PFAM_domain     9697..10074
                     /aSDomain="DNA_pol3_tau_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12170.10"
                     /description="DNA polymerase III tau subunit V interacting
                     with alpha"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1231_0008"
                     /evalue="1.90E-24"
                     /label="ctg1_1231"
                     /locus_tag="ctg1_1231"
                     /protein_end="838"
                     /protein_start="712"
                     /score="86.4"
                     /tool="antismash"
                     /translation="IRFAHQQDEWAYLIKRMGLGGRMRQFALHSIFTKQGNSLHIDVDE
                     SQKHLDTPMLRQRLDAALSSIYEHNVSLSINFAKGVIDSPYLIQQKIDAGRHQQAIDVI
                     TSDENIVQFQQVFSAEIDENSI"
     CDS             10111..10473
                     /locus_tag="ctg1_1232"
                     /transl_table=11
                     /translation="MLINVLKEREKVMFKGGMGNMMKQAQQMQDRMQKAQDEIATLEVV
                     GEAGAGLVKVTMLGNHNVRRVQLDESLMEDDKDMIEDLLAAACNDAVRRVAEETQERMG
                     KVTGGMQLPPGMKMPF"
     aSDomain        10150..10458
                     /aSDomain="TIGR00103"
                     /aSTool="tigrfam"
                     /description="DNA_YbaB_EbfC: DNA-binding protein, YbaB/EbfC
                     family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1232_0003"
                     /evalue="6.30E-35"
                     /identifier="TIGR00103"
                     /label="ctg1_1232"
                     /locus_tag="ctg1_1232"
                     /protein_end="116"
                     /protein_start="13"
                     /score="117.4"
                     /tool="antismash"
                     /translation="FKGGMGNMMKQAQQMQDRMQKAQDEIATLEVVGEAGAGLVKVTML
                     GNHNVRRVQLDESLMEDDKDMIEDLLAAACNDAVRRVAEETQERMGKVTGGMQLPPGM"
     PFAM_domain     10174..10440
                     /aSDomain="YbaB_DNA_bd"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02575.18"
                     /description="YbaB/EbfC DNA-binding family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1232_0009"
                     /evalue="1.40E-30"
                     /label="ctg1_1232"
                     /locus_tag="ctg1_1232"
                     /protein_end="110"
                     /protein_start="21"
                     /score="105.5"
                     /tool="antismash"
                     /translation="MKQAQQMQDRMQKAQDEIATLEVVGEAGAGLVKVTMLGNHNVRRV
                     QLDESLMEDDKDMIEDLLAAACNDAVRRVAEETQERMGKVTGGM"
ORIGIN
        1 catttaacat gggtagcatt gatgttggta gttcagctgg tggactaagt ggtcctggtg
       61 catttggacg agatggtgat gcgacaccta tcgttcgtat agaaccaaaa tatccaacgc
