LOCUS       c00001_NZ_ARWH..       10843 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_ARWH01000001.1 Methyloversatilis universalis Fam500
            Metunv3DRAFT_Contig245.1_C, whole genome shotgun sequence.
ACCESSION   NZ_ARWH01000001
VERSION     NZ_ARWH01000001
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:54:53
            Original ID  :: NZ_ARWH01000001.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3017953
            Orig. end    :: 3028796
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10843
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3022953:3023796](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5843)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10843
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10843
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="11"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1446..1898
                     /locus_tag="ctg1_2704"
                     /transl_table=11
                     /translation="MSAAHYTDTLNALIATCRDGEHGFNACATHAQASQLKTLFRERAD
                     AYRSAAETLQNVVSRSGVEPDASGSVSGALHRGWVSLRSTLPGDDNLAMLNEAERAEDR
                     ALTRYRDALSQSLPADIRLMVEHQLRAARQSHDRIRLLRDQYRAIA"
     PFAM_domain     1464..1787
                     /aSDomain="DUF2383"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09537.12"
                     /description="Domain of unknown function (DUF2383)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2704_0381"
                     /evalue="4.70E-35"
                     /label="ctg1_2704"
                     /locus_tag="ctg1_2704"
                     /protein_end="114"
                     /protein_start="6"
                     /score="120.3"
                     /tool="antismash"
                     /translation="TDTLNALIATCRDGEHGFNACATHAQASQLKTLFRERADAYRSAA
                     ETLQNVVSRSGVEPDASGSVSGALHRGWVSLRSTLPGDDNLAMLNEAERAEDRALTRYR
                     DALS"
     aSDomain        1470..1874
                     /aSDomain="TIGR02284"
                     /aSTool="tigrfam"
                     /description="TIGR02284: conserved hypothetical protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2704_0092"
                     /evalue="4.40E-38"
                     /identifier="TIGR02284"
                     /label="ctg1_2704"
                     /locus_tag="ctg1_2704"
                     /protein_end="143"
                     /protein_start="8"
                     /score="128.7"
                     /tool="antismash"
                     /translation="TLNALIATCRDGEHGFNACATHAQASQLKTLFRERADAYRSAAET
                     LQNVVSRSGVEPDASGSVSGALHRGWVSLRSTLPGDDNLAMLNEAERAEDRALTRYRDA
                     LSQSLPADIRLMVEHQLRAARQSHDRIRLLR"
     CDS             2046..2699
                     /locus_tag="ctg1_2705"
                     /transl_table=11
                     /translation="MKRIHALATSLLLAAGVAQAATVHGEDFESGSTPAGWSGAGTVQS
                     TGSFASLGFGQQHLRVEGSNAAVLTLNNLGAHTAITLSFDLVLWDSIDGNPGGFPYGDM
                     FQLRADNVTLIEQLFGNYGTNGSEGPGSTLVQNDANRGYGFWVDSARRVELTFAHTADT
                     VRFEFQYPNSQGSSDESFGLDNLQVSITPVPEPGSWALLLGGLGLVGLASRRRG"
     PFAM_domain     2619..2693
                     /aSDomain="PEP-CTERM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07589.13"
                     /description="PEP-CTERM motif"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2705_0382"
                     /evalue="1.70E-06"
                     /label="ctg1_2705"
                     /locus_tag="ctg1_2705"
