LOCUS       c00015_NZ_AEVT..       10864 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AEVT01000108.1 Vibrio sinaloensis DSM 21326 VISI1226_71, whole
            genome shotgun sequence.
ACCESSION   NZ_AEVT01000108
VERSION     NZ_AEVT01000108
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:34:00
            Original ID  :: NZ_AEVT01000108.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6092
            Orig. end    :: 16956
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10864
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11092:11956](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5864
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10864
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10864
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(2216..4387)
                     /locus_tag="ctg15_8"
                     /transl_table=11
                     /translation="MDPSLLLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAW
                     LMSVEQASPFSIMSVTFTNKAAAEMRGRIEELMMGSASGMWNGTFHGICHRILRAHYLD
                     AKLPEDFQIIDTDDQVRLLRRLIKAQNLDEKQWPAKQVAWWINGKKDEGLRPNHIDAFH
                     DPITKTYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDKKHIREHYQARFKHILVDEF
                     QDTNNIQYAWLRMMAGPDAHVMIVGDDDQSIYGWRGAKIENIEKFTLEFPSVNTIRLEQ
                     NYRSTKTILEASNALIANNTERMGKELWTEGAEGEPISVYSAYNELDEARFAVNKIKEW
                     QDKGGALNDAAMLYRNNAQSRVLEEALIQASLPYRIYGGMRFFERQEIKDALSYLRLMA
                     NRNDDAAFERVVNTPTRGLGDKTLETIRFAARDQGSTMWEASIRLLDDKVLAGRAAGAL
                     SRFVELINALEDDTCEMALHEQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTATR
                     QFEKPEEAEEMTLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVE
                     EGMFPSQMSAEEAGRLEEERRLCYVGMTRAMEKLYITYAEMRRLYGQDKYHKPSRFIRE
                     LPETCLDEVRMKAQVSRPASSGRFSQTVVKENFNETGFSLGSRVMHPKFGEGTIINFEG
                     SGPQSRVQVAFNGEGIKWLVTAYAKLETL"
     aSDomain        complement(2225..4372)
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg15_8_0001"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg15_8"
                     /locus_tag="ctg15_8"
                     /protein_end="721"
                     /protein_start="5"
                     /score="1321.7"
                     /tool="antismash"
                     /translation="LLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QASPFSIMSVTFTNKAAAEMRGRIEELMMGSASGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDTDDQVRLLRRLIKAQNLDEKQWPAKQVAWWINGKKDEGLRPNHIDAFHDPITK
                     TYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDKKHIREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMAGPDAHVMIVGDDDQSIYGWRGAKIENIEKFTLEFPSVNTIRLEQNYRST
                     KTILEASNALIANNTERMGKELWTEGAEGEPISVYSAYNELDEARFAVNKIKEWQDKGG
                     ALNDAAMLYRNNAQSRVLEEALIQASLPYRIYGGMRFFERQEIKDALSYLRLMANRNDD
                     AAFERVVNTPTRGLGDKTLETIRFAARDQGSTMWEASIRLLDDKVLAGRAAGALSRFVE
                     LINALEDDTCEMALHEQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTATRQFEKP
                     EEAEEMTLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMEKLYITYAEMRRLYGQDKYHKPSRFIRELPETC
                     LDEVRMKAQVSRPASSGRFSQTVVKENFNETGFSLGSRVMHPKFGEGTIINFEGSGPQS
                     RVQVAFNGEGIKWLVTAYAKLE"
     PFAM_domain     complement(2540..3559)