      121 aagcagcacg tgatggcaaa gaaggttggg tacaactttc attcacaatt gatgagttag
      181 gtggagtaac tgacgttgaa gtaattgacg cagatccaaa acgtatcttt gaccgtgaag
      241 ctaaacgcgc actgcgtaag tggaagtacc gtcctaagat cattgacgga aaaccacaga
      301 aacaaccagg tttacaagtt caattagact ttaaacttaa ccaaggcaac taaggaggcg
      361 agtaatgaga aatttttcta aagtaactgc tcttgcgatt cttatgtctg tgtcgggtgc
      421 tactttaagt gcatctgttt tagcagcgcc agattacgca aagattgaag agcgtaaaaa
      481 agcaaaaact aaaatcatgg gcgagcgtac tggtaaaaag gtaattaaag catttgactt
      541 gtacaacgaa gaaaaagttg atgaagcaat tgttttgctt agagagattg aaccttcgaa
      601 tgactttgat aaagcgaccg taaatcgtta cttaggtagc atgtacgctc aaaaagaaaa
      661 gtatgacgaa gcgattaagt actctaagca agcagttgcc cctgatgttt taaactttgc
      721 tgatcaagaa caaactctaa agctgttagg tgatttatac gctggcacag aaaagtatca
      781 agaagccaaa aaagcttatg ttacttggat ggattttacc ggtgaagaag atcctacggt
      841 ttacacgcgt attgcccaag ctaactatca gttagagcaa tttcgtgatg tttttgaacc
      901 agcagataag gcaattaaac ttcaaaaaga acctaataaa ggtccttacc aattaaaact
      961 gggtgcatac tttgaactta aagattatgc aaacatggtt aagattggcg aagagattgt
     1021 tcgtgtatgg cctgatgata aaaaagcttg ggttagctta ggtaaatatt acctacaaac
     1081 cgaagactat caaaaaggtt tagcaacgat ggaagttgct tacaagaacg gttactttga
     1141 aaatgaagtt gagtataaag tcttatctaa cttttattct ctaaacgaga tcccttttag
     1201 agcagctgta acgctagaaa aggccgttaa gagtgaaaaa gtaaaacgta caaagcagaa
     1261 tgttagcgcg attgctagta actatcatcg ctctaaggat ctagaaaaag ctgctaagta
     1321 ctacgaagaa gctgctaaat ttgatgacga cgctgaactt taccgtaaag ctggttcatt
     1381 acttttacaa tctgaaaaat tcagtgctgc tgttgttcgt ttgaacaaag cattagagct
     1441 tggctctgac aaaaaaggta ctatttattc agatttagct gaagcgtatt actatcaagg
     1501 taagtataag caagcatatg ctgcaattac taaagctatg gatgaccctc gcacacgtaa
     1561 gtttgcaaaa ggttggtcta catatattaa agacaaagcc gctcgcaacg gtgttaaaat
     1621 ttaattttaa ttagctaaag caacttataa aaagcccctc tggggctttt tttattggaa
     1681 ctactatgta taaaaagctc tctttttcat tactactgtg cttattttta gctgcatgtt
     1741 caaagcagcc tcaaccttat gagtcatttg aagacgcaca agttgcttta aaaactttaa
     1801 acatggcact tgtacaacca gacgctaaaa aaattgatag gattactaaa gagcaattgg
     1861 tattttctga tgcgtattta gttaaacgtc atactattta tcagaaccta atgggtatgg
     1921 agcttaatct caatcaaatt gcacaagtaa actacttggt tattgcagag cgctttcctg
     1981 agcgctattt taattggccg gctcaagtag acgtattaaa aaacatgctt gcttttgagg
     2041 ggtcaaaaag tacgccggat aatattatta cttggcttaa gttaacccaa gatacgctag
     2101 acagtgctaa acaaagcaat ttaaagctga ataaaattga gctcacacta ctacaaagct
     2161 atgtattgag tgcgataggt agtaatgacg ttcaaccagc gcttaagagt catataagag
     2221 cttttagcga ttatttaact agttataagc ctagaggtag tgttggtctg agaggcctgc