                     /protein_end="216"
                     /protein_start="191"
                     /score="27.9"
                     /tool="antismash"
                     /translation="PVPEPGSWALLLGGLGLVGLASRRR"
     aSDomain        2622..2693
                     /aSDomain="TIGR02595"
                     /aSTool="tigrfam"
                     /description="PEP_exosort: PEP-CTERM protein-sorting
                     domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2705_0093"
                     /evalue="1.10E-04"
                     /identifier="TIGR02595"
                     /label="ctg1_2705"
                     /locus_tag="ctg1_2705"
                     /protein_end="216"
                     /protein_start="192"
                     /score="20.8"
                     /tool="antismash"
                     /translation="VPEPGSWALLLGGLGLVGLASRRR"
     CDS             complement(2767..3141)
                     /locus_tag="ctg1_2706"
                     /transl_table=11
                     /translation="MAIGWLGAVKAVPWGDVIAAAPTVVQGANALWDRVAGKRRREDAP
                     PPVPPEGGVDARTAALEHAVVELQKEAQAASQLIRSLAEQNAQLVREIGALRLRIRVLA
                     VAGAGGLVVAGVALATVLSR"
     CDS             complement(3189..3683)
                     /locus_tag="ctg1_2707"
                     /transl_table=11
                     /translation="MNKQKKMISAFGAAWLACVCALPAQADEGHVLSLQFGPYVHHWDR
                     DPEHNNTPGMLGLEYTAPSRWLAGASFLRNSFDQPTEYYYAGKRWDLDGLSPHLYVKVT
                     AGALLGYTGRYEDKIPFNHKGTAFAVIPALGYQVDRYSAQVALLGTAGVMFTFGIDLGR
                     W"
     CDS             complement(3771..4235)
                     /locus_tag="ctg1_2708"
                     /transl_table=11
                     /translation="MNALFRLYDLSAPLVRAADLLRPLLLLALRLYLASVFFRSGLTKI
                     ADWDTTLYLFTEEYAVPLLPPAIAAFMGTAGELLLPPLLALGLAGRFAALGLTVVNAMA
                     VLSYPALLGFECPAALQSHIAWGAGLLALLSFGPGALSADHLIAARRASR"
     PFAM_domain     complement(3915..4163)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2708_0383"
                     /evalue="5.20E-16"
                     /label="ctg1_2708"
                     /locus_tag="ctg1_2708"
                     /protein_end="107"
                     /protein_start="24"
                     /score="59.1"
                     /tool="antismash"
                     /translation="LLLALRLYLASVFFRSGLTKIADWDTTLYLFTEEYAVPLLPPAIA
                     AFMGTAGELLLPPLLALGLAGRFAALGLTVVNAMAVLS"
     CDS             complement(4232..5017)
                     /locus_tag="ctg1_2709"
                     /transl_table=11
                     /translation="MSALREAQRRFGAALAGAAGEPDALPLLAGDPVRNRALLSVYRAT
                     SVANAVAALRLAFPVCAQITGDDFFDALARRYRDACPSSDGDLNRYSAGFPAFLDGFGP
                     VSALPYLPDVARLEWAVHEATTAADAEPAGGRLFAGLDADALARARLRFVPGFALLASD
                     WPVADIWLGHADDAKALARIDLTSAQCAVVWREGWRVRVAALAPAAYALWQALCRREAV
                     GTAWAAACAVEPAFDPGPAFAQALSAGWLHAIDFEEDVP"
     PFAM_domain     complement(4721..4999)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2709_0384"
                     /evalue="4.10E-18"
                     /label="ctg1_2709"
                     /locus_tag="ctg1_2709"
                     /protein_end="99"
                     /protein_start="6"
                     /score="65.5"
                     /tool="antismash"
                     /translation="AQRRFGAALAGAAGEPDALPLLAGDPVRNRALLSVYRATSVANAV
                     AALRLAFPVCAQITGDDFFDALARRYRDACPSSDGDLNRYSAGFPAFL"