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_8_0002"
                     /evalue="6.80E-83"
                     /label="ctg15_8"
                     /locus_tag="ctg15_8"
                     /protein_end="616"
                     /protein_start="276"
                     /score="279.1"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNALIANNTERMGKELWTEGAEGEPISVY
                     SAYNELDEARFAVNKIKEWQDKGGALNDAAMLYRNNAQSRVLEEALIQASLPYRIYGGM
                     RFFERQEIKDALSYLRLMANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDQGSTMWE
                     ASIRLLDDKVLAGRAAGALSRFVELINALEDDTCEMALHEQTDHVIKYSGLFAMYEQEK
                     GEKSKARIENLEELVTATRQFEKPEEAEEMTLLTAFLTHAALEAGEGQADEFEDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMEKLYITYAE
                     "
     PFAM_domain     complement(3575..4360)
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_8_0001"
                     /evalue="2.80E-74"
                     /label="ctg15_8"
                     /locus_tag="ctg15_8"
                     /protein_end="271"
                     /protein_start="9"
                     /score="250.6"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQASP
                     FSIMSVTFTNKAAAEMRGRIEELMMGSASGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDTDDQVRLLRRLIKAQNLDEKQWPAKQVAWWINGKKDEGLRPNHIDAFHDPITKTYLQ
                     LYTAYQEACDRAGLVDFAEILLRAHELLRDKKHIREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMAGPDAHVMIVGDDDQSIYGWRGAKIENIEKFTLEF"
     CDS             4661..4921
                     /locus_tag="ctg15_9"
                     /transl_table=11
                     /translation="MKKSNLAVTAAVTGLIALGGTMLTAAPAVAAEKEKCYGVAKAGKN
                     DCATKTSSCAGTAKEDNQSDAFVVVPKGLCGKLSGGSTQSS"
     PFAM_domain     4757..4906
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_9_0003"
                     /evalue="6.10E-22"
                     /label="ctg15_9"
                     /locus_tag="ctg15_9"
                     /protein_end="82"
                     /protein_start="32"
                     /score="77.5"
                     /tool="antismash"
                     /translation="KEKCYGVAKAGKNDCATKTSSCAGTAKEDNQSDAFVVVPKGLCGK
                     LSGGS"
     CDS             5001..5864
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_10"
                     /sec_met_domain="DUF692 (E-value: 1.4e-90, bitscore: 295.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKNDNYHQHIGVGLRTPHLDFFTQHQPALSWLEIHSENYFQPHSA
                     ARQQLRCIAQDYQISCHGIGLSLGSVERVNQTHLKQLKNLIDEINPFLVSDHLSWSENG
                     GHYFNDLLPLPYTEEALAVFCRNVSEVQDYLQRPMLIENPSSYVKFDHSTITEWEFLAE
                     VQRRTDCRLLLDLNNVHVSAFNHGFDTQTYLDAIPAQFVDEIHLAGFTVKQLDKGEIWI
                     DTHSQPVSDEVWALYEQWLAKHGTRHTLIEWDLDIPAPEVLLAEASKAHQRLINHSKDI
                     EQKVAS"
     PFAM_domain     5028..5816
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_10_0004"
                     /evalue="3.70E-106"
                     /label="ctg15_10"
                     /locus_tag="ctg15_10"
                     /protein_end="272"
                     /protein_start="9"
                     /score="354.2"
                     /tool="antismash"
                     /translation="IGVGLRTPHLDFFTQHQPALSWLEIHSENYFQPHSAARQQLRCIA
                     QDYQISCHGIGLSLGSVERVNQTHLKQLKNLIDEINPFLVSDHLSWSENGGHYFNDLLP
                     LPYTEEALAVFCRNVSEVQDYLQRPMLIENPSSYVKFDHSTITEWEFLAEVQRRTDCRL