     2281 caaatgggtc acagtggtat cagagcaaac ttaattactt cagtggcgaa gtacattcac
     2341 cgctagagtg ggttactatt ttaaatgaaa atataaaagt attagatcgt gttgcattcg
     2401 acagtaaatt gtctatttct cataaaaaat cgtttttagt gcagtatcta tcggatgaaa
     2461 aattaattga agggcttgat tggcaggctg attatcaaga cttacctgca atggcgagca
     2521 atatgaacat gtctgataaa gataaaacat tgatgcttgc aatgatggaa tcagatattg
     2581 gcattcatta ccatgcgtgg actttgccac aggcgaaggt aaaccttatg aaacgcttag
     2641 aaattaccca agaagaggct caatatttag ttgaagatat aatactctac ccagggcaat
     2701 catttagctt tatacaacaa attatataat gatttgaaag tgcgcttatt gtgcgcactt
     2761 tgtacaccgt tgagttgcgg ggtctagttc aagtgatttg gctggtattt tttcttcaca
     2821 gtcgcagcag tagccatatt gcccaatttc tatttggctg accgccgctt ctaatttagt
     2881 catgcgactg atcaaaaacg catactcagg acctagcttc tctgctgcac agtctaacca
     2941 ttcattgttt gctgtattat ctaaaatttg tattaaatgc tgatgtgtag ggtaggctga
     3001 tttagaaagc atagttaata tctttaattt aatttgtgct atttcatcgt ttagtctttt
     3061 ttgatgatgc attatcagta caaccttatt aaactggctt cacgttatac tgatattatc
     3121 tagaggcttt aggttagccg ttatgatttg aatcaagttg cggtgctttg gcgtatttat
     3181 ttaatacgct tgccacatct tctttacttt ttaaacgcct gatttcatca aataaatcga
     3241 tcgcttgcgg gtattggcgt ttaaggtaac ctagccattg ctttgtacga gaagcaaaat
     3301 acttttcatc ttttgcaggg tcttgatgaa tagcagagtg gattaagtga taaataatat
     3361 gctcccattg aaggccatca tattgttcat tatttacatg agctttaatt ttttttgcta
     3421 aatcagggtg cgaaagggcg ccacgaccaa gcatcaaatc agtacatcca cttcgttttt
     3481 ggcaaagcat tgcgtcctca acttgccaaa tttcaccatt ggcaacaacg gcaatatttt
     3541 tatcttttat tattggtgga attttttccc aataagctgg cgggttataa ccatcacgtt
     3601 tggttctggc gtgtatagct acactatttg cgcctgcgct taccacagca tcaacaattt
     3661 cttggctgtt actgtcgtca tcaaagccta agcgaatttt tgcacttact tcatgtttat
     3721 catctacagc atctcggact gctttaataa tcgtatacat gtggtcagga tctttaagca
     3781 gtacagcacc ccctcgacta cgattaacgg tttttgctgg gcaaccaaag ttaaggtcga
     3841 ccccatgaga tcctaaagca attgctctta ctgcattttc ggctaacgga tttgcttctt
     3901 ggccgagtaa ttgaacacgc acaggagtac ctgctcgcgt aaatccatta ttatgtagtt
     3961 cagggcaaaa tcgatgaaaa actttatcag gtaagcatgt ttcaaccact cttacaaact
     4021 cggtaacgca caaatcgaac ccaccaatgt ctgtgagtaa ttggcgcatt ttaaaatcaa
     4081 cgacaccttc cataggtgct aaaacaagtt tcataaagtg attaattttg ataaaaaact
     4141 ggacgcatag tttacctgta aatcacacat tgataaatct gtaattacca accatattta
     4201 atgtagaaac cgcaaaagta aatattatga aaataaatga aattttttat tctcgtacag
     4261 gtctacttaa gcatacaagc aatttaaaat acatttttat tgctgagatt tacaatactt
     4321 gattaaagag agtcacaaaa tgaatacagt taaaaaaaat acaatcgcgt taactttagg