     CDS             complement(5001..5843)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2710"
                     /sec_met_domain="DUF692 (E-value: 1.1e-88, bitscore: 294.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLDLATGIGLRQPHYAQLLAERPPLGFVEVHSENFFHEGGASLG
                     VLERTRAHYPVSLHGVGLALASADGGDAAHVDRLAALVDRIEPARVSEHLCWGRVDGRH
                     FNDLLPFPYTGEALSLVAARVSAVQDRLKRPLLIENLSAYVRFRDSEMSEADFLAELVC
                     LTGCGLLLDLNNLYVNACNFGEDAFDMLAALPLHAVGEIHVAGHAQTEYGLIDTHGSRV
                     CDEVWALLRAVRAAGVRAPVLVEWDTDLPSLDVLLDEAARAADAGDATAREVGHVRAA"
     PFAM_domain     complement(5049..5825)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2710_0385"
                     /evalue="1.50E-101"
                     /label="ctg1_2710"
                     /locus_tag="ctg1_2710"
                     /protein_end="265"
                     /protein_start="6"
                     /score="339.1"
                     /tool="antismash"
                     /translation="TGIGLRQPHYAQLLAERPPLGFVEVHSENFFHEGGASLGVLERTR
                     AHYPVSLHGVGLALASADGGDAAHVDRLAALVDRIEPARVSEHLCWGRVDGRHFNDLLP
                     FPYTGEALSLVAARVSAVQDRLKRPLLIENLSAYVRFRDSEMSEADFLAELVCLTGCGL
                     LLDLNNLYVNACNFGEDAFDMLAALPLHAVGEIHVAGHAQTEYGLIDTHGSRVCDEVWA
                     LLRAVRAAGVRAPVLVEWDTDLPSLDVLLDEAARAAD"
     CDS             complement(5861..6127)
                     /locus_tag="ctg1_2711"
                     /transl_table=11
                     /translation="MNKSVALHAALASVLALGVVANPALAEDKGAKEKCFGVAKKGAND
                     CATANGSHSCAGQAKADNDPNEWKFVPAGTCEKMGGKTSAPAR"
     PFAM_domain     complement(5885..6034)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2711_0386"
                     /evalue="4.30E-25"
                     /label="ctg1_2711"
                     /locus_tag="ctg1_2711"
                     /protein_end="81"
                     /protein_start="31"
                     /score="87.6"
                     /tool="antismash"
                     /translation="KEKCFGVAKKGANDCATANGSHSCAGQAKADNDPNEWKFVPAGTC
                     EKMGG"
     CDS             complement(6232..7122)
                     /gene_functions="other (smcogs) SMCOG1108:ROK family
                     protein (Score: 216.4; E-value: 1.1e-65)"
                     /gene_kind="other"
                     /locus_tag="ctg1_2712"
                     /transl_table=11
                     /translation="MRIGVDLGGTKTELIALADDGTVRLRRRMPTPAGDYPATVALIAA
                     MVAQAEAALGARASVGIGTPGSVSPVSGLMRNANSTCLNGRPLKQDLEAALDREIRIAN
                     DANCFALSEAVDGAGQGGAVVFGVILGTGVGGGVVVNGLVLNGANGIAGEWGHNPLPPG
                     ADSEGVAPACYCGRRGCVETWLSGPALAADHLRVAGEAVAPEAIAARAAAGDVACEATL
                     LRYETRLARALAGVINLLDPDVIVLGGGLSSLDRLYRNVPLRWTPHVFSDAIATRLRPP
                     LHGDSSGVRGAAWLW"
     PFAM_domain     complement(6235..7116)
                     /aSDomain="ROK"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00480.22"
                     /description="ROK family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2712_0387"
                     /evalue="2.30E-74"
                     /label="ctg1_2712"
                     /locus_tag="ctg1_2712"
                     /protein_end="296"
                     /protein_start="2"
                     /score="250.6"
                     /tool="antismash"
                     /translation="IGVDLGGTKTELIALADDGTVRLRRRMPTPAGDYPATVALIAAMV
                     AQAEAALGARASVGIGTPGSVSPVSGLMRNANSTCLNGRPLKQDLEAALDREIRIANDA