                     LLDLNNVHVSAFNHGFDTQTYLDAIPAQFVDEIHLAGFTVKQLDKGEIWIDTHSQPVSD
                     EVWALYEQWLAKHGTRHTLIEWDLDIPAPEVLLAEASKAHQ"
     CDS             5861..6622
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MTVSLSDLQSQFAKALHYQASGEECHILSDVFSADERMQIYRNNF
                     IMSLSEVLEATYPMVYALVGEECFSQLARQHVLKRPLKAGDVTYYGEYFSDTIEQFPAV
                     VEAAPYAAEVARFEWHIDMAQQQQGCVSVQTSLLPLAKIAQVDPEQQSAIHLHLLPGVI
                     PFHSNYAVFALQKAIETNQFDQLDLSQAEYGVICCTAQGTTWTQSIDSGPFELLQHLHS
                     GSTLGEIPAEYLQHLNQLVESNLVAGFTLAH"
     PFAM_domain     5882..6148
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_11_0005"
                     /evalue="2.60E-20"
                     /label="ctg15_11"
                     /locus_tag="ctg15_11"
                     /protein_end="96"
                     /protein_start="7"
                     /score="72.5"
                     /tool="antismash"
                     /translation="LQSQFAKALHYQASGEECHILSDVFSADERMQIYRNNFIMSLSEV
                     LEATYPMVYALVGEECFSQLARQHVLKRPLKAGDVTYYGEYFSD"
     CDS             6633..7088
                     /locus_tag="ctg15_12"
                     /transl_table=11
                     /translation="MSESVKNILNSYDNLVEKAQAIFVPLLLLFCRLWVAWVFFNSGLT
                     KISTWDSTLFLFEYEYQVPLLPWQLAAYMGTAAELILPLFVALGLLTRPMAAILFVFNI
                     IAVVSYPVLWEQGFFDHQLWGLMILIVVVWGPGPFSVDKVLRNKVAG"
     PFAM_domain     6711..6956
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_12_0006"
                     /evalue="9.00E-18"
                     /label="ctg15_12"
                     /locus_tag="ctg15_12"
                     /protein_end="108"
                     /protein_start="26"
                     /score="64.8"
                     /tool="antismash"
                     /translation="LLLFCRLWVAWVFFNSGLTKISTWDSTLFLFEYEYQVPLLPWQLA
                     AYMGTAAELILPLFVALGLLTRPMAAILFVFNIIAVV"
     CDS             complement(7085..7303)
                     /locus_tag="ctg15_13"
                     /transl_table=11
                     /translation="MQTLTKSMVLTGMMLFTISGCAELKQAGSDIGHATKDATTAIGHA
                     ARDTTKAIGHASRDAVNSVKDDLSSED"
     CDS             complement(7436..9445)
                     /locus_tag="ctg15_14"
                     /transl_table=11
                     /translation="MSNPLLTFTDLPPFSQIKPEHVKPAVEQVIAECRAKIDQVLQDNT
                     TPSWDNVVAPIEEVDDRLSRIWSPVSHMNSVVNSDELREAYESCLPLLSEYGTWVGQHK
                     GLFEAYKAIKADASYQALTQAQKKTITDSLRDFELSGIGLPADEQHRYGEISKRMSELS
                     SKFSNNVLDATMGWAKHVADEKELAGMPESALAAAKAAAEAKELDGYLLTLDIPSYLPV
                     MTYCDNQELRKELYEAYVTRASDRGPKAGEWDNSEIINEQLKLRHEVARMLGFNTYSEK
                     SLATKMAESSAQVLGFLNDLATKAKPQGEREVEELRQFANSEFGVEELFLWDIAYYSEK
                     QKQHLFQISDEELRPYFPEQKAVSGLFEVLKRVFGMTVQEREGVDTWHESVRFFDIFDG
                     DNTLRGSFYLDLYAREHKRGGAWMDDCRGRRVTLSGELQTPVAYLTCNFNRPVGDKPAL
                     FTHDEVVTLFHEFGHGIHHMLTQVETGAVSGINGVPWDAVELPSQFLENWCWEEEALAF
                     ISGHFETGEPLPKEMLDKMLAAKNFQSAMFILRQLEFGLFDFTLHTEFDPEVGPRVLET
                     LAEVKGKVAVLPSLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVLSSDAFSRFEEDGIFN
                     TETGKSFLNHILEMGGERRADGTFQAFPRARATD"
     PFAM_domain     complement(7460..8782)
