GCF_024453815.1_ASM2445381v1_genomic - 3 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP072934.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	betalactone	367,302	397,302	TP-1161	RiPP:Thiopeptide	8%
Region 2	terpene	1,837,737	1,858,600	carotenoid	Terpene	25%
Region 3	T1PKS	2,120,284	2,165,014	coelichelin	NRP	18%

NZ_CP072934.1 - Region 1 - betalactone

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Location: 367,302 - 397,302 nt. (total: 30,001 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001343.1	0.22	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001526.1	0.21	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0000583.1	0.20	RiPP	grisemycin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.1	0.20	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001525.1	0.20	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0001075.1	0.19	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0001465.1	0.19	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0001334.1	0.19	Alkaloid	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000938.1	0.18	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000713.1	0.18	Saccharide	ribostamycin	Streptomyces ribosidificus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001343.1	0.54	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001526.1	0.54	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0000583.1	0.53	RiPP	grisemycin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.1	0.53	Terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001525.1	0.53	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0001075.1	0.51	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0001465.1	0.51	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0001334.1	0.51	Alkaloid	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000938.1	0.50	Other (Aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000713.1	0.50	Saccharide	ribostamycin	Streptomyces ribosidificus

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP072934.1 - Region 2 - terpene

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Location: 1,837,737 - 1,858,600 nt. (total: 20,864 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.31	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000650.1	0.25	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001120.1	0.17	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000637.1	0.16	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.1	0.14	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000636.1	0.13	Terpene	carotenoid	Brevibacterium linens
BGC0000140.1	0.05	Polyketide	4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Streptomyces sp. 88-682
BGC0001043.1	0.05	NRP, Polyketide	SGR PTMs	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000966.1	0.05	NRP, Polyketide	caerulomycin A	Actinoalloteichus sp. WH1-2216-6
BGC0000990.1	0.05	NRP, Polyketide	epothilone	Sorangium cellulosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.65	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000650.1	0.58	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001120.1	0.47	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000637.1	0.46	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.1	0.44	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000636.1	0.41	Terpene	carotenoid	Brevibacterium linens
BGC0000140.1	0.24	Polyketide	4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Streptomyces sp. 88-682
BGC0001043.1	0.24	NRP, Polyketide	SGR PTMs	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000966.1	0.22	NRP, Polyketide	caerulomycin A	Actinoalloteichus sp. WH1-2216-6
BGC0000990.1	0.21	NRP, Polyketide	epothilone	Sorangium cellulosum

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP072934.1 - Region 3 - T1PKS

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Location: 2,120,284 - 2,165,014 nt. (total: 44,731 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.24	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.21	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001163.1	0.21	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001161.1	0.21	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0000410.1	0.20	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001281.1	0.20	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0001264.1	0.19	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.19	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001897.1	0.19	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.57	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001162.1	0.54	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001163.1	0.54	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001161.1	0.54	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0000410.1	0.53	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001281.1	0.52	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0001264.1	0.52	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.52	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001897.1	0.51	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 2120283 - 2165014:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1962

PKS_AT (625..908): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: fatty_acid

Prediction, score:

fatty_acid: 87.0
Methoxymalonyl-CoA: 58.2
Methylmalonyl-CoA: 57.0
Ethylmalonyl-CoA: 42.5
Propionyl-CoA: 35.2
Isobutyryl-CoA: 23.5
trans-1,2-CPDA: 23.1
inactive: 17.5
2-Methylbutyryl-CoA: 16.1
Acetyl-CoA: 14.2
CHC-CoA: 8.9
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Malonyl-CoA: -4.2

ctg1_1963

CAL_domain (65..516): pk

minowa: Acetyl-CoA

Prediction, score:

Acetyl-CoA: 32.7
NH2: 7.2
shikimic_acid: 6.9
AHBA: 5.7
fatty_acid: 0.0