                     NCFALSEAVDGAGQGGAVVFGVILGTGVGGGVVVNGLVLNGANGIAGEWGHNPLPPGAD
                     SEGVAPACYCGRRGCVETWLSGPALAADHLRVAGEAVAPEAIAARAAAGDVACEATLLR
                     YETRLARALAGVINLLDPDVIVLGGGLSSLDRLYRNVPLRWTPHVFSDAIATRLRPPLH
                     GDSSGVRGAAWLW"
     CDS             7150..7515
                     /locus_tag="ctg1_2713"
                     /transl_table=11
                     /translation="MPFITFRFPHAMIVTFKSRATADTLMFGDNARQLLALMGKPFEPQ
                     GIITPEQLPAALDALKRAADESRTAQRAQPEEDDAEERPPAMVMPVSLAQRAVPLIEQL
                     ERSLRAGEPVTWDSQGQ"
     PFAM_domain     7183..7497
                     /aSDomain="DUF1840"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08895.13"
                     /description="Domain of unknown function (DUF1840)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2713_0388"
                     /evalue="3.10E-31"
                     /label="ctg1_2713"
                     /locus_tag="ctg1_2713"
                     /protein_end="116"
                     /protein_start="11"
                     /score="108.0"
                     /tool="antismash"
                     /translation="MIVTFKSRATADTLMFGDNARQLLALMGKPFEPQGIITPEQLPAA
                     LDALKRAADESRTAQRAQPEEDDAEERPPAMVMPVSLAQRAVPLIEQLERSLRAGEPVT
                     W"
     CDS             7678..7980
                     /locus_tag="ctg1_2714"
                     /transl_table=11
                     /translation="MLGPALAEVLRAWLADVPGLIGALQTACDRGNAAEAALTAHALKG
                     SCSNVGALRLQSLARDVEHRLRERPAECGAASIALAQLRAEYENAADFIRTRLDR"
     PFAM_domain     7699..7947
                     /aSDomain="Hpt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01627.25"
                     /description="Hpt domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2714_0389"
                     /evalue="5.80E-12"
                     /label="ctg1_2714"
                     /locus_tag="ctg1_2714"
                     /protein_end="90"
                     /protein_start="7"
                     /score="45.8"
                     /tool="antismash"
                     /translation="EVLRAWLADVPGLIGALQTACDRGNAAEAALTAHALKGSCSNVGA
                     LRLQSLARDVEHRLRERPAECGAASIALAQLRAEYENA"
     CDS             7977..8159
                     /locus_tag="ctg1_2715"
                     /transl_table=11
                     /translation="MTELLLEDPAPVAPDMPSESECCESGCERCVWTVYQESKLEYERL
                     YAAWLERHPEARPGL"
     PFAM_domain     8007..8108
                     /aSDomain="Oxidored-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09791.11"
                     /description="Oxidoreductase-like protein, N-terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2715_0390"
                     /evalue="1.40E-09"
                     /label="ctg1_2715"
                     /locus_tag="ctg1_2715"
                     /protein_end="44"
                     /protein_start="10"
                     /score="37.5"
                     /tool="antismash"
                     /translation="PVAPDMPSESECCESGCERCVWTVYQESKLEYER"
     CDS             complement(8232..8570)
                     /locus_tag="ctg1_2716"
                     /transl_table=11
                     /translation="MKEIRAIIRPNKLPKLRTVLREMPGFPGMSVAKVEGFGAPRTHAP
                     HNIKEELTDYSAKVRIEIVSPDELVDEIVRRIINVACTGQTGDGLVWVVPVDRAVFINK
                     TTVGSPHG"
     PFAM_domain     complement(8265..8561)
                     /aSDomain="P-II"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00543.24"