                     /aSDomain="Peptidase_M3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01432.22"
                     /description="Peptidase family M3"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_14_0008"
                     /evalue="5.30E-154"
                     /label="ctg15_14"
                     /locus_tag="ctg15_14"
                     /protein_end="662"
                     /protein_start="221"
                     /score="514.0"
                     /tool="antismash"
                     /translation="VMTYCDNQELRKELYEAYVTRASDRGPKAGEWDNSEIINEQLKLR
                     HEVARMLGFNTYSEKSLATKMAESSAQVLGFLNDLATKAKPQGEREVEELRQFANSEFG
                     VEELFLWDIAYYSEKQKQHLFQISDEELRPYFPEQKAVSGLFEVLKRVFGMTVQEREGV
                     DTWHESVRFFDIFDGDNTLRGSFYLDLYAREHKRGGAWMDDCRGRRVTLSGELQTPVAY
                     LTCNFNRPVGDKPALFTHDEVVTLFHEFGHGIHHMLTQVETGAVSGINGVPWDAVELPS
                     QFLENWCWEEEALAFISGHFETGEPLPKEMLDKMLAAKNFQSAMFILRQLEFGLFDFTL
                     HTEFDPEVGPRVLETLAEVKGKVAVLPSLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVL
                     SSDAFSRFEEDGIFNTETGKSFLNHILEMGGERRADGTFQAF"
     PFAM_domain     complement(9002..9367)
                     /aSDomain="TOP_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19310.1"
                     /description="Neurolysin/Thimet oligopeptidase, N-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_14_0007"
                     /evalue="1.20E-28"
                     /label="ctg15_14"
                     /locus_tag="ctg15_14"
                     /protein_end="148"
                     /protein_start="26"
                     /score="99.5"
                     /tool="antismash"
                     /translation="EQVIAECRAKIDQVLQDNTTPSWDNVVAPIEEVDDRLSRIWSPVS
                     HMNSVVNSDELREAYESCLPLLSEYGTWVGQHKGLFEAYKAIKADASYQALTQAQKKTI
                     TDSLRDFELSGIGLPADE"
     CDS             9621..10460
                     /locus_tag="ctg15_15"
                     /transl_table=11
                     /translation="LLSYRHSFHAGNHADVIKHIVQSLILDALKQKDKPFVYHDTHSGV
                     GRYDLTHEWSEKTGEYKQGIERVWQQDTIPQAIQSYLESIKVLNNGDALRYYPGSPRVA
                     RAQLRQQDRMVLTELHPADYPLLEQEFHRDRQVKIFKEDGFKRLKASLPPQERRGLVLI
                     DPPYELAREYRDVVQAIFQSHKRWATGIYAIWYPVVNRYDIEDMIEGLAGLGIRKILQI
                     ELGVSPDTNERGMTASGMIVINPPWKLESQMKEILPFLKEAIAPATGHWKVDWIVPE"
     PFAM_domain     9717..10451
                     /aSDomain="RsmJ"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04378.15"
                     /description="Ribosomal RNA large subunit methyltransferase
                     D, RlmJ"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_15_0009"
                     /evalue="1.90E-115"
                     /label="ctg15_15"
                     /locus_tag="ctg15_15"
                     /protein_end="277"
                     /protein_start="32"
                     /score="384.4"
                     /tool="antismash"
                     /translation="DKPFVYHDTHSGVGRYDLTHEWSEKTGEYKQGIERVWQQDTIPQA
                     IQSYLESIKVLNNGDALRYYPGSPRVARAQLRQQDRMVLTELHPADYPLLEQEFHRDRQ
                     VKIFKEDGFKRLKASLPPQERRGLVLIDPPYELAREYRDVVQAIFQSHKRWATGIYAIW
                     YPVVNRYDIEDMIEGLAGLGIRKILQIELGVSPDTNERGMTASGMIVINPPWKLESQMK
                     EILPFLKEAIAPATGHWKVDWIV"
ORIGIN
        1 ggtttactgg gatgcaaaaa agcagcagtt aaccagtttt gatggccgtg aaaccgcccc