     4381 tgcagtagtt gttggctctg caagctttgt atctgcagat gtacaagcca acccatttga
     4441 gtttcaacaa ttagtgacag gttaccaact agacgctaaa gaaggtaagt gtggtgaagg
     4501 taaatgtggc ggcgatgcta aagatgcaaa agctaaaaca gaaggtaagt gcggcgaagg
     4561 taaatgtggc ggcgatgcaa aagatgcaaa agctaaaaca gaaggtaagt gcggcgaagg
     4621 taaatgtggc ggcgatgcaa aagatgcaaa agctaaaaca gaaggtaagt gcggcgaagg
     4681 taaatgtggc ggcgatgcaa aagatgcaaa agctaaaaca gaaggcaagt gtggcgaagg
     4741 taaatgtggc ggcgacgcaa aagatgcaaa agctaaaaca gaaggcaagt gtggtgaagg
     4801 taaatgtggc ggcgatgcaa aagatgcaaa agctaaaaca gaaggcaaat gtggtgaagg
     4861 taaatgcggc ggcgatgcta aaaaaactaa aaaagaaggt aagtgcggcg aaggtaaatg
     4921 tggcggtcgt taatatctta ttctaaataa gttatgctaa aagggcctta aggccctttt
     4981 ttgataagtt agaggtagtt atgacacaaa tccagagtac agatttcggg atggtgggcc
     5041 ttggcctacg acgagaaatg cttgatgaac tgcttgaaca cgtacctaat caagtagatt
     5101 ttttggaagt tgcgccagag aactggttaa aactaggtgg acgctttaaa aagcaattta
     5161 gaacattaac agatgcaaat aattttgtgt gtcatggatt atcactgtct atcggttcac
     5221 ccgaaccact ggatgtcgaa tttgttgagt ctttaaaagt tttttttgaa gagcacaata
     5281 taaaaatttt tagtgagcac ttaagttact gttccggtac aggccatatg tatgacttaa
     5341 tgcctattcc ttttacacaa gatgcaatag cacatgttgt ccctcgtatt aaacaagtac
     5401 aagacatact tgagcagcaa attgcgatag aaaatgtttc ctattatggc gctcctggac
     5461 agcaattatc agagctggaa tttacaaata ccattttaga gcaagcagac tgcaagcttt
     5521 tactggatgt gaataacatt tatgtgaatt cgattaatca tggctataac gcacaagcat
     5581 ttttaacagg gttaccctct aatcgtatcg cctatgggca cgttgcaggc cattataatg
     5641 aggctgatga cttaatagtt gatacacatg gtgctgatgt cattgatcct gtgtgggagc
     5701 tactggataa agcatatgaa gtgcatggcg tatttccaac cttgcttgag cgcgatttta
     5761 atatccctac catgaatatt ttaaccaaag agttagatat aattcatgag ctacaagcta
     5821 aacacattac ttcaacggtt tcaaaacaac gagcttaata taagccttta taaatattaa
     5881 aagagtgcct ggttatgagc tttattgaaa tacaaaacga atttatggcg catattcgcg
     5941 agcctaaaaa aaataaaaag cccagcggta tcgaagacag acgtatggcc atttatcgcg
     6001 acctattttt taataacatt gaaggtttta tatcatcagg ctttccggta ttaaaaacct
     6061 tatatacaga caagcaatgg ctggttcttg tacgccagtt ttttagcgaa tatgattgtc
     6121 attcgccgta ctttttagat atagcagggg agtttattaa ttacttatca agtgattata
     6181 aaatgaaaag atacgatccc gtgtttatgc tagaacttgc acattatgaa tgggtagagc
     6241 tagatgtatc gattgcacac gaagatgagc aagagcaaaa attacaaaca acagcgctta
     6301 ctagttctgc tttgtattta tcgaaaacgg caagaaattt aagttatcaa tttccggttc
     6361 aaaatattag caatcgcttt aaaccaaaag agccatcacc tcagcctaat tattttgttg
     6421 tatatagaga tgaagatgat gacgttcaat ttctggctac gaatgcgatg actgctttgt
     6481 tactatcaat tattgaggca agtgatggag cgacatttga cgacgtttgc cagcaggtat