                     /description="Nitrogen regulatory protein P-II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2716_0391"
                     /evalue="4.10E-25"
                     /label="ctg1_2716"
                     /locus_tag="ctg1_2716"
                     /protein_end="102"
                     /protein_start="3"
                     /score="88.4"
                     /tool="antismash"
                     /translation="IRAIIRPNKLPKLRTVLREMPGFPGMSVAKVEGFGAPRTHAPHNI
                     KEELTDYSAKVRIEIVSPDELVDEIVRRIINVACTGQTGDGLVWVVPVDRAVFI"
ORIGIN
        1 cggttgcgct gtacgcgccg tccggtctgg tggtcgccca tccggatgcc gcccgcatcg
       61 gcaaaccggc ggaaggcctg ccggaagagg cgctggcggc gctgcgcgaa ggccgcgcac
      121 tgcagtggaa ggatgccgcc ggcgtacgcc acttcctgca gcgtgtttcg ctgagcgaca
      181 gcgacgcctg gtggggcagc gtggtgtcgg tgccggaatc ggtcatcacc gcctcggccg
      241 acgcactgcg caacaccgcc atcgtgatgg gcatcgtcag cgtgctgctg accgccggcg
      301 tgcttttcct gctgctgcgc gccctcaccc gtccgctgca gaccctggcc gaagccatgc
      361 aggcgctggc cggtggcgag ggcgacctga cgcgccgcct gccggacacc ggcagccagg
      421 acgaactggg tctggtcgcg cgttcggtga acgccttcct cgccagcctg cagcgcatgt
      481 tcatcgaggt acgtgaccag agccagaccc tggtgggcgg catccgcgac gtgtccgacg
      541 ccaccggccg cattgccgac agctcccgca cgctggccgg caccaccggc gacaacgccg
      601 ccaccatcga ggaaatcacg gtgtccatcg gccacatcgc cagccatgcc ggcgaagcca
      661 atggcgtcat gctggacacc tgcgccgcct cgcaacgcag cggcatggtg gtgcaggaca
      721 tgcaggccca catgcgcgac atcgccggca gcatggaaac cttggccggt tcgctgaacg
      781 ggctggcgga acgttcgctg cagatcaacg gcatcgtgca ggtgatccgc gaaatcgccg
      841 accagaccaa tctgctggcg ctgaacgcgg cgatcgaggc ggcgcgcgcc ggcgaacagg
      901 gccgcggctt cgcggtggtg gcggacgagg tgcgcaagct ggccgagcgc accagcagcg
      961 ccaccaccga aatccgcgac atgatagacg ccatgcgcag cgacaccggt gaagcggtca
     1021 gcagcatgca tacgacccgc gaagcggtgg aagccggtgt cgagcgggcc gcgcgggtgg
     1081 cggaggaaat cgccggcatc gaggcaggca tgcagcgcgc cgccgaacgg gtgcgcgaaa
     1141 ttgccgaagc cacgcaggaa cagtcggccg ccaccaccgc gctggcgcag tcggccgaac
     1201 aggcgtcggg cgtggtgcag agcaccgacg acgccatcca gcacacttcg gcaacgctgg
     1261 ggcagatcgg tcgcgcctcc gatcacctgg gcgatctggt gggccgcttc cggctgtaag
     1321 ggcgccgcgg ccgtcggcgc aggactacgc gaccctgcgc cgggcgccca cacgcgcccg
     1381 gcacgggccc tcctagcatg gggaacaggc ggccatggcc gcttcctcac gccaggagaa
     1441 agcccatgag tgcagcgcac tacaccgaca ccctgaacgc cctgatcgcc acctgtcgcg
     1501 acggcgaaca cggtttcaac gcctgcgcga cgcacgcgca ggccagtcag ctcaagacac
     1561 tgttccgcga acgcgccgat gcctaccgca gtgccgcgga aacgctgcag aacgtggtgt
     1621 cccgcagcgg cgtcgagccg gacgccagcg gctcggtgag cggcgcgctt catcgcggct
     1681 gggtcagtct gcgcagcacg ctgcccggcg acgacaacct ggccatgctg aacgaggccg
     1741 aacgcgctga ggacagggca ctgacgcgtt accgggatgc gctgtcgcag tcgctgccgg
     1801 cggacatccg gctcatggtc gagcaccagc tgcgggcggc acgccagagc cacgaccgta
     1861 tccgcctgct gcgcgaccag taccgcgcca tcgcctgagc acggccatcg cctgagcacg
     1921 gccatcgccg gaaagcaagc gcgggaagaa gtgccacgaa ctgcacaccc ccctgtttgc
     1981 gggacttgac cgcagatccg ggcgcgccat catggacgga caacacccaa cagagaggtc
     2041 agtccatgaa acgcatacac gccctcgcca cgtcgctgct gcttgcggcc ggcgtcgccc
     2101 aggccgccac ggtgcacggc gaggatttcg aatcgggcag cacgccggcc ggctggagcg
     2161 gcgccggcac cgtgcagtcg accggcagct tcgccagcct gggcttcggc cagcagcacc
     2221 tgcgggtcga aggcagcaat gccgcggtac tcacgctgaa caatctgggg gcgcacaccg
     2281 ccatcacgct gagcttcgac ctggtgctgt gggacagcat cgacggcaat ccgggcggct
     2341 tcccgtatgg cgacatgttc cagctgcgcg ccgacaacgt gacgctgatc gaacagctgt