       61 actgaatgcc actccccgcc tattccaaaa tgaacaaggt gaacctctta agttttatga
      121 cgctgtcgtc ggaggccgct ctgtcggaac cccaggcacc gtcaagctgc tgtgggaaac
      181 ccatcagaag tacggcaagt tagcctggtc taaactgatc gaacccgtgg taaaagtggc
      241 agaacaaggc tttgaaatta gcccgcgcct agcgacgatg atcgagaaag atgcagagcg
      301 attaagccgc tttacagcca ccaaacagta cttcttcaat tcagatggta cacctaaggt
      361 agccggtaca ctcctcaaaa accctcaata cgcgcagaca ctcacgctta tctccaaaca
      421 aggagccgat gcattttatc aaggcgatgt cgccgctgac attatccgaa ccgtgcaatc
      481 cgcgccaggt aatccaggcg ttctcgcaca gcaagatttc gaccaatacc aaattaaaca
      541 acgccctgcc gtatgttccg cttatcagag ctatcagatc tgtggcatgg ggcctcctag
      601 ctctggggca ttaaccgtcg gtcagattct ggcaatgact gaatcattcg acctgcagca
      661 atggggggct aatgaccctc gttcttggca agtgatcgcc gatgcttctc gcctcgcctt
      721 tgccgatcgc ggcatgtata tggccgatga agattatgtg ccaatgccaa ctcaaggact
      781 tatcgatcga gaatatctca agcagcgtgc cgctctaata cagcccggta aggcactaaa
      841 gacggtcagc gcgggcacac caccttggaa ctacgcgcag catcaaagtg aagaccaatc
      901 catcgagcta ccctcgacca gccatttcaa cattgttgat aagcaaggta acgtagtctc
      961 gatgaccaca accatagaaa acgcatttgg ctctcgttta atggtgcgcg gcttcctcct
     1021 gaacaatgaa ttgaccgatt tctccttcaa aactcatcat caaggccgac ccattgccaa
     1081 tcgcttagag ccaggcaagc gcccaagatc ctcgatggct ccgacaatag ttatgcacaa
     1141 taaccaacct taccttgcaa tagggtctcc aggtggcagc cgcatcatag ggtatgtttc
     1201 tcaagccatt atcgcgcacc ttcagtggga catggatatt caacaagcca ttaatcagcc
     1261 tcacctattg aatcgttttg gcactctgga tgtagaagca ggaacacaag cggaatcttt
     1321 cgctcctgaa cttgaaaaaa tgggtttcaa agtgaacgtg cgtgacttga attctggatt
     1381 gcatgcaatt ttattcacta aagatggact agaaggtgct gcagatcctc gtcgtgaagg
     1441 gcgtgcgata ggccaataac atcgatcgtc ccacttgctt gtgcgagatc tctcacaagc
     1501 aagtgagcca aaatagcttt ttcgctaaga gtactatcat taactatcag taagtgattg
     1561 atctaaaata acttgtacat ttttagtcca atttattgaa taagaaatcg ttttcgcggt
     1621 gttgctgaaa agccctactc aagtaatatg aaccttgtcg gaaggatgct gacacggaac
     1681 aggaaattac cacggattag gtaatcttca ggaagaagat acggttgctt aggatgagta
     1741 atcggcaagg aaagcaaatt ggacattgaa cggacgcaat agtaactagg atggttgcta
     1801 ctaaggatgg gaaatggaca cctctggacg aggcaaggac tgatcatcag gatgatgaag
     1861 ggacaccgct cagggaacaa gtgatgtgag ctaacgagga ttgttagtgg accaggatag
     1921 ggtcaaggac accgctagga tggcgagaaa aggactaagc tgaaggacgt cagcatacta
     1981 tcaaggattc gatgcatgga gcacttttag tagccggatt gctgcgagta agactataac
     2041 cccgacgggc ttgcgccctc ggggtttttc tttatctgtt ctcttcatat ttgaacttta
     2101 gactgcgttg tctgctttca ctcgccccat cacgtaggtt ccttatgctc aggggcttcg
     2161 ttcaattgtc gctttgtcta caagtcgaat actgttgaaa aattaaactt agcggttata
     2221 acgtttctag tttggcataa gccgtcacta gccacttaat cccttcgcca ttaaaggcca
     2281 cttgcacacg gctttgtggg ccgctgcctt caaagttaat aatggtccct tcaccaaact
     2341 tagggtgcat cactcgcgag cctaggctaa agccggtttc gttaaagttt tctttaacca
     2401 ccgtttggct aaatcgtcct gagctggctg ggcggctgac ttgcgccttc atccgtactt
     2461 catccaagca ggtttcaggc agttcgcgaa taaatcgcga tggcttgtgg tatttatctt
     2521 ggccatacaa gcgacgcatt tctgcgtagg taatgtagag cttttccatt gctcgggtca
     2581 taccgacata acaaaggcgt cgttcttctt ctaaacgtcc agcttcttcc gcagacatct
     2641 ggctagggaa catgccctct tctaccccga ccataaagac aagcgggaac tccagacctt
     2701 tcgcactgtg cagcgtcatc agttgcacgg catcttcaaa ttcatcagcc tgaccttcac