     6541 tcgctcatgc accacaattt aatgcagagc aaattgctca aggcgcattg gttaccctta
     6601 atgcaatggt tgaacgcggt gtaattgtga caaaaaatca agattaaggt ctttattgat
     6661 gattttacat cgtctattat ggcagcctta tttgtcgtgc ttaataaaag gttgtaccaa
     6721 tgtcagatga taaagacttt aaagatccgt tcaacgctac ttattttctt gctttcttag
     6781 ctgtatttgc agggattggt tgtttaaatg caatattagg ctggatcact agcttaactt
     6841 aaaatgcata gcgtttatta aggctgttgc ttacttcagc cttgaaccac tttattttaa
     6901 ttacccccca tagttaatac ttcttttata gtaacgccaa actcgcaatt aaaggttagt
     6961 taaggttata atcacctgct ttgtaatata aacaattgag cagttaaaat tatgactcaa
     7021 gtaacaccag caattatcaa aaacagcata actacaattg ctgattatcc aaagccgggc
     7081 atcatgtttc gcgatgtaac cactttaatg gcaaatccag aagcctttaa agcaactatt
     7141 gacgcgttta tcgcagaata taaagatcag ggttttacta aaataattgg cacagaatca
     7201 cgtggcttta tttttggtgc gccactgtct tacgcattag gcattccgtt tattccagtt
     7261 cgtaaaccag gtaagttacc acgcgaagtt attcgtcaag attacttact tgagtatggt
     7321 gaagacacgc tagagctgca tgttgatgca attgtacctg gcgataaagt attattagtt
     7381 gatgacttat tagcaactgg cggcacaatt gaagccaccg ctaaattagt tcataaacta
     7441 ggtggcaaag ccacagatgc tgcatttgtt gtatcactac cagaacttgg tggcgagcag
     7501 cgcatcaaaa aaatgggtat taaaatccta aaattggttg aattcgaagg cgagtaatcg
     7561 atgagttatc aggttctagc gagaaaatgg cgtcctcaaa cctttcatga attggttggg
     7621 cagtctcatg ttaagcaagc gcttgtaaat gcgcttacac aaaatagact gcatcacgct
     7681 tatttattca ctggaacccg cggtgtaggt aaaaccacta ttgcgcgtat ttttgctaaa
     7741 agcttaaatt gcgacgaagg tatatctgca aatccgtgtg gccaatgtag cagctgttta
     7801 gatatagaag cagggcgcta cattgactta ctcgaaatag atgcggcttc tcgtacaaaa
     7861 gtagaagaca cccgcgaaat actcgataac gttcaatatg caccaacacg tggacgttat
     7921 aaagtatacc taatcgatga agttcacatg ctttctaagc acagctttaa tgcgcttttg
     7981 aaaacgcttg aagagccacc agagcatgtg aaatttttat tggcgacgac cgatcctcaa
     8041 aaactaccag ttactatttt atctcgctgt ttacaattca acctaaatgc cttgtcgcaa
     8101 agtgaaatta aaacacagct tgaacacgta cttactcaag agcagcttag ctttgacact
     8161 gatgcactta gcattatttc aaaagccgct gatggcagta tgcgtgatgc gcttagctta
     8221 actgaccaag ctattgcaca aacaaatggt gatattaata atcaagcagt acaaacaatg
     8281 cttggtttaa tggatactca ttatagccaa agtttgcttg cagcattact tgcacaagat
     8341 ggcgctgcgc taatggatga gattgcacag gtggcaagtc gtaatcctaa ttatgttgca
     8401 ttgcttgatg atttaattgc acttacgcat ttgacccaac taacccagtt agtgccagaa
     8461 gcggcagggc tagatgaaaa aaatgtagat tatattgctc atgttgcaca acatacgagc
     8521 ccacaacaaa ttcaaattta ttatcagtta ctgttaaatg gtaaaaaaga tttacaatgg
     8581 gcaccagagc ctcgtttagg ttttgaaatg ataatgctaa gattattagc atttaagcct
     8641 acagacgctc aacaaactgt acacacagta aacgaagagc cggccccaaa taaacaaggc