     2401 tcggcaacta cggaaccaac ggctcggagg gtccgggcag cacgctggtc cagaacgacg
     2461 ccaatcgcgg ctatggcttc tgggtagaca gtgcccgccg ggtcgagctt accttcgccc
     2521 acaccgccga caccgtgcgc ttcgaattcc agtatccgaa cagccagggt tcgtccgatg
     2581 agtccttcgg actcgacaac ctgcaggtca gcatcacgcc ggtgccggaa cccggcagct
     2641 gggcactgct gctgggcggc ctcggtctgg tcggcctggc ttcacgccgc cgcggctgat
     2701 ccgcatcgcc gatgaaaaag ggccgccctg ggggcggccc tttttcatgc gccggccggc
     2761 gcgtactcag cgcgacagta cggtggccag cgccacaccc gccacgacca gcccccctgc
     2821 gccggccacc gccagcaccc ggatgcgcag gcgcagcgcg ccgatctcgc gcaccagctg
     2881 cgcattctgc tcggccagcg agcggatgag ctgggaggcg gcctgcgcct ccttctgcag
     2941 ttcgacgacc gcgtgttcca gcgccgctgt ccgcgcgtcc acaccgccct cgggcggcac
     3001 cggcggcggc gcgtcctccc tgcgacgctt gcccgccacc cggtcccaca gcgcattcgc
     3061 gccctgcacc acggtgggtg cggcggcgat cacatcaccc cacggcaccg ccttgactgc
     3121 gcccagccag cctattgcca tcactcaacc ccgttgcgga aacatccgga gactacctca
     3181 gccccgcctt accagcgtcc gaggtctatg ccgaaggtaa acatcacgcc ggcggtaccc
     3241 agcagcgcca cctgcgcgct gtagcggtcc acctgatagc cgagcgccgg gatgacggcg
     3301 aaagcggtgc ccttgtggtt gaagggaatc ttgtcctcgt agcgcccggt atagccgagc
     3361 agcgcgccgg cagtcacctt gacgtagaga tgggggctca ggccgtcgag atcccagcgc
     3421 ttgccggcgt agtagtactc ggtcggctgg tcgaacgaat tgcgcaggaa ggacgcgcca
     3481 gccagccagc gcgacggcgc cgtgtattcc aggcccagca tgcccggcgt gttgttgtgt
     3541 tcggggtcgc ggtcccagtg atgcacgtag ggaccgaact gcagactcag cacatggcct
     3601 tcatccgcct gcgccggcag tgcgcacacg cacgccagcc atgccgcacc gaatgcggaa
     3661 atcattttct tctgtttgtt catcttgcct gaccgggctg caatatccat cgggcaggca
     3721 tgctgcctgt cctgttcccc ggaaggcgga acgcaatgtt gctggatgtt tcaccggctg
     3781 gcacgccggg cggcgatcag gtggtctgcc gacagggcgc ccggtccgaa agacagcagc
     3841 gccagcagcc cggcacccca tgcgatatgg gactgcagcg cggccgggca ttcgaagccg
     3901 agcagcgccg ggtaggacag caccgccatc gcattcacca ccgtcagccc gagcgccgcg
     3961 aaacggccgg cgagaccgag cgccagcagt ggcggcagca gcagttcgcc cgcggtcccc
     4021 atgaaggcgg cgatcgccgg gggcagcagc ggaaccgcgt actcctcggt aaacagatag
     4081 agcgtggtgt cccagtcggc gatcttggtc agcccggagc ggaagaacac cgacgcgaga
     4141 tagagcctca gcgcgagcag cagcagcggg cgcagcaggt cggccgcgcg caccagcggc
     4201 gccgacaggt cgtacaggcg gaacagcgca ttcatggcac atcctcctca aagtcaatcg
     4261 cgtgcagcca gccggcggac agcgcctgcg caaaggcggg accgggatcg aacgccggct
     4321 cgacggcaca ggccgcggcc caggccgtgc cgaccgcttc gcgccggcac agagcctgcc
     4381 acagcgcata cgcagcaggt gcaagggcgg ccacccgcac ccgccagccc tcgcgccaca
     4441 ccaccgcgca ctgggcagag gtcagatcga tgcgtgccag cgccttcgca tcgtcggcat
     4501 gaccgagcca gatgtcggcc accggccagt cgctggccag cagcgcgaaa ccgggcacga
     4561 aacgcaggcg cgcccgcgcc agcgcatccg catcgagacc ggcgaacagc cggccgccgg
     4621 ccggctccgc gtccgccgcc gtggtggcct catgaaccgc ccactccagc cgcgcgacgt
     4681 cgggcagata gggcagcgcg ctcaccggac cgaaaccgtc aaggaaagcc gggaagccgg
     4741 cgctgtagcg gttgagatcg ccgtcggagg acggacaggc atcgcgatag cgacgcgcca
     4801 gcgcgtcgaa gaaatcgtca ccggtgatct gcgcgcacac cggaaatgcc aggcgcaacg
     4861 cggccaccgc attggccacc gaggtggcgc gatagaccga cagcagcgcg cggttgcgga
     4921 ccgggtcgcc agccagcagc ggcagcgcgt ccggctcgcc ggcggcaccg gccagcgcgg
     4981 cgccaaagcg ccgctgcgcc tcacgcagcg cggacatggc ccacctcccg cgcagtcgca
     5041 tcgcccgcgt cggcggcgcg tgccgcctcg tccagcagca cgtcgagcga gggcagatcg
     5101 gtgtcccact ccaccagcac cggtgcgcgt acgccggccg cacgcaccgc gcgcaacagc
     5161 gcccacactt cgtcgcacac ccggctgccg tgggtgtcga tcaggccgta ttcggtctgc