     2761 ctgcttccag agcagcgtga gtcaaaaacg ccgtaagcaa ggtcatttct tcggcttctt
     2821 ctggcttttc gaattggcgc gttgctgtga ccaattcttc caagttttcg attcttgctt
     2881 tggatttttc gcctttttct tgctcataca tagcaaacag acccgaatat ttgatcacat
     2941 ggtcggtttg ctcatgcaac gccatttcgc aagtgtcgtc ttcaagagcg ttgatcagtt
     3001 caacaaatcg acttaacgca cctgctgctc gacctgcgag tactttatcg tctagcagac
     3061 gaatactggc ttcccacatg gtactgccct gatcacgcgc agcaaatcga atggtttcta
     3121 aagtcttatc gcctaagcct cgagtcggag tgttcacgac acgctcaaac gcggcatcat
     3181 cattacgatt ggccattaag cgtaaataac tcagcgcatc tttgatttct tggcgctcga
     3241 agaatcgcat accgccataa attcgatacg gaagactggc ttgtatcaag gcttcttcta
     3301 atacacgtga ctgggcatta tttcgataca gcattgcagc atcgttcaag gctccgcctt
     3361 tatcttgcca ctctttgatc ttattaacgg caaagcgcgc ttcatctaac tcgttataag
     3421 cggagtagac agagataggc tcaccttctg cgccctcagt ccacaactct ttgcccattc
     3481 gctcggtatt attcgcaatc agagcgttcg acgcttcaag aatggtcttg gtcgaacgat
     3541 agttctgttc aagacgaatg gtattaacgc ttggaaattc gagggtaaac ttctcgatgt
     3601 tttcaatctt cgctccgcgc caaccataaa tcgattggtc atcgtcacca acgatcatca
     3661 cgtgggcgtc aggccccgcc atcatgcgca gccaagcgta ttggatgtta ttggtatctt
     3721 ggaactcatc gaccaaaatg tgcttaaatc gagcttgata atgctcgcga atatgctttt
     3781 tatcgcgcaa tagctcatgg gcacgaagca agatttcagc aaaatcaacc aagcccgctc
     3841 tatcacatgc ttcttggtag gcggtataaa gctgcaagta ggttttggtg atcgggtcat
     3901 ggaaagcatc aatatgattc ggacgcaggc cttcatcttt tttgccattg atccaccaag
     3961 caacttgctt cgccggccac tgcttttcat cgaggttttg cgctttaatc aatcgacgca
     4021 acaaacgaac ctggtcgtcg gtgtcaatga tctggaagtc ttccggtagc ttagcatcta
     4081 gatagtgagc acgaagaata cggtgacaaa tgccatggaa ggtaccattc cacatgcctg
     4141 atgcactgcc catcatcagc tcttcaatgc ggcctcgcat ttcagccgcg gctttattgg
     4201 taaaggtcac cgacatgatc gagaaaggtg aagcttgctc cacagacatc agccaagcga
     4261 tgcgatggac caatacgcga gttttaccac tccctgctcc ggcaagaaca agtaagtttt
     4321 caagaggggc ggcaacggct tcacgctgct tgtcatttag accatcaaga agtaatgaag
     4381 gatccattct aggctcagct actggttatc tatacatgaa aaatgattat aacctaaaca
     4441 ccctatccat ttcagaacaa aaactagaaa tttttccgtt caattactcc attaaaatca
     4501 gcactttaaa taaccaaaac aaataaaacc ttatttttat ataaattatc tgaaagtttt
     4561 tttggccgct tttctatcct tttatttaag caagttgatg aaatagctaa tgattcactt
     4621 gcccacataa gtaaaggaaa taaagtctga ggaaattaag atgaaaaaat caaatcttgc
     4681 tgttactgct gctgttactg gtctaatcgc tctaggtggc accatgctaa ctgctgcacc
     4741 ggctgtcgca gctgaaaaag aaaaatgcta cggcgtagca aaagcaggca aaaatgactg
     4801 tgcaactaaa acaagttctt gtgctggtac agcaaaagaa gacaaccaat cagatgcatt
     4861 tgttgtggtt cctaaaggac tttgtggcaa gttgtctggc ggtagcactc agtcttcata
     4921 attcttctct gctgtccata agatgaacgg cccaggctca acaggccgtt catctccatt
     4981 cactcgcaaa ggactcgccc gtgaaaaacg ataattatca tcaacacatc ggtgtagggt
     5041 tgcgaacgcc tcatttggat ttttttaccc aacatcagcc tgcgctctct tggttagaaa
     5101 tccacagcga aaactatttt cagccccact ctgctgctcg ccagcaattg cgttgcattg
     5161 cgcaagacta tcaaatcagc tgtcacggta ttggtttatc tcttggcagt gttgaacgtg
     5221 ttaatcaaac acatttaaaa caactcaaaa acctgattga tgaaattaac cctttcttgg
     5281 tctccgatca tttgagttgg agtgaaaatg gcgggcacta ctttaatgac ttgctgcctc
     5341 ttccgtatac cgaagaagcg ttggcggtat tttgtcgcaa tgtaagcgaa gtacaagatt
     5401 acctgcaacg ccctatgctg atcgagaatc catccagcta tgtaaagttt gaccactcga