     8701 cgcgcaaatg cactgcgaga tatattaaat aaaaataaaa catcgcaaaa cactgtagct
     8761 agccaaagta gtgtccctgt aaataatact aagccagtta gcaatacaga gcagcctaaa
     8821 tcccttgaga tagagccttt accaaatgtt gccgctcaga catcgaataa tgatgtcgta
     8881 caaagtaata atgagcctgc ccaagttgca gtagagcaac cggttcaaca aagtgaaaac
     8941 gcttttgaac aacaggcttc agctaatgat caaccacaaa ccaatgttgt ttcggatgct
     9001 caagcccagc gccaaagtga agatgaagct tacatgcaac atagtgatgc tgagcaaacg
     9061 ctagcttcgc agtttgatga tataatgagt agcgctgtag atcagggttt taaacctgca
     9121 cctactgcaa actcagagtc ttcaccagag cccttaacaa atcataatgc aagtacgcca
     9181 atagctgaac aagaagcgca ggcgcaatct gccattgctc gtattttacg tgacagaaac
     9241 atatcgggtg cgggtaggtt atcaggcaag agtacaagta catctgcaaa taatgtagca
     9301 gtgcagccaa gccaagtgcc cgctaaaaag ccagaacagc atccaagaat gcctaaagcc
     9361 caaagtgttc atcaaggtag tgcagataca agtgcaagtg agcttaatag cccttcaagt
     9421 actgcgtctg gcgatatccc tccttgggca actgatagcg aaggtgagag tgaaaaaaag
     9481 catgagctcc cagtaacagg gggccaaacc caggcacata atcactccaa cataaagcca
     9541 gctagtaaga ttgattttaa agcaaagcac caaacaatta ctgaaaatct tgcgccagaa
     9601 ttacttgagc aaataaaccc tcaaaaagcg cctgaaatag tgccagagga agtaagtatt
     9661 cctgcccctg atgattttca aagcccaatt agtgaaatta gatttgcaca tcaacaagat
     9721 gaatgggctt atttaattaa acgtatggga ctgggtggtc gtatgcgcca atttgcattg
     9781 cattcaatat ttaccaagca aggcaacagt ttacatatag acgttgatga atcacaaaag
     9841 catttagata caccgatgct tcgccaaaga ttagatgccg cattgtcgag tatttatgag
     9901 cataacgtgt cgttaagtat taattttgct aagggagtta ttgactctcc ttatcttatt
     9961 cagcaaaaaa ttgatgcagg tcgtcatcaa caagcaatcg atgtgatcac atctgatgaa
    10021 aacatagtac aatttcagca agtatttagc gccgaaattg acgaaaacag tattcaggca
    10081 ttgtaattac ttacaatcgc ccttatgttc atgttaatta atgtattaaa agaaagagag
    10141 aaagttatgt ttaaaggtgg aatgggcaac atgatgaagc aagcgcagca aatgcaagat
    10201 cgcatgcaaa aagcccaaga cgaaatcgca acattagaag ttgttggcga agccggtgcc
    10261 ggtttagtta aagtaaccat gcttggtaac cacaatgtac gtcgtgttca gcttgatgaa
    10321 agccttatgg aagacgacaa agacatgatt gaagacttac ttgcagcagc atgtaacgat
    10381 gctgtacgcc gtgttgctga agaaacacaa gagcgcatgg gtaaagtaac tggcggtatg
    10441 caattaccac caggtatgaa aatgccgttt taagtaaata atgcaacttt cagatagttt
    10501 aaatcagctt atagaagcac ttcgctgtca accgggcata ggtccaaagt cggcgcaacg
    10561 tattgctttt cacttgcttg agcgcgaccg aaagggaggc actcagctgg gcaatgcatt
    10621 gactaaagca atgacagcca tagggcattg tcagtcttgt cgtacttttt gcgaacaagc
    10681 tcagtgcgat atttgtttaa gtacaaaacg ccaagacagc ggcatattat gtgttgttga
    10741 atcgcctact gatgtgcttg ccattgagca aacaggtcag tatttagggc tatactttgt
    10801 tttaatgggt catttatcgc caattgacgg tatcggccct aaagaaattg gcttagac
//