     5221 gcgtgaccgg cgacatggat ttcgccgacc gcgtgcagcg gcagggcggc cagcatgtca
     5281 aaggcgtcct cgccgaaatt gcaggcattg acgtacagat tgttcagatc gagcagcagg
     5341 ccgcagccgg tcaggcacac cagctcggcc aggaagtcgg cttcgctcat ttcgctgtca
     5401 cgaaagcgca cataggccga caggttctcg atcagcagcg gccgcttcag cctgtcctgc
     5461 actgccgaca cgcgggcggc caccagagac agcgcctcgc cggtataggg aaaggggagc
     5521 aggtcattga aatggcggcc gtcgacgcgg ccccagcaca ggtgttccga cacccgggcc
     5581 ggttcaatcc ggtcgaccag cgccgccagc cggtcaacat gcgcggcatc gccgccgtcg
     5641 gccgacgcca gcgccagacc gacgccatgc aggctgaccg ggtaatgggc gcgcgtccgc
     5701 tcaagcacac cgagcgaggc gccgccctca tgaaagaagt tctcgctgtg cacctcgacg
     5761 aagccgagtg gtggacgctc ggccagcagc tgcgcgtagt gcggctggcg cagcccgatg
     5821 ccggtggcca ggtcgaggtt catcgcgggc gtccctgcgc tcagcgggcc ggcgccgagg
     5881 tcttgccgcc catcttttcg caggtgccgg ccggcacgaa cttccattcg ttcggatcat
     5941 tgtcggcctt ggcctgaccg gcgcagctgt ggctgccatt ggcggtggcg cagtcgttgg
     6001 cgcccttctt ggcgacgccg aaacacttct ccttggcgcc cttgtcttcg gccagcgccg
     6061 gattggcgac cacgccgagg gccagaacgg aagcgagagc agcgtgcagc gcgacggact
     6121 tgttcatctg gaaactcctt gagtcgtgaa tggaaaaccc tgaggccagg ggacatgcac
     6181 cgcagtagac cggcgcggtg gcgattcctt acagcgtggt gcgcggaccg ctcaccacag
     6241 ccaggccgcc ccccggacgc cggacgaatc gccgtgcagc ggcggccgca gccgggtggc
     6301 gatggcgtcg gagaacacgt gcggcgtcca gcgcagcggg acgttgcggt acagacggtc
     6361 gagcgacgac agaccgccgc caagcacgat cacgtccgga tccagcagat tgatcacgcc
     6421 ggccagcgca cgcgccaacc gggtttcgta gcgcagcagc gtcgcctcgc aggcgacgtc
     6481 gccggccgcg gcacgagcgg cgatggcttc gggcgcgacc gcctcaccgg cgacgcgaag
     6541 atgatcggcc gccagcgccg ggccggacag ccaggtttcg acgcagccgc gacggccgca
     6601 gtagcaggcc ggcgccacac cttcgctgtc cgcgcccggt ggcagagggt tgtggcccca
     6661 ctcgccggcg atgccgttgg cgccattcag caccaatccg ttcaccacca cgccgccacc
     6721 gacaccggtg ccgaggatga cgccgaacac caccgcgccg ccctgcccgg cgccgtccac
     6781 cgcctcggac agcgcgaagc agttggcgtc attcgcgatg cgtatttcgc ggtccagcgc
     6841 cgcttcaaga tcctgtttca gcggccggcc gttcaggcag gtcgaattgg cgttgcgcat
     6901 caggccgctg accggcgaca ccgacccggg cgtaccgatg ccgaccgagg cgcgcgcccc
     6961 gagcgccgcc tccgcctgcg ccaccatggc cgcgatcagc gccaccgtgg ccggatagtc
     7021 gccggccggc gtcggcatgc ggcggcgcag ccgcaccgtg ccatcgtcgg ccagcgcgat
     7081 cagttcggtc ttggtgcccc cgaggtccac gcctatgcgc atggcgcacc ccgccacttc
     7141 cgggagacaa tgcccttcat cacctttaga tttccgcacg ccatgatcgt caccttcaag
     7201 tcacgcgcta ccgccgacac cctgatgttc ggcgacaacg cccgccagct gcttgcgctg
     7261 atgggcaagc ccttcgagcc acagggaatt atcacgccgg aacagctgcc ggccgcactc
     7321 gatgccctga aacgggctgc cgacgaaagc cgcaccgcgc agcgcgcaca gccggaagaa
     7381 gacgatgccg aggagcgccc gccggcgatg gtgatgccag tctcgctggc ccagcgcgcg
     7441 gtgccgctga tcgaacagct ggagcgctcg ctgcgcgccg gcgaaccggt gacctgggac
     7501 agccagggtc agtaagcggg cgttcaagcg gcggcccggc cggccgtaga cccggctcat
     7561 acgcgctctc gggcgctcgc ctggaatgtc atgaccgctt ccgccacacc gctcgccgcc
     7621 gacgccgcca cgtcggtacc ggttttcgac cgcagccggc tcgaggagct gaaagccatg
     7681 ctcggcccgg cgctggccga agtgctgcgc gcctggctgg ccgacgtgcc gggcctgatc
     7741 ggtgcgctgc agaccgcgtg cgatcgcggc aacgcggccg aggccgccct cactgcgcac
     7801 gcgctgaagg gcagctgcag caacgtcggc gcgctccgac tgcagtcgct ggcgcgcgac
     7861 gtcgagcacc ggctgcgcga gcggcccgca gaatgcggtg cagcatcgat tgcactggcg
     7921 cagttgcgcg ccgagtacga gaatgcggcc gatttcattc gcacacgact ggatcgatga
     7981 ccgaactgct gctggaagac ccggcgcccg tcgcgcctga catgccctcc gaatccgaat