     5461 ccattaccga atgggaattt ctagcagaag ttcagcgccg aacagattgt cgcttattgc
     5521 tcgatctcaa caacgttcac gtctctgcgt tcaatcatgg cttcgacaca caaacgtact
     5581 tagatgcgat ccctgctcaa tttgtcgatg agattcactt ggcaggtttt actgtaaagc
     5641 agttagacaa aggtgaaatc tggattgata cccacagtca acccgtcagt gatgaggtgt
     5701 gggccttata tgaacagtgg ttggcaaaac atggcactcg ccacacttta atcgaatggg
     5761 atttggacat tcccgccccc gaagtgttgc tcgcggaggc aagtaaagct caccaacgcc
     5821 ttatcaatca ttcgaaagac attgagcaaa aggtggcgtc atgactgttt ctctgtccga
     5881 tctgcaaagc caatttgcca aagccttaca ttatcaagca tcaggggaag agtgccatat
     5941 tctcagtgat gtgtttagtg cagatgaacg aatgcagatc taccgcaata acttcatcat
     6001 gagtttaagt gaagtattag aggcaaccta ccctatggtg tacgccttgg ttggcgagga
     6061 atgcttttct cagctagcaa gacagcatgt gctgaagcgt cctcttaaag cgggtgatgt
     6121 gacctattac ggcgaatact tttcagacac gattgaacag tttccagcgg tcgtggaagc
     6181 cgcaccttat gctgcagaag tggcacgctt tgaatggcat atcgatatgg cacagcagca
     6241 gcaaggatgc gtatcagtgc aaaccagttt gctgccactg gcgaagattg ctcaagtcga
     6301 cccagagcaa caaagcgcta tccatctgca tctgctcccc ggagttattc cattccactc
     6361 gaattacgcg gtgtttgcgc tgcaaaaggc aattgaaacc aaccaatttg atcaactcga
     6421 cttatcacaa gccgagtatg gtgtgatttg ttgcactgct caaggcacaa cttggactca
     6481 gagcatagat tctgggccgt ttgaattatt acagcacctt cattctggaa gtacattagg
     6541 cgagatccct gccgagtacc tccaacatct aaaccaactt gttgaaagca acttagttgc
     6601 tggatttacg ctcgcgcatt aaggggaaag ctatgtcgga atcagtcaaa aatatactca
     6661 atagctatga caatttggtc gaaaaagcgc aagccatatt cgttccttta ttattgttgt
     6721 tctgtcgcct ttgggtggct tgggtctttt ttaattcggg attaaccaag atctccacat
     6781 gggacagtac gctattttta tttgagtatg aatatcaagt acccctgttg ccttggcaac
     6841 tcgccgccta catgggcacg gctgcagagc tgatcctacc gctctttgtc gccttaggat
     6901 tactgacacg accgatggct gcaatattgt ttgtattcaa tattattgcg gtggtgtctt
     6961 accctgtgtt gtgggaacaa ggcttctttg accaccaatt gtggggatta atgatcctga
     7021 tcgttgtcgt ctggggacca ggaccatttt ctgtggataa agtactgcga aataaagtcg
     7081 cgggttaatc ttccgaactt aggtcatctt taactgagtt gaccgcatcg cgcgaggcat
     7141 gaccaatcgc tttggtagtg tctcgagcag catgaccaat cgctgtagtg gcgtcttttg
     7201 ttgcgtgacc aatatcactt cctgcttgtt ttagctcagc acaacccgaa atcgtaaaca
     7261 acatcattcc ggttagtacc atcgatttag tcagtgtctg catattacct ccttgcctac
     7321 taagcgtttt atcataacag aaaaaaagcc cctgactcat cagagtcagg ggctgtatta
     7381 gttgttggac gagtatcgtg tttaagcgct gatacccgag tgacgcagta gagcatcaat
     7441 ctgtggctcg cgccctcgga aacgcttgaa aagttccatc ggctcttcgc tcccccccca
     7501 tctcaagaat atggttcagg aagcttttac cagtctcggt attaaagatg ccgtcttctt
     7561 caaagcgtga gaaggcgtct gaggataaaa cttctgccca taggtagctg tagtaaccgg
     7621 cgctgtagcc accagcaaaa atatgactga agctgtgcga gaaacggttc cactccaaac
     7681 ttggtagtac cgcaacttta cctttgactt cagctaaggt ttccaacaca cgcgggccaa
     7741 cttctgggtc aaactcagtg tgaagggtga aatcgaataa accaaactct agctggcgta
     7801 gaatgaacat cgccgattgg aagttcttcg ccgcaagcat cttatcaagc atctcttttg
     7861 gcagtggctc gccggtttca aagtgaccag agataaatgc cagcgcttct tcttcccaac
     7921 accagttttc caagaattgg cttggtaact cgaccgcatc ccatggcacg ccgttaatgc
     7981 cagagaccgc gcctgtttca acttgagtca gcatatggtg aataccgtgg ccaaactcgt
     8041 ggaacaaagt gaccacttca tcatgagtaa atagcgctgg cttatcaccc acagggcggt
     8101 tgaagttaca cgtcaagtac gccaccggag tttgcaactc acccgatagt gtgacacgac