     8041 gctgcgaatc cggctgcgag cgctgcgtct ggaccgtgta tcaggaaagc aagctcgaat
     8101 acgagcgcct gtacgccgcc tggctcgaac gccacccgga agcccgcccc ggcctctgac
     8161 accagaaaaa aagccccgca gccgcccgga cgggcgcgct gcggggctgc agggacgatg
     8221 cgtcgccggc ttcagccgtg cggcgaaccc acggtcgtct tgttgatgaa caccgcccgg
     8281 tccaccggca ctacccacac cagaccgtca ccggtctggc cggtgcaggc cacgttgatg
     8341 atgcggcgga cgatttcatc caccagttca tcaggcgaca cgatttcgat gcggaccttg
     8401 gccgaatagt cggtcagctc ttccttgatg ttgtgcggcg cgtgcgtgcg cggtgcgccg
     8461 aaaccctcga ccttggcgac gctcatgccg ggaaagcccg gcatttcgcg cagcaccgtg
     8521 cgcagcttgg gcagcttgtt cggccggatg atggcgcgga tttccttcat gacatgatct
     8581 ccagtaactc ttgggcgctc aggcctcgaa cggcttgtcg tcgaaccagg tgtacagcgc
     8641 cggcaccacc accagcgtca gcagcgtgca ggtgatcagg ccgccgatca ccacgatggc
     8701 cagcggccgc tgcacttcgg agcccggtcc ggtcgcgaac aggaaaggca ccagacccag
     8761 cagcgccacg gtggcggtca tcatgaccgg gcggaaacgc atcttcgcgc cctgcaccac
     8821 cgcctgcatc agctccatgc cctcgttgcg cagaccgcgg atgtaggaca ccagcaccac
     8881 gccgttcagc gtggcaatgc cccacagcgc gatgaagccc accgacgccg gcaccgacag
     8941 gtattcgccg ctgacgaaca ggccgatcac gccaccgatg gacgcgaacg gcagcacggt
     9001 gatgatgagg gtcgcgaaac gcagcgagcc gaacagcagg aacagcagga agaagatggc
     9061 cgcgatggtg atcggcacga tgatggacag gtggccgagc gcgcgctcca tgttctggaa
     9121 ctggccgccc cactcgaagt agtaagcctc gggcagctgc acctgcgcct tcaccttctg
     9181 ctgcagttcg gccacgaaac cgccgaggtc gcgattggcc acgttgatgc cgatcacgat
     9241 gcggcgcttg ccggtctcgc gcgaaatctg cgccggaccg tcgcgcacgt cgatggtggc
     9301 caggctggac agcggaatgc ccgcgccatc cggcgttggc accagcatgt tgcggatggc
     9361 ctcgatgttg tcgcggaagc gctcgggcag gcgcaccacc gcggcaaaac ggcgctcgcc
     9421 ctcgaacacg tcggtcacct gacgtccgcc gatggcggct tcgatcaggt cgttcacgtc
     9481 gccgacgttc aggccgtagc gggcgatggt cgggcggtcg atttccaccg tcaggtactg
     9541 ctggccggtc acccgctcga tcttgatttc gctcgcgccg ggcaccgcgc gcgccacccg
     9601 cgcgatctcg tccgccttgg ccttcagcag atcgaggtcg tcaccgaaaa tcttcaccgc
     9661 gacgtcagcc cgcaccccgg tcaccatttc gtcgacgcgg tcggaaatcg gctgcgccat
     9721 gatgatgttg acgccaggca gcgccttcag tttctcgcgg atctgttcct ggatggtttc
     9781 ctgggtccag ccctccggcc actcgtctcg cggcttcagc gacacgatgg gggtggactc
     9841 gttctgcgac tgcgggtcgg ccggcgattc gccgcggccg acgccggaca ccgccgattt
     9901 cacgcccggc acctccatca ccagccgcat cgcctcgcgc tccatgcgca gcgattcctg
     9961 cagcgaaatg ttgggcaccc ggtccatcgc cggcaccacc gaaccttcct tcatttccgg
    10021 aatgaaggcg gtaccgagga agggcagcag caggacggca ccgacgaagg cgccgacggc
    10081 cagcgccacc gtcttcctgg tgttcttcac cgcccactcc agcatcggca cgtagggctt
    10141 cttcagcatg cggataagcc aggtgtcatg atcggcaccg cccttgagca tgtaggaaca
    10201 cagcaccggc gtcagcgtga gcgacagcac cagcgacacg ccgagcgcga tggcgatggt
    10261 gtaggccagc ggcgcgaaca tcttgccttc catgccctgc agcgtcatca gcggcaggaa
    10321 caccaggatg atgatgccga taccgaagat gaccggcgtc gccacttcca tcaccgcgga
    10381 caggatgatg cggatgcggc tcgcaccctc ctcctgcgcg tgacccagac gctcgaaggc
    10441 gttctccacc accaccaccg aaccatccac catcaggccg atggcgatgg ccagaccgcc
    10501 cagcgacatc aggttggcgg acagaccgat ctggttcatg aacatgaagg tgaccagcgg
    10561 cgtgatgacc agcgtggcaa tcacgatgac cgacgaccgc aggtcgccga ggaagaggta
    10621 gagcacgatg acgacgaaga tgacgccttc gatcagcacc ttgatcacag tggccagcgc
    10681 ggcgtcgacc agttccgagc ggtcgtagta ggcctcaatc ttcaggccgc cgggcagcat
    10741 gttgttgtcg ttgatctcgg ccaccttcct cttgatgtcc gacaccaccg ccttggcatt
    10801 gccgcccgcc atcatcatca ccacgccgcc gaccgcttcg gtg
//