     8161 gaccacgaca atcatccatc caagcaccgc cacgtttgtg ttcacgtgcg tacaaatcaa
     8221 gatagaagct accacgcaaa gtgttgtcac catcaaagat atcgaaaaag cgcacagact
     8281 catgccaagt atccacgccc tcacgctctt gtaccgtcat accaaagaca cgcttaagca
     8341 cttcaaatag gccgctgacc gctttttgct ctgggaagta agggcgcagc tcttcatcag
     8401 aaatttggaa tagatgctgt ttttgtttct cgctgtagta agcgatatcc cacaagaaca
     8461 actcttcaac accgaactcg ctattagcaa actgacgaag ctcttcaact tctcgctcac
     8521 cttgaggttt cgctttcgtc gctaagtcat tcaaaaagcc caacacttgt gcggaagact
     8581 cggccatctt ggtggctaac gacttttcac tgtaggtgtt aaagcctagc atgcgcgcga
     8641 cttcgtgacg caacttaagc tgctcattga tgatttcgct attgtcccac tcgcccgctt
     8701 tcggaccgcg atcagaggcg cgagtcacgt acgcttcgta cagctctttg cgcagctctt
     8761 ggttatcaca ataggtcatc actggcagat aagacgggat atccagtgtc agcaagtagc
     8821 catctagctc ttttgcttct gcggctgctt tcgctgcagc aagcgccgat tccggcatac
     8881 ctgccaactc tttctcgtct gctacgtgct tggcccagcc catagtggca tcaagaacat
     8941 tgttggagaa tttagaactc agctctgaca tgcgtttgct gatttcaccg tagcgatgct
     9001 gctcatccgc aggtaaacca ataccagaca gctcaaagtc acgcagtgaa tctgtgatgg
     9061 ttttcttttg cgcttgcgtt aacgcttgat aagacgcatc ggctttgatc gctttgtaag
     9121 cttcaaataa ccctttgtgc tgaccaaccc aagtcccata ctcagacaac aatggtaggc
     9181 aactttcata tgcttcacgt aactcgtcac tgttcaccac cgagttcata tggctcactg
     9241 gtgaccaaat acggcttaaa cgatcgtcca cttcctcaat cggtgccacc acattatccc
     9301 agcttggggt cgtattatct tgcagcactt gatcaatctt agcgcggcat tctgcgataa
     9361 cttgctcaac agcaggctta acgtgctctg gtttaatctg tgaaaacggt ggaagatccg
     9421 taaaagtcag tagagggtta gacataaagc attccttttg attcaaagat ggcgtctcgc
     9481 ggcacctttt ttaattctgt gacgtcttaa tttgtaattc tcagatagta aatataggta
     9541 ggttcagcaa ttttcaatag taacgtatac taactaccat cattcatcat gctctttgca
     9601 cctattctga gagaaatatt ttgttaagtt accgtcacag ctttcacgct ggcaaccacg
     9661 ccgacgttat taagcatatt gttcaaagcc ttatcctgga tgctttgaaa caaaaagata
     9721 agccgtttgt ctaccatgac actcattctg gtgtcggccg ctacgatttg acccacgaat
     9781 ggtcggaaaa aacgggcgaa tacaagcaag gtattgaacg cgtttggcaa caagacacca
     9841 ttccacaagc aattcaaagc tacttagaat caatcaaggt gctaaacaat ggggatgcat
     9901 tgcgctacta cccaggctca ccgcgagtgg cacgcgctca actgcgtcag caagatcgca
     9961 tggtgctcac tgaactgcac cctgccgatt acccactact agagcaagaa ttccatcgtg
    10021 accgccaagt aaagatcttc aaagaagacg gcttcaagcg cttaaaagcg agcttaccgc
    10081 cgcaagagcg tcgtggtttg gtcttgattg accctcctta tgaactggcc agagagtacc
    10141 gcgatgtcgt acaagcgatt ttccagagcc acaagcgctg ggcaacaggc atctacgcca
    10201 tttggtaccc cgtggtcaat cgctatgata ttgaagacat gatcgaaggt ttagcgggac
    10261 tcggcattcg taaaattctg caaattgaac tcggcgtatc accggacact aacgagcgcg
    10321 ggatgacggc atctggcatg atcgtgatta acccgccgtg gaaactggaa agccagatga
    10381 aagagattct tcctttcttg aaggaagcaa ttgcgccggc aaccggtcat tggaaagtag
    10441 attggattgt tcctgaataa tccagattca ttaagcagag tacaaatggc tctgttttat
    10501 cgctaaatgt cataaccacg acctcttttt ctcattggga aatcccagtg ggtcgattta
    10561 tgataagaga caaaggacag ctatgcgtgg cggattgagt ttatatctca tcgccccaat
    10621 attggtggca tagcaatcaa taattcaaaa gctcggagaa agtaatggcg actcattttg
    10681 actatatctg tatcggcggc ggcagcggcg gcatcgcatc agcaaaccgc gcagcgatgt
    10741 acggtgctaa agttgcactg atcgaagctc aagatcttgg cggtacgtgt gtaaacgttg
    10801 gctgtgtgcc gaaaaaggtg atgtggcatg gtgcgcaagt tgcagaagca atgaacctat
    10861 acgc
//
